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Items: 1 to 50 of 64

1.

Aberrant endocytosis leads to the loss of normal mitotic spindle orientation during epithelial glandular morphogenesis.

Clancy JW, Sheehan CS, Tricarico CJ, D'Souza-Schorey C.

J Biol Chem. 2018 Jun 14. pii: jbc.RA117.001640. doi: 10.1074/jbc.RA117.001640. [Epub ahead of print]

2.

Regulation and mechanisms of extracellular vesicle biogenesis and secretion.

D'Souza-Schorey C, Schorey JS.

Essays Biochem. 2018 May 15;62(2):125-133. doi: 10.1042/EBC20170078. Print 2018 May 15. Review.

PMID:
29666210
3.

Extracellular Vesicles in Cancer: Purpose and Promise.

Clancy J, D'Souza-Schorey C.

Cancer J. 2018 Mar/Apr;24(2):65-69. doi: 10.1097/PPO.0000000000000306.

PMID:
29601332
4.

The formation of giant plasma membrane vesicles enable new insights into the regulation of cholesterol efflux.

Sedgwick A, Olivia Balmert M, D'Souza-Schorey C.

Exp Cell Res. 2018 Apr 15;365(2):194-207. doi: 10.1016/j.yexcr.2018.03.001. Epub 2018 Mar 6.

PMID:
29522754
5.

The biology of extracellular microvesicles.

Sedgwick AE, D'Souza-Schorey C.

Traffic. 2018 May;19(5):319-327. doi: 10.1111/tra.12558. Epub 2018 Mar 25. Review.

PMID:
29479795
6.

Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer.

Sedgwick AE, D'Souza-Schorey C.

Cancers (Basel). 2016 Aug 29;8(9). pii: E80. doi: 10.3390/cancers8090080. Review.

7.

Biology and biogenesis of shed microvesicles.

Tricarico C, Clancy J, D'Souza-Schorey C.

Small GTPases. 2017 Oct 2;8(4):220-232. doi: 10.1080/21541248.2016.1215283. Epub 2016 Aug 5. Review.

8.

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion.

Sedgwick AE, Clancy JW, Olivia Balmert M, D'Souza-Schorey C.

Sci Rep. 2015 Oct 13;5:14748. doi: 10.1038/srep14748.

9.

Tumor-derived microvesicles in the tumor microenvironment: How vesicle heterogeneity can shape the future of a rapidly expanding field.

Clancy JW, Tricarico CJ, D'Souza-Schorey C.

Bioessays. 2015 Dec;37(12):1309-16. doi: 10.1002/bies.201500068. Epub 2015 Oct 6. Review.

PMID:
26439878
10.

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.

Clancy JW, Sedgwick A, Rosse C, Muralidharan-Chari V, Raposo G, Method M, Chavrier P, D'Souza-Schorey C.

Nat Commun. 2015 Apr 21;6:6919. doi: 10.1038/ncomms7919.

11.

Biology and proteomics of extracellular vesicles: harnessing their clinical potential.

D'Souza-Schorey C, Di Vizio D.

Expert Rev Proteomics. 2014 Jun;11(3):251-3. doi: 10.1586/14789450.2014.874290. Epub 2014 Jan 29.

12.

ARF6-regulated endocytosis of growth factor receptors links cadherin-based adhesion to canonical Wnt signaling in epithelia.

Pellon-Cardenas O, Clancy J, Uwimpuhwe H, D'Souza-Schorey C.

Mol Cell Biol. 2013 Aug;33(15):2963-75. doi: 10.1128/MCB.01698-12. Epub 2013 May 28.

13.

The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis.

Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp SR, Thomas KR, D'Souza-Schorey C, Odelberg SJ, Li DY.

Sci Signal. 2013 Mar 5;6(265):ra14. doi: 10.1126/scisignal.2003398.

14.

Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment.

Monteleon CL, Sedgwick A, Hartsell A, Dai M, Whittington C, Voytik-Harbin S, D'Souza-Schorey C.

