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Items: 1 to 50 of 57

1.

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.

de Menezes MN, Salles ÉM, Vieira F, Amaral EP, Zuzarte-Luís V, Cassado A, Epiphanio S, Alvarez JM, Alves-Filho JC, Mota MM, D'Império-Lima MR.

Sci Rep. 2019 May 20;9(1):7575. doi: 10.1038/s41598-019-44125-2.

2.

Correction: CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria.

Borges da Silva H, Machado de Salles É, Faquim-Mauro EL, Sardinha LR, Álvarez JM, D'Império Lima MR.

PLoS One. 2019 Mar 25;14(3):e0211506. doi: 10.1371/journal.pone.0211506. eCollection 2019.

3.

Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis.

Amaral EP, Machado de Salles É, Barbosa Bomfim CC, Salgado RM, Almeida FM, de Souza PC, Alvarez JM, Hirata MH, Lasunskaia EB, D'Império-Lima MR.

J Infect Dis. 2019 Feb 23;219(6):964-974. doi: 10.1093/infdis/jiy586.

PMID:
30307561
4.

CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria.

Borges da Silva H, Machado de Salles É, Lima-Mauro EF, Sardinha LR, Álvarez JM, D'Império Lima MR.

PLoS One. 2018 Aug 27;13(8):e0202522. doi: 10.1371/journal.pone.0202522. eCollection 2018. Erratum in: PLoS One. 2019 Mar 25;14(3):e0211506.

5.

MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control.

Santana DY, Salgado RM, Fevereiro M, Silva do Nascimento R, Fonseca R, Saraiva Câmara NO, Epiphanio S, Marinho CRF, Barreto-Chaves ML, D' Império-Lima MR, Álvarez JM.

PLoS Negl Trop Dis. 2018 Aug 1;12(8):e0006617. doi: 10.1371/journal.pntd.0006617. eCollection 2018 Aug.

6.

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Amaral EP, Riteau N, Moayeri M, Maier N, Mayer-Barber KD, Pereira RM, Lage SL, Kubler A, Bishai WR, D'Império-Lima MR, Sher A, Andrade BB.

Front Immunol. 2018 Jun 21;9:1427. doi: 10.3389/fimmu.2018.01427. eCollection 2018.

7.

Programmed Cell Death Protein 1-PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection.

Fonseca R, Salgado RM, Borges da Silva H, do Nascimento RS, D'Império-Lima MR, Alvarez JM.

Front Immunol. 2018 May 7;9:997. doi: 10.3389/fimmu.2018.00997. eCollection 2018.

8.

Correction: Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice.

Sercundes MK, Ortolan LS, Debone D, Soeiro-Pereira PV, Gomes E, Aitken EH, Condino-Neto A, Russo M, D' Império Lima MR, Alvarez JM, Portugal S, Marinho CRF, Epiphanio S.

PLoS Pathog. 2017 Nov 15;13(11):e1006730. doi: 10.1371/journal.ppat.1006730. eCollection 2017 Nov.

9.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

Salles ÉM, Menezes MN, Siqueira R, Borges da Silva H, Amaral EP, Castillo-Méndez SI, Cunha I, Cassado ADA, Vieira FS, Olivieri DN, Tadokoro CE, Alvarez JM, Coutinho-Silva R, D'Império-Lima MR.

PLoS Pathog. 2017 Aug 31;13(8):e1006595. doi: 10.1371/journal.ppat.1006595. eCollection 2017 Aug.

10.

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis.

Nascimento IP, Rodriguez D, Santos CC, Amaral EP, Rofatto HK, Junqueira-Kipnis AP, Gonçalves EDC, D'Império-Lima MR, Hirata MH, Silva CL, Winter N, Gicquel B, Mills KHG, Pizza M, Rappuoli R, Leite LCC.

Sci Rep. 2017 May 18;7(1):2109. doi: 10.1038/s41598-017-02003-9.

11.

P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis.

Bomfim CCB, Amaral EP, Cassado ADA, Salles ÉM, do Nascimento RS, Lasunskaia E, Hirata MH, Álvarez JM, D'Império-Lima MR.

Front Immunol. 2017 Apr 13;8:435. doi: 10.3389/fimmu.2017.00435. eCollection 2017.

