Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 49

1.

Co-administration of GM-CSF expressing RNA is a powerful tool to enhance potency of SAM-based vaccines.

Manara C, Brazzoli M, Piccioli D, Taccone M, D'Oro U, Maione D, Frigimelica E.

Vaccine. 2019 Jun 18. pii: S0264-410X(19)30479-7. doi: 10.1016/j.vaccine.2019.04.028. [Epub ahead of print]

PMID:
31227353
2.

Mixed mucosal-parenteral immunizations with the broadly conserved pathogenic Escherichia coli antigen SslE induce a robust mucosal and systemic immunity without affecting the murine intestinal microbiota.

Naili I, Vinot J, Baudner BC, Bernalier-Donadille A, Pizza M, Desvaux M, Jubelin G, D'Oro U, Buonsanti C.

Vaccine. 2019 Jan 7;37(2):314-324. doi: 10.1016/j.vaccine.2018.10.008. Epub 2018 Nov 30.

3.

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7.

Salvi V, Gianello V, Busatto S, Bergese P, Andreoli L, D'Oro U, Zingoni A, Tincani A, Sozzani S, Bosisio D.

JCI Insight. 2018 May 17;3(10). pii: 98204. doi: 10.1172/jci.insight.98204. eCollection 2018 May 17.

4.

Alum/Toll-Like Receptor 7 Adjuvant Enhances the Expansion of Memory B Cell Compartment Within the Draining Lymph Node.

Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D'Oro U, Piccioli D.

Front Immunol. 2018 Apr 9;9:641. doi: 10.3389/fimmu.2018.00641. eCollection 2018.

5.

Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells.

Tulli L, Cattaneo F, Vinot J, Baldari CT, D'Oro U.

Front Immunol. 2018 Mar 1;9:330. doi: 10.3389/fimmu.2018.00330. eCollection 2018.

6.

Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells.

Cioncada R, Maddaluno M, Vo HTM, Woodruff M, Tavarini S, Sammicheli C, Tortoli M, Pezzicoli A, De Gregorio E, Carroll MC, D'Oro U, Piccioli D.

PLoS One. 2017 Oct 31;12(10):e0185843. doi: 10.1371/journal.pone.0185843. eCollection 2017.

7.

Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model.

Misiak A, Leuzzi R, Allen AC, Galletti B, Baudner BC, D'Oro U, O'Hagan DT, Pizza M, Seubert A, Mills KHG.

Vaccine. 2017 Sep 18;35(39):5256-5263. doi: 10.1016/j.vaccine.2017.08.009. Epub 2017 Aug 18.

8.

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis.

Vulpis E, Cecere F, Molfetta R, Soriani A, Fionda C, Peruzzi G, Caracciolo G, Palchetti S, Masuelli L, Simonelli L, D'Oro U, Abruzzese MP, Petrucci MT, Ricciardi MR, Paolini R, Cippitelli M, Santoni A, Zingoni A.

Oncoimmunology. 2017 Jan 13;6(3):e1279372. doi: 10.1080/2162402X.2017.1279372. eCollection 2017.

9.

Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines.

Buonsanti C, Balocchi C, Harfouche C, Corrente F, Galli Stampino L, Mancini F, Tontini M, Malyala P, Bufali S, Baudner B, De Gregorio E, Valiante NM, O'Hagan DT, Rappuoli R, D'Oro U.

Sci Rep. 2016 Jul 21;6:29063. doi: 10.1038/srep29063.

10.

The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine.

Donadei A, Balocchi C, Mancini F, Proietti D, Gallorini S, O'Hagan DT, D'Oro U, Berti F, Baudner BC, Adamo R.

Eur J Pharm Biopharm. 2016 Oct;107:110-9. doi: 10.1016/j.ejpb.2016.07.004. Epub 2016 Jul 5.

PMID:
27388628
11.

Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide.

