Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 74


Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.

Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VL, Souza AS, Guimarães ALA, Bellio M, Marcondes de Souza J, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST.

Nat Commun. 2019 Sep 5;10(1):3890. doi: 10.1038/s41467-019-11866-7.


Dynamics of Zika Virus Capsid Protein in Solution: The Properties and Exposure of the Hydrophobic Cleft Are Controlled by the α-Helix 1 Sequence.

Morando MA, Barbosa GM, Cruz-Oliveira C, Da Poian AT, Almeida FCL.

Biochemistry. 2019 May 21;58(20):2488-2498. doi: 10.1021/acs.biochem.9b00194. Epub 2019 May 6.


Fast NMR method to probe solvent accessibility and disordered regions in proteins.

Faustino AF, Barbosa GM, Silva M, Castanho MARB, Da Poian AT, Cabrita EJ, Santos NC, Almeida FCL, Martins IC.

Sci Rep. 2019 Feb 7;9(1):1647. doi: 10.1038/s41598-018-37599-z.


Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope.

Neris RLS, Figueiredo CM, Higa LM, Araujo DF, Carvalho CAM, Verçoza BRF, Silva MOL, Carneiro FA, Tanuri A, Gomes AMO, Bozza MT, Da Poian AT, Cruz-Oliveira C, Assunção-Miranda I.

Sci Rep. 2018 Jun 28;8(1):9805. doi: 10.1038/s41598-018-27855-7.


Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaar2749. doi: 10.1126/scitranslmed.aar2749.


Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.

Kavanagh Williamson M, Coombes N, Juszczak F, Athanasopoulos M, Khan MB, Eykyn TR, Srenathan U, Taams LS, Dias Zeidler J, Da Poian AT, Huthoff H.

Viruses. 2018 Mar 7;10(3). pii: E114. doi: 10.3390/v10030114.


Anaplerotic Role of Glucose in the Oxidation of Endogenous Fatty Acids during Dengue Virus Infection.

Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT.

mSphere. 2018 Jan 31;3(1). pii: e00458-17. doi: 10.1128/mSphere.00458-17. eCollection 2018 Jan-Feb.


Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells.

Hegedus A, Kavanagh Williamson M, Khan MB, Dias Zeidler J, Da Poian AT, El-Bacha T, Struys EA, Huthoff H.

AIDS Res Hum Retroviruses. 2017 Dec;33(12):1236-1247. doi: 10.1089/AID.2017.0165. Epub 2017 Oct 4.


Metabolomic Analysis Reveals Vitamin D-induced Decrease in Polyol Pathway and Subtle Modulation of Glycolysis in HEK293T Cells.

Santos GC, Zeidler JD, Pérez-Valencia JA, Sant'Anna-Silva ACB, Da Poian AT, El-Bacha T, Almeida FCL.

Sci Rep. 2017 Aug 25;7(1):9510. doi: 10.1038/s41598-017-10006-9.


Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria.

Zeidler JD, Fernandes-Siqueira LO, Carvalho AS, Cararo-Lopes E, Dias MH, Ketzer LA, Galina A, Da Poian AT.

J Biol Chem. 2017 Aug 25;292(34):14176-14187. doi: 10.1074/jbc.M117.786582. Epub 2017 Jun 29.


Development of standard methods for Zika virus propagation, titration, and purification.

Coelho SVA, Neris RLS, Papa MP, Schnellrath LC, Meuren LM, Tschoeke DA, Leomil L, Verçoza BRF, Miranda M, Thompson FL, Da Poian AT, Souza TML, Carneiro FA, Damaso CR, Assunção-Miranda I, de Arruda LB.

J Virol Methods. 2017 Aug;246:65-74. doi: 10.1016/j.jviromet.2017.04.011. Epub 2017 Apr 23.


Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.

Cruz-Oliveira C, Almeida AF, Freire JM, Caruso MB, Morando MA, Ferreira VNS, Assunção-Miranda I, Gomes AMO, Castanho MARB, Da Poian AT.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00053-17. doi: 10.1128/AAC.00053-17. Print 2017 Jun.


Non-Canonical Roles of Dengue Virus Non-Structural Proteins.

Zeidler JD, Fernandes-Siqueira LO, Barbosa GM, Da Poian AT.

Viruses. 2017 Mar 13;9(3). pii: E42. doi: 10.3390/v9030042. Review.


Proteomic analysis of the secretome of HepG2 cells indicates differential proteolytic processing after infection with dengue virus.

Caruso MB, Trugilho MR, Higa LM, Teixeira-Ferreira AS, Perales J, Da Poian AT, Zingali RB.

J Proteomics. 2017 Jan 16;151:106-113. doi: 10.1016/j.jprot.2016.07.011. Epub 2016 Jul 15.


1H Nuclear Magnetic Resonance Metabolomics of Plasma Unveils Liver Dysfunction in Dengue Patients.

El-Bacha T, Struchiner CJ, Cordeiro MT, Almeida FCL, Marques ET Jr, Da Poian AT.