Mol Biol Cell. 2012 Dec;23(23):4495-505. doi: 10.1091/mbc.E12-03-0246. Epub 2012 Oct 10.

15.

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.

Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR.

Am J Pathol. 2012 Nov;181(5):1573-84. doi: 10.1016/j.ajpath.2012.07.030. Epub 2012 Sep 27.

16.

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers.

D'Souza-Schorey C, Clancy JW.

Genes Dev. 2012 Jun 15;26(12):1287-99. doi: 10.1101/gad.192351.112. Review.

17.

Modeling disease using three dimensional cell culture: multi-lumen and inverted cyst phenotypes.

Monteleon CL, D'Souza-Schorey C.

Front Biosci (Elite Ed). 2012 Jun 1;4:2764-71. Review.

PMID:
22652685
18.

Role for a Cindr-Arf6 axis in patterning emerging epithelia.

Johnson RI, Sedgwick A, D'Souza-Schorey C, Cagan RL.

Mol Biol Cell. 2011 Dec;22(23):4513-26. doi: 10.1091/mbc.E11-04-0305. Epub 2011 Oct 5.

19.

Small GTPase signaling in cell physiology and disease. A preface.

D'Souza-Schorey C.

Curr Drug Targets. 2011 Jul 1;12(8):1187. No abstract available.

PMID:
21561418
20.

Endocytic trafficking and Wnt/β-catenin signaling.

Pellón-Cárdenas O, Schweitzer J, D'Souza-Schorey C.

Curr Drug Targets. 2011 Jul 1;12(8):1216-22. Review.

PMID:
21561414
21.

ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.

Schweitzer JK, Sedgwick AE, D'Souza-Schorey C.

Semin Cell Dev Biol. 2011 Feb;22(1):39-47. doi: 10.1016/j.semcdb.2010.09.002. Epub 2010 Sep 15. Review.

22.

Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.

Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C.

Mol Biol Cell. 2010 Jul 1;21(13):2355-66. doi: 10.1091/mbc.E09-09-0824. Epub 2010 May 12.

23.

Microvesicles: mediators of extracellular communication during cancer progression.

Muralidharan-Chari V, Clancy JW, Sedgwick A, D'Souza-Schorey C.

J Cell Sci. 2010 May 15;123(Pt 10):1603-11. doi: 10.1242/jcs.064386. Review.

24.

ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.

Muralidharan-Chari V, Clancy J, Plou C, Romao M, Chavrier P, Raposo G, D'Souza-Schorey C.

Curr Biol. 2009 Dec 1;19(22):1875-85. doi: 10.1016/j.cub.2009.09.059. Epub 2009 Nov 5.

25.

Neurodegeneration in Niemann-Pick Type C disease and Huntington's disease: impact of defects in membrane trafficking.

Schweitzer JK, Krivda JP, D'Souza-Schorey C.

Curr Drug Targets. 2009 Jul;10(7):653-65. Review.

PMID:
19601769
26.

ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.

Schweitzer JK, Pietrini SD, D'Souza-Schorey C.

PLoS One. 2009;4(4):e5193. doi: 10.1371/journal.pone.0005193. Epub 2009 Apr 14.

27.

ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo.

Muralidharan-Chari V, Hoover H, Clancy J, Schweitzer J, Suckow MA, Schroeder V, Castellino FJ, Schorey JS, D'Souza-Schorey C.

Cancer Res. 2009 Mar 15;69(6):2201-9. doi: 10.1158/0008-5472.CAN-08-1301. Epub 2009 Mar 10.

28.

ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.

Hu B, Shi B, Jarzynka MJ, Yiin JJ, D'Souza-Schorey C, Cheng SY.

Cancer Res. 2009 Feb 1;69(3):794-801. doi: 10.1158/0008-5472.CAN-08-2110. Epub 2009 Jan 20.

29.

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.

Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P.

J Cell Biol. 2008 Jun 16;181(6):985-98. doi: 10.1083/jcb.200709076. Epub 2008 Jun 9.

30.

ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development.

Tushir JS, D'Souza-Schorey C.

