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Items: 1 to 50 of 68

1.

Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy.

Rebelo S, da Cruz E Silva EF, da Cruz E Silva OA.

Mutat Res Rev Mutat Res. 2015 Oct-Dec;766:42-7. doi: 10.1016/j.mrrev.2015.07.004. Epub 2015 Aug 5. Review.

PMID:
26596547
2.

BRI2 and BRI3 are functionally distinct phosphoproteins.

Martins F, Rebelo S, Santos M, Cotrim CZ, da Cruz e Silva EF, da Cruz e Silva OA.

Cell Signal. 2016 Jan;28(1):130-44. doi: 10.1016/j.cellsig.2015.10.012. Epub 2015 Oct 26.

PMID:
26515131
3.

Protein phosphatase 1 is a key player in nuclear events.

Rebelo S, Santos M, Martins F, da Cruz e Silva EF, da Cruz e Silva OA.

Cell Signal. 2015 Dec;27(12):2589-98. doi: 10.1016/j.cellsig.2015.08.007. Epub 2015 Aug 11. Review.

PMID:
26275498
4.

Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction.

Silva JV, Yoon S, Domingues S, Guimarães S, Goltsev AV, da Cruz E Silva EF, Mendes JF, da Cruz E Silva OA, Fardilha M.

BMC Bioinformatics. 2015 Jan 16;16:12. doi: 10.1186/s12859-014-0432-9.

5.

Characterisation of several ankyrin repeat protein variant 2, a phosphoprotein phosphatase 1-interacting protein, in testis and spermatozoa.

Silva JV, Korrodi-Gregório L, Luers G, Cardoso MJ, Patrício A, Maia N, da Cruz E Silva EF, Fardilha M.

Reprod Fertil Dev. 2016 Jun;28(7):1009-1019. doi: 10.1071/RD14303.

PMID:
25562328
6.

Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation.

Santos M, Domingues SC, Costa P, Muller T, Galozzi S, Marcus K, da Cruz e Silva EF, da Cruz e Silva OA, Rebelo S.

PLoS One. 2014 Dec 2;9(12):e113732. doi: 10.1371/journal.pone.0113732. eCollection 2014.

7.

LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression.

Santos M, Costa P, Martins F, da Cruz e Silva EF, da Cruz e Silva OA, Rebelo S.

Mol Cell Biochem. 2015 Jan;399(1-2):143-53. doi: 10.1007/s11010-014-2241-x. Epub 2014 Oct 17.

PMID:
25323962
8.

RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.

Domingues SC, Konietzko U, Henriques AG, Rebelo S, Fardilha M, Nishitani H, Nitsch RM, da Cruz E Silva EF, da Cruz E Silva OA.

J Alzheimers Dis. 2014;42(4):1415-33. doi: 10.3233/JAD-132495.

PMID:
25024339
9.

Complexing Aβ prevents the cellular anomalies induced by the Peptide alone.

Henriques AG, Oliveira JM, Gomes B, Ruivo R, da Cruz e Silva EF, da Cruz e Silva OA.

J Mol Neurosci. 2014 Aug;53(4):661-8. doi: 10.1007/s12031-014-0233-7. Epub 2014 Mar 7.

10.

An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model.

Korrodi-Gregório L, Margarida Lopes A, Esteves SL, Afonso S, Lemos de Matos A, Lissovsky AA, da Cruz e Silva OA, da Cruz e Silva EF, Esteves PJ, Fardilha M.

PLoS One. 2013 Oct 10;8(10):e77236. doi: 10.1371/journal.pone.0077236. eCollection 2013.

11.

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

Santos M, Rebelo S, Van Kleeff PJ, Kim CE, Dauer WT, Fardilha M, da Cruz E Silva OA, da Cruz E Silva EF.

PLoS One. 2013 Oct 7;8(10):e76788. doi: 10.1371/journal.pone.0076788. eCollection 2013.

12.

