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Items: 1 to 50 of 67

1.

Stenosis coexists with compromised α1-adrenergic contractions in the ascending aorta of a mouse model of Williams-Beuren syndrome.

Jiménez-Altayó F, Ortiz-Romero P, Puertas-Umbert L, Dantas AP, Pérez B, Vila E, D'Ocon P, Campuzano V.

Sci Rep. 2020 Jan 21;10(1):889. doi: 10.1038/s41598-020-57803-3.

2.

Beta-blockers: Historical Perspective and Mechanisms of Action.

Oliver E, Mayor F Jr, D'Ocon P.

Rev Esp Cardiol (Engl Ed). 2019 Oct;72(10):853-862. doi: 10.1016/j.rec.2019.04.006. Epub 2019 Jun 6. Review. English, Spanish.

PMID:
31178382
3.

Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension.

Vila E, Solé M, Masip N, Puertas-Umbert L, Amaro S, Dantas AP, Unzeta M, D'Ocon P, Planas AM, Chamorro Á, Jiménez-Altayó F.

Biochem Pharmacol. 2019 Jun;164:115-128. doi: 10.1016/j.bcp.2019.04.002. Epub 2019 Apr 4.

PMID:
30954486
4.

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation.

Rodriguez-Serrano M, Rueda J, Buendía F, Monto F, Aguero J, Osa A, Cano O, Martínez-Dolz L, D'Ocon P.

Front Pharmacol. 2019 Feb 19;10:93. doi: 10.3389/fphar.2019.00093. eCollection 2019.

5.

Dexamethasone Preconditioning in Cardiac Procedures Reduces Decreased Antithrombin Activity and Is Associated to Beneficial Outcomes: Role of Endothelium.

Muedra V, Moreno L, Rodilla V, Arce C, Montó F, Blázquez Á, Pérez P, D'Ocón P.

Front Pharmacol. 2018 Sep 25;9:1014. doi: 10.3389/fphar.2018.01014. eCollection 2018.

6.

A History of the Pharmacological Treatment of Bipolar Disorder.

López-Muñoz F, Shen WW, D'Ocon P, Romero A, Álamo C.

Int J Mol Sci. 2018 Jul 23;19(7). pii: E2143. doi: 10.3390/ijms19072143. Review.

7.

RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.

Wang YY, Mesirca P, Marqués-Sulé E, Zahradnikova A Jr, Villejoubert O, D'Ocon P, Ruiz C, Domingo D, Zorio E, Mangoni ME, Benitah JP, Gómez AM.

JCI Insight. 2017 Apr 20;2(8). pii: 91872. doi: 10.1172/jci.insight.91872. eCollection 2017 Apr 20.

8.

Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing.

Arce C, Vicente D, Segura V, Flacco N, Montó F, Almenar L, Agüero J, Rueda J, Jiménez-Altayó F, Vila E, Noguera MA, D'Ocon P, Ivorra MD.

Br J Pharmacol. 2017 Jul;174(13):2015-2030. doi: 10.1111/bph.13800. Epub 2017 May 10.

9.

Changes in the expression of α1B-adrenoceptor in peripheral mononuclear cells correlates with blood pressure and plasmatic homocysteine.

Oliver E, Montó F, Rovira E, Valldecabres C, Muedra V, D'Ocon P.

Biomed Pharmacother. 2017 Apr;88:721-727. doi: 10.1016/j.biopha.2017.01.061. Epub 2017 Jan 30.

PMID:
28152482
10.

Methodological Approach to Use Fresh and Cryopreserved Vessels as Tools to Analyze Pharmacological Modulation of the Angiogenic Growth.

Vicente D, Hernández B, Segura V, Pascual D, Fornaciari G, Monto F, Mirabet V, Montesinos MC, DʼOcon P.

J Cardiovasc Pharmacol. 2016 Sep;68(3):230-40. doi: 10.1097/FJC.0000000000000407.

PMID:
27631438
11.

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

Salerno S, Marini AM, Fornaciari G, Simorini F, La Motta C, Taliani S, Sartini S, Da Settimo F, García-Argáez AN, Gia O, Cosconati S, Novellino E, D'Ocon P, Fioravanti A, Orlandi P, Bocci G, Dalla Via L.

