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Items: 1 to 50 of 232

1.

Experimental autoimmune encephalomyelitis potentiates mouse mast cell protease 4-dependent pressor responses to centrally or systemically administered big endothelin-1.

Desbiens L, Lapointe C, Gendron L, Gharagozloo M, Vincent L, Pejler G, Gris D, D'Orleans-Juste P.

J Pharmacol Exp Ther. 2019 Jun 27. pii: jpet.118.256016. doi: 10.1124/jpet.118.256016. [Epub ahead of print]

2.

Endothelins in inflammatory neurological diseases.

D'Orléans-Juste P, Akide Ndunge OB, Desbiens L, Tanowitz HB, Desruisseaux MS.

Pharmacol Ther. 2019 Feb;194:145-160. doi: 10.1016/j.pharmthera.2018.10.001. Epub 2018 Oct 3. Review.

PMID:
30291906
3.

Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.

Houde M, Schwertani A, Touil H, Desbiens L, Sarrhini O, Lecomte R, Lepage M, Gagnon H, Takai S, Pejler G, Jacques D, Gobeil F Jr, Day R, D'Orléans-Juste P.

Front Pharmacol. 2018 Aug 31;9:868. doi: 10.3389/fphar.2018.00868. eCollection 2018.

4.

Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis.

Hassan GS, Jacques D, D'Orléans-Juste P, Magder S, Bkaily G.

Can J Physiol Pharmacol. 2018 Jul;96(7):655-661. doi: 10.1139/cjpp-2018-0093. Epub 2018 May 14.

PMID:
29756482
5.

Neuropeptide Y and its receptors in ventricular endocardial endothelial cells.

Jacques D, D'Orléans-Juste P, Magder S, Bkaily G.

Can J Physiol Pharmacol. 2017 Oct;95(10):1224-1229. doi: 10.1139/cjpp-2017-0290. Epub 2017 Jul 24. Review.

PMID:
28738162
6.

Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells.

Mikhail M, Vachon PH, D'Orléans-Juste P, Jacques D, Bkaily G.

Can J Physiol Pharmacol. 2017 Oct;95(10):1298-1305. doi: 10.1139/cjpp-2017-0412. Epub 2017 Jul 21.

PMID:
28732172
7.

Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice.

Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P.

Can J Physiol Pharmacol. 2017 Aug;95(8):954-960. doi: 10.1139/cjpp-2017-0314. Epub 2017 Jul 13.

PMID:
28704616
8.

Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.

Desbiens L, Lapointe C, Gharagozloo M, Mahmoud S, Pejler G, Gris D, D'Orléans-Juste P.

Mediators Inflamm. 2016;2016:9797021. doi: 10.1155/2016/9797021. Epub 2016 Aug 17.

9.

Endothelin-1: Biosynthesis, Signaling and Vasoreactivity.

Houde M, Desbiens L, D'Orléans-Juste P.

Adv Pharmacol. 2016;77:143-75. doi: 10.1016/bs.apha.2016.05.002. Epub 2016 Jun 21. Review.

PMID:
27451097
10.

Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice.

Houde M, Desbiens L, Schwertani A, Pejler G, Iglarz M, D'Orléans-Juste P.

Life Sci. 2016 Aug 15;159:71-75. doi: 10.1016/j.lfs.2016.03.018. Epub 2016 Mar 12.

PMID:
26976326
11.

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.

Simard E, Söllradl T, Maltais JS, Boucher J, D'Orléans-Juste P, Grandbois M.

PLoS One. 2015 Aug 6;10(8):e0128881. doi: 10.1371/journal.pone.0128881. eCollection 2015.

12.

Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment.

Simplicio JA, Resstel LB, Tirapelli DP, D'Orléans-Juste P, Tirapelli CR.

Vascul Pharmacol. 2015 Oct;73:124-37. doi: 10.1016/j.vph.2015.06.015. Epub 2015 Jun 30.

PMID:
26141931
13.

Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation.

