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Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.


Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

Schanstra JP, Luong TT, Makridakis M, Van Linthout S, Lygirou V, Latosinska A, Alesutan I, Boehme B, Schelski N, Von Lewinski D, Mullen W, Nicklin S, Delles C, Feuillet G, Denis C, Lang F, Pieske B, Bascands JL, Mischak H, Saulnier-Blache JS, Voelkl J, Vlahou A, Klein J.

JCI Insight. 2019 May 16;4(10). pii: 125638. doi: 10.1172/jci.insight.125638. eCollection 2019 May 16.


Vascular biomedicine in an era of chronic disease and multimorbidity.

Currie G, Delles C.

Clin Sci (Lond). 2019 May 14;133(9):1137-1143. doi: 10.1042/CS20180764. Print 2019 May 15. Review.


Urinary Sodium Excretion, Blood Pressure, and Risk of Future Cardiovascular Disease and Mortality in Subjects Without Prior Cardiovascular Disease.

Welsh CE, Welsh P, Jhund P, Delles C, Celis-Morales C, Lewsey JD, Gray S, Lyall D, Iliodromiti S, Gill JMR, Sattar N, Mark PB.

Hypertension. 2019 Jun;73(6):1202-1209. doi: 10.1161/HYPERTENSIONAHA.119.12726.


Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp.

Small HY, McNeilly S, Mary S, Sheikh AM, Delles C.

Sci Rep. 2019 May 3;9(1):6897. doi: 10.1038/s41598-019-43326-z.


Optimizing observer performance of clinic blood pressure measurement: a position statement from the Lancet Commission on Hypertension Group.

Padwal R, Campbell NRC, Schutte AE, Olsen MH, Delles C, Etyang A, Cruickshank JK, Stergiou G, Rakotz MK, Wozniak G, Jaffe MG, Benjamin I, Parati G, Sharman JE.

J Hypertens. 2019 Apr 23. doi: 10.1097/HJH.0000000000002112. [Epub ahead of print]


Response to the letter regarding the hypothesis paper "Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema".

Rossitto G, Touyz RM, Petrie MC, Delles C.

Clin Sci (Lond). 2019 Mar 19;133(6):761. doi: 10.1042/CS20190154. Print 2019 Mar 29.


The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

Schutte AE, Gona PN, Delles C, Uys AS, Burger A, Mels CM, Kruger R, Smith W, Fourie CM, Botha S, Lammertyn L, van Rooyen JM, Gafane-Matemane LF, Mokwatsi GG, Breet Y, Kruger HS, Zyl TV, Pieters M, Zandberg L, Louw R, Moss SJ, Khumalo IP, Huisman HW.

Eur J Prev Cardiol. 2019 Mar;26(5):458-470. doi: 10.1177/2047487318822354. Epub 2019 Jan 6.


Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation.

Lucas-Herald AK, Zürbig P, Mason A, Kinning E, Brown CE, Mansoorian B, Mullen W, Ahmed SF, Delles C.

Proteomics Clin Appl. 2019 Mar;13(2):e1800135. doi: 10.1002/prca.201800135. Epub 2018 Dec 27.


Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema.

Rossitto G, Touyz RM, Petrie MC, Delles C.

Clin Sci (Lond). 2018 Dec 13;132(24):2609-2613. doi: 10.1042/CS20180575. Print 2018 Dec 21. Review.


Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood IY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Davey Smith G, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499-2512. doi: 10.1161/CIRCULATIONAHA.118.034942. Epub 2018 Aug 15.


Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood LY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Smith GD, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499–2512.


Development of the certificate course in the management of hypertension in Africa (CCMH-Africa): proceedings of the first continental faculty meeting, Nairobi, Kenya, 25-26 February 2018.

Dzudie A, Ojji D, Damasceno A, Sani MU, Kramoh E, Kacou JB, Anisiuba B, Ogola E, Awad M, Nel G, Otieno H, Toure AI, Kane A, Kengne AP, Ngwasiri C, Ba H, Kingue S, Mipinda B, Mbolla BE, Weldehana A, Bukachi F, Gitura B, Kitio B, Rayner B, Shutte AE, Mocumbi AO, Mayosi B, Jose A, Sandeep B, Weber M, Delles C, Cappuccio F, Gamra H, Prabhakaran D, Poulter N, Subhani S; PASCAR task force on hypertension.