J Virol. 2016 Jul 27;90(16):7429-7443. doi: 10.1128/JVI.00187-16. Print 2016 Aug 15.


Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX.

Assunção-Miranda I, Cruz-Oliveira C, Neris RL, Figueiredo CM, Pereira LP, Rodrigues D, Araujo DF, Da Poian AT, Bozza MT.

J Appl Microbiol. 2016 Mar;120(3):790-804. doi: 10.1111/jam.13038.


Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection.

Freire JM, Santos NC, Veiga AS, Da Poian AT, Castanho MA.

FEBS J. 2015 Jun;282(12):2267-78. doi: 10.1111/febs.13274. Epub 2015 Apr 11. Review.


Receptors and routes of dengue virus entry into the host cells.

Cruz-Oliveira C, Freire JM, Conceição TM, Higa LM, Castanho MA, Da Poian AT.

FEMS Microbiol Rev. 2015 Mar;39(2):155-70. doi: 10.1093/femsre/fuu004. Epub 2014 Dec 22. Review.


Understanding dengue virus capsid protein disordered N-Terminus and pep14-23-based inhibition.

Faustino AF, Guerra GM, Huber RG, Hollmann A, Domingues MM, Barbosa GM, Enguita FJ, Bond PJ, Castanho MA, Da Poian AT, Almeida FC, Santos NC, Martins IC.

ACS Chem Biol. 2015 Feb 20;10(2):517-26. doi: 10.1021/cb500640t. Epub 2014 Nov 20.


Modulation of α-enolase post-translational modifications by dengue virus: increased secretion of the basic isoforms in infected hepatic cells.

Higa LM, Curi BM, Aguiar RS, Cardoso CC, De Lorenzi AG, Sena SL, Zingali RB, Da Poian AT.

PLoS One. 2014 Aug 29;9(8):e88314. doi: 10.1371/journal.pone.0088314. eCollection 2014.


Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein.

Freire JM, Veiga AS, Conceição TM, Kowalczyk W, Mohana-Borges R, Andreu D, Santos NC, Da Poian AT, Castanho MA.

PLoS One. 2013 Dec 5;8(12):e81450. doi: 10.1371/journal.pone.0081450. eCollection 2013.


Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action.

Freire JM, Veiga AS, Rego de Figueiredo I, de la Torre BG, Santos NC, Andreu D, Da Poian AT, Castanho MA.

FEBS J. 2014 Jan;281(1):191-215. doi: 10.1111/febs.12587. Epub 2013 Nov 28.


Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis.

Assunção-Miranda I, Cruz-Oliveira C, Da Poian AT.

Biomed Res Int. 2013;2013:973516. doi: 10.1155/2013/973516. Epub 2013 Aug 28. Review.


Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation.

Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT.

Blood. 2013 Nov 14;122(20):3405-14. doi: 10.1182/blood-2013-05-504449. Epub 2013 Sep 5.


Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid.

Freire JM, Veiga AS, de la Torre BG, Santos NC, Andreu D, Da Poian AT, Castanho MA.

Biopolymers. 2013 Jul;100(4):325-36. doi: 10.1002/bip.22266.


Dengue virus capsid protein interacts specifically with very low-density lipoproteins.

Faustino AF, Carvalho FA, Martins IC, Castanho MA, Mohana-Borges R, Almeida FC, Da Poian AT, Santos NC.

Nanomedicine. 2014 Jan;10(1):247-55. doi: 10.1016/j.nano.2013.06.004. Epub 2013 Jun 20.


IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection.

Guabiraba R, Besnard AG, Marques RE, Maillet I, Fagundes CT, Conceição TM, Rust NM, Charreau S, Paris I, Lecron JC, Renauld JC, Quesniaux V, Da Poian AT, Arruda LB, Souza DG, Ryffel B, Teixeira MM.

Eur J Immunol. 2013 Jun;43(6):1529-44. doi: 10.1002/eji.201243229. Epub 2013 Apr 17.


Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases.

Hottz ED, Oliveira MF, Nunes PC, Nogueira RM, Valls-de-Souza R, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza PT, Bozza FA.

J Thromb Haemost. 2013 May;11(5):951-62. doi: 10.1111/jth.12178.


Essential role of RIG-I in the activation of endothelial cells by dengue virus.

da Conceição TM, Rust NM, Berbel AC, Martins NB, do Nascimento Santos CA, Da Poian AT, de Arruda LB.

Virology. 2013 Jan 20;435(2):281-92. doi: 10.1016/j.virol.2012.09.038. Epub 2012 Oct 22.


Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy.

El-Bacha T, Da Poian AT.

Int J Biochem Cell Biol. 2013 Jan;45(1):41-6. doi: 10.1016/j.biocel.2012.09.021. Epub 2012 Oct 2. Review.


Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death.

Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T.

PLoS One. 2012;7(4):e33871. doi: 10.1371/journal.pone.0033871. Epub 2012 Apr 2.


The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif.

Martins IC, Gomes-Neto F, Faustino AF, Carvalho FA, Carneiro FA, Bozza PT, Mohana-Borges R, Castanho MA, Almeida FC, Santos NC, Da Poian AT.

