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Items: 1 to 50 of 57

1.

Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer.

Tacconi C, Ungaro F, Correale C, Arena V, Massimino L, Detmar M, Spinelli A, Carvello M, Mazzone M, Oliveira AI, Rubbino F, Garlatti V, Spanò S, Lugli E, Colombo FS, Malesci A, Peyrin-Biroulet L, Vetrano S, Danese S, D'Alessio S.

Cancer Res. 2019 Jun 25. pii: canres.3657.2018. doi: 10.1158/0008-5472.CAN-18-3657. [Epub ahead of print]

PMID:
31239267
2.

Crimean-Congo Hemorrhagic Fever Virus Genome in Tick from Migratory Bird, Italy.

Mancuso E, Toma L, Polci A, d'Alessio SG, Di Luca M, Orsini M, Di Domenico M, Marcacci M, Mancini G, Spina F, Goffredo M, Monaco F.

Emerg Infect Dis. 2019 Jul;25(7):1418-1420. doi: 10.3201/eid2507.181345.

3.

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.

Romano B, Elangovan S, Erreni M, Sala E, Petti L, Kunderfranco P, Massimino L, Restelli S, Sinha S, Lucchetti D, Anselmo A, Colombo FS, Stravalaci M, Arena V, D'Alessio S, Ungaro F, Inforzato A, Izzo AA, Sgambato A, Day AJ, Vetrano S.

Stem Cells. 2019 Jul;37(7):973-987. doi: 10.1002/stem.3010. Epub 2019 May 14.

PMID:
30942926
4.

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11.

Ungaro F, Colombo P, Massimino L, Ugolini GS, Correale C, Rasponi M, Garlatti V, Rubbino F, Tacconi C, Spaggiari P, Spinelli A, Carvello M, Sacchi M, Spanò S, Vetrano S, Malesci A, Peyrin-Biroulet L, Danese S, D'Alessio S.

Int J Cancer. 2019 Mar 19. doi: 10.1002/ijc.32286. [Epub ahead of print]

PMID:
30889293
5.

Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease.

Ungaro F, Massimino L, Furfaro F, Rimoldi V, Peyrin-Biroulet L, D'Alessio S, Danese S.

Gut Microbes. 2019;10(2):149-158. doi: 10.1080/19490976.2018.1511664. Epub 2018 Sep 25.

PMID:
30252582
6.

Can IL-23 be a good target for ulcerative colitis?

Allocca M, Furfaro F, Fiorino G, Gilardi D, D'Alessio S, Danese S.

Best Pract Res Clin Gastroenterol. 2018 Feb - Apr;32-33:95-102. doi: 10.1016/j.bpg.2018.05.016. Epub 2018 May 23. Review.

PMID:
30060945
7.

Actors and Factors in the Resolution of Intestinal Inflammation: Lipid Mediators As a New Approach to Therapy in Inflammatory Bowel Diseases.

Ungaro F, Rubbino F, Danese S, D'Alessio S.

Front Immunol. 2017 Oct 23;8:1331. doi: 10.3389/fimmu.2017.01331. eCollection 2017. Review.

8.

TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice.

Kökten T, Gibot S, Lepage P, D'Alessio S, Hablot J, Ndiaye NC, Busby-Venner H, Monot C, Garnier B, Moulin D, Jouzeau JY, Hansmannel F, Danese S, Guéant JL, Muller S, Peyrin-Biroulet L.

J Crohns Colitis. 2018 Jan 24;12(2):230-244. doi: 10.1093/ecco-jcc/jjx129.

PMID:
28961797
9.

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice.

Ungaro F, Tacconi C, Massimino L, Corsetto PA, Correale C, Fonteyne P, Piontini A, Garzarelli V, Calcaterra F, Della Bella S, Spinelli A, Carvello M, Rizzo AM, Vetrano S, Petti L, Fiorino G, Furfaro F, Mavilio D, Maddipati KR, Malesci A, Peyrin-Biroulet L, D'Alessio S, Danese S.

