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Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema.

Cappetta D, De Angelis A, Spaziano G, Tartaglione G, Piegari E, Esposito G, Ciuffreda LP, Liparulo A, Sgambato M, Russo TP, Rossi F, Berrino L, Urbanek K, D'Agostino B.

Stem Cells Int. 2018 Mar 14;2018:9492038. doi: 10.1155/2018/9492038. eCollection 2018.


Gas exchange and breathing pattern in women with postmenopausal bone fragility.

Polverino F, de Torres JP, Santoriello C, Capuozzo A, Mauro I, Rojas-Quintero J, D'Agostino B, Pistolesi M, Celli B, Polverino M, Owen CA.

Respir Med. 2018 Apr;137:141-146. doi: 10.1016/j.rmed.2018.03.006. Epub 2018 Mar 7.


Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma.

Bruno F, Spaziano G, Liparulo A, Roviezzo F, Nabavi SM, Sureda A, Filosa R, D'Agostino B.

Eur J Med Chem. 2018 Jun 10;153:65-72. doi: 10.1016/j.ejmech.2017.10.020. Epub 2017 Oct 10. Review.


Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice.

Roviezzo F, Sorrentino R, Terlizzi M, Riemma MA, Iacono VM, Rossi A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Front Immunol. 2017 Oct 18;8:1336. doi: 10.3389/fimmu.2017.01336. eCollection 2017.


Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach.

Gallelli L, Falcone D, Cannataro R, Perri M, Serra R, Pelaia G, Maselli R, Savino R, Spaziano G, D'Agostino B.

Drug Des Devel Ther. 2017 Jan 23;11:265-272. doi: 10.2147/DDDT.S118485. eCollection 2017.


New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness.

Spaziano G, Cappetta D, Urbanek K, Piegari E, Esposito G, Matteis M, Sgambato M, Tartaglione G, Russo R, De Palma R, Rossi F, De Angelis A, D'Agostino B.

Mediators Inflamm. 2016;2016:3917471. doi: 10.1155/2016/3917471. Epub 2016 Dec 20.


Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.

Peduto A, Scuotto M, Krauth V, Roviezzo F, Rossi A, Temml V, Esposito V, Stuppner H, Schuster D, D'Agostino B, Schiraldi C, de Rosa M, Werz O, Filosa R.

Eur J Med Chem. 2017 Feb 15;127:715-726. doi: 10.1016/j.ejmech.2016.10.046. Epub 2016 Oct 22.


Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate.

Roviezzo F, Sorrentino R, Iacono VM, Brancaleone V, Terlizzi M, Riemma MA, Bertolino A, Rossi A, Matteis M, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2016 Nov;113(Pt A):626-635. doi: 10.1016/j.phrs.2016.09.014. Epub 2016 Oct 3.


Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness.

Spaziano G, Sorrentino R, Matteis M, Malgieri G, Sgambato M, Russo TP, Terlizzi M, Roviezzo F, Rossi F, Pinto A, Fattorusso R, D'Agostino B.

Clin Exp Allergy. 2017 Feb;47(2):208-216. doi: 10.1111/cea.12808. Epub 2016 Oct 5.


Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model.

Urbanek K, De Angelis A, Spaziano G, Piegari E, Matteis M, Cappetta D, Esposito G, Russo R, Tartaglione G, De Palma R, Rossi F, D'Agostino B.

PLoS One. 2016 Jul 19;11(7):e0158746. doi: 10.1371/journal.pone.0158746. eCollection 2016.


The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuotto M, Roviezzo F, Spaziano G, de Rosa M, Stuppner H, Schuster D, D'Agostino B, Werz O.

Biochem Pharmacol. 2016 Jul 15;112:60-71. doi: 10.1016/j.bcp.2016.04.019. Epub 2016 May 5.


Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma.

Singh SR, Sullo N, Matteis M, Spaziano G, McDonald J, Saunders R, Woodman L, Urbanek K, De Angelis A, De Palma R, Berair R, Pancholi M, Mistry V, Rossi F, Guerrini R, Calò G, D'Agostino B, Brightling CE, Lambert DG.