Boucher J, Simard É, Froehlich U, D'Orléans-Juste P, Grandbois M.

Anal Biochem. 2015 Jun 1;478:73-81. doi: 10.1016/j.ab.2015.03.017. Epub 2015 Mar 21.

PMID:
25800564
14.

Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells.

Bkaily G, Avedanian L, Al-Khoury J, Chamoun M, Semaan R, Jubinville-Leblanc C, D'Orléans-Juste P, Jacques D.

Can J Physiol Pharmacol. 2015 Apr;93(4):291-7. doi: 10.1139/cjpp-2014-0519. Epub 2015 Jan 21.

PMID:
25741585
15.

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.

Semaan W, Desbiens L, Houde M, Labonté J, Gagnon H, Yamamoto D, Takai S, Laidlaw T, Bkaily G, Schwertani A, Pejler G, Levesque C, Desjardins R, Day R, D'Orléans-Juste P.

Biochem Pharmacol. 2015 Mar 15;94(2):91-100. doi: 10.1016/j.bcp.2015.02.001. Epub 2015 Feb 7.

PMID:
25667044
16.

Are sildenafil derivatives useful even in unborn males?

D'Orléans-Juste P, Houde M, Semaan W.

Hypertension. 2013 Oct;62(4):685-6. doi: 10.1161/HYPERTENSIONAHA.113.01870. Epub 2013 Aug 12. No abstract available.

PMID:
23940200
17.

High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722.

Brochu I, Houde M, Desbiens L, Simard E, Gobeil F, Semaan W, Bkaily G, D'Orléans-Juste P.

Br J Pharmacol. 2013 Sep;170(2):266-77. doi: 10.1111/bph.12259.

18.

Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

Houde M, Jamain MD, Labonté J, Desbiens L, Pejler G, Gurish M, Takai S, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2013 Jul;346(1):31-7. doi: 10.1124/jpet.112.202275. Epub 2013 Apr 17.

19.

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

Bramall AN, Szego MJ, Pacione LR, Chang I, Diez E, D'Orleans-Juste P, Stewart DJ, Hauswirth WW, Yanagisawa M, McInnes RR.

PLoS One. 2013;8(2):e58023. doi: 10.1371/journal.pone.0058023. Epub 2013 Feb 28.

20.

8-BuS-ATP derivatives as specific NTPDase1 inhibitors.

Lecka J, Gillerman I, Fausther M, Salem M, Munkonda MN, Brosseau JP, Cadot C, Martín-Satué M, d'Orléans-Juste P, Rousseau E, Poirier D, Künzli B, Fischer B, Sévigny J.

Br J Pharmacol. 2013 May;169(1):179-96. doi: 10.1111/bph.12135.

21.

Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist.

Savard M, Labonté J, Dubuc C, Neugebauer W, D'Orléans-Juste P, Gobeil F Jr.

Biol Chem. 2013 Mar;394(3):353-60. doi: 10.1515/hsz-2012-0295.

PMID:
23362191
22.

Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells.

Abdel-Samad D, Perreault C, Ahmarani L, Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D.

Neuropeptides. 2012 Dec;46(6):373-82. doi: 10.1016/j.npep.2012.09.003. Epub 2012 Oct 26.

PMID:
23107364
23.

Loss of endothelial furin leads to cardiac malformation and early postnatal death.

Kim W, Essalmani R, Szumska D, Creemers JW, Roebroek AJ, D'Orleans-Juste P, Bhattacharya S, Seidah NG, Prat A.

Mol Cell Biol. 2012 Sep;32(17):3382-91. doi: 10.1128/MCB.06331-11. Epub 2012 Jun 25.

24.

Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice.

You Z, Genest J Jr, Barrette PO, Hafiane A, Behm DJ, D'Orleans-Juste P, Schwertani AG.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1809-16. doi: 10.1161/ATVBAHA.112.252973. Epub 2012 Jun 21.

PMID:
22723440
25.

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R.

