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Machine learning in drug-target interaction prediction: current state and future directions.

D'Souza S, K V P, S B.

Drug Discov Today. 2020 Mar 12. pii: S1359-6446(20)30103-3. doi: 10.1016/j.drudis.2020.03.003. [Epub ahead of print]


Encapsulation of Variabilin in Stearic Acid Solid Lipid Nanoparticles Enhances Its Anticancer Activity in Vitro.

Lerata MS, D'Souza S, Sibuyi NRS, Dube A, Meyer M, Samaai T, Antunes EM, Beukes DR.

Molecules. 2020 Feb 14;25(4). pii: E830. doi: 10.3390/molecules25040830.


Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline.

Fung ITH, Sankar P, Zhang Y, Robison LS, Zhao X, D'Souza SS, Salinero AE, Wang Y, Qian J, Kuentzel ML, Chittur SV, Temple S, Zuloaga KL, Yang Q.

J Exp Med. 2020 Apr 6;217(4). pii: e20190915. doi: 10.1084/jem.20190915.


Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum.

Ndumiso M, Buchtová N, Husselmann L, Mohamed G, Klein A, Aucamp M, Canevet D, D'Souza S, Maphasa RE, Boury F, Dube A.

Colloids Surf B Biointerfaces. 2020 Apr;188:110816. doi: 10.1016/j.colsurfb.2020.110816. Epub 2020 Jan 22.


Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.

Nayak G, Zhang KX, Vemaraju S, Odaka Y, Buhr ED, Holt-Jones A, Kernodle S, Smith AN, Upton BA, D'Souza S, Zhan JJ, Diaz N, Nguyen MT, Mukherjee R, Gordon SA, Wu G, Schmidt R, Mei X, Petts NT, Batie M, Rao S, Hogenesch JB, Nakamura T, Sweeney A, Seeley RJ, Van Gelder RN, Sanchez-Gurmaches J, Lang RA.

Cell Rep. 2020 Jan 21;30(3):672-686.e8. doi: 10.1016/j.celrep.2019.12.043.


Clustering of health, crime and social-welfare inequality in 4 million citizens from two nations.

Richmond-Rakerd LS, D'Souza S, Andersen SH, Hogan S, Houts RM, Poulton R, Ramrakha S, Caspi A, Milne BJ, Moffitt TE.

Nat Hum Behav. 2020 Mar;4(3):255-264. doi: 10.1038/s41562-019-0810-4. Epub 2020 Jan 20.


The Association Between Persistence and Change in Early Childhood Behavioural Problems and Preschool Cognitive Outcomes.

D'Souza S, Underwood L, Peterson ER, Morton SMB, Waldie KE.

Child Psychiatry Hum Dev. 2020 Jan 6. doi: 10.1007/s10578-019-00953-x. [Epub ahead of print]


Standardizing the approach to late onset sepsis in neonates through antimicrobial stewardship: a quality improvement initiative.

Lamba V, D'souza S, Carafa C, Zepf A, Bassel CL, Gutierrez M, Balakrishnan M.

J Perinatol. 2020 Jan 6. doi: 10.1038/s41372-019-0577-5. [Epub ahead of print]


Mucosal-associated invariant T cells restrict allergic airway inflammation.

Ye L, Pan J, Pasha MA, Shen X, D'Souza SS, Fung ITH, Wang Y, Guo B, Tang DD, Yang Q.

J Allergy Clin Immunol. 2019 Dec 23. pii: S0091-6749(19)32595-3. doi: 10.1016/j.jaci.2019.12.891. [Epub ahead of print] No abstract available.


A critical role for c-Myc in group 2 innate lymphoid cell activation.

Ye L, Pan J, Liang M, Pasha MA, Shen X, D'Souza SS, Fung ITH, Wang Y, Patel G, Tang DD, Yang Q.

Allergy. 2019 Dec 13. doi: 10.1111/all.14149. [Epub ahead of print]


IFN-γ and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon.

Walrath T, Malizia RA, Zhu X, Sharp SP, D'Souza SS, Lopez-Soler R, Parr B, Kartchner B, Lee EC, Stain SC, Iwakura Y, O'Connor W Jr.

Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G479-G489. doi: 10.1152/ajpgi.00208.2019. Epub 2019 Dec 2.


Distinct ocular surface soluble factor profile in human corneal dystrophies.