Br J Pharmacol. 2016 Apr;173(8):1286-301. doi: 10.1111/bph.13416. Epub 2016 Mar 6.


Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation.

Nigro E, Matteis M, Roviezzo F, Mattera Iacono V, Scudiero O, Spaziano G, Tartaglione G, Urbanek K, Filosa R, Daniele A, D'Agostino B.

Pharmacol Res. 2016 Jan;103:114-22. doi: 10.1016/j.phrs.2015.10.004. Epub 2015 Oct 20.


Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation.

Roviezzo F, Bertolino A, Sorrentino R, Terlizzi M, Matteis M, Calderone V, Mattera V, Martelli A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2015 Oct;100:85-92. doi: 10.1016/j.phrs.2015.07.032. Epub 2015 Aug 1.


Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.

Spaziano G, Luongo L, Guida F, Petrosino S, Matteis M, Palazzo E, Sullo N, de Novellis V, Di Marzo V, Rossi F, Maione S, D'Agostino B.

Biomed Res Int. 2015;2015:980983. doi: 10.1155/2015/980983. Epub 2015 Mar 19.


Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.

Filosa R, Peduto A, Schaible AM, Krauth V, Weinigel C, Barz D, Petronzi C, Bruno F, Roviezzo F, Spaziano G, D'Agostino B, De Rosa M, Werz O.

Eur J Med Chem. 2015 Apr 13;94:132-9. doi: 10.1016/j.ejmech.2015.02.042. Epub 2015 Feb 24.


Adiponectin in asthma: implications for phenotyping.

Nigro E, Daniele A, Scudiero O, Ludovica Monaco M, Roviezzo F, D'Agostino B, Mazzarella G, Bianco A.

Curr Protein Pept Sci. 2015;16(3):182-7. Review.


S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms.

Roviezzo F, Sorrentino R, Bertolino A, De Gruttola L, Terlizzi M, Pinto A, Napolitano M, Castello G, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.

Br J Pharmacol. 2015 Apr;172(7):1882-93. doi: 10.1111/bph.13033. Epub 2015 Jan 23.


Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide.

Gallelli L, Falcone D, Scaramuzzino M, Pelaia G, D'Agostino B, Mesuraca M, Terracciano R, Spaziano G, Maselli R, Navarra M, Savino R.

BMC Pharmacol Toxicol. 2014 Nov 29;15:67. doi: 10.1186/2050-6511-15-67.


Effects of sex hormones on bronchial reactivity during the menstrual cycle.

Matteis M, Polverino F, Spaziano G, Roviezzo F, Santoriello C, Sullo N, Bucci MR, Rossi F, Polverino M, Owen CA, D'Agostino B.

BMC Pulm Med. 2014 Jul 1;14:108. doi: 10.1186/1471-2466-14-108.


Recumbent deoxygenation in mild/moderate liver cirrhosis: the "clinodeoxia". The ortho-clino paradigm.

Polverino F, Santoriello C, Andò F, Girbino G, Cappetta D, D'Agostino B, Vatrella A, Polverino M, Milic-Emili J.

Respir Med. 2014 Jul;108(7):1040-8. doi: 10.1016/j.rmed.2014.04.003. Epub 2014 Apr 15.


Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

Schaible AM, Filosa R, Temml V, Krauth V, Matteis M, Peduto A, Bruno F, Luderer S, Roviezzo F, Di Mola A, de Rosa M, D'Agostino B, Weinigel C, Barz D, Koeberle A, Pergola C, Schuster D, Werz O.

Br J Pharmacol. 2014 May;171(9):2399-412. doi: 10.1111/bph.12592.


Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, Bucci M, De Palma R, Urbanek K, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.

Clin Sci (Lond). 2014 Apr;126(8):545-56. doi: 10.1042/CS20130272.


C-reactive protein and carotid intima-media thickness in children with sleep disordered breathing.

