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Items: 1 to 50 of 184

1.

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice.

Ikpa PT, Doktorova M, Meijsen KF, Nieuwenhuijze NDA, Verkade HJ, Jonker JW, de Jonge HR, Bijvelds MJC.

Cell Mol Gastroenterol Hepatol. 2019 Aug 27. pii: S2352-345X(19)30112-2. doi: 10.1016/j.jcmgh.2019.08.006. [Epub ahead of print]

2.

NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells.

Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M.

Am J Physiol Cell Physiol. 2019 Jul 31. doi: 10.1152/ajpcell.00351.2018. [Epub ahead of print]

PMID:
31365292
3.

Assessing cell-specific effects of genetic variations using tRNA microarrays.

Polte C, Wedemeyer D, Oliver KE, Wagner J, Bijvelds MJC, Mahoney J, de Jonge HR, Sorscher EJ, Ignatova Z.

BMC Genomics. 2019 Jul 16;20(Suppl 8):549. doi: 10.1186/s12864-019-5864-1.

4.

Transcriptome analysis of the distal small intestine of Cftr null mice.

Ikpa PT, Meijsen KF, Nieuwenhuijze NDA, Dulla K, de Jonge HR, Bijvelds MJC.

Genomics. 2019 Jun 25. pii: S0888-7543(19)30298-8. doi: 10.1016/j.ygeno.2019.06.028. [Epub ahead of print]

5.

Mini-gut: a promising model for drug development.

Yin YB, de Jonge HR, Wu X, Yin YL.

Drug Discov Today. 2019 Jun 15. pii: S1359-6446(19)30025-X. doi: 10.1016/j.drudis.2019.06.006. [Epub ahead of print] Review.

PMID:
31212027
6.

Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR.

Bose SJ, Bijvelds MJC, Wang Y, Liu J, Cai Z, Bot AGM, de Jonge HR, Sheppard DN.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L71-L86. doi: 10.1152/ajplung.00034.2019. Epub 2019 Apr 10.

7.

Enteroids for Nutritional Studies.

Yin YB, de Jonge HR, Wu X, Yin YL.

Mol Nutr Food Res. 2019 Aug;63(16):e1801143. doi: 10.1002/mnfr.201801143. Epub 2019 Apr 10. Review.

PMID:
30883003
8.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis.

Berkers G, van Mourik P, Vonk AM, Kruisselbrink E, Dekkers JF, de Winter-de Groot KM, Arets HGM, Marck-van der Wilt REP, Dijkema JS, Vanderschuren MM, Houwen RHJ, Heijerman HGM, van de Graaf EA, Elias SG, Majoor CJ, Koppelman GH, Roukema J, Bakker M, Janssens HM, van der Meer R, Vries RGJ, Clevers HC, de Jonge HR, Beekman JM, van der Ent CK.

Cell Rep. 2019 Feb 12;26(7):1701-1708.e3. doi: 10.1016/j.celrep.2019.01.068.

9.

Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants.

van Willigen M, Vonk AM, Yeoh HY, Kruisselbrink E, Kleizen B, van der Ent CK, Egmond MR, de Jonge HR, Braakman I, Beekman JM, van der Sluijs P.

Life Sci Alliance. 2019 Jan 18;2(1). pii: e201800172. doi: 10.26508/lsa.201800172. Print 2019 Feb.

10.

IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation.

van de Peppel IP, Doktorova M, Berkers G, de Jonge HR, Houwen RHJ, Verkade HJ, Jonker JW, Bodewes FAJA.

J Cyst Fibros. 2019 Mar;18(2):286-293. doi: 10.1016/j.jcf.2018.09.001. Epub 2018 Sep 29.

PMID:
30279125
11.

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function.

de Winter-de Groot KM, Janssens HM, van Uum RT, Dekkers JF, Berkers G, Vonk A, Kruisselbrink E, Oppelaar H, Vries R, Clevers H, Houwen RHJ, Escher JC, Elias SG, de Jonge HR, de Rijke YB, Tiddens HAWM, van der Ent CK, Beekman JM.

Eur Respir J. 2018 Sep 17;52(3). pii: 1702529. doi: 10.1183/13993003.02529-2017. Print 2018 Sep.

PMID:
30166324
12.