Shetty R, Naidu JR, Nair AP, Vaidya TA, D'Souza S, Matalia H, Deshpande V, Sethu S, Ghosh A, Chakrabarty K.

Ocul Surf. 2019 Nov 19. pii: S1542-0124(19)30233-2. doi: 10.1016/j.jtos.2019.11.007. [Epub ahead of print]


Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma.

D'Souza S, Ormond DR, Costabile J, Thompson JA.

PLoS One. 2019 Nov 21;14(11):e0225323. doi: 10.1371/journal.pone.0225323. eCollection 2019.


Thermal stress responses of Sodalis glossinidius, an indigenous bacterial symbiont of hematophagous tsetse flies.

Roma JS, D'Souza S, Somers PJ, Cabo LF, Farsin R, Aksoy S, Runyen-Janecky LJ, Weiss BL.

PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007464. doi: 10.1371/journal.pntd.0007464. eCollection 2019 Nov.



Shetty R, D'Souza S.

J Cataract Refract Surg. 2019 Nov;45(11):1693-1694. doi: 10.1016/j.jcrs.2019.08.051. No abstract available.


Antenatal determinants of early childhood talking delay and behavioural difficulties.

D'Souza S, Crawford CN, Buckley J, Underwood L, Peterson ER, Bird A, Morton SMB, Waldie KE.

Infant Behav Dev. 2019 Nov;57:101388. doi: 10.1016/j.infbeh.2019.101388. Epub 2019 Oct 18.


Blockade of IL-4Rα inhibits group 2 innate lymphoid cell responses in asthma patients.

Patel G, Pan J, Ye L, Shen X, Rosloff D, D'Souza SS, Fung ITH, Celstin J, Sun W, Sankar P, Zhang Y, Pasha MA, Yang Q.

Clin Exp Allergy. 2020 Feb;50(2):267-270. doi: 10.1111/cea.13514. Epub 2019 Nov 5. No abstract available.


Compartmentalized effects of aging on group 2 innate lymphoid cell development and function.

D'Souza SS, Shen X, Fung ITH, Ye L, Kuentzel M, Chittur SV, Furuya Y, Siebel CW, Maillard IP, Metzger DW, Yang Q.

Aging Cell. 2019 Dec;18(6):e13019. doi: 10.1111/acel.13019. Epub 2019 Aug 20.


Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Oct 17;134(16):1298-1311. doi: 10.1182/blood.2019000040.


Trehalose augments autophagy to mitigate stress induced inflammation in human corneal cells.

Panigrahi T, Shivakumar S, Shetty R, D'souza S, Nelson EJR, Sethu S, Jeyabalan N, Ghosh A.

Ocul Surf. 2019 Oct;17(4):699-713. doi: 10.1016/j.jtos.2019.08.004. Epub 2019 Aug 11.


Microsimulation model of child and adolescent overweight: making use of what we already know.

Shackleton N, Chang K, Lay-Yee R, D'Souza S, Davis P, Milne B.

Int J Obes (Lond). 2019 Nov;43(11):2322-2332. doi: 10.1038/s41366-019-0426-9. Epub 2019 Aug 7.


Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin.

Samkange T, D'Souza S, Obikeze K, Dube A.

J Pharm Pharmacol. 2019 Oct;71(10):1497-1507. doi: 10.1111/jphp.13147. Epub 2019 Aug 5.


The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells.

Shahbazi M, Cundiff P, Zhou W, Lee P, Patel A, D'Souza SL, Abbasi F, Quertermous T, Knowles JW.

Stem Cell Res Ther. 2019 Jul 29;10(1):228. doi: 10.1186/s13287-019-1319-5.


Persistence and change in behavioural problems during early childhood.

D'Souza S, Underwood L, Peterson ER, Morton SMB, Waldie KE.

BMC Pediatr. 2019 Jul 26;19(1):259. doi: 10.1186/s12887-019-1631-3.


Understanding the Journey of Human Hematopoietic Stem Cell Development.

Kumar A, D'Souza SS, Thakur AS.

Stem Cells Int. 2019 May 6;2019:2141475. doi: 10.1155/2019/2141475. eCollection 2019. Review.


Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye.