Cortez A, Li Y, Miller AT, Zhang X, Yue K, Maginnis J, Hampton J, Hall de S, Shapiro M, Nayak B, D'Oro U, Li C, Skibinski D, Mbow ML, Singh M, O'Hagan DT, Cooke MP, Valiante NM, Wu TY.

J Med Chem. 2016 Jun 23;59(12):5868-78. doi: 10.1021/acs.jmedchem.6b00489. Epub 2016 Jun 13.

PMID:
27270029
12.

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design.

Rappuoli R, Bottomley MJ, D'Oro U, Finco O, De Gregorio E.

J Exp Med. 2016 Apr 4;213(4):469-81. doi: 10.1084/jem.20151960. Epub 2016 Mar 28. Review.

13.

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.

Knudsen NP, Olsen A, Buonsanti C, Follmann F, Zhang Y, Coler RN, Fox CB, Meinke A, D'Oro U, Casini D, Bonci A, Billeskov R, De Gregorio E, Rappuoli R, Harandi AM, Andersen P, Agger EM.

Sci Rep. 2016 Jan 21;6:19570. doi: 10.1038/srep19570.

14.

Development and Application of a Novel SPE-Method for Bioassay-Guided Fractionation of Marine Extracts.

Cutignano A, Nuzzo G, Ianora A, Luongo E, Romano G, Gallo C, Sansone C, Aprea S, Mancini F, D'Oro U, Fontana A.

Mar Drugs. 2015 Sep 11;13(9):5736-49. doi: 10.3390/md13095736.

15.

Ultrastructural Visualization of Vaccine Adjuvant Uptake In Vitro and In Vivo.

Giusti F, Seubert A, Cantisani R, Tortoli M, D'Oro U, Ferlenghi I, Dallai R, Piccioli D.

Microsc Microanal. 2015 Aug;21(4):791-5. doi: 10.1017/S1431927615013744.

PMID:
26223548
16.

CD8 T-cell priming upon mRNA vaccination is restricted to bone-marrow-derived antigen-presenting cells and may involve antigen transfer from myocytes.

Lazzaro S, Giovani C, Mangiavacchi S, Magini D, Maione D, Baudner B, Geall AJ, De Gregorio E, D'Oro U, Buonsanti C.

Immunology. 2015 Oct;146(2):312-26. doi: 10.1111/imm.12505. Epub 2015 Aug 28.

17.

The potential of adjuvants to improve immune responses against TdaP vaccines: A preclinical evaluation of MF59 and monophosphoryl lipid A.

Agnolon V, Bruno C, Leuzzi R, Galletti B, D'Oro U, Pizza M, Seubert A, O'Hagan DT, Baudner BC.

Int J Pharm. 2015 Aug 15;492(1-2):169-76. doi: 10.1016/j.ijpharm.2015.06.030. Epub 2015 Jul 3.

PMID:
26149936
18.

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells.

Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U.

Hum Vaccin Immunother. 2015;11(8):2038-50. doi: 10.1080/21645515.2015.1027467.

19.

Gaps in knowledge and prospects for research of adjuvanted vaccines.

Seder R, Reed SG, O'Hagan D, Malyala P, D'Oro U, Laera D, Abrignani S, Cerundolo V, Steinman L, Bertholet S.

Vaccine. 2015 Jun 8;33 Suppl 2:B40-3. doi: 10.1016/j.vaccine.2015.03.057.

PMID:
26022566
20.

The Human Pathogen Streptococcus pyogenes Releases Lipoproteins as Lipoprotein-rich Membrane Vesicles.

Biagini M, Garibaldi M, Aprea S, Pezzicoli A, Doro F, Becherelli M, Taddei AR, Tani C, Tavarini S, Mora M, Teti G, D'Oro U, Nuti S, Soriani M, Margarit I, Rappuoli R, Grandi G, Norais N.

Mol Cell Proteomics. 2015 Aug;14(8):2138-49. doi: 10.1074/mcp.M114.045880. Epub 2015 May 27.

21.

