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One small step for mice, one giant leap for GWAS?

Herman MA, Campbell JE, D'Alessio DA.

J Clin Invest. 2019 Oct 1;129(10):4083-4085. doi: 10.1172/JCI131650.


Glucagon lowers glycemia when β-cells are active.

Capozzi ME, Wait JB, Koech J, Gordon AN, Coch RW, Svendsen B, Finan B, D'Alessio DA, Campbell JE.

JCI Insight. 2019 Jul 23;5. pii: 129954. doi: 10.1172/jci.insight.129954.


The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control.

Douros JD, Tong J, D'Alessio DA.

Endocr Rev. 2019 Oct 1;40(5):1394-1423. doi: 10.1210/er.2018-00183.


Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.

Gray SM, Niu J, Zhang A, Svendsen B, Campbell JE, D'Alessio DA, Tong J.

Diabetes. 2019 Sep;68(9):1795-1805. doi: 10.2337/db19-0079. Epub 2019 Jun 14.


Correction to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB.

Diabetologia. 2019 May;62(5):873. doi: 10.1007/s00125-019-4845-x.


Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia.

Salehi M, Gastaldelli A, D'Alessio DA.

Diabetes Obes Metab. 2019 Jun;21(6):1513-1517. doi: 10.1111/dom.13676. Epub 2019 Mar 27.


Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery.

Salehi M, Gastaldelli A, D'Alessio DA.

Gut. 2019 Oct;68(10):1838-1845. doi: 10.1136/gutjnl-2018-317760. Epub 2019 Feb 16.


β Cell tone is defined by proglucagon peptides through cAMP signaling.

Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE.

JCI Insight. 2019 Mar 7;4(5). pii: 126742. doi: 10.1172/jci.insight.126742. eCollection 2019 Mar 7.


LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.

Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D'Alessio DA, Haupt A.

Mol Metab. 2018 Dec;18:3-14. doi: 10.1016/j.molmet.2018.09.009. Epub 2018 Oct 3.


Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB.

Diabetes Care. 2018 Dec;41(12):2669-2701. doi: 10.2337/dci18-0033. Epub 2018 Oct 4.


Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB.

Diabetologia. 2018 Dec;61(12):2461-2498. doi: 10.1007/s00125-018-4729-5. Erratum in: Diabetologia. 2019 May;62(5):873.


Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.

Page LC, Gastaldelli A, Gray SM, D'Alessio DA, Tong J.

Diabetes. 2018 Oct;67(10):1976-1985. doi: 10.2337/db18-0451. Epub 2018 Jul 31.


Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes?

Buse JB, D'Alessio DA, Riddle MC.

Diabetes Care. 2018 Aug;41(8):1560-1562. doi: 10.2337/dci18-0025. Epub 2018 Jun 25. No abstract available.


Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.

Douros JD, Lewis AG, Smith EP, Niu J, Capozzi M, Wittmann A, Campbell J, Tong J, Wagner C, Mahbod P, Seeley R, D'Alessio DA.

Diabetes. 2018 Aug;67(8):1504-1511. doi: 10.2337/db18-0081. Epub 2018 May 14.


Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.

Salehi M, Gastaldelli A, D'Alessio DA.

Diabetes Obes Metab. 2018 Apr;20(4):872-878. doi: 10.1111/dom.13165. Epub 2017 Dec 18.


Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.

Crowley MJ, Williams JW Jr, Kosinski AS, D'Alessio DA, Buse JB.

Diabetes Care. 2017 Dec;40(12):1787-1789. doi: 10.2337/dc17-1528. Epub 2017 Oct 19.


β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes.

Elder DA, Hornung LN, Khoury JC, D'Alessio DA.

J Adolesc Health. 2017 Dec;61(6):703-708. doi: 10.1016/j.jadohealth.2017.06.007. Epub 2017 Sep 19.


The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA.

Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16.


DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.

Campbell JE, D'Alessio DA.