Adenylyl cyclase 6 is involved in the hyposecretory status of experimental colitis.

Romero-Calvo I, Ocón B, Gámez-Belmonte R, Hernández-Chirlaque C, de Jonge HR, Bijvelds MJ, Martínez-Augustin O, Sánchez de Medina F.

Pflugers Arch. 2018 Nov;470(11):1705-1717. doi: 10.1007/s00424-018-2187-z. Epub 2018 Aug 9.

PMID:
30094477
13.

Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers.

Yin J, Tse CM, Avula LR, Singh V, Foulke-Abel J, de Jonge HR, Donowitz M.

Cell Mol Gastroenterol Hepatol. 2018 Feb 9;5(4):591-609. doi: 10.1016/j.jcmgh.2018.02.002. eCollection 2018.

14.

Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.

Bijvelds MJC, Tresadern G, Hellemans A, Smans K, Nieuwenhuijze NDA, Meijsen KF, Bongartz JP, Ver Donck L, de Jonge HR, Schuurkes JAJ, De Maeyer JH.

J Biol Chem. 2018 May 25;293(21):8173-8181. doi: 10.1074/jbc.RA118.002835. Epub 2018 Apr 13.

15.

Editorial overview: Respiratory: Transformational therapies for cystic fibrosis.

Sheppard DN, Bear CE, de Jonge HR.

Curr Opin Pharmacol. 2017 Jun;34:viii-xi. doi: 10.1016/j.coph.2017.11.006. No abstract available.

PMID:
29221574
16.

Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives.

Debray D, Narkewicz MR, Bodewes FAJA, Colombo C, Housset C, de Jonge HR, Jonker JW, Kelly DA, Ling SC, Poynard T, Sogni P, Trauner M, Witters P, Baumann U, Wilschanski M, Verkade HJ.

J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):443-448. doi: 10.1097/MPG.0000000000001676.

PMID:
28753176
17.

β2-Adrenergic receptor agonists activate CFTR in intestinal organoids and subjects with cystic fibrosis.

Vijftigschild LA, Berkers G, Dekkers JF, Zomer-van Ommen DD, Matthes E, Kruisselbrink E, Vonk A, Hensen CE, Heida-Michel S, Geerdink M, Janssens HM, van de Graaf EA, Bronsveld I, de Winter-de Groot KM, Majoor CJ, Heijerman HG, de Jonge HR, Hanrahan JW, van der Ent CK, Beekman JM.

Eur Respir J. 2016 Sep;48(3):768-79. doi: 10.1183/13993003.01661-2015. Epub 2016 Jul 28.

18.

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.

Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, Janssens HM, Bronsveld I, van de Graaf EA, Nieuwenhuis EE, Houwen RH, Vleggaar FP, Escher JC, de Rijke YB, Majoor CJ, Heijerman HG, de Winter-de Groot KM, Clevers H, van der Ent CK, Beekman JM.

Sci Transl Med. 2016 Jun 22;8(344):344ra84. doi: 10.1126/scitranslmed.aad8278.

PMID:
27334259
19.

The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.

van der Mark VA, de Jonge HR, Chang JC, Ho-Mok KS, Duijst S, Vidović D, Carlon MS, Oude Elferink RP, Paulusma CC.

Biochim Biophys Acta. 2016 Sep;1863(9):2280-8. doi: 10.1016/j.bbamcr.2016.06.005. Epub 2016 Jun 11.

20.

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.

Ikpa PT, Sleddens HF, Steinbrecher KA, Peppelenbosch MP, de Jonge HR, Smits R, Bijvelds MJ.

Histochem Cell Biol. 2016 Oct;146(4):445-55. doi: 10.1007/s00418-016-1453-4. Epub 2016 May 31.

21.

Potentiator synergy in rectal organoids carrying S1251N, G551D, or F508del CFTR mutations.

Dekkers JF, Van Mourik P, Vonk AM, Kruisselbrink E, Berkers G, de Winter-de Groot KM, Janssens HM, Bronsveld I, van der Ent CK, de Jonge HR, Beekman JM.

J Cyst Fibros. 2016 Sep;15(5):568-78. doi: 10.1016/j.jcf.2016.04.007. Epub 2016 May 5.

22.

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M.

J Biol Chem. 2016 Feb 19;291(8):3759-66. doi: 10.1074/jbc.R114.635995. Epub 2015 Dec 16. Review.