J Biol Chem. 2012 Apr 27;287(18):14703-17. doi: 10.1074/jbc.M111.323220. Epub 2012 Mar 6.

26.

Endothelin and bradykinin: 'brothers-in-arms' in Chagas vasculopathies?

D'Orléans-Juste P, Bkaily G, Rae GA.

Br J Pharmacol. 2012 Mar;165(5):1330-2. doi: 10.1111/j.1476-5381.2011.01636.x.

27.

Peptide and non-peptide antagonists targeting endothelin receptors in physiology and pathology.

Houde M, Labonté J, D'Orléans-Juste P.

Curr Pharm Des. 2011;17(25):2613-25. Review.

PMID:
21728984
28.

Nuclear membrane receptors for ET-1 in cardiovascular function.

Bkaily G, Avedanian L, Al-Khoury J, Provost C, Nader M, D'Orléans-Juste P, Jacques D.

Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R251-63. doi: 10.1152/ajpregu.00736.2009. Epub 2010 Nov 17. Review.

29.

ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium.

Avedanian L, Riopel J, Bkaily G, Nader M, D'Orleans-Juste P, Jacques D.

Can J Physiol Pharmacol. 2010 Aug;88(8):817-29. doi: 10.1139/Y10-057.

30.

Introduction.

D'Orléans-Juste P, Benigni A, Davenport AP, Pollock DM.

Can J Physiol Pharmacol. 2010 Jun;88(6):v-vi. English, French. No abstract available.

PMID:
20642024
31.

The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation.

Kauffenstein G, Fürstenau CR, D'Orléans-Juste P, Sévigny J.

Br J Pharmacol. 2010 Feb 1;159(3):576-85. doi: 10.1111/j.1476-5381.2009.00566.x. Epub 2010 Jan 8.

32.

Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic.

Ross B, D'Orléans-Juste P, Giaid A.

Am J Respir Cell Mol Biol. 2010 Jan;42(1):16-20. doi: 10.1165/rcmb.2009-0175TR. Epub 2009 Aug 28. Review.

PMID:
19717811
33.

Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.

Bousette N, D'Orleans-Juste P, Kiss RS, You Z, Genest J, Al-Ramli W, Qureshi ST, Gramolini A, Behm D, Ohlstein EH, Harrison SM, Douglas SA, Giaid A.

Circ Res. 2009 Sep 25;105(7):686-95, 19 p following 695. doi: 10.1161/CIRCRESAHA.107.168799. Epub 2009 Aug 20.

PMID:
19696412
34.

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.

Kauffenstein G, Drouin A, Thorin-Trescases N, Bachelard H, Robaye B, D'Orléans-Juste P, Marceau F, Thorin E, Sévigny J.

Cardiovasc Res. 2010 Jan 1;85(1):204-13. doi: 10.1093/cvr/cvp265.

35.

Roles of endothelin ETA and ETB receptors in nociception and chemical, thermal and mechanical hyperalgesia induced by endothelin-1 in the rat hindpaw.

Motta EM, Chichorro JG, D'Orléans-Juste P, Rae GA.

Peptides. 2009 May;30(5):918-25. doi: 10.1016/j.peptides.2009.01.011. Epub 2009 Feb 7.

PMID:
19428770
36.

Design, synthesis and pharmacological characterization of fluorescein-derived endothelin antagonists Bq-123 and Bq-788.

Brosseau JP, Neugebauer WA, Gobeil F Jr, D'Orléans-Juste P.

Adv Exp Med Biol. 2009;611:443-4. No abstract available.

PMID:
19400258
37.

Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo.

Simard E, Jin D, Takai S, Miyazaki M, Brochu I, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2009 Feb;328(2):540-8. doi: 10.1124/jpet.108.142992. Epub 2008 Nov 5.

PMID:
18987301
38.

Forefronts in endothelin.

D'Orleans-Juste P, Kohan D, Benigni A.