Cardiovasc J Afr. 2018 Sep/Oct;29(5):331-334. doi: 10.5830/CVJA-2018-055.


Ascorbic acid lowers central blood pressure and asymmetric dimethylarginine in chronic kidney disease.

Gillis K, Stevens KK, Bell E, Patel RK, Jardine AG, Morris STW, Schneider MP, Delles C, Mark PB.

Clin Kidney J. 2018 Aug;11(4):532-539. doi: 10.1093/ckj/sfx158. Epub 2018 Feb 6.


Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study.

Kerr DMI, Brooksbank KJM, Taylor RG, Pinel K, Rios FJ, Touyz RM, Delles C.

J Hypertens. 2019 Jan;37(1):154-166. doi: 10.1097/HJH.0000000000001890.


Ldlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.

Saulnier-Blache JS, Wilson R, Klavins K, Graham D, Alesutan I, Kastenmüller G, Wang-Sattler R, Adamski J, Roden M, Rathmann W, Seissler J, Meisinger C, Koenig W, Thiery J, Suhre K, Peters A, Kuro-O M, Lang F, Dallmann G, Delles C, Voelkl J, Waldenberger M, Bascands JL, Klein J, Schanstra JP.

Atherosclerosis. 2018 Sep;276:140-147. doi: 10.1016/j.atherosclerosis.2018.07.024. Epub 2018 Jul 21.


Precision Medicine and Personalized Medicine in Cardiovascular Disease.

Currie G, Delles C.

Adv Exp Med Biol. 2018;1065:589-605. doi: 10.1007/978-3-319-77932-4_36. Review.


Utilizing proteomics to understand and define hypertension: where are we and where do we go?

Delles C, Carrick E, Graham D, Nicklin SA.

Expert Rev Proteomics. 2018 Jul;15(7):581-592. doi: 10.1080/14789450.2018.1493927. Epub 2018 Jul 12. Review.


Circulating MicroRNAs Implicate Multiple Atherogenic Abnormalities in the Long-Term Cardiovascular Sequelae of Preeclampsia.

Dayan N, Schlosser K, Stewart DJ, Delles C, Kaur A, Pilote L.

Am J Hypertens. 2018 Sep 11;31(10):1093-1097. doi: 10.1093/ajh/hpy069.


Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes.

Tofte N, Lindhardt M, Adamova K, Beige J, Beulens JWJ, Birkenfeld AL, Currie G, Delles C, Dimos I, Francová L, Frimodt-Møller M, Girman P, Göke R, Havrdova T, Kooy A, Mischak H, Navis G, Nijpels G, Noutsou M, Ortiz A, Parvanova A, Persson F, Ruggenenti PL, Rutters F, Rychlík I, Spasovski G, Speeckaert M, Trillini M, von der Leyen H, Rossing P.

Diabet Med. 2018 Oct;35(10):1375-1382. doi: 10.1111/dme.13669. Epub 2018 Jun 6.


Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial.

Ravassa S, Trippel T, Bach D, Bachran D, González A, López B, Wachter R, Hasenfuss G, Delles C, Dominiczak AF, Pieske B, Díez J, Edelmann F.

Eur J Heart Fail. 2018 Sep;20(9):1290-1299. doi: 10.1002/ejhf.1194. Epub 2018 Apr 30.


Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.

Lygirou V, Latosinska A, Makridakis M, Mullen W, Delles C, Schanstra JP, Zoidakis J, Pieske B, Mischak H, Vlahou A.

J Transl Med. 2018 Apr 17;16(1):104. doi: 10.1186/s12967-018-1476-9.


Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria.

Currie GE, von Scholten BJ, Mary S, Flores Guerrero JL, Lindhardt M, Reinhard H, Jacobsen PK, Mullen W, Parving HH, Mischak H, Rossing P, Delles C.

Cardiovasc Diabetol. 2018 Apr 6;17(1):50. doi: 10.1186/s12933-018-0697-9.


Blood pressure targets in the elderly.

Currie G, Delles C.

J Hypertens. 2018 Feb;36(2):234-236. doi: 10.1097/HJH.0000000000001576. No abstract available.


Sex differences in hypertension and other cardiovascular diseases.

Delles C, Currie G.