Eur J Med Chem. 2015 Oct 20;103:29-43. doi: 10.1016/j.ejmech.2015.08.027. Epub 2015 Aug 14.

PMID:
26318056
12.

β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.

Montó F, Oliver E, Vicente D, Buendía F, Rueda J, Agüero J, Almenar L, Valldecabres C, Rovira E, Muedra V, Noguera MA, Ivorra MD, DʼOcon P.

J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.

PMID:
26248277
13.

Glucocorticoids as modulators of expression and activity of Antithrombin (At): potential clinical relevance.

Barettino D, Masiá S, Montó F, Pérez P, D'Ocon P, Moreno L, Muedra V.

Thromb Res. 2015 Jan;135(1):183-91. doi: 10.1016/j.thromres.2014.10.026. Epub 2014 Nov 5.

PMID:
25466848
14.

Endothelial NT-3 delivered by vasculature and CSF promotes quiescence of subependymal neural stem cells through nitric oxide induction.

Delgado AC, Ferrón SR, Vicente D, Porlan E, Perez-Villalba A, Trujillo CM, D'Ocón P, Fariñas I.

Neuron. 2014 Aug 6;83(3):572-85. doi: 10.1016/j.neuron.2014.06.015. Epub 2014 Jul 18.

15.

β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

Perez-Aso M, Flacco N, Carpena N, Montesinos MC, D'Ocon P, Ivorra MD.

Vascul Pharmacol. 2014 May-Jun;61(2-3):80-9. doi: 10.1016/j.vph.2014.04.003. Epub 2014 Apr 24.

PMID:
24768830
16.

Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models.

Montó F, Arce C, Noguera MA, Ivorra MD, Flanagan J, Roller M, Issaly N, D'Ocon P.

Food Funct. 2014 Apr;5(4):786-96. doi: 10.1039/c3fo60539f.

PMID:
24573510
17.

Role of endothelial nitric oxide in pulmonary and systemic arteries during hypoxia.

Nuñez C, Victor VM, Martí M, D'Ocon P.

Nitric Oxide. 2014 Feb 15;37:17-27. doi: 10.1016/j.niox.2013.12.008. Epub 2013 Dec 21.

PMID:
24365975
18.

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries.

Flacco N, Parés J, Serna E, Segura V, Vicente D, Pérez-Aso M, Noguera MA, Ivorra MD, McGrath JC, D'Ocon P.

Pharmacol Res Perspect. 2013 Oct;1(1):e00001. doi: 10.1002/prp2.1. Epub 2013 Aug 28.

19.

The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation.

Perez-Aso M, Segura V, Montó F, Barettino D, Noguera MA, Milligan G, D'Ocon P.

Biochim Biophys Acta. 2013 Oct;1833(10):2322-33. doi: 10.1016/j.bbamcr.2013.06.013. Epub 2013 Jun 21.

20.

Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.

Vicente D, Montó F, Oliver E, Buendía F, Rueda J, Agüero J, Almenar L, Barettino D, D'Ocon P.

Life Sci. 2013 Jul 30;93(2-3):108-15. doi: 10.1016/j.lfs.2013.05.025. Epub 2013 Jun 11.

PMID:
23770231
21.

Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting.

Segura V, Pérez-Aso M, Montó F, Carceller E, Noguera MA, Pediani J, Milligan G, McGrath IC, D'Ocon P.

PLoS One. 2013 May 24;8(5):e64996. doi: 10.1371/journal.pone.0064996. Print 2013.

22.

Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.

Flacco N, Segura V, Perez-Aso M, Estrada S, Seller JF, Jiménez-Altayó F, Noguera MA, D'Ocon P, Vila E, Ivorra MD.

Br J Pharmacol. 2013 May;169(2):413-25. doi: 10.1111/bph.12121.

23.

Antithrombin activity and outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass.

Muedra V, Barettino D, D'Ocón P, Zuñiga A, Moreno L.

Blood Coagul Fibrinolysis. 2013 Jun;24(4):454-7. doi: 10.1097/MBC.0b013e32835d5422.