J Clin Invest. 2017 Mar 1;127(3):793-795. doi: 10.1172/JCI92845. Epub 2017 Feb 20.


Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.

Ghosal S, Packard AEB, Mahbod P, McKlveen JM, Seeley RJ, Myers B, Ulrich-Lai Y, Smith EP, D'Alessio DA, Herman JP.

J Neurosci. 2017 Jan 4;37(1):184-193. doi: 10.1523/JNEUROSCI.1104-16.2016.


Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.

Salehi M, D'Alessio DA.

Surg Obes Relat Dis. 2016 Jul;12(6):1230-5. doi: 10.1016/j.soard.2016.05.008. Epub 2016 May 11. Review.


Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care.

Wolfe BM, D'Alessio DA.

Obesity (Silver Spring). 2016 Jun;24(6):1205-6. doi: 10.1002/oby.21531. No abstract available.


The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?

Aulinger BA, Vahl TP, Prigeon RL, D'Alessio DA, Elder DA.

Am J Physiol Endocrinol Metab. 2016 May 1;310(9):E774-81. doi: 10.1152/ajpendo.00496.2015. Epub 2016 Mar 15.


Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus.

Gibb RD, McRorie JW Jr, Russell DA, Hasselblad V, D'Alessio DA.

Am J Clin Nutr. 2015 Dec;102(6):1604-14. doi: 10.3945/ajcn.115.106989. Epub 2015 Nov 11.


Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.

Inge TH, Prigeon RL, Elder DA, Jenkins TM, Cohen RM, Xanthakos SA, Benoit SC, Dolan LM, Daniels SR, D'Alessio DA.

J Pediatr. 2015 Nov;167(5):1042-8.e1. doi: 10.1016/j.jpeds.2015.08.020. Epub 2015 Sep 9.


Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion.

Salehi M, Woods SC, D'Alessio DA.

Obesity (Silver Spring). 2015 Oct;23(10):2046-52. doi: 10.1002/oby.21186. Epub 2015 Aug 28.


Mouse handling limits the impact of stress on metabolic endpoints.

Ghosal S, Nunley A, Mahbod P, Lewis AG, Smith EP, Tong J, D'Alessio DA, Herman JP.

Physiol Behav. 2015 Oct 15;150:31-7. doi: 10.1016/j.physbeh.2015.06.021. Epub 2015 Jun 13.


Diet-induced obese mice retain endogenous leptin action.

Ottaway N, Mahbod P, Rivero B, Norman LA, Gertler A, D'Alessio DA, Perez-Tilve D.

Cell Metab. 2015 Jun 2;21(6):877-82. doi: 10.1016/j.cmet.2015.04.015. Epub 2015 May 14.


Controversial Issues: When the drugs don't work, can surgery provide a different outcome for diabetic adolescents?

Beamish AJ, D'Alessio DA, Inge TH.

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):946-8. doi: 10.1016/j.soard.2015.03.006. Epub 2015 Apr 9. Review. No abstract available.


Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.

Sandoval DA, D'Alessio DA.

Physiol Rev. 2015 Apr;95(2):513-48. doi: 10.1152/physrev.00013.2014. Review.


β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity.

Aulinger BA, Vahl TP, Wilson-Pérez HE, Prigeon RL, D'Alessio DA.

J Clin Endocrinol Metab. 2015 Jun;100(6):2489-96. doi: 10.1210/jc.2014-4009. Epub 2015 Mar 31.


Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.

Begg DP, May AA, Mul JD, Liu M, D'Alessio DA, Seeley RJ, Woods SC.

Diabetes. 2015 Jul;64(7):2457-66. doi: 10.2337/db14-1364. Epub 2015 Feb 9.


Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes.

Elder DA, Hornung LN, Herbers PM, Prigeon R, Woo JG, D'Alessio DA.

J Pediatr. 2015 Mar;166(3):672-8. doi: 10.1016/j.jpeds.2014.11.029. Epub 2014 Dec 31.


Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia.