Gastroenterology. 2017 Nov;153(5):1363-1377.e6. doi: 10.1053/j.gastro.2017.07.048. Epub 2017 Aug 4.

10.

PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue.

Spadaccini M, D'Alessio S, Peyrin-Biroulet L, Danese S.

Int J Mol Sci. 2017 Jun 15;18(6). pii: E1276. doi: 10.3390/ijms18061276. Review.

11.

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

Van Welden S, De Vos M, Wielockx B, Tavernier SJ, Dullaers M, Neyt S, Descamps B, Devisscher L, Devriese S, Van den Bossche L, Holvoet T, Baeyens A, Correale C, D'Alessio S, Vanhove C, De Vos F, Verhasselt B, Breier G, Lambrecht BN, Janssens S, Carmeliet P, Danese S, Elewaut D, Laukens D, Hindryckx P.

J Pathol. 2017 Mar;241(4):547-558. doi: 10.1002/path.4861. Epub 2017 Jan 27.

PMID:
27981571
12.

Medical cannabis laws and juvenile cannabis use: A reply to Wall et al.

Stolzenberg L, D'Alessio SJ.

Int J Drug Policy. 2016 Aug;34:104-5. doi: 10.1016/j.drugpo.2016.05.001. Epub 2016 May 9. No abstract available.

PMID:
27450318
13.

Beyond Intestinal Barrier: The Blood Endothelium as a Second Wall of Defense Against Bacterial Invasion.

Ungaro F, Tacconi C, D'Alessio S.

Gastroenterology. 2016 Jun;150(7):1678-1680. doi: 10.1053/j.gastro.2016.04.024. Epub 2016 Apr 29. No abstract available.

PMID:
27140488
14.

Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1.

Mazzieri R, Pietrogrande G, Gerasi L, Gandelli A, Colombo P, Moi D, Brombin C, Ambrosi A, Danese S, Mignatti P, Blasi F, D'Alessio S.

Cancer Res. 2015 Nov 15;75(22):4895-909. doi: 10.1158/0008-5472.CAN-15-0378. Epub 2015 Nov 2.

15.

Targeting lymphatics in inflammatory bowel disease.

D'Alessio S, Tacconi C, Danese S.

Oncotarget. 2015 Oct 27;6(33):34047-8. doi: 10.18632/oncotarget.6026. No abstract available.

16.

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes.

Alfano M, Cinque P, Giusti G, Proietti S, Nebuloni M, Danese S, D'Alessio S, Genua M, Portale F, Lo Porto M, Singhal PC, Rastaldi MP, Saleem MA, Mavilio D, Mikulak J.

Sci Rep. 2015 Sep 18;5:13647. doi: 10.1038/srep13647.

17.

The effect of medical cannabis laws on juvenile cannabis use.

Stolzenberg L, D'Alessio SJ, Dariano D.

Int J Drug Policy. 2016 Jan;27:82-8. doi: 10.1016/j.drugpo.2015.05.018. Epub 2015 Jun 6.

PMID:
26123892
18.

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.

Sala E, Genua M, Petti L, Anselmo A, Arena V, Cibella J, Zanotti L, D'Alessio S, Scaldaferri F, Luca G, Arato I, Calafiore R, Sgambato A, Rutella S, Locati M, Danese S, Vetrano S.

Gastroenterology. 2015 Jul;149(1):163-176.e20. doi: 10.1053/j.gastro.2015.03.013. Epub 2015 Mar 17.

PMID:
25790743
19.

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.

Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D'Alessio S, Danese S.

Gastroenterology. 2015 Jun;148(7):1438-51.e8. doi: 10.1053/j.gastro.2015.03.005. Epub 2015 Mar 6.

20.

VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.

D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S.

J Clin Invest. 2014 Sep;124(9):3863-78. doi: 10.1172/JCI72189. Epub 2014 Aug 8.

21.

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme.

