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2002 3
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DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma.
Wu H, Zhang J, Bai Y, Zhang S, Zhang Z, Tong W, Han P, Fu B, Zhang Y, Shen Z. Wu H, et al. Aging (Albany NY). 2021 Oct 4;13(19):23020-23035. doi: 10.18632/aging.203593. Epub 2021 Oct 4. Aging (Albany NY). 2021. PMID: 34609335 Free PMC article.
Analysis showed that poor overall survival (OS) in HCC patients was correlated with high expression level of DCP1A (eRNA) and PRKCD (target gene). The up-regulation of DCP1A was associated with advanced tumor stage, larger tumor size and higher histological grade. . …
Analysis showed that poor overall survival (OS) in HCC patients was correlated with high expression level of DCP1A (eRNA) and PRKCD ( …
mRNA decapping factor Dcp1a is essential for embryonic growth in mice.
Ibayashi M, Aizawa R, Tsukamoto S. Ibayashi M, et al. Biochem Biophys Res Commun. 2021 May 28;555:128-133. doi: 10.1016/j.bbrc.2021.03.117. Epub 2021 Apr 1. Biochem Biophys Res Commun. 2021. PMID: 33813271
To extend our understanding of Dcp1a function in vivo, we employed a transgenic rescue strategy to produce Dcp1a-deficient mice using the CRISPR/Cas9 system. ...Moreover, the embryonic lethality was fully rescued by transgenic expression of exogenous human Dcp1a …
To extend our understanding of Dcp1a function in vivo, we employed a transgenic rescue strategy to produce Dcp1a-deficient mic …
Porcine Deltacoronavirus nsp5 Cleaves DCP1A To Decrease Its Antiviral Activity.
Zhu X, Chen J, Tian L, Zhou Y, Xu S, Long S, Wang D, Fang L, Xiao S. Zhu X, et al. J Virol. 2020 Jul 16;94(15):e02162-19. doi: 10.1128/JVI.02162-19. Print 2020 Jul 16. J Virol. 2020. PMID: 32461317 Free PMC article.
Interestingly, the Q343 cleavage site is highly conserved in DCP1A homologs from other mammalian species. Further analyses demonstrated that nsp5 encoded by seven tested CoVs that can infect human or pig also cleaved pDCP1A and human DCP1A, suggesting that DCP1A …
Interestingly, the Q343 cleavage site is highly conserved in DCP1A homologs from other mammalian species. Further analyses demonstrat …
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY. Huang HX, et al. Front Immunol. 2023 May 22;14:1196031. doi: 10.3389/fimmu.2023.1196031. eCollection 2023. Front Immunol. 2023. PMID: 37283741 Free PMC article.
Here, we demonstrated that SADS-CoV nsp5 significantly inhibits the Sendai virus (SEV)-induced production of IFN-beta and inflammatory cytokines. SADS-CoV nsp5 targets and cleaves mRNA-decapping enzyme 1a (DCP1A) via its protease activity to inhibit the IRF3 and NF-kappaB …
Here, we demonstrated that SADS-CoV nsp5 significantly inhibits the Sendai virus (SEV)-induced production of IFN-beta and inflammatory cytok …
Expression of DCP1a in gastric cancer and its biological function and mechanism in chemotherapy resistance in gastric cancer cells.