24.

[Role of antithrombin iii in cardiac surgery].

Muedra V, Barettino D, D'Ocón P.

Rev Esp Anestesiol Reanim. 2013 Nov;60(9):519-27. doi: 10.1016/j.redar.2012.09.025. Epub 2012 Dec 8. Spanish.

PMID:
23228672
25.

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.

Montó F, Oliver E, Vicente D, Rueda J, Agüero J, Almenar L, Ivorra MD, Barettino D, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.

26.

Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure.

Agüero J, Almenar L, Montó F, Oliver E, Sánchez-Lázaro I, Vicente D, Martínez-Dolz L, D'Ocon P, Rueda J, Salvador A.

J Card Fail. 2012 Jan;18(1):53-61. doi: 10.1016/j.cardfail.2011.10.008. Epub 2011 Nov 25.

PMID:
22196842
27.

Increased endothelin-1 vasoconstriction in mesenteric resistance arteries after superior mesenteric ischaemia-reperfusion.

Martínez-Revelles S, Caracuel L, Márquez-Martín A, Dantas A, Oliver E, D'Ocon P, Vila E.

Br J Pharmacol. 2012 Feb;165(4):937-50. doi: 10.1111/j.1476-5381.2011.01617.x.

28.

Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors.

Segura V, Flacco N, Oliver E, Barettino D, D'Ocon P, Ivorra MD.

Eur J Pharmacol. 2010 Sep 1;641(1):41-8. doi: 10.1016/j.ejphar.2010.05.016. Epub 2010 May 23.

29.

beta-Adrenoceptor and GRK3 expression in human lymphocytes is related to blood pressure and urinary albumin excretion.

Oliver E, Rovira E, Montó F, Valldecabres C, Julve R, Muedra V, Ruiz N, Barettino D, D'Ocon P.

J Hypertens. 2010 Jun;28(6):1281-9. doi: 10.1097/HJH.0b013e3283383564.

30.

Myocardial and peripheral lymphocytic transcriptomic dissociation of beta-adrenoceptors and G protein-coupled receptor kinases in heart transplantation.

Agüero J, Almenar L, D'Ocon P, Oliver E, Montó F, Rueda J, Vicente D, Martínez-Dolz L, Salvador A.

J Heart Lung Transplant. 2009 Nov;28(11):1166-71. doi: 10.1016/j.healun.2009.06.003. Epub 2009 Sep 26.

PMID:
19782607
31.

Regulation of oxygen distribution in tissues by endothelial nitric oxide.

Victor VM, Nuñez C, D'Ocón P, Taylor CT, Esplugues JV, Moncada S.

Circ Res. 2009 May 22;104(10):1178-83. doi: 10.1161/CIRCRESAHA.109.197228. Epub 2009 Apr 30.

PMID:
19407240
32.

The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.

Oliver E, Martí D, Montó F, Flacco N, Moreno L, Barettino D, Ivorra MD, D'Ocon P.

J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. doi: 10.1124/jpet.108.146043. Epub 2008 Dec 5. Erratum in: J Pharmacol Exp Ther. 2010 Aug;334(2):679.

PMID:
19060223
33.

Correlation between beta-adrenoceptors and G-protein-coupled receptor kinases in pretransplantation heart failure.

Agüero J, Almenar L, D'Ocon P, Oliver E, Montó F, Moro J, Castelló A, Rueda J, Martínez-Dolz L, Sánchez-Lazaro I, Montero JA.

Transplant Proc. 2008 Nov;40(9):3014-6. doi: 10.1016/j.transproceed.2008.09.011.

PMID:
19010176
34.

Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants.

Esplugues JV, Rocha M, Nuñez C, Bosca I, Ibiza S, Herance JR, Ortega A, Serrador JM, D'Ocon P, Victor VM.

Circ Res. 2006 Nov 10;99(10):1067-75. Epub 2006 Oct 19.

PMID:
17053193
35.

8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes.

Ivorra MD, Valiente M, Martínez S, Madrero Y, Noguera MA, Cassels BK, Sobarzo EM, D'Ocon P.