23.

Value of Organoids from Comparative Epithelia Models.

Schwarz JS, de Jonge HR, Forrest JN Jr.

Yale J Biol Med. 2015 Nov 24;88(4):367-74. eCollection 2015 Dec. Review.

24.

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

Vidović D, Carlon MS, da Cunha MF, Dekkers JF, Hollenhorst MI, Bijvelds MJ, Ramalho AS, Van den Haute C, Ferrante M, Baekelandt V, Janssens HM, De Boeck K, Sermet-Gaudelus I, de Jonge HR, Gijsbers R, Beekman JM, Edelman A, Debyser Z.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):288-98. doi: 10.1164/rccm.201505-0914OC.

PMID:
26509335
25.

ANP and CNP activate CFTR expressed in Xenopus laevis oocytes by direct activation of PKA.

Stahl K, Stahl M, de Jonge HR, Forrest JN Jr.

J Recept Signal Transduct Res. 2015;35(5):493-504. doi: 10.3109/10799893.2015.1015738. Epub 2015 May 27.

PMID:
26016495
26.

Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors.

Bijvelds MJ, Loos M, Bronsveld I, Hellemans A, Bongartz JP, Ver Donck L, Cox E, de Jonge HR, Schuurkes JA, De Maeyer JH.

J Infect Dis. 2015 Dec 1;212(11):1806-15. doi: 10.1093/infdis/jiv300. Epub 2015 May 21.

PMID:
25999056
27.

Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, Woodrooffe K, Schuetz JD, Valasani KR, de Jonge HR, Shanmukhappa SK, Shata MT, Buddington RK, Parthasarathi K, Naren AP.

J Biol Chem. 2015 May 1;290(18):11246-57. doi: 10.1074/jbc.M114.605410. Epub 2015 Mar 11.

28.

Cholic acid induces a Cftr dependent biliary secretion and liver growth response in mice.

Bodewes FA, Bijvelds MJ, de Vries W, Baller JF, Gouw AS, de Jonge HR, Verkade HJ.

PLoS One. 2015 Feb 13;10(2):e0117599. doi: 10.1371/journal.pone.0117599. eCollection 2015.

29.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M.

Stem Cell Res Ther. 2013;4 Suppl 1:S3. doi: 10.1186/scrt364. Epub 2013 Dec 20. Review.

30.

Cystic fibrosis: toward personalized therapies.

Ikpa PT, Bijvelds MJ, de Jonge HR.

Int J Biochem Cell Biol. 2014 Jul;52:192-200. doi: 10.1016/j.biocel.2014.02.008. Epub 2014 Feb 20. Review.

PMID:
24561283
31.

cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland.

De Jonge HR, Tilly BC, Hogema BM, Pfau DJ, Kelley CA, Kelley MH, Melita AM, Morris MT, Viola RM, Forrest JN Jr.

Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C343-53. doi: 10.1152/ajpcell.00326.2013. Epub 2013 Nov 20.

32.

Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets.

Fisher JT, Tyler SR, Zhang Y, Lee BJ, Liu X, Sun X, Sui H, Liang B, Luo M, Xie W, Yi Y, Zhou W, Song Y, Keiser N, Wang K, de Jonge HR, Engelhardt JF.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):837-44. doi: 10.1165/rcmb.2012-0433OC.

33.

A functional CFTR assay using primary cystic fibrosis intestinal organoids.

Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, Brandsma AM, de Jong NW, Bijvelds MJ, Scholte BJ, Nieuwenhuis EE, van den Brink S, Clevers H, van der Ent CK, Middendorp S, Beekman JM.

Nat Med. 2013 Jul;19(7):939-45. doi: 10.1038/nm.3201. Epub 2013 Jun 2.

PMID:
23727931
34.

Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors.

Wilke M, Bot A, Jorna H, Scholte BJ, de Jonge HR.

PLoS One. 2012;7(12):e52070. doi: 10.1371/journal.pone.0052070. Epub 2012 Dec 21.

35.

Bile acid handling in cystic fibrosis: marked phenotypic differences between mouse models.

Bijvelds MJ, de Jonge HR, Verkade HJ.