"Omics" of human sperm: profiling protein phosphatases.

Fardilha M, Ferreira M, Pelech S, Vieira S, Rebelo S, Korrodi-Gregorio L, Sousa M, Barros A, Silva V, da Cruz e Silva OA, da Cruz e Silva EF.

OMICS. 2013 Sep;17(9):460-72. doi: 10.1089/omi.2012.0119. Epub 2013 Jul 29.

13.

TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network.

Korrodi-Gregório L, Vieira SI, Esteves SL, Silva JV, Freitas MJ, Brauns AK, Luers G, Abrantes J, Esteves PJ, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF.

Biol Open. 2013 Mar 8;2(5):453-65. doi: 10.1242/bio.20131065. Print 2013 May 15.

14.

Identification of a novel complex AβPP:Fe65:PP1 that regulates AβPP Thr668 phosphorylation levels.

Rebelo S, Domingues SC, Santos M, Fardilha M, Esteves SL, Vieira SI, Vintém AP, Wu W, da Cruz E Silva EF, da Cruz E Silva OA.

J Alzheimers Dis. 2013;35(4):761-75. doi: 10.3233/JAD-130095.

PMID:
23531501
15.

Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.

Korrodi-Gregório L, Ferreira M, Vintém AP, Wu W, Muller T, Marcus K, Vijayaraghavan S, Brautigan DL, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF.

BMC Cell Biol. 2013 Mar 18;14:15. doi: 10.1186/1471-2121-14-15.

16.

Protein phosphatase 1γ isoforms linked interactions in the brain.

Esteves SL, Korrodi-Gregório L, Cotrim CZ, van Kleeff PJ, Domingues SC, da Cruz e Silva OA, Fardilha M, da Cruz e Silva EF.

J Mol Neurosci. 2013 May;50(1):179-97. doi: 10.1007/s12031-012-9902-6. Epub 2012 Oct 19.

PMID:
23080069
17.

Protein phosphatase 1α interacting proteins in the human brain.

Esteves SL, Domingues SC, da Cruz e Silva OA, Fardilha M, da Cruz e Silva EF.

OMICS. 2012 Jan-Feb;16(1-2):3-17. doi: 10.1089/omi.2011.0041.

18.

Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.

Domingues SC, Henriques AG, Fardilha M, da Cruz E Silva EF, da Cruz E Silva OA.

J Neurochem. 2011 Dec;119(5):1086-98. doi: 10.1111/j.1471-4159.2011.07420.x. Epub 2011 Oct 14.

19.

Identification of the human testis protein phosphatase 1 interactome.

Fardilha M, Esteves SL, Korrodi-Gregório L, Vintém AP, Domingues SC, Rebelo S, Morrice N, Cohen PT, da Cruz e Silva OA, da Cruz e Silva EF.

Biochem Pharmacol. 2011 Nov 15;82(10):1403-15. doi: 10.1016/j.bcp.2011.02.018. Epub 2011 Mar 5.

PMID:
21382349
20.

Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease.

da Cruz e Silva OA, Henriques AG, Domingues SC, da Cruz e Silva EF.

CNS Neurol Disord Drug Targets. 2010 Dec;9(6):720-6. Review.

PMID:
20942790
21.

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.

Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA.

Mol Neurodegener. 2010 Oct 11;5:40. doi: 10.1186/1750-1326-5-40.

22.

Biological responses of brushite-forming Zn- and ZnSr- substituted beta-tricalcium phosphate bone cements.

Pina S, Vieira SI, Rego P, Torres PM, da Cruz e Silva OA, da Cruz e Silva EF, Ferreira JM.

Eur Cell Mater. 2010 Sep 7;20:162-77.

23.

In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements.

Pina S, Vieira SI, Torres PM, Goetz-Neunhoeffer F, Neubauer J, da Cruz E Silva OA, da Cruz E Silva EF, Ferreira JM.