J Hypertens. 2018 Apr;36(4):768-770. doi: 10.1097/HJH.0000000000001655. No abstract available.


Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997.

Delles C, Rankin NJ, Boachie C, McConnachie A, Ford I, Kangas A, Soininen P, Trompet S, Mooijaart SP, Jukema JW, Zannad F, Ala-Korpela M, Salomaa V, Havulinna AS, Welsh P, Würtz P, Sattar N.

Eur J Heart Fail. 2018 Apr;20(4):663-673. doi: 10.1002/ejhf.1076. Epub 2017 Dec 11.


Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker.

Pontillo C, Zhang ZY, Schanstra JP, Jacobs L, Zürbig P, Thijs L, Ramírez-Torres A, Heerspink HJL, Lindhardt M, Klein R, Orchard T, Porta M, Bilous RW, Charturvedi N, Rossing P, Vlahou A, Schepers E, Glorieux G, Mullen W, Delles C, Verhamme P, Vanholder R, Staessen JA, Mischak H, Jankowski J.

Kidney Int Rep. 2017 Nov;2(6):1066-1075. doi: 10.1016/j.ekir.2017.06.004.


Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.

Krochmal M, Kontostathi G, Magalhães P, Makridakis M, Klein J, Husi H, Leierer J, Mayer G, Bascands JL, Denis C, Zoidakis J, Zürbig P, Delles C, Schanstra JP, Mischak H, Vlahou A.

Sci Rep. 2017 Nov 9;7(1):15160. doi: 10.1038/s41598-017-15359-9.


The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study.

Schmieder RE, Wagner F, Mayr M, Delles C, Ott C, Keicher C, Hrabak-Paar M, Heye T, Aichner S, Khder Y, Yates D, Albrecht D, Langenickel T, Freyhardt P, Janka R, Bremerich J.

Eur Heart J. 2017 Nov 21;38(44):3308-3317. doi: 10.1093/eurheartj/ehx525.


Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population.

Feng YM, Thijs L, Zhang ZY, Yang WY, Huang QF, Wei FF, Kuznetsova T, Jennings AM, Delles C, Lennox R, Verhamme P, Dominiczak A, Staessen JA.

Nephrol Dial Transplant. 2018 Mar 1;33(3):426-435. doi: 10.1093/ndt/gfx256.


Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.

Krochmal M, Cisek K, Filip S, Markoska K, Orange C, Zoidakis J, Gakiopoulou C, Spasovski G, Mischak H, Delles C, Vlahou A, Jankowski J.

Sci Rep. 2017 Aug 22;7(1):9091. doi: 10.1038/s41598-017-09393-w.


Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure.

Zhang ZY, Ravassa S, Nkuipou-Kenfack E, Yang WY, Kerr SM, Koeck T, Campbell A, Kuznetsova T, Mischak H, Padmanabhan S, Dominiczak AF, Delles C, Staessen JA.

J Am Heart Assoc. 2017 Aug 7;6(8). pii: e005432. doi: 10.1161/JAHA.116.005432.


Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: A population study.

Knez J, Marrachelli VG, Cauwenberghs N, Winckelmans E, Zhang Z, Thijs L, Brguljan-Hitij J, Plusquin M, Delles C, Monleon D, Redón J, Staessen JA, Nawrot TS, Kuznetsova T.

PLoS One. 2017 Jul 13;12(7):e0181036. doi: 10.1371/journal.pone.0181036. eCollection 2017.


Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma.

Gajjala PR, Jankowski V, Heinze G, Bilo G, Zanchetti A, Noels H, Liehn E, Perco P, Schulz A, Delles C, Kork F, Biessen E, Narkiewicz K, Kawecka-Jaszcz K, Floege J, Soranna D, Zidek W, Jankowski J.

Hypertension. 2017 Aug;70(2):412-419. doi: 10.1161/HYPERTENSIONAHA.116.08906. Epub 2017 Jun 26.


Healthy Vascular Aging.

Currie G, Delles C.

Hypertension. 2017 Aug;70(2):229-231. doi: 10.1161/HYPERTENSIONAHA.117.09122. Epub 2017 May 30. No abstract available.


Evaluation of the systemic micro- and macrovasculature in stable angina: A case-control study.