Iannuzzi A, Licenziati MR, De Michele F, Verga MC, Santoriello C, Di Buono L, Renis M, Lembo L, D'Agostino B, Cappetta D, Polverino M, Polverino F.

J Clin Sleep Med. 2013 May 15;9(5):493-8. doi: 10.5664/jcsm.2674.


Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice.

Sullo N, Roviezzo F, Matteis M, Ianaro A, Calò G, Guerrini R, De Gruttola L, Spaziano G, Cirino G, Rossi F, D'Agostino B.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L657-64. doi: 10.1152/ajplung.00358.2012. Epub 2013 Mar 15.


Airways allergic inflammation and L. reuterii treatment in asthmatic children.

Miraglia Del Giudice M, Maiello N, Decimo F, Fusco N, D' Agostino B, Sullo N, Capasso M, Salpietro V, Gitto E, Ciprandi G, Marseglia GL, Perrone L.

J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1 Suppl):S35-40.


In vitro diagnosis of the first case of amitraz resistance in Rhipicephalus microplus in Santo Tomé (Corrientes), Argentina.

Cutullé C, Lovis L, D'Agostino BI, Balbiani GG, Morici G, Citroni D, Reggi J, Caracostantogolo JL.

Vet Parasitol. 2013 Feb 18;192(1-3):296-300. doi: 10.1016/j.vetpar.2012.10.014. Epub 2012 Oct 23.


Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction.

Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, Lucattelli M, Polverino F, Lungarella G, Cirino G, Rossi F, D'Agostino B.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):198-203. doi: 10.1165/rcmb.2012-0167OC. Epub 2012 Nov 9.


The effects of nociceptin peptide (N/OFQ)-receptor (NOP) system activation in the airways.

Singh SR, Sullo N, D'Agostino B, Brightling CE, Lambert DG.

Peptides. 2013 Jan;39:36-46. doi: 10.1016/j.peptides.2012.10.008. Epub 2012 Nov 1. Review.


Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.

Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, Maione S, Di Marzo V.

Pharmacol Res. 2012 Sep;66(3):243-50. doi: 10.1016/j.phrs.2012.05.005. Epub 2012 May 24.


Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R, Perretti M, Cirino G.

J Pharmacol Exp Ther. 2011 Jun;337(3):830-7. doi: 10.1124/jpet.111.179168. Epub 2011 Mar 18.


[Hospital consumption of antibiotics at the Policlinico Hospital of the Second University of Naples: results of retrospective data collection].

Rafaniello C, Ianniello B, Sullo N, De Rosa S, Sportiello L, Rossi F, D'Agostino B, Capuano A.

Infez Med. 2010 Dec;18(4):235-42. Italian.


Mesenchymal stem cell therapy for the treatment of chronic obstructive pulmonary disease.

D'Agostino B, Sullo N, Siniscalco D, De Angelis A, Rossi F.

Expert Opin Biol Ther. 2010 May;10(5):681-7. doi: 10.1517/14712591003610614. Review.


Exercise capacity and cytochrome oxidase activity in muscle mitochondria of COPD patients.

D'Agostino B, Polverino M, Cirino G, Lombardi A, Grassi B, Sullo N, Santoriello C, Polverino F, Orlotti D, Matteis M, Rossi F.

Respir Med. 2010 Jan;104(1):83-90. doi: 10.1016/j.rmed.2009.07.016. Epub 2009 Aug 27.


Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.

Roviezzo F, D'Agostino B, Brancaleone V, De Gruttola L, Bucci M, De Dominicis G, Orlotti D, D'Aiuto E, De Palma R, Rossi F, Sorrentino R, Cirino G.

Am J Respir Cell Mol Biol. 2010 May;42(5):572-7. doi: 10.1165/rcmb.2009-0108OC. Epub 2009 Jun 25.


Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung.

D'Agostino B, Orlotti D, Calò G, Sullo N, Russo M, Guerrini R, De Nardo M, Mazzeo F, Candeletti S, Rossi F.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):250-4. doi: 10.1165/rcmb.2008-0488OC. Epub 2009 May 15.


