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Items: 13

1.

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.

Cho S, Zammarchi F, Williams DG, Havenith CEG, Monks NR, Tyrer P, D'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M 3rd, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH.

Mol Cancer Ther. 2018 Oct;17(10):2176-2186. doi: 10.1158/1535-7163.MCT-17-0982. Epub 2018 Jul 31.

PMID:
30065100
2.

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.

Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S, D'Hooge F, Williams DG, Tiberghien A, Howard PW, Hartley JA, van Berkel PH.

Blood. 2018 Mar 8;131(10):1094-1105. doi: 10.1182/blood-2017-10-813493. Epub 2018 Jan 3.

3.

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.

Harper J, Lloyd C, Dimasi N, Toader D, Marwood R, Lewis L, Bannister D, Jovanovic J, Fleming R, D'Hooge F, Mao S, Marrero AM, Korade M 3rd, Strout P, Xu L, Chen C, Wetzel L, Breen S, van Vlerken-Ysla L, Jalla S, Rebelatto M, Zhong H, Hurt EM, Hinrichs MJ, Huang K, Howard PW, Tice DA, Hollingsworth RE, Herbst R, Kamal A.

Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.

4.

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin.

Kemp GC, Tiberghien AC, Patel NV, D'Hooge F, Nilapwar SM, Adams LR, Corbett S, Williams DG, Hartley JA, Howard PW.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1154-1158. doi: 10.1016/j.bmcl.2017.01.074. Epub 2017 Jan 30.

PMID:
28188066
5.

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

Flynn MJ, Zammarchi F, Tyrer PC, Akarca AU, Janghra N, Britten CE, Havenith CE, Levy JN, Tiberghien A, Masterson LA, Barry C, D'Hooge F, Marafioti T, Parren PW, Williams DG, Howard PW, van Berkel PH, Hartley JA.

Mol Cancer Ther. 2016 Nov;15(11):2709-2721. Epub 2016 Aug 17.

6.

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry.

VanBrunt MP, Shanebeck K, Caldwell Z, Johnson J, Thompson P, Martin T, Dong H, Li G, Xu H, D'Hooge F, Masterson L, Bariola P, Tiberghien A, Ezeadi E, Williams DG, Hartley JA, Howard PW, Grabstein KH, Bowen MA, Marelli M.

Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359. Epub 2015 Sep 11.

PMID:
26332743
7.

The development of boronic acids as sensors and separation tools.

Fossey JS, D'Hooge F, van den Elsen JM, Pereira Morais MP, Pascu SI, Bull SD, Marken F, Jenkins AT, Jiang YB, James TD.

Chem Rec. 2012 Oct;12(5):464-78. doi: 10.1002/tcr.201200006. Epub 2012 Jul 13.

PMID:
22791631
8.

Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.

Boutureira O, Bernardes GJ, D'Hooge F, Davis BG.

Chem Commun (Camb). 2011 Sep 28;47(36):10010-2. doi: 10.1039/c1cc13524d. Epub 2011 Aug 11.

PMID:
21833430
9.

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.

Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE 3rd, Davis BG.

Nat Chem Biol. 2011 Apr;7(4):228-35. doi: 10.1038/nchembio.539. Epub 2011 Mar 6.

10.

Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins.

Boutureira O, D'Hooge F, Fernández-González M, Bernardes GJ, Sánchez-Navarro M, Koeppe JR, Davis BG.

Chem Commun (Camb). 2010 Nov 21;46(43):8142-4. doi: 10.1039/c0cc01576h. Epub 2010 Aug 16.

PMID:
20714547
11.

Diol appended quenchers for fluorescein boronic acid.

Elfeky SA, Flower SE, Masumoto N, D'Hooge F, Labarthe L, Chen W, Len C, James TD, Fossey JS.

Chem Asian J. 2010 Mar 1;5(3):581-8. doi: 10.1002/asia.200900386.

PMID:
20127786
12.

Dye displacement assay for saccharide detection with boronate hydrogels.

Ma WM, Pereira Morais MP, D'Hooge F, van den Elsen JM, Cox JP, James TD, Fossey JS.

Chem Commun (Camb). 2009 Feb 7;(5):532-4. doi: 10.1039/b814379j. Epub 2008 Dec 19.

PMID:
19283281
13.

Boronate affinity saccharide electrophoresis: a novel carbohydrate analysis tool.

Jackson TR, Springall JS, Rogalle D, Masumoto N, Ching Li H, D'Hooge F, Perera SP, Jenkins AT, James TD, Fossey JS, van den Elsen JM.

Electrophoresis. 2008 Nov;29(20):4185-91. doi: 10.1002/elps.200800178. Erratum in: Electrophoresis. 2008 Dec;29(24):5067.

PMID:
18925583

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