Laurenzana A, Biagioni A, D'Alessio S, Bianchini F, Chillà A, Margheri F, Luciani C, Mazzanti B, Pimpinelli N, Torre E, Danese S, Calorini L, Del Rosso M, Fibbi G.

Oncotarget. 2014 Jun 15;5(11):3711-27.

22.

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation.

Genua M, D'Alessio S, Cibella J, Gandelli A, Sala E, Correale C, Spinelli A, Arena V, Malesci A, Rutella S, Ploplis VA, Vetrano S, Danese S.

Gut. 2015 Apr;64(4):589-600. doi: 10.1136/gutjnl-2013-305933. Epub 2014 May 21. Erratum in: Gut. 2015 Sep;64(9):1465.

PMID:
24848264
23.

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease.

D'Alessio S, Tacconi C, Fiocchi C, Danese S.

Curr Opin Gastroenterol. 2013 Nov;29(6):608-13. doi: 10.1097/MOG.0b013e328365d37c. Review.

PMID:
24100721
24.
25.

The protein C pathway in intestinal barrier function: challenging the hemostasis paradigm.

D'Alessio S, Genua M, Vetrano S.

Ann N Y Acad Sci. 2012 Jul;1258:78-85. doi: 10.1111/j.1749-6632.2012.06557.x. Review.

PMID:
22731719
26.

Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice.

Curnis F, Gasparri AM, Longhi R, Colombo B, D'Alessio S, Pastorino F, Ponzoni M, Corti A.

Cell Mol Life Sci. 2012 Aug;69(16):2791-803. doi: 10.1007/s00018-012-0955-z. Epub 2012 Mar 14.

PMID:
22415324
27.

The urokinase receptor as an entertainer of signal transduction.

D'Alessio S, Blasi F.

Front Biosci (Landmark Ed). 2009 Jan 1;14:4575-87. Review.

PMID:
19273372
28.

uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro.

D'Alessio S, Gerasi L, Blasi F.

J Cell Sci. 2008 Dec 1;121(Pt 23):3922-32. doi: 10.1242/jcs.037549. Epub 2008 Nov 11.

29.

Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.

D'Alessio S, Ferrari G, Cinnante K, Scheerer W, Galloway AC, Roses DF, Rozanov DV, Remacle AG, Oh ES, Shiryaev SA, Strongin AY, Pintucci G, Mignatti P.

J Biol Chem. 2008 Jan 4;283(1):87-99. Epub 2007 Nov 8.

30.
31.

Plasminogen activators and inhibitor type-1 in alveolar osteitis.

Serratì S, Margheri F, Bruschi S, D'Alessio S, Pucci M, Fibbi G, Tonelli P, Del Rosso M.

Eur J Oral Sci. 2006 Dec;114(6):500-3.

PMID:
17184232
32.

A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts.

Mazzieri R, Furlan F, D'Alessio S, Zonari E, Talotta F, Verde P, Blasi F.

Oncogene. 2007 Feb 1;26(5):725-32. Epub 2006 Jul 31.

PMID:
16878153
33.

Cytokine-dependent invasiveness in B16 murine melanoma cells: role of uPA system and MMP-9.

Bianchini F, D'Alessio S, Fibbi G, Del Rosso M, Calorini L.

Oncol Rep. 2006 Mar;15(3):709-14.

PMID:
16465434
34.

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.

Mazzieri R, D'Alessio S, Kenmoe RK, Ossowski L, Blasi F.

Mol Biol Cell. 2006 Jan;17(1):367-78. Epub 2005 Nov 2.

35.

Rheumatoid synovial fibroblasts constitutively express the fibrinolytic pattern of invasive tumor-like cells.

Guiducci S, Del Rosso A, Cinelli M, Margheri F, D'Alessio S, Fibbi G, Matucci Cerinic M, Del Rosso M.

Clin Exp Rheumatol. 2005 May-Jun;23(3):364-72.

PMID:
15971425
36.

The urokinase-type plasminogen activator, its receptor and u-PA inhibitor type-1 affect in vitro growth and invasion of Kaposi's sarcoma and capillary endothelial cells: role of HIV-Tat protein.