Vaccine adjuvant MF59 promotes retention of unprocessed antigen in lymph node macrophage compartments and follicular dendritic cells.

Cantisani R, Pezzicoli A, Cioncada R, Malzone C, De Gregorio E, D'Oro U, Piccioli D.

J Immunol. 2015 Feb 15;194(4):1717-25. doi: 10.4049/jimmunol.1400623. Epub 2015 Jan 14.

22.

Rational design of small molecules as vaccine adjuvants.

Wu TY, Singh M, Miller AT, De Gregorio E, Doro F, D'Oro U, Skibinski DA, Mbow ML, Bufali S, Herman AE, Cortez A, Li Y, Nayak BP, Tritto E, Filippi CM, Otten GR, Brito LA, Monaci E, Li C, Aprea S, Valentini S, Calabrό S, Laera D, Brunelli B, Caproni E, Malyala P, Panchal RG, Warren TK, Bavari S, O'Hagan DT, Cooke MP, Valiante NM.

Sci Transl Med. 2014 Nov 19;6(263):263ra160. doi: 10.1126/scitranslmed.3009980.

23.

Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines.

Seubert A, D'Oro U, Scarselli M, Pizza M.

Expert Rev Vaccines. 2014 Oct;13(10):1191-204. doi: 10.1586/14760584.2014.942641. Epub 2014 Sep 3. Review.

PMID:
25183193
24.

Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants.

Rossi O, Pesce I, Giannelli C, Aprea S, Caboni M, Citiulo F, Valentini S, Ferlenghi I, MacLennan CA, D'Oro U, Saul A, Gerke C.

J Biol Chem. 2014 Sep 5;289(36):24922-35. doi: 10.1074/jbc.M114.566570. Epub 2014 Jul 14.

25.

Mandibular distraction in hemifacial microsomia is not a permanent treatment: a long-term evaluation.

Ascenço AS, Balbinot P, Junior IM, D'Oro U, Busato L, da Silva Freitas R.

J Craniofac Surg. 2014 Mar;25(2):352-4. doi: 10.1097/01.scs.0000436741.90536.bf.

PMID:
24531243
26.

Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells.

Cantisani R, Sammicheli C, Tavarini S, D'Oro U, Wack A, Piccioli D.

Hum Immunol. 2011 Nov;72(11):1018-21. doi: 10.1016/j.humimm.2011.08.008. Epub 2011 Aug 10.

PMID:
21867739
27.

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.

Seubert A, Calabro S, Santini L, Galli B, Genovese A, Valentini S, Aprea S, Colaprico A, D'Oro U, Giuliani MM, Pallaoro M, Pizza M, O'Hagan DT, Wack A, Rappuoli R, De Gregorio E.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11169-74. doi: 10.1073/pnas.1107941108. Epub 2011 Jun 20.

28.

A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.

Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A.

J Immunol. 2011 Apr 1;186(7):4213-22. doi: 10.4049/jimmunol.1003585. Epub 2011 Mar 7.

29.

DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.

Cavalieri D, Rivero D, Beltrame L, Buschow SI, Calura E, Rizzetto L, Gessani S, Gauzzi MC, Reith W, Baur A, Bonaiuti R, Brandizi M, De Filippo C, D'Oro U, Draghici S, Dunand-Sauthier I, Gatti E, Granucci F, Gündel M, Kramer M, Kuka M, Lanyi A, Melief CJ, van Montfoort N, Ostuni R, Pierre P, Popovici R, Rajnavolgyi E, Schierer S, Schuler G, Soumelis V, Splendiani A, Stefanini I, Torcia MG, Zanoni I, Zollinger R, Figdor CG, Austyn JM.

Immunome Res. 2010 Nov 19;6:10. doi: 10.1186/1745-7580-6-10.

30.

Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.

Kuka M, Baronio R, Valentini S, Monaci E, Muzzi A, Aprea S, De Gregorio E, D'Oro U.