Ruan T, Zhang Y, Liu W, Li Y, Wang D, Du Z, Tao K, Wu C. Ruan T, et al. Dig Liver Dis. 2020 Nov;52(11):1351-1358. doi: 10.1016/j.dld.2020.06.031. Epub 2020 Jul 6. Dig Liver Dis. 2020. PMID: 32646734
METHODS: Using IHC staining and Western blot to check the expression of DCP1a in tissues and the cell lines. SGC7901 and BGC823 cells were transfected with DCP1a siRNA, and the expression of DCP1a protein and mRNA were detected. ...And signal pathways were al …
METHODS: Using IHC staining and Western blot to check the expression of DCP1a in tissues and the cell lines. SGC7901 and BGC823 cells …
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
Wang X, Chang L, Wang H, Su A, Wu Z. Wang X, et al. DNA Cell Biol. 2017 Jul;36(7):565-570. doi: 10.1089/dna.2017.3633. Epub 2017 May 10. DNA Cell Biol. 2017. PMID: 28488892
Here, we aim to investigate different effects of overexpressed Dcp1a or GW182 on cytoplasmic aggregates formation and influence on miRNA pathway. ...Notably, the ability of miRNA to regulate its target was enhanced by the granules induced by Dcp1a and G3BP1 expressi …
Here, we aim to investigate different effects of overexpressed Dcp1a or GW182 on cytoplasmic aggregates formation and influence on mi …
Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression.
Li C, Zhu L, Liu JX, Guo J, Xie J, Shi CM, Sun QY, Huang GN, Li JY. Li C, et al. Cell Mol Life Sci. 2023 Nov 25;80(12):372. doi: 10.1007/s00018-023-05030-0. Cell Mol Life Sci. 2023. PMID: 38001238 Free PMC article.
Strikingly, cordycepin was found to suppress the elevation of DCP1A protein by inhibiting polyadenylation during postovulatory aging, consequently impeding the decapping of maternal mRNAs. In humans, the increased degradation of DCP1A and total mRNA during postovula …
Strikingly, cordycepin was found to suppress the elevation of DCP1A protein by inhibiting polyadenylation during postovulatory aging, …
mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation.
Roy N, Sundar S, Pillai M, Patell-Socha F, Ganesh S, Aloysius A, Rumman M, Gala H, Hughes SM, Zammit PS, Dhawan J. Roy N, et al. Skelet Muscle. 2021 Jul 8;11(1):18. doi: 10.1186/s13395-021-00270-9. Skelet Muscle. 2021. PMID: 34238354 Free PMC article.
Expression and organization of Fmrp and Dcp1a varies during primary MuSC activation on myofibers, with Fmrp puncta prominent in quiescence, but Dcp1a puncta appearing during activation/proliferation. ...However, knockdown of either Fmrp or Dcp1a led to compro …
Expression and organization of Fmrp and Dcp1a varies during primary MuSC activation on myofibers, with Fmrp puncta prominent in quies …
LncRNA HOXD-AS2 regulates miR-3681-5p/DCP1A axis to promote the progression of non-small cell lung cancer.
Zhang Y, Ma H. Zhang Y, et al. J Thorac Dis. 2023 Mar 31;15(3):1289-1301. doi: 10.21037/jtd-23-153. Epub 2023 Mar 27. J Thorac Dis. 2023. PMID: 37065560 Free PMC article.
Luciferase reporter assay was conducted to evaluate the binding of miR-3681-5p with HOXD-AS2 or DCP1A. Protein expression of DCP1A was assessed via Western blot. ...Moreover, animal experiments affirmed that HOXD-AS2 promoted tumor growth in vivo. CONCLUSIONS: HOXD- …
Luciferase reporter assay was conducted to evaluate the binding of miR-3681-5p with HOXD-AS2 or DCP1A. Protein expression of DCP1A …
MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation.
Wu C, Zhu X, Tao K, Liu W, Ruan T, Wan W, Zhang C, Zhang W. Wu C, et al. Mol Carcinog. 2018 Oct;57(10):1421-1431. doi: 10.1002/mc.22868. Epub 2018 Jul 12. Mol Carcinog. 2018. PMID: 29964337
Our previous work discovered that the expression of the mRNA-decapping enzymes 1a (DCP1A) is upregulated in CRCs. However, the relationships between MALAT1 and DCP1A in the development of CRC and the underlying mechanisms are still unclear. In this study, we investi …
Our previous work discovered that the expression of the mRNA-decapping enzymes 1a (DCP1A) is upregulated in CRCs. However, the relati …
130 results