Can J Physiol Pharmacol. 2008 Jun;86(6):v-vi. doi: 10.1139/y08-902. No abstract available.

39.

Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells.

Bkaily G, Choufani S, Avedanian L, Ahmarani L, Nader M, Jacques D, D'Orléans-Juste P, Al Khoury J.

Can J Physiol Pharmacol. 2008 Aug;86(8):546-56. doi: 10.1139/Y08-048.

40.

Distinct modulation of the endothelin-1 pathway in iNOS-/- and eNOS-/- mice.

Labonté J, Brochu I, Simard E, D'Orléans-Juste P.

Can J Physiol Pharmacol. 2008 Aug;86(8):516-25. doi: 10.1139/Y08-042.

41.

Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.

D'Orléans-Juste P, Houde M, Rae GA, Bkaily G, Carrier E, Simard E.

Vascul Pharmacol. 2008 Aug-Sep;49(2-3):51-62. doi: 10.1016/j.vph.2008.06.007. Epub 2008 Jul 12. Review.

PMID:
18675382
42.

Nonselective ETA/ETB-receptor blockade increases systemic blood pressure of Bio 14.6 cardiomyopathic hamsters.

Honoré JC, Carrier E, Fecteau MH, Tirapelli CR, Bkaily G, D'Orleans-Juste P.

Can J Physiol Pharmacol. 2008 Jun;86(6):394-401. doi: 10.1139/Y08-041.

43.

Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats.

Tirapelli CR, Legros E, Brochu I, Honoré JC, Lanchote VL, Uyemura SA, de Oliveira AM, D'Orléans-Juste P.

Br J Pharmacol. 2008 Jul;154(5):971-81. doi: 10.1038/bjp.2008.157. Epub 2008 May 12.

44.

Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation.

Savard M, Barbaz D, Bélanger S, Müller-Esterl W, Bkaily G, D'orléans-Juste P, Coté J, Bovenzi V, Gobeil F Jr.

J Cell Physiol. 2008 Jul;216(1):234-44. doi: 10.1002/jcp.21398.

PMID:
18264983
45.

Characterization of the non-adrenergic/non-cholinergic response to perivascular nerve stimulation in the double-perfused mesenteric bed of the mouse.

Legros E, Tirapelli CR, Carrier E, Brochu I, Fournier A, D'Orléans-Juste P.

Br J Pharmacol. 2007 Dec;152(7):1049-59. Epub 2007 Oct 1.

46.

The inducible nitric-oxide synthase modulates endothelin-1-dependent release of prostacyclin and inhibition of platelet aggregation ex vivo in the mouse.

Carrier E, Brochu I, de Brum-Fernandes AJ, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2007 Dec;323(3):972-8. Epub 2007 Sep 20.

PMID:
17885093
47.

Adventitia contribution to vascular contraction: hints provided by tissue-engineered substitutes.

Auger FA, D'Orléans-Juste P, Germain L.

Cardiovasc Res. 2007 Sep 1;75(4):669-78. Epub 2007 Jun 8. Review.

PMID:
17631875
48.

A new paradigm: calcium independent and caveolae internalization dependent release of nitric oxide by the endothelial nitric oxide synthase.

Bkaily G, D'Orleans-Juste P, Jacques D.

Circ Res. 2006 Oct 13;99(8):793-4. Review. No abstract available.

PMID:
17038647
49.

ETB receptor dependent alteration in aortic responses to ET-1 in the cardiomyopathic hamster.

Al-Khoury J, Bkaily G, Chahine M, Jacques D, D'Orléans-Juste P.

Can J Physiol Pharmacol. 2006 Jul;84(7):787-94.

PMID:
16998542
50.

Tissue-engineered human vascular media produced in vitro by the self-assembly approach present functional properties similar to those of their native blood vessels.

Laflamme K, Roberge CJ, Pouliot S, D'Orléans-Juste P, Auger FA, Germain L.

Tissue Eng. 2006 Aug;12(8):2275-81.

PMID:
16968167

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