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Items: 1 to 50 of 233

1.

Functional profiling of nucleotide Excision repair in breast cancer.

Rajkumar-Calkins AS, Szalat R, Dreze M, Khan I, Frazier Z, Reznichenkov E, Schnorenberg MR, Tsai YF, Nguyen H, Kochupurakkal B, D'Andrea AD, Shapiro GI, Lazaro JB, Mouw KW.

DNA Repair (Amst). 2019 Aug 30;82:102697. doi: 10.1016/j.dnarep.2019.102697. [Epub ahead of print]

PMID:
31499327
2.

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.

Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, Matulonis UA, Liu JF, D'Andrea AD, Shapiro GI.

Clin Cancer Res. 2019 Aug 13. doi: 10.1158/1078-0432.CCR-19-0448. [Epub ahead of print]

PMID:
31409614
3.

Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids.

Hill SJ, D'Andrea AD.

Cancer Discov. 2019 Jul;9(7):828-830. doi: 10.1158/2159-8290.CD-19-0527.

PMID:
31262743
4.

The Fanconi Anemia Pathway in Cancer.

Niraj J, Färkkilä A, D'Andrea AD.

Annu Rev Cancer Biol. 2019 Mar;3:457-478. doi: 10.1146/annurev-cancerbio-030617-050422. Epub 2018 Dec 3.

5.

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.

Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA.

Lancet Oncol. 2019 Apr;20(4):570-580. doi: 10.1016/S1470-2045(18)30905-7. Epub 2019 Mar 14.

PMID:
30880072
6.

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ.

Mol Cell. 2019 Mar 7;73(5):885-899.e6. doi: 10.1016/j.molcel.2018.12.008. Epub 2019 Jan 24.

PMID:
30686591
7.

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.

Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD.

Mol Cell. 2018 Dec 20;72(6):925-941.e4. doi: 10.1016/j.molcel.2018.10.045.

PMID:
30576655
8.

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.

He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D.

Nature. 2018 Nov;563(7732):522-526. doi: 10.1038/s41586-018-0670-5. Epub 2018 Oct 31.

PMID:
30464262
9.

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.

Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA.

Mol Cell. 2018 Nov 1;72(3):568-582.e6. doi: 10.1016/j.molcel.2018.09.014. Epub 2018 Oct 18.

PMID:
30344097
10.

Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD.

Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13.

PMID:
30213835
11.

Mechanisms of PARP inhibitor sensitivity and resistance.

D'Andrea AD.

DNA Repair (Amst). 2018 Nov;71:172-176. doi: 10.1016/j.dnarep.2018.08.021. Epub 2018 Aug 23. Review.

PMID:
30177437
12.

Functional analysis of Fanconi anemia mutations in China.

Li N, Ding L, Li B, Wang J, D'Andrea AD, Chen J.

Exp Hematol. 2018 Oct;66:32-41.e8. doi: 10.1016/j.exphem.2018.07.003. Epub 2018 Jul 19.

PMID:
30031030
13.

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer.

Li Q, Damish AW, Frazier Z, Liu D, Reznichenko E, Kamburov A, Bell A, Zhao H, Jordan EJ, Gao SP, Ma J, Abbosh PH, Bellmunt J, Plimack ER, Lazaro JB, Solit DB, Bajorin D, Rosenberg JE, D'Andrea AD, Riaz N, Van Allen EM, Iyer G, Mouw KW.

Clin Cancer Res. 2019 Feb 1;25(3):977-988. doi: 10.1158/1078-0432.CCR-18-1001. Epub 2018 Jul 6.

PMID:
29980530
14.

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.

Andrews AM, McCartney HJ, Errington TM, D'Andrea AD, Macara IG.

Nat Commun. 2018 Jul 3;9(1):2592. doi: 10.1038/s41467-018-05008-8.

15.

DNA Repair Deficiency and Immunotherapy Response.

Mouw KW, D'Andrea AD.

J Clin Oncol. 2018 Jun 10;36(17):1710-1713. doi: 10.1200/JCO.2018.78.2425. Epub 2018 Apr 23. No abstract available.

PMID:
29683789
16.

NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair.

Deraska PV, O'Leary C, Reavis HD, Labe S, Dinh TK, Lazaro JB, Sweeney C, D'Andrea AD, Kozono D.

Cell Death Discov. 2018 Feb 7;4:10. doi: 10.1038/s41420-017-0008-3. eCollection 2018 Dec.

17.

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

Rondinelli B, Gogola E, Yücel H, Duarte AA, van de Ven M, van der Sluijs R, Konstantinopoulos PA, Jonkers J, Ceccaldi R, Rottenberg S, D'Andrea AD.

Nat Cell Biol. 2017 Nov;19(11):1371-1378. doi: 10.1038/ncb3626. Epub 2017 Oct 16.

PMID:
29035360
18.

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.

Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, Rosebrock D, Livitz D, Kübler K, Mouw KW, Kamburov A, Maruvka YE, Leshchiner I, Lander ES, Golub TR, Zick A, Orthwein A, Lawrence MS, Batra RN, Caldas C, Haber DA, Laird PW, Shen H, Ellisen LW, D'Andrea AD, Chanock SJ, Foulkes WD, Getz G.

Nat Genet. 2017 Oct;49(10):1476-1486. doi: 10.1038/ng.3934. Epub 2017 Aug 21.

PMID:
28825726
19.

DNA Damage and Repair Biomarkers of Immunotherapy Response.

Mouw KW, Goldberg MS, Konstantinopoulos PA, D'Andrea AD.

Cancer Discov. 2017 Jul;7(7):675-693. doi: 10.1158/2159-8290.CD-17-0226. Epub 2017 Jun 19. Review.

20.

Aldehydes Pose a Threat to BRCA2 Mutation Carriers.

Parmar K, D'Andrea AD.

Cell. 2017 Jun 1;169(6):979-981. doi: 10.1016/j.cell.2017.05.021.

21.

Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.

Howitt BE, Strickland KC, Sholl LM, Rodig S, Ritterhouse LL, Chowdhury D, D'Andrea AD, Matulonis UA, Konstantinopoulos PA.

Oncoimmunology. 2017 Jan 6;6(2):e1277308. doi: 10.1080/2162402X.2016.1277308. eCollection 2017.

22.

Biallelic inactivation of REV7 is associated with Fanconi anemia.

Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, d'Enghien CD, Bluteau O, Cuccuini W, Gachet S, de Latour RP, Leblanc T, Socié G, Baruchel A, Stoppa-Lyonnet D, D'Andrea AD, Soulier J.

J Clin Invest. 2017 Mar 1;127(3):1117. doi: 10.1172/JCI92946. Epub 2017 Mar 1. No abstract available.

23.

HSP90 Shapes the Consequences of Human Genetic Variation.

Karras GI, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S.

Cell. 2017 Feb 23;168(5):856-866.e12. doi: 10.1016/j.cell.2017.01.023. Epub 2017 Feb 16.

24.

PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.

Jo U, Cai W, Wang J, Kwon Y, D'Andrea AD, Kim H.

PLoS Genet. 2016 Dec 1;12(12):e1006465. doi: 10.1371/journal.pgen.1006465. eCollection 2016 Dec.

25.

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.

Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D'Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI.

Cell Rep. 2016 Nov 22;17(9):2367-2381. doi: 10.1016/j.celrep.2016.10.077.

26.

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma.

Mouw KW, Cleary JM, Reardon B, Pike J, Braunstein LZ, Kim J, Amin-Mansour A, Miao D, Damish A, Chin J, Ott PA, Fuchs CS, Martin NE, Getz G, Carter S, Mamon HJ, Hornick JL, Van Allen EM, D'Andrea AD.

Clin Cancer Res. 2017 Jun 15;23(12):3214-3222. doi: 10.1158/1078-0432.CCR-16-2017. Epub 2016 Nov 16.

27.

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.

Davis MI, Pragani R, Fox JT, Shen M, Parmar K, Gaudiano EF, Liu L, Tanega C, McGee L, Hall MD, McKnight C, Shinn P, Nelson H, Chattopadhyay D, D'Andrea AD, Auld DS, DeLucas LJ, Li Z, Boxer MB, Simeonov A.

J Biol Chem. 2016 Nov 18;291(47):24628-24640. Epub 2016 Sep 28.

28.

Biallelic inactivation of REV7 is associated with Fanconi anemia.

Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d'Enghien C, Bluteau O, Cuccuini W, Gachet S, Peffault de Latour R, Leblanc T, Socié G, Baruchel A, Stoppa-Lyonnet D, D'Andrea AD, Soulier J.

J Clin Invest. 2016 Sep 1;126(9):3580-4. doi: 10.1172/JCI88010. Epub 2016 Aug 8. Erratum in: J Clin Invest. 2017 Mar 1;127(3):1117.

29.

Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.

Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N.

Mol Cell. 2016 Jul 21;63(2):249-260. doi: 10.1016/j.molcel.2016.05.031. Epub 2016 Jun 30.

30.

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.

Kais Z, Rondinelli B, Holmes A, O'Leary C, Kozono D, D'Andrea AD, Ceccaldi R.

Cell Rep. 2016 Jun 14;15(11):2488-99. doi: 10.1016/j.celrep.2016.05.031. Epub 2016 Jun 2.

31.

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK; kConFab Investigators, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balmaña J, Serra V, Johnson N.

Cancer Res. 2016 May 1;76(9):2778-90. doi: 10.1158/0008-5472.CAN-16-0186.

32.

The Fanconi anaemia pathway: new players and new functions.

Ceccaldi R, Sarangi P, D'Andrea AD.

Nat Rev Mol Cell Biol. 2016 Jun;17(6):337-49. doi: 10.1038/nrm.2016.48. Epub 2016 May 5. Review.

PMID:
27145721
33.

Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer.