Planta Med. 2005 Oct;71(10):897-903.

PMID:
16254819
36.

Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO.

Núñez C, Víctor VM, Tur R, Alvarez-Barrientos A, Moncada S, Esplugues JV, D'Ocón P.

Circ Res. 2005 Nov 11;97(10):1063-9. Epub 2005 Oct 13.

PMID:
16224067
37.

Correlation between mRNA levels and functional role of alpha1-adrenoceptor subtypes in arteries: evidence of alpha1L as a functional isoform of the alpha1A-adrenoceptor.

Martí D, Miquel R, Ziani K, Gisbert R, Ivorra MD, Anselmi E, Moreno L, Villagrasa V, Barettino D, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1923-32. Epub 2005 Jun 10.

38.
39.

Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation metabolite.

Abarca B, Ballesteros R, Bielsa P, Moragues J, D'Ocon P, García-Zaragozá E, Noguera MA.

Eur J Med Chem. 2003 May;38(5):501-11.

PMID:
12767600
40.

Cytosolic Ca2+ and phosphoinositide hydrolysis linked to constitutively active alpha 1D-adrenoceptors in vascular smooth muscle.

Gisbert R, Pérez-Vizcaino F, Cogolludo AL, Noguera MA, Ivorra MD, Tamargo J, D'Ocon P.

J Pharmacol Exp Ther. 2003 Jun;305(3):1006-14. Epub 2003 Mar 6.

PMID:
12626653
41.

Functional characterization of alpha 1-adrenoceptor subtypes in vascular tissues using different experimental approaches: a comparative study.

Gisbert R, Madrero Y, Sabino V, Noguera MA, Ivorra MD, D'Ocon P.

Br J Pharmacol. 2003 Jan;138(2):359-68.

42.

Alterations by age of calcium handling in rat resistance arteries.

Rubio C, Moreno A, Briones A, Ivorra MD, D'Ocon P, Vila E.

J Cardiovasc Pharmacol. 2002 Dec;40(6):832-40.

PMID:
12451316
43.

Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries.

Ziani K, Gisbert R, Noguera MA, Ivorra MD, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H475-81.

44.

Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.

Gisbert R, Ziani K, Miquel R, Noguera MA, Ivorra MD, Anselmi E, D'Ocon P.

Br J Pharmacol. 2002 Jan;135(1):206-16.

45.

Comparative effects of the novel vasotocin analogue F-180 vs. vasopressin and terlipressin on systemic and splanchnic isolated vessels from portal hypertensive rats.

Ramírez MC, Martínez-Cuesta MA, D'Ocon P, Noguera MA, García-Zaragoza E, Bosch J, Melin P, Esplugues JV.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Sep;364(3):199-204.

PMID:
11521161
46.

Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources.

Noguera MA, Ivorra MD, Lugnier C, D'Ocon P.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Jun;363(6):612-9.

PMID:
11414656
47.

Functional evidence of a constitutively active population of alpha(1D)-adrenoceptors in rat aorta.

Gisbert R, Noguera MA, Ivorra MD, D'Ocon P.

J Pharmacol Exp Ther. 2000 Nov;295(2):810-7.

PMID:
11046122
48.

Mechanism of vascular relaxation by thaligrisine: functional and binding assays.

Tur R, Magraner J, Catret M, Elorriaga M, Ivorra MD, D'Ocon P, Bermejo A, Cabedo N, Cortes D, Anselmi E.

Life Sci. 2000 Aug 18;67(13):1535-48.

PMID:
10983849
49.

Halogenated derivatives of boldine with high selectivity for alpha1A-adrenoceptors in rat cerebral cortex.

Martinez S, Madrero Y, Elorriaga M, Noguera MA, Cassels B, Sobarzo E, D'Ocon P, Ivorra MD.

Life Sci. 1999;64(14):1205-14.

PMID:
10210263
50.

Characterization of two different Ca2+ entry pathways dependent on depletion of internal Ca2+ pools in rat aorta.

Noguera MA, Madrero Y, Ivorra MD, D'Ocon P.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Feb;357(2):92-9.

PMID:
9521481

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