Gastroenterology. 2012 Dec;143(6):e19-20; author reply e20. doi: 10.1053/j.gastro.2012.08.052. Epub 2012 Oct 19. No abstract available.

PMID:
23085355
36.

The small airways accordion: concurrent or alternating fluid absorption and secretion?

de Jonge HR, Sheppard DN.

J Physiol. 2012 Aug 1;590(15):3409-10. doi: 10.1113/jphysiol.2012.239657. No abstract available.

37.

Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.

Xiao F, Li J, Singh AK, Riederer B, Wang J, Sultan A, Park H, Lee MG, Lamprecht G, Scholte BJ, De Jonge HR, Seidler U.

J Physiol. 2012 Nov 1;590(21):5317-34. doi: 10.1113/jphysiol.2012.232124. Epub 2012 Jul 16.

38.

Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice.

Bodewes FA, Wouthuyzen-Bakker M, Bijvelds MJ, Havinga R, de Jonge HR, Verkade HJ.

Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G1035-42. doi: 10.1152/ajpgi.00258.2011. Epub 2012 Feb 2.

39.

Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis.

Wouthuyzen-Bakker M, Bijvelds MJ, de Jonge HR, De Lisle RC, Burgerhof JG, Verkade HJ.

Pediatr Res. 2012 Jan;71(1):4-12. doi: 10.1038/pr.2011.4.

40.

The role of rectal chloride secretion in childhood constipation.

Bekkali N, de Jonge HR, van den Wijngaard RM, van der Steeg AF, Bijlsma PB, Taminiau JA, Desjeux JF, Benninga MA.

Neurogastroenterol Motil. 2011 Nov;23(11):1007-12. doi: 10.1111/j.1365-2982.2011.01751.x. Epub 2011 Aug 17.

PMID:
21848627
41.

New clinical diagnostic procedures for cystic fibrosis in Europe.

De Boeck K, Derichs N, Fajac I, de Jonge HR, Bronsveld I, Sermet I, Vermeulen F, Sheppard DN, Cuppens H, Hug M, Melotti P, Middleton PG, Wilschanski M; ECFS Diagnostic Network Working Group; EuroCareCF WP3 Group on CF diagnosis.

J Cyst Fibros. 2011 Jun;10 Suppl 2:S53-66. doi: 10.1016/S1569-1993(11)60009-X. Review.

42.

Mouse models of cystic fibrosis: phenotypic analysis and research applications.

Wilke M, Buijs-Offerman RM, Aarbiou J, Colledge WH, Sheppard DN, Touqui L, Bot A, Jorna H, de Jonge HR, Scholte BJ.

J Cyst Fibros. 2011 Jun;10 Suppl 2:S152-71. doi: 10.1016/S1569-1993(11)60020-9. Review.

43.

Assessment of CFTR function in homozygous R117H-7T subjects.

de Nooijer RA, Nobel JM, Arets HG, Bot AG, van Berkhout FT, de Rijke YB, de Jonge HR, Bronsveld I.

J Cyst Fibros. 2011 Sep;10(5):326-32. doi: 10.1016/j.jcf.2011.03.009. Epub 2011 Apr 19.

44.

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.

Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C126-36. doi: 10.1152/ajpcell.00311.2010. Epub 2011 Mar 23.

45.

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2011 Jun 15;43(11):674-84. doi: 10.1152/physiolgenomics.00258.2010. Epub 2011 Mar 22.

46.

D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.

Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M.

Gastroenterology. 2011 Feb;140(2):560-71. doi: 10.1053/j.gastro.2010.10.042. Epub 2010 Oct 23.

47.

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2010 Nov 15;42A(3):200-10. doi: 10.1152/physiolgenomics.00001.2010. Epub 2010 Aug 24.

48.

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW.

Mol Pharmacol. 2010 Jun;77(6):922-30. doi: 10.1124/mol.109.062679. Epub 2010 Mar 3.

PMID:
20200141
49.

Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.

Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC.

Gastroenterology. 2010 Feb;138(2):649-58. doi: 10.1053/j.gastro.2009.09.055. Epub 2009 Oct 1.

50.

Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.

Bijvelds MJ, Bot AG, Escher JC, De Jonge HR.

Gastroenterology. 2009 Sep;137(3):976-85. doi: 10.1053/j.gastro.2009.05.037. Epub 2009 May 18.

PMID:
19454284

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