Dinh TK, Fendler W, Chałubińska-Fendler J, Acharya SS, O'Leary C, Deraska PV, D'Andrea AD, Chowdhury D, Kozono D.

Radiat Oncol. 2016 Apr 27;11:61. doi: 10.1186/s13014-016-0636-4.

34.

TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

Zhang H, Kozono DE, O'Connor KW, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano EF, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D'Andrea AD.

Cell Stem Cell. 2016 May 5;18(5):668-81. doi: 10.1016/j.stem.2016.03.002. Epub 2016 Mar 24.

35.

Nucleotide excision repair (NER) alterations as evolving biomarkers and therapeutic targets in epithelial cancers.

Mouw KW, D'Andrea AD, Konstantinopoulos PA.

Oncoscience. 2015 Dec 29;2(12):942-3. eCollection 2015. No abstract available.

36.

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.

Strickland KC, Howitt BE, Shukla SA, Rodig S, Ritterhouse LL, Liu JF, Garber JE, Chowdhury D, Wu CJ, D'Andrea AD, Matulonis UA, Konstantinopoulos PA.

Oncotarget. 2016 Mar 22;7(12):13587-98. doi: 10.18632/oncotarget.7277.

37.

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.

Konstantinopoulos PA, Ceccaldi R, Shapiro GI, D'Andrea AD.

Cancer Discov. 2015 Nov;5(11):1137-54. doi: 10.1158/2159-8290.CD-15-0714. Epub 2015 Oct 13. Review.

38.

Repair Pathway Choices and Consequences at the Double-Strand Break.

Ceccaldi R, Rondinelli B, D'Andrea AD.

Trends Cell Biol. 2016 Jan;26(1):52-64. doi: 10.1016/j.tcb.2015.07.009. Epub 2015 Oct 1. Review.

39.

Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.

Howitt BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S, Stover E, Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, Konstantinopoulos PA.

JAMA Oncol. 2015 Dec;1(9):1319-23. doi: 10.1001/jamaoncol.2015.2151.

PMID:
26181000
40.

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.

Xie J, Kim H, Moreau LA, Puhalla S, Garber J, Al Abo M, Takeda S, D'Andrea AD.

J Clin Invest. 2015 Apr;125(4):1523-32. doi: 10.1172/JCI79325. Epub 2015 Mar 9.

41.

USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1.

Kushwaha D, O'Leary C, Cron KR, Deraska P, Zhu K, D'Andrea AD, Kozono D.

Cancer Biol Ther. 2015;16(3):392-401. doi: 10.1080/15384047.2014.1002358.

42.

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD.

Nature. 2015 Feb 12;518(7538):258-62. doi: 10.1038/nature14184. Epub 2015 Feb 2.

43.

A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance.

Ceccaldi R, O'Connor KW, Mouw KW, Li AY, Matulonis UA, D'Andrea AD, Konstantinopoulos PA.

Cancer Res. 2015 Feb 15;75(4):628-34. doi: 10.1158/0008-5472.CAN-14-2593. Epub 2015 Jan 29.

44.

Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.

Wojtaszek JL, Wang S, Kim H, Wu Q, D'Andrea AD, Zhou P.

Nucleic Acids Res. 2014 Dec 16;42(22):13997-4005. doi: 10.1093/nar/gku1153. Epub 2014 Nov 20.

45.

Crosstalk between the nucleotide excision repair and Fanconi anemia/BRCA pathways.

Mouw KW, D'Andrea AD.

DNA Repair (Amst). 2014 Jul;19:130-4. doi: 10.1016/j.dnarep.2014.03.019. Epub 2014 Apr 24.

PMID:
24768451
46.

Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.

Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto JA, D'Andrea AD.

Mol Cell. 2014 Apr 10;54(1):107-118. doi: 10.1016/j.molcel.2014.02.017. Epub 2014 Mar 20.

47.

The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

Polito D, Cukras S, Wang X, Spence P, Moreau L, D'Andrea AD, Kee Y.

J Biol Chem. 2014 Mar 7;289(10):7003-10. doi: 10.1074/jbc.M113.533976. Epub 2014 Jan 22.

48.

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, George J; Australian Ovarian Cancer Study Group, Davis S, D'Andrea AD, Simpson K, Hahn WC, Bowtell DD.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19489-94. doi: 10.1073/pnas.1314302110. Epub 2013 Nov 11.

49.

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K.

Mol Cancer Ther. 2013 Dec;12(12):2651-62. doi: 10.1158/1535-7163.MCT-13-0103-T. Epub 2013 Oct 15.

50.

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.

Johnson N, Johnson SF, Yao W, Li YC, Choi YE, Bernhardy AJ, Wang Y, Capelletti M, Sarosiek KA, Moreau LA, Chowdhury D, Wickramanayake A, Harrell MI, Liu JF, D'Andrea AD, Miron A, Swisher EM, Shapiro GI.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17041-6. doi: 10.1073/pnas.1305170110. Epub 2013 Oct 1.

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