Neisius U, Olson E, Rossi SH, Ibrahim HA, Currie G, Dominiczak AF, Delles C.

PLoS One. 2017 May 25;12(5):e0178412. doi: 10.1371/journal.pone.0178412. eCollection 2017.


Vasoreactivity in CADASIL: Comparison to structural MRI and neuropsychology.

Moreton FC, Cullen B, Delles C, Santosh C, Gonzalez RL, Dani K, Muir KW.

J Cereb Blood Flow Metab. 2018 Jun;38(6):1085-1095. doi: 10.1177/0271678X17710375. Epub 2017 May 24.


Risk for Incident Heart Failure: A Subject-Level Meta-Analysis From the Heart "OMics" in AGEing (HOMAGE) Study.

Jacobs L, Efremov L, Ferreira JP, Thijs L, Yang WY, Zhang ZY, Latini R, Masson S, Agabiti N, Sever P, Delles C, Sattar N, Butler J, Cleland JGF, Kuznetsova T, Staessen JA, Zannad F; Heart “OMics” in AGEing (HOMAGE) investigators.

J Am Heart Assoc. 2017 May 2;6(5). pii: e005231. doi: 10.1161/JAHA.116.005231. Review.


Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.

Mary S, Small HY, Siwy J, Mullen W, Giri A, Delles C.

Hypertension. 2017 May;69(5):910-918. doi: 10.1161/HYPERTENSIONAHA.116.08826. Epub 2017 Mar 27.


Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy.

Small HY, Cornelius DC, Guzik TJ, Delles C.

Placenta. 2017 Aug;56:59-64. doi: 10.1016/j.placenta.2017.03.003. Epub 2017 Mar 7. Review.


Prediction of acute coronary syndromes by urinary proteome analysis.

Htun NM, Magliano DJ, Zhang ZY, Lyons J, Petit T, Nkuipou-Kenfack E, Ramirez-Torres A, von Zur Muhlen C, Maahs D, Schanstra JP, Pontillo C, Pejchinovski M, Snell-Bergeon JK, Delles C, Mischak H, Staessen JA, Shaw JE, Koeck T, Peter K.

PLoS One. 2017 Mar 8;12(3):e0172036. doi: 10.1371/journal.pone.0172036. eCollection 2017.


Genomics and Precision Medicine for Clinicians and Scientists in Hypertension.

Dominiczak A, Delles C, Padmanabhan S.

Hypertension. 2017 Apr;69(4):e10-e13. doi: 10.1161/HYPERTENSIONAHA.116.08252. Epub 2017 Feb 13. Review. No abstract available.


The Future of "Omics" in Hypertension.

Currie G, Delles C.

Can J Cardiol. 2017 May;33(5):601-610. doi: 10.1016/j.cjca.2016.11.023. Epub 2016 Dec 7. Review.


Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: Prevalence and subsequent outcomes.

Carty DM, Doogan F, Welsh P, Dominiczak AF, Delles C.

Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:366-369. doi: 10.1016/j.ejogrb.2017.01.048. Epub 2017 Jan 25.


HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia.

Small HY, Akehurst C, Sharafetdinova L, McBride MW, McClure JD, Robinson SW, Carty DM, Freeman DJ, Delles C.

Physiol Genomics. 2017 Mar 1;49(3):193-200. doi: 10.1152/physiolgenomics.00106.2016. Epub 2017 Jan 27.


Systems Biology Approach in Hypertension Research.

Delles C, Husi H.

Methods Mol Biol. 2017;1527:69-79. doi: 10.1007/978-1-4939-6625-7_6. Review.


Chronic kidney disease.

Delles C, Vanholder R.

Clin Sci (Lond). 2017 Feb 1;131(3):225-226. doi: 10.1042/CS20160624. No abstract available.


Diastolic Left Ventricular Function in Relation to Urinary and Serum Collagen Biomarkers in a General Population.

Zhang ZY, Ravassa S, Yang WY, Petit T, Pejchinovski M, Zürbig P, López B, Wei FF, Pontillo C, Thijs L, Jacobs L, González A, Koeck T, Delles C, Voigt JU, Verhamme P, Kuznetsova T, Díez J, Mischak H, Staessen JA.

PLoS One. 2016 Dec 13;11(12):e0167582. doi: 10.1371/journal.pone.0167582. eCollection 2016.


Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.

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