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Items: 47


Physician and patient tools to improve chronic kidney disease care.

Sequist TD, Holliday AM, Orav EJ, Bates DW, Denker BM.

Am J Manag Care. 2018 Apr 1;24(4):e107-e114.


Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.

Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J, Denker BM, Kong T.

J Cell Sci. 2016 Oct 1;129(19):3675-3684. Epub 2016 Aug 5.


Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury.

Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L.

Am J Pathol. 2015 May;185(5):1207-15. doi: 10.1016/j.ajpath.2015.02.003. Epub 2015 Mar 7.


Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells.

Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T.

Physiol Genomics. 2015 Feb;47(2):24-32. doi: 10.1152/physiolgenomics.00090.2014. Epub 2014 Dec 9.


Developmental upregulation of an alternative form of pcp2 with reduced GDI activity.

Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M.

Cerebellum. 2014 Apr;13(2):207-14. doi: 10.1007/s12311-013-0529-0.


H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury.

Yu W, Beaudry S, Negoro H, Boucher I, Tran M, Kong T, Denker BM.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6680-5. doi: 10.1073/pnas.1116800109. Epub 2012 Apr 9.


Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis.

Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak MR, Henderson JM, Denker BM.

Lab Invest. 2012 May;92(5):662-75. doi: 10.1038/labinvest.2011.198. Epub 2012 Jan 16.


The biology of epithelial cell tight junctions in the kidney.

Denker BM, Sabath E.

J Am Soc Nephrol. 2011 Apr;22(4):622-5. doi: 10.1681/ASN.2010090922. Epub 2011 Mar 17.


Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

Dowal L, Sim DS, Dilks JR, Blair P, Beaudry S, Denker BM, Koukos G, Kuliopulos A, Flaumenhaft R.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2951-6. doi: 10.1073/pnas.1014863108. Epub 2011 Jan 31.


Primary care management of chronic kidney disease.

Allen AS, Forman JP, Orav EJ, Bates DW, Denker BM, Sequist TD.

J Gen Intern Med. 2011 Apr;26(4):386-92. doi: 10.1007/s11606-010-1523-6. Epub 2010 Oct 5.


Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis.

Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM.

Cell Signal. 2011 Jan;23(1):213-21. doi: 10.1016/j.cellsig.2010.09.005. Epub 2010 Sep 17.


Regulation of integrin expression by Gα12: An additional potential mechanism modulating cell attachment.

Kong T, Xu D, Tran M, Denker BM.

Cell Adh Migr. 2010 Jul-Sep;4(3):372-6. Epub 2010 Jul 1.


Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway.

Yu W, Kong T, Beaudry S, Tran M, Negoro H, Yanamadala V, Denker BM.

J Biol Chem. 2010 Apr 2;285(14):10243-51. doi: 10.1074/jbc.M109.070821. Epub 2010 Jan 27.


G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.

Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM.

Mol Biol Cell. 2009 Nov;20(21):4596-610. doi: 10.1091/mbc.E09-03-0220. Epub 2009 Sep 23.


Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.

Sabath E, Negoro H, Beaudry S, Paniagua M, Angelow S, Shah J, Grammatikakis N, Yu AS, Denker BM.

J Cell Sci. 2008 Mar 15;121(Pt 6):814-24. doi: 10.1242/jcs.014878. Epub 2008 Feb 19.


Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS).

Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR.

Gene. 2008 Feb 29;410(1):44-52. doi: 10.1016/j.gene.2007.11.014. Epub 2007 Dec 3.


Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity.

Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16080-5. Epub 2007 Sep 27.


Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.

Yanamadala V, Negoro H, Gunaratnam L, Kong T, Denker BM.

J Biol Chem. 2007 Aug 17;282(33):24352-63. Epub 2007 Jun 12.


Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?

Zhu D, Tate RI, Ruediger R, Meigs TE, Denker BM.

Mol Pharmacol. 2007 May;71(5):1268-76. Epub 2007 Feb 15.


Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM.

J Biol Chem. 2004 Dec 31;279(53):54983-6. Epub 2004 Nov 3.


Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein.

Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, Pollak MR.

PLoS Biol. 2004 Jun;2(6):e167. Epub 2004 Jun 15.


Polycystin-1L2 is a novel G-protein-binding protein.

Yuasa T, Takakura A, Denker BM, Venugopal B, Zhou J.

Genomics. 2004 Jul;84(1):126-38.


Galpha12 regulates epithelial cell junctions through Src tyrosine kinases.

Meyer TN, Hunt J, Schwesinger C, Denker BM.

Am J Physiol Cell Physiol. 2003 Nov;285(5):C1281-93. Epub 2003 Jul 30.


Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellum.

Redd KJ, Oberdick J, McCoy J, Denker BM, Luo Y.

J Neurosci Res. 2002 Dec 1;70(5):631-7.


Expanding role of G proteins in tight junction regulation: Galpha(s) stimulates TJ assembly.

Saha C, Nigam SK, Denker BM.

Biochem Biophys Res Commun. 2001 Jul 13;285(2):250-6.


Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity.

Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK.

J Biol Chem. 2001 Jun 22;276(25):22048-55. Epub 2001 Apr 9.


Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions.

Saha C, Nigam SK, Denker BM.

J Biol Chem. 1998 Aug 21;273(34):21629-33.


Molecular structure and assembly of the tight junction.

Denker BM, Nigam SK.

Am J Physiol. 1998 Jan;274(1):F1-9. doi: 10.1152/ajprenal.1998.274.1.F1. Review.


Analysis of the N-terminal binding domain of Go alpha.

Busconi L, Denker BM.

Biochem J. 1997 Nov 15;328 ( Pt 1):23-31.


Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis.

Denker BM, Saha C, Khawaja S, Nigam SK.

J Biol Chem. 1996 Oct 18;271(42):25750-3.


Analysis of G-protein alpha and beta gamma subunits by in vitro translation.

Neer EJ, Denker BM, Thomas TC, Schmidt CJ.

Methods Enzymol. 1994;237:226-39. No abstract available.


Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus.

Denker BM, Schmidt CJ, Neer EJ.

J Biol Chem. 1992 May 15;267(14):9998-10002.


Characterization of a mastoparan-stimulated nucleotidase from bovine brain.

Denker BM, Tempst P, Neer EJ.

Biochem J. 1991 Sep 1;278 ( Pt 2):341-5.


Structural and functional studies of cross-linked Go protein subunits.

Yi F, Denker BM, Neer EJ.

J Biol Chem. 1991 Feb 25;266(6):3900-6.


GO associates with another 40 kDa brain protein.

Denker BM, Neer EJ.

FEBS Lett. 1991 Feb 11;279(1):98-100.


Isolation of proteins related to the Rh polypeptides from nonhuman erythrocytes.

Saboori AM, Denker BM, Agre P.

J Clin Invest. 1989 Jan;83(1):187-91.


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