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Items: 1 to 50 of 104

1.

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP.

Tambini MD, Yao W, D'Adamio L.

Aging Cell. 2019 Dec;18(6):e13033. doi: 10.1111/acel.13033. Epub 2019 Sep 9.

2.

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.

Acquarone E, Argyrousi EK, van den Berg M, Gulisano W, Fà M, Staniszewski A, Calcagno E, Zuccarello E, D'Adamio L, Deng SX, Puzzo D, Arancio O, Fiorito J.

Mol Neurodegener. 2019 Jun 27;14(1):26. doi: 10.1186/s13024-019-0326-4.

3.

Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.

Yao W, Tambini MD, Liu X, D'Adamio L.

J Neurosci. 2019 Aug 28;39(35):6992-7005. doi: 10.1523/JNEUROSCI.0207-19.2019. Epub 2019 Jun 24.

PMID:
31235642
4.

The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms.

Yao W, Yin T, Tambini MD, D'Adamio L.

Sci Rep. 2019 Mar 19;9(1):4862. doi: 10.1038/s41598-019-41340-9.

5.

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade.

Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O.

J Alzheimers Dis. 2019;68(1):415. doi: 10.3233/JAD-189015. No abstract available.

PMID:
30883364
6.

Correction: Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.

Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L.

Transl Psychiatry. 2018 Aug 31;8(1):172. doi: 10.1038/s41398-018-0188-5.

7.

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade.

Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O.

J Alzheimers Dis. 2018;64(s1):S611-S631. doi: 10.3233/JAD-179935. Review.

PMID:
29865055
8.

Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D'Adamio L, Rajadhyaksha AM.

J Neurosci. 2018 Mar 14;38(11):2780-2795. doi: 10.1523/JNEUROSCI.0599-17.2018. Epub 2018 Feb 19.

9.

A role for tau in learning, memory and synaptic plasticity.

Biundo F, Del Prete D, Zhang H, Arancio O, D'Adamio L.

Sci Rep. 2018 Feb 16;8(1):3184. doi: 10.1038/s41598-018-21596-3.

10.

Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.

Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L.

Transl Psychiatry. 2017 Aug 8;7(8):e1198. doi: 10.1038/tp.2017.165. Erratum in: Transl Psychiatry. 2018 Aug 31;8(1):172.

11.

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.

Puzzo D, Piacentini R, Fá M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O.

Elife. 2017 Jul 11;6. pii: e26991. doi: 10.7554/eLife.26991.

12.
13.

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.

Biundo F, Ishiwari K, Del Prete D, D'Adamio L.

Oncotarget. 2016 Mar 15;7(11):11923-44. doi: 10.18632/oncotarget.7389.

14.

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O.

Sci Rep. 2016 Jan 20;6:19393. doi: 10.1038/srep19393.

15.

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.

Fanutza T, Del Prete D, Ford MJ, Castillo PE, D'Adamio L.

Elife. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743.

16.

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

Biundo F, Ishiwari K, Del Prete D, D'Adamio L.

Neurobiol Learn Mem. 2015 Dec;126:18-30. doi: 10.1016/j.nlm.2015.10.009. Epub 2015 Oct 31.

17.

The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.

Li M, Pehar M, Liu Y, Bhattacharyya A, Zhang SC, O'Riordan KJ, Burger C, D'Adamio L, Puglielli L.

Neurobiol Aging. 2015 Oct;36(10):2725-36. doi: 10.1016/j.neurobiolaging.2015.06.021. Epub 2015 Jun 21.

18.
19.

Presenilin-ryanodine receptor connection.

D'Adamio L, Castillo PE.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14825-6. doi: 10.1073/pnas.1313996110. Epub 2013 Aug 30. No abstract available.

20.

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.

Lombino F, Biundo F, Tamayev R, Arancio O, D'Adamio L.

PLoS One. 2013;8(2):e57120. doi: 10.1371/journal.pone.0057120. Epub 2013 Feb 22.

21.

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L.

Mol Neurodegener. 2012 Dec 10;7:60. doi: 10.1186/1750-1326-7-60.

22.

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.

Matrone C, Luvisetto S, La Rosa LR, Tamayev R, Pignataro A, Canu N, Yang L, Barbagallo AP, Biundo F, Lombino F, Zheng H, Ammassari-Teule M, D'Adamio L.

Aging Cell. 2012 Dec;11(6):1084-93. doi: 10.1111/acel.12009. Epub 2012 Oct 12.

23.

Proteomic characterization of a mouse model of familial Danish dementia.

Vitale M, Renzone G, Matsuda S, Scaloni A, D'Adamio L, Zambrano N.

J Biomed Biotechnol. 2012;2012:728178. doi: 10.1155/2012/728178. Epub 2012 Apr 26.

24.

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.

Tamayev R, D'Adamio L.

Mol Neurodegener. 2012 Apr 26;7:19. doi: 10.1186/1750-1326-7-19.

25.

Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.

Tamayev R, D'Adamio L.

J Neurosci. 2012 Apr 18;32(16):5481-5. doi: 10.1523/JNEUROSCI.5193-11.2012.

26.

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.