12.

Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice.

Sercundes MK, Ortolan LS, Debone D, Soeiro-Pereira PV, Gomes E, Aitken EH, Condino-Neto A, Russo M, D' Império Lima MR, Alvarez JM, Portugal S, Marinho CR, Epiphanio S.

PLoS Pathog. 2016 Dec 7;12(12):e1006054. doi: 10.1371/journal.ppat.1006054. eCollection 2016 Dec. Erratum in: PLoS Pathog. 2017 Nov 15;13(11):e1006730.

13.

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control.

Figliuolo VR, Chaves SP, Savio LEB, Thorstenberg MLP, Machado Salles É, Takiya CM, D'Império-Lima MR, de Matos Guedes HL, Rossi-Bergmann B, Coutinho-Silva R.

Purinergic Signal. 2017 Jun;13(2):143-152. doi: 10.1007/s11302-016-9544-1. Epub 2016 Nov 19.

14.

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions.

Amaral EP, Conceição EL, Costa DL, Rocha MS, Marinho JM, Cordeiro-Santos M, D'Império-Lima MR, Barbosa T, Sher A, Andrade BB.

BMC Microbiol. 2016 Oct 28;16(1):251.

15.

Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-γ.

Cabral-Marques O, Ramos RN, Schimke LF, Khan TA, Amaral EP, Barbosa Bomfim CC, Junior OR, França TT, Arslanian C, Carola Correia Lima JD, Weber CW, Ferreira JF, Tavares FS, Sun J, D'Imperio Lima MR, Seelaender M, Garcia Calich VL, Marzagão Barbuto JA, Costa-Carvalho BT, Riemekasten G, Seminario G, Bezrodnik L, Notarangelo L, Torgerson TR, Ochs HD, Condino-Neto A.

J Allergy Clin Immunol. 2017 Mar;139(3):900-912.e7. doi: 10.1016/j.jaci.2016.07.018. Epub 2016 Aug 20.

PMID:
27554817
16.

Interferon-gamma reduces the proliferation of M. tuberculosis within macrophages from a patient with a novel hypomorphic NEMO mutation.

Khan TA, Schimke LF, Amaral EP, Ishfaq M, Barbosa Bonfim CC, Rahman H, Iqbal A, D'Império Lima MR, Costa Carvalho BT, Cabral-Marques O, Condino-Neto A.

Pediatr Blood Cancer. 2016 Oct;63(10):1863-6. doi: 10.1002/pbc.26098. Epub 2016 Jul 8.

PMID:
27391872
17.

The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom.

Moreira V, Teixeira C, Borges da Silva H, D'Império Lima MR, Dos-Santos MC.

Toxicon. 2016 Aug;118:121-8. doi: 10.1016/j.toxicon.2016.04.042. Epub 2016 Apr 21.

PMID:
27109323
18.

IFN-γ Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases.

Borges da Silva H, Fonseca R, Alvarez JM, D'Império Lima MR.

J Immunol Res. 2015;2015:202816. doi: 10.1155/2015/202816. Epub 2015 Oct 5. Review.

19.

Splenic Macrophage Subsets and Their Function during Blood-Borne Infections.

Borges da Silva H, Fonseca R, Pereira RM, Cassado Ados A, Álvarez JM, D'Império Lima MR.

Front Immunol. 2015 Sep 22;6:480. doi: 10.3389/fimmu.2015.00480. eCollection 2015. Review.

20.

Tuberculosis in an autosomal recessive case of chronic granulomatous disease due to mutation of the NCF1 gene.

Khan TA, Cabral-Marques O, Schimke LF, de Oliveira EB Jr, Amaral EP, D'Império Lima MR, Scancetti Tavares F, Costa Carvalho BT, Condino-Neto A.

Allergol Immunopathol (Madr). 2016 May-Jun;44(3):276-9. doi: 10.1016/j.aller.2015.04.003. Epub 2015 Sep 26. No abstract available.

PMID:
26409780
21.

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death.

Amaral EP, Lasunskaia EB, D'Império-Lima MR.

Microbes Infect. 2016 Jan;18(1):11-20. doi: 10.1016/j.micinf.2015.09.005. Epub 2015 Sep 11. Review.

22.