Margheri F, D'Alessio S, Serratì S, Pucci M, Del Rosso A, Benelli R, Ferrari N, Noonan DM, Albini A, Fibbi G, Del Rosso M.

Int J Oncol. 2005 Jul;27(1):223-35.

PMID:
15942664
37.

Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases.

Margheri F, D'Alessio S, Serratí S, Pucci M, Annunziato F, Cosmi L, Liotta F, Angeli R, Angelucci A, Gravina GL, Rucci N, Bologna M, Teti A, Monia B, Fibbi G, Del Rosso M.

Gene Ther. 2005 Apr;12(8):702-14.

PMID:
15674398
38.

Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis.

D'Alessio S, Fibbi G, Cinelli M, Guiducci S, Del Rosso A, Margheri F, Serratì S, Pucci M, Kahaleh B, Fan P, Annunziato F, Cosmi L, Liotta F, Matucci-Cerinic M, Del Rosso M.

Arthritis Rheum. 2004 Oct;50(10):3275-85.

39.

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice.

D'Alessio S, Margheri F, Pucci M, Del Rosso A, Monia BP, Bologna M, Leonetti C, Scarsella M, Zupi G, Fibbi G, Del Rosso M.

Int J Cancer. 2004 May 20;110(1):125-33.

40.
41.

Multiple pathways of cell invasion are regulated by multiple families of serine proteases.

Del Rosso M, Fibbi G, Pucci M, D'Alessio S, Del Rosso A, Magnelli L, Chiarugi V.

Clin Exp Metastasis. 2002;19(3):193-207. Review.

PMID:
12067200
42.

Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance.

Angiolella L, Micocci MM, D'Alessio S, Girolamo A, Maras B, Cassone A.

Antimicrob Agents Chemother. 2002 Jun;46(6):1688-94.

43.

Inhibition of contact hypersensitivity reaction to picryl chloride: effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases.

Mattei M, Carnieri E, Politi V, D'Alessio S, Sella A, Cassol M, Robeva A, Colizzi V, Sumerska T.

Int Immunopharmacol. 2002 Apr;2(5):699-710.

PMID:
12013508
44.

Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain.

Gioia M, Fasciglione GF, Marini S, D'Alessio S, De Sanctis G, Diekmann O, Pieper M, Politi V, Tschesche H, Coletta M.

J Biol Chem. 2002 Jun 28;277(26):23123-30. Epub 2002 Apr 12.

45.

Growth factor-dependent proliferation and invasion of muscle satellite cells require the cell-associated fibrinolytic system.

Fibbi G, D'Alessio S, Pucci M, Cerletti M, Del Rosso M.

Biol Chem. 2002 Jan;383(1):127-36.

PMID:
11928807
46.

Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system.

Fibbi G, Pucci M, D'Alessio S, Grappone C, Pellegrini G, Salzano R, Casini A, Milani S, Del Rosso M.

Growth Factors. 2001;19(2):87-100.

PMID:
11769974
47.

Conformationally constrained analogues of endogenous tripeptide inhibitors of zinc metalloproteinases.

D'Alessio S, Gallina C, Gavuzzo E, Giordano C, Gorini B, Mazza F, Paglialunga Paradisi M, Panini G, Pochetti G.

Eur J Med Chem. 2001 Jan;36(1):43-53.

PMID:
11231048
48.
49.

Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.

Gavuzzo E, Pochetti G, Mazza F, Gallina C, Gorini B, D'Alessio S, Pieper M, Tschesche H, Tucker PA.

J Med Chem. 2000 Sep 7;43(18):3377-85.

PMID:
10978185
50.

Cleavage of bovine collagen I by neutrophil collagenase MMP-8. Effect of pH on the catalytic properties as compared to synthetic substrates.

Marini S, Fasciglione GF, de Sanctis G, D'Alessio S, Politi V, Coletta M.

J Biol Chem. 2000 Jun 23;275(25):18657-63.

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