Tamayev R, Matsuda S, Arancio O, D'Adamio L.

EMBO Mol Med. 2012 Mar;4(3):171-9. doi: 10.1002/emmm.201100195. Epub 2012 Jan 23.

27.

APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.

Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L.

J Neurosci. 2011 Aug 17;31(33):11756-61. doi: 10.1523/JNEUROSCI.1960-11.2011.

28.

Increased AβPP processing in familial Danish dementia patients.

Matsuda S, Tamayev R, D'Adamio L.

J Alzheimers Dis. 2011;27(2):385-91. doi: 10.3233/JAD-2011-110785.

29.

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L.

EMBO J. 2011 May 17;30(12):2501-9. doi: 10.1038/emboj.2011.161.

30.

The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.

Barbagallo AP, Wang Z, Zheng H, D'Adamio L.

PLoS One. 2011 Mar 22;6(3):e18006. doi: 10.1371/journal.pone.0018006.

31.

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

Barbagallo AP, Wang Z, Zheng H, D'Adamio L.

J Biol Chem. 2011 Mar 18;286(11):8717-21. doi: 10.1074/jbc.C111.219873. Epub 2011 Jan 25.

32.

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

Barbagallo AP, Weldon R, Tamayev R, Zhou D, Giliberto L, Foreman O, D'Adamio L.

PLoS One. 2010 Nov 16;5(11):e15503. doi: 10.1371/journal.pone.0015503.

33.

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.

Tamayev R, Matsuda S, Fà M, Arancio O, D'Adamio L.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20822-7. doi: 10.1073/pnas.1011689107. Epub 2010 Nov 22.

34.

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.

Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L.

J Neurosci. 2010 Nov 3;30(44):14915-24. doi: 10.1523/JNEUROSCI.3917-10.2010.

35.

Role of cystatin C in neuroprotection and its therapeutic implications.

D'Adamio L.

Am J Pathol. 2010 Nov;177(5):2163-5. doi: 10.2353/ajpath.2010.100829. Epub 2010 Sep 23. No abstract available.

36.

Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo.

Giliberto L, d'Abramo C, Acker CM, Davies P, D'Adamio L.

PLoS One. 2010 Jul 16;5(7):e11609. doi: 10.1371/journal.pone.0011609.

37.

Generation and initial characterization of FDD knock in mice.

Giliberto L, Matsuda S, Vidal R, D'Adamio L.

PLoS One. 2009 Nov 18;4(11):e7900. doi: 10.1371/journal.pone.0007900.

38.

CD74 interacts with APP and suppresses the production of Abeta.

Matsuda S, Matsuda Y, D'Adamio L.

Mol Neurodegener. 2009 Oct 22;4:41. doi: 10.1186/1750-1326-4-41.

39.

Modeling familial British and Danish dementia.

Garringer HJ, Murrell J, D'Adamio L, Ghetti B, Vidal R.

Brain Struct Funct. 2010 Mar;214(2-3):235-44. doi: 10.1007/s00429-009-0221-9. Epub 2009 Sep 25. Review.

PMID:
19779737
40.

Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles.

Matsuda S, Matsuda Y, Snapp EL, D'Adamio L.

Neurobiol Aging. 2011 Aug;32(8):1400-8. doi: 10.1016/j.neurobiolaging.2009.08.005. Epub 2009 Sep 12.

41.

The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.

Tamayev R, Zhou D, D'Adamio L.

Mol Neurodegener. 2009 Jul 14;4:28. doi: 10.1186/1750-1326-4-28.

42.

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.

Matsuda S, Matsuda Y, D'Adamio L.

J Biol Chem. 2009 Jun 5;284(23):15815-25. doi: 10.1074/jbc.M109.006403. Epub 2009 Apr 14.

43.

Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.

Zhou D, Zambrano N, Russo T, D'Adamio L.

J Alzheimers Dis. 2009;16(2):301-7. doi: 10.3233/JAD-2009-0970.

PMID:
19221419
44.

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Giliberto L, Zhou D, Weldon R, Tamagno E, De Luca P, Tabaton M, D'Adamio L.

Mol Neurodegener. 2008 Sep 2;3:12. doi: 10.1186/1750-1326-3-12.

45.

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L.

J Neurosci. 2008 Aug 27;28(35):8668-76. doi: 10.1523/JNEUROSCI.2094-08.2008.

46.

Functional cloning of genes regulating apoptosis in neuronal cells.

Visconti R, D'Adamio L.

Methods Mol Biol. 2007;399:125-31. doi: 10.1007/978-1-59745-504-6_9. Review.

PMID:
18309929
47.

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.

Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B.

Cell. 2006 Jul 14;126(1):163-75.

48.

Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.

Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A.

J Biol Chem. 2006 Feb 3;281(5):2631-8. Epub 2005 Nov 18.

49.

Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.

D'Ambrosio C, Arena S, Fulcoli G, Scheinfeld MH, Zhou D, D'Adamio L, Scaloni A.

Mol Cell Proteomics. 2006 Jan;5(1):97-113. Epub 2005 Sep 29.

50.

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.

Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L.

J Biol Chem. 2005 Aug 12;280(32):28912-6. Epub 2005 Jun 27.

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