Khamar P, Nair AP, Shetty R, Vaidya T, Subramani M, Ponnalagu M, Dhamodaran K, D'souza S, Ghosh A, Pahuja N, Deshmukh R, Ahuja P, Sainani K, Nuijts RMMA, Das D, Ghosh A, Sethu S.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2532-2542. doi: 10.1167/iovs.19-26914.


Current Applications of Diffusion Tensor Imaging and Tractography in Intracranial Tumor Resection.

Costabile JD, Alaswad E, D'Souza S, Thompson JA, Ormond DR.

Front Oncol. 2019 May 29;9:426. doi: 10.3389/fonc.2019.00426. eCollection 2019. Review.


Economic burden of specific learning disability: A prevalence-based cost of illness study of its direct, indirect, and intangible costs.

Karande S, D'souza S, Gogtay N, Shiledar M, Sholapurwala R.

J Postgrad Med. 2019 Jul-Sep;65(3):152-159. doi: 10.4103/jpgm.JPGM_413_18.


People are neglected, not diseases: the relationship between disability and neglected tropical diseases.

Hamill LC, Haslam D, Abrahamsson S, Hill B, Dixon R, Burgess H, Jensen K, D'Souza S, Schmidt E, Downs P.

Trans R Soc Trop Med Hyg. 2019 Dec 1;113(12):829-834. doi: 10.1093/trstmh/trz036.


Pain management after photorefractive keratectomy.

Shetty R, Dalal R, Nair AP, Khamar P, D'Souza S, Vaishnav R.

J Cataract Refract Surg. 2019 Jul;45(7):972-976. doi: 10.1016/j.jcrs.2019.01.032. Epub 2019 Apr 24.


Current approaches for RNA-labelling to identify RNA-binding proteins.

Gemmill D, D'souza S, Meier-Stephenson V, Patel TR.

Biochem Cell Biol. 2020 Feb;98(1):31-41. doi: 10.1139/bcb-2019-0041. Epub 2019 Mar 30.


Prevalence of trachoma in the Republic of Chad: results of 41 population-based surveys.

Dézoumbé D, Djada DA, Harba TT, Biao JE, Kali B, Bernasconi J, Hiron D, Bengraïne K, D'Souza S, Willis R, Bakhtiari A, Resnikoff S, Courtright P, Solomon AW.

Ophthalmic Epidemiol. 2018 Dec;25(sup1):143-154. doi: 10.1080/09286586.2018.1546877.


A Population-Based Trachoma Prevalence Survey Covering Seven Districts of Sangha and Likouala Departments, Republic of the Congo.

Missamou F, Marlhand H, Dzabatou-Babeaux ASP, Sendzi S, Bernasconi J, D'Souza S, Bakhtiari A, Millar T, Willis R, Bengraïne K, Resnikoff S, Solomon AW.

Ophthalmic Epidemiol. 2018 Dec;25(sup1):155-161. doi: 10.1080/09286586.2018.1546878.


Patterns of Exposure to Cumulative Risk Through Age 2 and Associations with Problem Behaviors at Age 4.5: Evidence from Growing Up in New Zealand.

Wallander JL, Berry S, Carr PA, Peterson ER, Waldie KE, Marks E, D'Souza S, Morton SMB.

J Abnorm Child Psychol. 2019 Aug;47(8):1277-1288. doi: 10.1007/s10802-019-00521-w.


Cutting Edge: Core Binding Factor β Is Required for Group 2 Innate Lymphoid Cell Activation.

Shen X, Liang M, Chen X, Pasha MA, D'Souza SS, Hidde K, Howard J, Sultana DA, Fung ITH, Ye L, Pan J, Liu G, Drake JR, Drake LA, Zhu J, Bhandoola A, Yang Q.

J Immunol. 2019 Mar 15;202(6):1669-1673. doi: 10.4049/jimmunol.1800852. Epub 2019 Feb 6.


NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells with High Proliferation Potential from Human Pluripotent Stem Cells.

Kumar A, Lee JH, Suknuntha K, D'Souza SS, Thakur AS, Slukvin II.

J Immunol. 2019 Feb 1;202(3):770-776. doi: 10.4049/jimmunol.1801027. Epub 2018 Dec 21.


Procalcitonin and Other Common Biomarkers Do Not Reliably Identify Patients at Risk for Bacterial Infection After Congenital Heart Surgery.

D'Souza S, Guhadasan R, Jennings R, Siner S, Paulus S, Thorburn K, Chesters C, Downey C, Baines P, Lane S, Carrol E.