Revisiting mouse peritoneal macrophages: heterogeneity, development, and function.

Cassado Ados A, D'Império Lima MR, Bortoluci KR.

Front Immunol. 2015 May 19;6:225. doi: 10.3389/fimmu.2015.00225. eCollection 2015. Review.

23.

In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.

Borges da Silva H, Fonseca R, Cassado Ados A, Machado de Salles É, de Menezes MN, Langhorne J, Perez KR, Cuccovia IM, Ryffel B, Barreto VM, Marinho CR, Boscardin SB, Álvarez JM, D'Império-Lima MR, Tadokoro CE.

PLoS Pathog. 2015 Feb 6;11(2):e1004598. doi: 10.1371/journal.ppat.1004598. eCollection 2015 Feb.

24.

Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

Ortolan LS, Sercundes MK, Barboza R, Debone D, Murillo O, Hagen SC, Russo M, D' Império Lima MR, Alvarez JM, Amaku M, Marinho CR, Epiphanio S.

Mediators Inflamm. 2014;2014:872464. doi: 10.1155/2014/872464. Epub 2014 Sep 2.

25.

Chagas disease: still many unsolved issues.

Álvarez JM, Fonseca R, Borges da Silva H, Marinho CR, Bortoluci KR, Sardinha LR, Epiphanio S, D'Império Lima MR.

Mediators Inflamm. 2014;2014:912965. doi: 10.1155/2014/912965. Epub 2014 Jun 29. Review.

26.

Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis.

Amaral EP, Ribeiro SC, Lanes VR, Almeida FM, de Andrade MR, Bomfim CC, Salles EM, Bortoluci KR, Coutinho-Silva R, Hirata MH, Alvarez JM, Lasunskaia EB, D'Império-Lima MR.

PLoS Pathog. 2014 Jul 3;10(7):e1004188. doi: 10.1371/journal.ppat.1004188. eCollection 2014 Jul.

27.

IFN-γ-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria.

da Silva HB, de Salles EM, Panatieri RH, Boscardin SB, Rodríguez-Málaga SM, Alvarez JM, D'Império Lima MR.

J Immunol. 2013 Nov 15;191(10):5160-9. doi: 10.4049/jimmunol.1300462. Epub 2013 Oct 16.

28.

Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses.

Lage SL, Buzzo CL, Amaral EP, Matteucci KC, Massis LM, Icimoto MY, Carmona AK, D'Império Lima MR, Rodrigues MM, Ferreira LC, Amarante-Mendes GP, Bortoluci KR.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3321-30. doi: 10.1073/pnas.1305316110. Epub 2013 Aug 13.

29.

The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom.

Moreira V, Teixeira C, Borges da Silva H, D'Império Lima MR, Dos-Santos MC.

Toxicon. 2013 Jun 1;67:37-46. doi: 10.1016/j.toxicon.2013.02.010. Epub 2013 Mar 5.

PMID:
23474268
30.

Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine.

Rosas-Jorquera CE, Sardinha LR, Pretel FD, Bombeiro AL, D'Império Lima MR, Alvarez JM.

Clin Vaccine Immunol. 2013 Feb;20(2):248-54. doi: 10.1128/CVI.00032-12. Epub 2012 Dec 19.

31.

IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction.

Bombeiro AL, Gonçalves LA, Penha-Gonçalves C, Marinho CR, D'Império Lima MR, Chadi G, Álvarez JM.

PLoS One. 2012;7(11):e49022. doi: 10.1371/journal.pone.0049022. Epub 2012 Nov 12.

32.

Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection.

Elias RM, Correa-Costa M, Barreto CR, Silva RC, Hayashida CY, Castoldi A, Gonçalves GM, Braga TT, Barboza R, Rios FJ, Keller AC, Cenedeze MA, Hyane MI, D'Império-Lima MR, Figueiredo-Neto AM, Reis MA, Marinho CR, Pacheco-Silva A, Câmara NO.

PLoS One. 2012;7(8):e44004. doi: 10.1371/journal.pone.0044004. Epub 2012 Aug 31.

33.

Pathogenic Mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages.

Andrade MR, Amaral EP, Ribeiro SC, Almeida FM, Peres TV, Lanes V, D'Império-Lima MR, Lasunskaia EB.