J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):414-20. doi: 10.1002/jbm.b.31669.

PMID:
20574977
24.

Progesterone regulates the phosphorylation of protein phosphatases in the brain.

Amorim MA, Guerra-Araiza C, Pernía O, da Cruz e Silva EF, Garcia-Segura LM.

J Neurosci Res. 2010 Oct;88(13):2826-32. doi: 10.1002/jnr.22442.

PMID:
20568292
25.

Abeta promotes Alzheimer's disease-like cytoskeleton abnormalities with consequences to APP processing in neurons.

Henriques AG, Vieira SI, da Cruz E Silva EF, da Cruz E Silva OA.

J Neurochem. 2010 May;113(3):761-71. doi: 10.1111/j.1471-4159.2010.06643.x. Epub 2010 Mar 23.

26.

Understanding fatty acid metabolism through an active learning approach.

Fardilha M, Schrader M, da Cruz E Silva OA, da Cruz E Silva EF.

Biochem Mol Biol Educ. 2010 Mar;38(2):65-9. doi: 10.1002/bmb.20330.

27.

S655 phosphorylation enhances APP secretory traffic.

Vieira SI, Rebelo S, Domingues SC, da Cruz e Silva EF, da Cruz e Silva OA.

Mol Cell Biochem. 2009 Aug;328(1-2):145-54. doi: 10.1007/s11010-009-0084-7. Epub 2009 Apr 21.

PMID:
19381782
28.

Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures.

Henriques AG, Vieira SI, da Cruz e Silva EF, da Cruz e Silva OA.

J Mol Neurosci. 2009 Sep;39(1-2):248-55. doi: 10.1007/s12031-009-9192-9. Epub 2009 Apr 2.

29.

Monitoring "De Novo"APP synthesis by taking advantage of the reversible effect of cycloheximide.

Rebelo S, Vieira SI, da Cruz E Silva EF, da Cruz E Silva OA.

Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):602-8. doi: 10.1177/1533317508323572.

PMID:
19106277
30.

Intracellular sAPP retention in response to Abeta is mapped to cytoskeleton-associated structures.

Henriques AG, Vieira SI, Crespo-López ME, Guiomar de Oliveira MA, da Cruz e Silva EF, da Cruz e Silva OA.

J Neurosci Res. 2009 May 1;87(6):1449-61. doi: 10.1002/jnr.21959.

PMID:
19105196
31.

PP1 inhibition by Abeta peptide as a potential pathological mechanism in Alzheimer's disease.

Vintém AP, Henriques AG, da Cruz E Silva OA, da Cruz E Silva EF.

Neurotoxicol Teratol. 2009 Mar-Apr;31(2):85-8. doi: 10.1016/j.ntt.2008.11.001. Epub 2008 Nov 12.

PMID:
19028567
32.

Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.

da Cruz e Silva OA, Rebelo S, Vieira SI, Gandy S, da Cruz e Silva EF, Greengard P.

J Neurochem. 2009 Jan;108(2):319-30. doi: 10.1111/j.1471-4159.2008.05770.x. Epub 2008 Dec 2.

33.

Tyr687 dependent APP endocytosis and Abeta production.

Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA.

J Mol Neurosci. 2007;32(1):1-8.

PMID:
17873282
34.

Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.

Wu W, Baxter JE, Wattam SL, Hayward DG, Fardilha M, Knebel A, Ford EM, da Cruz e Silva EF, Fry AM.

J Biol Chem. 2007 Sep 7;282(36):26431-40. Epub 2007 Jul 11.

35.

Tyrosine 687 phosphorylated Alzheimer's amyloid precursor protein is retained intracellularly and exhibits a decreased turnover rate.

Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA.

Neurodegener Dis. 2007;4(2-3):78-87.

PMID:
17596701
36.

Differential distribution of Alzheimer's amyloid precursor protein family variants in human sperm.

Fardilha M, Vieira SI, Barros A, Sousa M, Da Cruz e Silva OA, Da Cruz e Silva EF.