Biochem J. 2012 Jun 15;444(3):405-15. doi: 10.1042/BJ20112219.


Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins.

Carvalho FA, Carneiro FA, Martins IC, Assunção-Miranda I, Faustino AF, Pereira RM, Bozza PT, Castanho MA, Mohana-Borges R, Da Poian AT, Santos NC.

J Virol. 2012 Feb;86(4):2096-108. doi: 10.1128/JVI.06796-11. Epub 2011 Nov 30.


Teaching energy metabolism using scientific articles: Implementation of a virtual learning environment for medical students.

de Espíndola MB, El-Bacha T, Giannella TR, Struchiner M, da Silva WS, Da Poian AT.

Biochem Mol Biol Educ. 2010 Mar;38(2):97-103. doi: 10.1002/bmb.20386.


Pro-inflammatory response resulting from sindbis virus infection of human macrophages: implications for the pathogenesis of viral arthritis.

Assunção-Miranda I, Bozza MT, Da Poian AT.

J Med Virol. 2010 Jan;82(1):164-74. doi: 10.1002/jmv.21649.


Dengue virus-induced regulation of the host cell translational machinery.

Villas-Bôas CS, Conceição TM, Ramírez J, Santoro AB, Da Poian AT, Montero-Lomelí M.

Braz J Med Biol Res. 2009 Nov;42(11):1020-6. doi: 10.1590/S0100-879X2009001100004.


Dengue virus capsid protein usurps lipid droplets for viral particle formation.

Samsa MM, Mondotte JA, Iglesias NG, Assunção-Miranda I, Barbosa-Lima G, Da Poian AT, Bozza PT, Gamarnik AV.

PLoS Pathog. 2009 Oct;5(10):e1000632. doi: 10.1371/journal.ppat.1000632. Epub 2009 Oct 23.


Gene expression analysis during dengue virus infection in HepG2 cells reveals virus control of innate immune response.

Conceição TM, El-Bacha T, Villas-Bôas CS, Coello G, Ramírez J, Montero-Lomeli M, Da Poian AT.

J Infect. 2010 Jan;60(1):65-75. doi: 10.1016/j.jinf.2009.10.003. Epub 2009 Nov 5. Erratum in: J Infect. 2010 Oct;61(4):360.


A real-time PCR procedure for detection of dengue virus serotypes 1, 2, and 3, and their quantitation in clinical and laboratory samples.

Conceição TM, Da Poian AT, Sorgine MH.

J Virol Methods. 2010 Jan;163(1):1-9. doi: 10.1016/j.jviromet.2009.10.001. Epub 2009 Oct 12. Review.


Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection.

Assunção-Miranda I, Amaral FA, Bozza FA, Fagundes CT, Sousa LP, Souza DG, Pacheco P, Barbosa-Lima G, Gomes RN, Bozza PT, Da Poian AT, Teixeira MM, Bozza MT.

FASEB J. 2010 Jan;24(1):218-28. doi: 10.1096/fj.09-139469. Epub 2009 Sep 23.


Interaction of the Dengue virus fusion peptide with membranes assessed by NMR: The essential role of the envelope protein Trp101 for membrane fusion.

Melo MN, Sousa FJ, Carneiro FA, Castanho MA, Valente AP, Almeida FC, Da Poian AT, Mohana-Borges R.

J Mol Biol. 2009 Sep 25;392(3):736-46. doi: 10.1016/j.jmb.2009.07.035. Epub 2009 Jul 17.


Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate.

Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Poian AT, Galina A.

Biochem J. 2009 Feb 1;417(3):717-26. doi: 10.1042/BJ20080805.


Secretome of HepG2 cells infected with dengue virus: implications for pathogenesis.

Higa LM, Caruso MB, Canellas F, Soares MR, Oliveira-Carvalho AL, Chapeaurouge DA, Almeida PM, Perales J, Zingali RB, Da Poian AT.

Biochim Biophys Acta. 2008 Nov;1784(11):1607-16. doi: 10.1016/j.bbapap.2008.06.015. Epub 2008 Jun 28.


Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering.

Stauffer F, Melo MN, Carneiro FA, Sousa FJ, Juliano MA, Juliano L, Mohana-Borges R, Da Poian AT, Castanho MA.

Mol Membr Biol. 2008 Feb;25(2):128-38. doi: 10.1080/09687680701633091.


Advances in the development of inactivated virus vaccines.

Stauffer F, El-Bacha T, Da Poian AT.

Recent Pat Antiinfect Drug Discov. 2006 Nov;1(3):291-6. Review.


A minor beta-structured conformation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein.

Sarzedas CG, Lima CS, Juliano MA, Juliano L, Valente AP, Da Poian AT, Almeida FC.

J Pept Sci. 2008 Apr;14(4):429-35.


Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus.

El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT.

Biochim Biophys Acta. 2007 Oct;1772(10):1158-66. Epub 2007 Sep 15.

Supplemental Content

Loading ...
Support Center