BMC Microbiol. 2012 Aug 3;12:166. doi: 10.1186/1471-2180-12-166.

34.

Early skin immunological disturbance after Plasmodium-infected mosquito bites.

da Silva HB, Caetano SS, Monteiro I, Gómez-Conde I, Hanson K, Penha-Gonçalves C, Olivieri DN, Mota MM, Marinho CR, D'Imperio Lima MR, Tadokoro CE.

Cell Immunol. 2012 May-Jun;277(1-2):22-32. doi: 10.1016/j.cellimm.2012.06.003. Epub 2012 Jun 20.

PMID:
22784562
35.

Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators.

Moreira V, Dos-Santos MC, Nascimento NG, Borges da Silva H, Fernandes CM, D'Império Lima MR, Teixeira C.

Toxicon. 2012 Jul;60(1):12-20. doi: 10.1016/j.toxicon.2012.03.004. Epub 2012 Mar 20.

PMID:
22465491
36.

Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease.

Zago CA, Bortoluci KR, Sardinha LR, Pretel FD, Castillo-Méndez SI, Freitas do Rosário AP, Hiyane MI, Muxel SM, Rodriguez-Málaga SM, Abrahamsohn IA, Álvarez JM, D'Império Lima MR.

PLoS One. 2012;7(1):e29894. doi: 10.1371/journal.pone.0029894. Epub 2012 Jan 17.

37.

Comparative analysis of activation phenotype, proliferation, and IFN-gamma production by spleen NK1.1(+) and NK1.1(-) T cells during Plasmodium chabaudi AS malaria.

Muxel SM, Freitas do Rosário AP, Sardinha LR, Castillo-Méndez SI, Zago CA, Rodriguez-Málaga SM, Alvarez Mosig JM, D'Império Lima MR.

J Interferon Cytokine Res. 2010 Jun;30(6):417-26. doi: 10.1089/jir.2009.0095.

38.

Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi.

Bombeiro AL, D'Império Lima MR, Chadi G, Alvarez JM.

Neuroimmunomodulation. 2010;17(2):67-78. doi: 10.1159/000258689. Epub 2009 Nov 17.

39.

Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.

Freitas do Rosário AP, Muxel SM, Rodríguez-Málaga SM, Sardinha LR, Zago CA, Castillo-Méndez SI, Alvarez JM, D'Império Lima MR.

J Immunol. 2008 Dec 15;181(12):8344-55.

40.

Characterization of the spleen B-cell compartment at the early and late blood-stage Plasmodium chabaudi malaria.

Castillo-Méndez SI, Zago CA, Sardinha LR, Freitas do Rosário AP, Alvarez JM, D'Império Lima MR.

Scand J Immunol. 2007 Aug-Sep;66(2-3):309-19.

41.

Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi.

Sardinha LR, Elias RM, Mosca T, Bastos KR, Marinho CR, D'Império Lima MR, Alvarez JM.

Infect Immun. 2006 Apr;74(4):2031-42.

42.

Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice.

Bastos KR, de Deus Vieira de Moraes L, Zago CA, Marinho CR, Russo M, Alvarez JM, D'Império Lima MR.

Immunology. 2005 Apr;114(4):499-506.

43.

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

Bastos KR, Marinho CR, Barboza R, Russo M, Alvarez JM, D'Império Lima MR.

Microbes Infect. 2004 May;6(6):630-6. Review.

PMID:
15158199
44.

Influence of the polyclonal activation induced by Plasmodium chabaudi on ongoing OVA-specific B- and T-cell responses.

Sardinha LR, D'Império Lima MR, Alvarez JM.

Scand J Immunol. 2002 Oct;56(4):408-16.

45.
46.

Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules.

Grisotto MG, D'Império Lima MR, Marinho CR, Tadokoro CE, Abrahamsohn IA, Alvarez JM.

Immunology. 2001 Feb;102(2):209-17.

47.
48.
49.

Activation of CD4+ and CD8+ parasite -specific T-cells by macrophages infected with live T. cruzi amastigotes.

Caulada-Benedetti Z, Vecchio LC, Pardi CC, Massironi SM, D'Império Lima MR, Abrahamsohn IA.

Immunol Lett. 1998 Sep;63(2):97-105.

PMID:
9761371
50.

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