Ann N Y Acad Sci. 2007 Jan;1096:196-206.

PMID:
17405931
37.

Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions.

Domingues SC, Henriques AG, Wu W, Da Cruz e Silva EF, Da Cruz e Silva OA.

Ann N Y Acad Sci. 2007 Jan;1096:184-95.

PMID:
17405930
38.

Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits.

Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC.

Neurochem Int. 2007 May;50(6):872-80. Epub 2007 Mar 7.

PMID:
17403555
39.

Isoform specific amyloid-beta protein precursor metabolism.

Henriques AG, Vieira SI, Rebelo S, Domingues SC, da Cruz e Silva EF, da Cruz e Silva OA.

J Alzheimers Dis. 2007 Mar;11(1):85-95.

PMID:
17361038
40.

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.

Browne GJ, Fardilha M, Oxenham SK, Wu W, Helps NR, da Cruz E Silva OA, Cohen PT, da Cruz E Silva EF.

Biochem J. 2007 Feb 15;402(1):187-96.

41.

A model system to study intracellular trafficking and processing of the Alzheimer's amyloid precursor protein.

da Cruz E Silva OA, Vieira SI, Rebelo S, da Cruz e Silva EF.

Neurodegener Dis. 2004;1(4-5):196-204.

42.

Sodium azide and 2-deoxy-D-glucose-induced cellular stress affects phosphorylation-dependent AbetaPP processing.

Henriques AG, Domingues SC, Fardilha M, da Cruz e Silva EF, da Cruz e Silva OA.

J Alzheimers Dis. 2005 Jun;7(3):201-12; discussion 255-62.

PMID:
16006663
43.

Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception.

Fardilha M, Wu W, Sá R, Fidalgo S, Sousa C, Mota C, da Cruz e Silva OA, da Cruz e Silva EF.

Ann N Y Acad Sci. 2004 Dec;1030:468-78.

PMID:
15659832
44.

Signal transduction therapeutics: relevance for Alzheimer's disease.

da Cruz e Silva OA, Fardilha M, Henriques AG, Rebelo S, Vieira S, da Cruz e Silva EF.

J Mol Neurosci. 2004;23(1-2):123-42. Review.

PMID:
15126698
45.

Monitoring protein phosphatase 1 isoform levels as a marker for cellular stress.

Amador FC, Henriques AG, da Cruz E Silva OA, da Cruz E Silva EF.

Neurotoxicol Teratol. 2004 May-Jun;26(3):387-95.

PMID:
15113600
46.

Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein.

Rebelo S, Henriques AG, da Cruz e Silva EF, da Cruz e Silva OA.

J Neurosci Res. 2004 May 1;76(3):406-14.

PMID:
15079870
47.

Preparation and characterization of recombinant protein phosphatase 1.

Watanabe T, da Cruz e Silva EF, Huang HB, Starkova N, Kwon YG, Horiuchi A, Greengard P, Nairn AC.

Methods Enzymol. 2003;366:321-38. No abstract available.

PMID:
14674258
48.

Protein phosphorylation and APP metabolism.

da Cruz e Silva EF, da Cruz e Silva OA.

Neurochem Res. 2003 Oct;28(10):1553-61. Review.

PMID:
14570401
49.

Inhibition of protein phosphatase 1 decreases PTH secretion from isolated dispersed parathyroid cells.

Matovcik LM, Rhee SS, Schaefer JF, da Cruz e Silva EF, Kinder BK.

Mol Cell Endocrinol. 1999 Aug 20;154(1-2):171-7.

PMID:
10509811
50.

Primate sperm contain protein phosphatase 1, a biochemical mediator of motility.

Smith GD, Wolf DP, Trautman KC, da Cruz e Silva EF, Greengard P, Vijayaraghavan S.

Biol Reprod. 1996 Mar;54(3):719-27.

PMID:
8835396

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