Pediatr Crit Care Med. 2019 Mar;20(3):243-251. doi: 10.1097/PCC.0000000000001826.


Infertility patient-provider communication and (dis)continuity of care: An exploration of illness identity transitions.

Palmer-Wackerly AL, Voorhees HL, D'Souza S, Weeks E.

Patient Educ Couns. 2019 Apr;102(4):804-809. doi: 10.1016/j.pec.2018.12.003. Epub 2018 Dec 3.


The Antibiotic Trimethoprim Displays Strong Mutagenic Synergy with 2-Aminopurine.

D'Souza S, Miller JE, Ahn J, Subandi R, Lozano D, Ramirez J, Goff M, Davidian C, Miller JH.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01577-18. doi: 10.1128/AAC.01577-18. Print 2019 Feb.


The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study.

Hann M, Roberts SA, D'Souza SW, Clayton P, Macklon N, Brison DR.

BMC Med. 2018 Nov 28;16(1):224. doi: 10.1186/s12916-018-1203-7.


Calming the Electrical Storm: Use of Stellate Ganglion Block and Thoracic Epidural in Intractable Ventricular Tachycardia.

D'souza S, Saksena S, Butani M.

Indian J Crit Care Med. 2018 Oct;22(10):743-745. doi: 10.4103/ijccm.IJCCM_33_18.


Is blue the new green? Repackaging menthol cigarettes in response to a flavour ban in Ontario, Canada.

Borland T, D'Souza SA, O'Connor S, Chaiton MO, Schwartz R.

Tob Control. 2019 Aug;28(e1):e7-e12. doi: 10.1136/tobaccocontrol-2018-054454. Epub 2018 Oct 30.


The effect of Ramadan fasting during pregnancy on perinatal outcomes: a systematic review and meta-analysis.

Glazier JD, Hayes DJL, Hussain S, D'Souza SW, Whitcombe J, Heazell AEP, Ashton N.

BMC Pregnancy Childbirth. 2018 Oct 25;18(1):421. doi: 10.1186/s12884-018-2048-y.


Outpatient Endovascular Tibial Artery Intervention in an Office-Based Setting Is as Safe and Effective as in a Hospital Setting.

D'Souza SM, Stout CL, Krol E, Dexter DJ, Ahanchi SS, Panneton JM.

J Endovasc Ther. 2018 Dec;25(6):666-672. doi: 10.1177/1526602818806691. Epub 2018 Oct 15.


Design and validation of an open-source modular Microplate Photoirradiation System for high-throughput photobiology experiments.

Katz S, Backeris P, Merck C, Suprun M, D'Souza S, Bishop DF, Desnick RJ, Moore K, Ubarretxena-Belandia I, Lemischka IR.

PLoS One. 2018 Oct 5;13(10):e0203597. doi: 10.1371/journal.pone.0203597. eCollection 2018.


Community-Based Reform Efforts: The Case of the Aging at Home Strategy.

Peckham A, Rudoler D, Li JM, D'Souza S.

Healthc Policy. 2018 Aug;14(1):30-43. doi: 10.12927/hcpol.2018.25550.


DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer.

Sharp SP, Malizia RA, Walrath T, D'Souza SS, Booth CJ, Kartchner BJ, Lee EC, Stain SC, O'Connor W Jr.

Gene. 2018 Nov 30;677:299-307. doi: 10.1016/j.gene.2018.08.016. Epub 2018 Aug 16.


Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex.

Rizzo AA, Vassel FM, Chatterjee N, D'Souza S, Li Y, Hao B, Hemann MT, Walker GC, Korzhnev DM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8191-E8200. doi: 10.1073/pnas.1801149115. Epub 2018 Aug 15.


Preventive measures in oral cancer: An overview.

D'souza S, Addepalli V.

Biomed Pharmacother. 2018 Nov;107:72-80. doi: 10.1016/j.biopha.2018.07.114. Epub 2018 Aug 3. Review.


Prenatal alcohol consumption and infant and child behavior: Evidence from the Growing Up in New Zealand Cohort.

Schoeps A, Peterson ER, Mia Y, Waldie KE, Underwood L, D'Souza S, Morton SMB.

Early Hum Dev. 2018 Aug;123:22-29. doi: 10.1016/j.earlhumdev.2018.06.011. Epub 2018 Jul 20.


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