Stem cell therapy: the great promise in lung disease.

Siniscalco D, Sullo N, Maione S, Rossi F, D'Agostino B.

Ther Adv Respir Dis. 2008 Jun;2(3):173-7. doi: 10.1177/1753465808092340. Review.


Interleukin-6 receptor superantagonist Sant7 inhibits TGF-beta-induced proliferation of human lung fibroblasts.

Gallelli L, Falcone D, Pelaia G, Renda T, Terracciano R, Malara N, Vatrella A, Sanduzzi A, D'Agostino B, Rossi F, Vancheri C, Maselli R, Marsico SA, Savino R.

Cell Prolif. 2008 Jun;41(3):393-407. doi: 10.1111/j.1365-2184.2008.00538.x. Epub 2008 Apr 24.


Affinity purification of IgG monoclonal antibodies using the D-PAM synthetic ligand: chromatographic comparison with protein A and thermodynamic investigation of the D-PAM/IgG interaction.

D'Agostino B, Bellofiore P, De Martino T, Punzo C, Rivieccio V, Verdoliva A.

J Immunol Methods. 2008 Apr 20;333(1-2):126-38. doi: 10.1016/j.jim.2008.01.014. Epub 2008 Feb 14.


Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma.

D'Agostino B, Roviezzo F, De Palma R, Terracciano S, De Nardo M, Gallelli L, Abbate GF, D'Aiuto E, Russo M, Cirino G, Rossi F.

Clin Exp Allergy. 2007 Oct;37(10):1436-43.


Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.

Cui YY, D'Agostino B, Risse PA, Marrocco G, Naline E, Zhang Y, Chen HZ, Finance O, Rinaldi-Carmona M, Rossi F, Advenier C.

Eur J Pharmacol. 2007 Nov 14;573(1-3):206-13. Epub 2007 Jul 3.


Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.

Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.

Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62. Epub 2007 Feb 22.


Effects of TGF-beta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion and cell proliferation in primary cultures of human lung fibroblasts.

Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D, Renda T, Galderisi U, Piegari E, Crimi N, Rossi F, Caputi M, Costanzo FS, Vancheri C, Maselli R, Marsico SA.

J Cell Physiol. 2007 Feb;210(2):489-97.


Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of MAP kinases.

Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffrè V, Galderisi U, De Nardo M, Mastruzzo C, Salinaro ET, Maniscalco M, Sofia M, Crimi N, Rossi F, Caputi M, Costanzo FS, Maselli R, Marsico SA, Vancheri C.

J Cell Biochem. 2005 Nov 1;96(4):858-68.


Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.

D'Agostino B, Marrocco G, De Nardo M, Calò G, Guerrini R, Gallelli L, Advenier C, Rossi F.

Br J Pharmacol. 2005 Mar;144(6):813-20.


Effects of hydrogen peroxide on MAPK activation, IL-8 production and cell viability in primary cultures of human bronchial epithelial cells.

Pelaia G, Cuda G, Vatrella A, Gallelli L, Fratto D, Gioffrè V, D'Agostino B, Caputi M, Maselli R, Rossi F, Costanzo FS, Marsico SA.

J Cell Biochem. 2004 Sep 1;93(1):142-52.


Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate.

Roviezzo F, Del Galdo F, Abbate G, Bucci M, D'Agostino B, Antunes E, De Dominicis G, Parente L, Rossi F, Cirino G, De Palma R.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11170-5. Epub 2004 Jul 14.


Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.

Rouget C, Cui YY, D'Agostino B, Faisy C, Naline E, Bardou M, Advenier C.

Br J Pharmacol. 2004 Mar;141(6):1077-83. Epub 2004 Mar 1.


Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit.

Gallelli L, D'Agostino B, Marrocco G, De Rosa G, Filippelli W, Rossi F, Advenier C.

Life Sci. 2003 Jan 24;72(10):1135-42.


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