EMBO J. 2007 Apr 4;26(7):1806-19. Epub 2007 Mar 15.

31.

ARF proteins: roles in membrane traffic and beyond.

D'Souza-Schorey C, Chavrier P.

Nat Rev Mol Cell Biol. 2006 May;7(5):347-58. Review.

PMID:
16633337
32.

Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering.

Lynch EA, Stall J, Schmidt G, Chavrier P, D'Souza-Schorey C.

Mol Biol Cell. 2006 May;17(5):2236-42. Epub 2006 Feb 15.

33.

Arf6 modulates the beta-actin specific capping protein, betacap73.

Welch AY, Riley KN, D'Souza-Schorey C, Herman IM.

Methods Enzymol. 2005;404:377-87.

PMID:
16413284
34.

Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.

Hoover H, Muralidharan-Chari V, Tague S, D'Souza-Schorey C.

Methods Enzymol. 2005;404:134-47.

PMID:
16413265
35.

Endocytosis resumes during late mitosis and is required for cytokinesis.

Schweitzer JK, Burke EE, Goodson HV, D'Souza-Schorey C.

J Biol Chem. 2005 Dec 16;280(50):41628-35. Epub 2005 Oct 5.

36.

A requirement for ARF6 during the completion of cytokinesis.

Schweitzer JK, D'Souza-Schorey C.

Exp Cell Res. 2005 Nov 15;311(1):74-83. Epub 2005 Sep 21.

PMID:
16181626
37.

Disassembling adherens junctions: breaking up is hard to do.

D'Souza-Schorey C.

Trends Cell Biol. 2005 Jan;15(1):19-26. Review.

PMID:
15653074
38.
39.

ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.

Tague SE, Muralidharan V, D'Souza-Schorey C.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9671-6. Epub 2004 Jun 21.

40.

Finishing the job: cytoskeletal and membrane events bring cytokinesis to an end.

Schweitzer JK, D'Souza-Schorey C.

Exp Cell Res. 2004 Apr 15;295(1):1-8. Review.

PMID:
15051485
41.

Betacap73-ARF6 interactions modulate cell shape and motility after injury in vitro.

Riley KN, Maldonado AE, Tellier P, D'Souza-Schorey C, Herman IM.

Mol Biol Cell. 2003 Oct;14(10):4155-61. Epub 2003 Jul 11.

42.

Modulation of Rac1 and ARF6 activation during epithelial cell scattering.

Palacios F, D'Souza-Schorey C.

J Biol Chem. 2003 May 9;278(19):17395-400. Epub 2003 Feb 27.

43.

Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.

Xu L, Frankel P, Jackson D, Rotunda T, Boshans RL, D'Souza-Schorey C, Foster DA.

Mol Cell Biol. 2003 Jan;23(2):645-54.

44.

ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly.

Palacios F, Schweitzer JK, Boshans RL, D'Souza-Schorey C.

Nat Cell Biol. 2002 Dec;4(12):929-36.

PMID:
12447393
45.

Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis.

Schweitzer JK, D'Souza-Schorey C.

J Biol Chem. 2002 Jul 26;277(30):27210-6. Epub 2002 May 16.

46.

Arfaptin 2 regulates the aggregation of mutant huntingtin protein.

Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C.

Nat Cell Biol. 2002 Mar;4(3):240-5.

PMID:
11854752
47.

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

Muchowski PJ, Ning K, D'Souza-Schorey C, Fields S.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):727-32. Epub 2002 Jan 15.

48.

Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function.

Alrutz MA, Srivastava A, Wong KW, D'Souza-Schorey C, Tang M, Ch'Ng LE, Snapper SB, Isberg RR.

Mol Microbiol. 2001 Nov;42(3):689-703.

49.

An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.

Palacios F, Price L, Schweitzer J, Collard JG, D'Souza-Schorey C.

EMBO J. 2001 Sep 3;20(17):4973-86.

50.

Actin assembly at membranes controlled by ARF6.

Schafer DA, D'Souza-Schorey C, Cooper JA.

Traffic. 2000 Nov;1(11):892-903.

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