Vahl TP, Aulinger BA, Smith EP, Drazen DL, Ulrich-Lai Y, Seeley RJ, Woods SC, D'Alessio DA.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E784-92. doi: 10.1152/ajpendo.00339.2014. Epub 2014 Aug 26.


Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.

Salehi M, D'Alessio DA.

Rev Endocr Metab Disord. 2014 Sep;15(3):171-9. doi: 10.1007/s11154-014-9291-y. Review.


The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.

Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA.

Cell Metab. 2014 Jun 3;19(6):1050-7. doi: 10.1016/j.cmet.2014.04.005. Epub 2014 May 15.


Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion.

Salehi M, Gastaldelli A, D'Alessio DA.

Diabetologia. 2014 Jul;57(7):1495-9. doi: 10.1007/s00125-014-3258-0. Epub 2014 May 6. No abstract available.


Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.

Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ.

J Clin Invest. 2014 Jun;124(6):2456-63. doi: 10.1172/JCI72434. Epub 2014 Apr 24.


Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia.

Salehi M, Gastaldelli A, D'Alessio DA.

J Clin Endocrinol Metab. 2014 Jun;99(6):2008-17. doi: 10.1210/jc.2013-2686. Epub 2014 Mar 10.


Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy.

Chambers AP, Smith EP, Begg DP, Grayson BE, Sisley S, Greer T, Sorrell J, Lemmen L, LaSance K, Woods SC, Seeley RJ, D'Alessio DA, Sandoval DA.

Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E424-32. doi: 10.1152/ajpendo.00469.2013. Epub 2013 Dec 24.


Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.

Salehi M, Gastaldelli A, D'Alessio DA.

Gastroenterology. 2014 Mar;146(3):669-680.e2. doi: 10.1053/j.gastro.2013.11.044. Epub 2013 Dec 4.


GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.

Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2014 Feb;63(2):505-13. doi: 10.2337/db13-0511. Epub 2013 Nov 1.


Going with the flow: adaptation of β-cell function to glucose fluxes after bariatric surgery.

Salehi M, D'Alessio DA.

Diabetes. 2013 Nov;62(11):3671-3. doi: 10.2337/db13-1213. No abstract available.


Improved glycemic control enhances the incretin effect in patients with type 2 diabetes.

An Z, Prigeon RL, D'Alessio DA.

J Clin Endocrinol Metab. 2013 Dec;98(12):4702-8. doi: 10.1210/jc.2013-1199. Epub 2013 Oct 3.


Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.

Clemmensen C, Smajilovic S, Smith EP, Woods SC, Bräuner-Osborne H, Seeley RJ, D'Alessio DA, Ryan KK.

Endocrinology. 2013 Nov;154(11):3978-83. doi: 10.1210/en.2013-1529. Epub 2013 Aug 19.


GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.

Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, DiMarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17.


High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats.

Mul JD, Begg DP, Barrera JG, Li B, Matter EK, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA.

Am J Physiol Regul Integr Comp Physiol. 2013 Jul 1;305(1):R68-77. doi: 10.1152/ajpregu.00588.2012. Epub 2013 Apr 24.


Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.

Begg DP, Mul JD, Liu M, Reedy BM, D'Alessio DA, Seeley RJ, Woods SC.

Endocrinology. 2013 Mar;154(3):1047-54. doi: 10.1210/en.2012-1929. Epub 2013 Jan 21.


Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4.

Jessen L, Aulinger BA, Hassel JL, Roy KJ, Smith EP, Greer TM, Woods SC, Seeley RJ, D'Alessio DA.

Endocrinology. 2012 Dec;153(12):5735-45. doi: 10.1210/en.2012-1358. Epub 2012 Oct 2.


Effect of vertical sleeve gastrectomy on food selection and satiation in rats.

Chambers AP, Wilson-Perez HE, McGrath S, Grayson BE, Ryan KK, D'Alessio DA, Woods SC, Sandoval DA, Seeley RJ.

Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1076-84. doi: 10.1152/ajpendo.00211.2012. Epub 2012 Aug 28.

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