PLoS One. 2010 Jul 9;5(7):e11491. doi: 10.1371/journal.pone.0011491.

31.

Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism.

Rizzetto L, Kuka M, De Filippo C, Cambi A, Netea MG, Beltrame L, Napolitani G, Torcia MG, D'Oro U, Cavalieri D.

J Immunol. 2010 Apr 15;184(8):4258-68. doi: 10.4049/jimmunol.0902972. Epub 2010 Mar 12.

32.

Immunology of TLR-independent vaccine adjuvants.

De Gregorio E, D'Oro U, Wack A.

Curr Opin Immunol. 2009 Jun;21(3):339-45. doi: 10.1016/j.coi.2009.05.003. Epub 2009 Jun 1. Review.

PMID:
19493664
33.

Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs.

Gallorini S, Berti F, Parente P, Baronio R, Aprea S, D'Oro U, Pizza M, Telford JL, Wack A.

J Immunol. 2007 Dec 15;179(12):8208-15.

34.

Mandible distraction using internal device: mathematical analysis of the results.

Freitas Rda S, Alonso N, Busato L, D'oro U, Ferreira MC.

J Craniofac Surg. 2007 Jan;18(1):29-38.

PMID:
17251832
35.

Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders.

Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, D'Oro U, Nuti S, Houghton M, Barnaba V, Pozzato G, Abrignani S.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18544-9. Epub 2005 Dec 9.

36.

Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.

Galgani M, De Rosa V, De Simone S, Leonardi A, D'Oro U, Napolitani G, Masci AM, Zappacosta S, Racioppi L.

J Biol Chem. 2004 Jul 30;279(31):32507-14. Epub 2004 May 27.

37.

Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation.

Napolitani G, Bortoletto N, Racioppi L, Lanzavecchia A, D'Oro U.

Eur J Immunol. 2003 Oct;33(10):2832-41.

38.

T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.

Soldaini E, Wack A, D'Oro U, Nuti S, Ulivieri C, Baldari CT, Abrignani S.

Eur J Immunol. 2003 Feb;33(2):455-64.

39.

Regulation of constitutive TCR internalization by the zeta-chain.

D'Oro U, Munitic I, Chacko G, Karpova T, McNally J, Ashwell JD.

J Immunol. 2002 Dec 1;169(11):6269-78.

40.

Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells.

Bortoletto N, Scotet E, Myamoto Y, D'Oro U, Lanzavecchia A.

Eur J Immunol. 2002 Nov;32(11):3102-7.

41.

Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein.

Crotta S, Stilla A, Wack A, D'Andrea A, Nuti S, D'Oro U, Mosca M, Filliponi F, Brunetto RM, Bonino F, Abrignani S, Valiante NM.

J Exp Med. 2002 Jan 7;195(1):35-41.

42.

Modulation of CD45 tyrosine phosphatase activity by antigen.

Lago Paz F, Galgani M, D'Oro U, Matarese G, Masci AM, Zappacosta S, Racioppi L.

Eur J Immunol. 2001 Mar;31(3):777-82.

43.

CD45 and Src-family kinases: and now for something completely different.

Ashwell JD, D'Oro U.

Immunol Today. 1999 Sep;20(9):412-6. Review. No abstract available.

PMID:
10462741
44.
45.
46.

The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.

Racioppi L, Matarese G, D'Oro U, De Pascale M, Masci AM, Fontana S, Zappacosta S.

Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10360-5.

47.
48.

HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.

Di Rosa F, D'Oro U, Ruggiero G, Racioppi L, Acquaviva A, Ferrone S, Fontana S, Zappacosta S.

Hum Immunol. 1993 Dec;38(4):251-60.

PMID:
8138420
49.

HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.

Ruggiero G, Racioppi L, Manzo C, Pirozzi G, D'Oro U, Ferrone S, Zappacosta S, Fontana S.

Eur J Immunol. 1991 Jan;21(1):29-33.

PMID:
1825060

Supplemental Content

Support Center