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Items: 12


Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.


Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.

Iwamoto N, D'Alessandro LA, Depner S, Hahn B, Kramer BA, Lucarelli P, Vlasov A, Stepath M, Böhm ME, Deharde D, Damm G, Seehofer D, Lehmann WD, Klingmüller U, Schilling M.

Sci Signal. 2016 Feb 2;9(413):ra13. doi: 10.1126/scisignal.aab1967.


T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes.

Mueller S, Huard J, Waldow K, Huang X, D'Alessandro LA, Bohl S, Börner K, Grimm D, Klamt S, Klingmüller U, Schilling M.

Mol Syst Biol. 2015 Mar;11(3):795.


Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

D'Alessandro LA, Samaga R, Maiwald T, Rho SH, Bonefas S, Raue A, Iwamoto N, Kienast A, Waldow K, Meyer R, Schilling M, Timmer J, Klamt S, Klingmüller U.

PLoS Comput Biol. 2015 Apr 23;11(4):e1004192. doi: 10.1371/journal.pcbi.1004192. eCollection 2015 Apr.


Unraveling liver complexity from molecular to organ level: challenges and perspectives.

D'Alessandro LA, Hoehme S, Henney A, Drasdo D, Klingmüller U.

Prog Biophys Mol Biol. 2015 Jan;117(1):78-86. doi: 10.1016/j.pbiomolbio.2014.11.005. Epub 2014 Nov 26. Review.


Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU.

Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014 Jan 2.


Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.

Shi L, Jong L, Wittig U, Lucarelli P, Stepath M, Mueller S, D'Alessandro LA, Klingmüller U, Müller W.

J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.


Hepatocellular carcinoma: a systems biology perspective.

D'Alessandro LA, Meyer R, Klingmüller U.

Front Physiol. 2013 Feb 25;4:28. doi: 10.3389/fphys.2013.00028. eCollection 2013.


A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes.

Pinna F, Sahle S, Beuke K, Bissinger M, Tuncay S, D'Alessandro LA, Gauges R, Raue A, Timmer J, Klingmüller U, Schirmacher P, Kummer U, Breuhahn K.

Front Physiol. 2012 Dec 31;3:466. doi: 10.3389/fphys.2012.00466. eCollection 2012.


Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.

Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnström M, Jirstrand M, Lehmann WD, Timmer J, Höfer T, Klingmüller U.

Front Physiol. 2012 Nov 28;3:451. doi: 10.3389/fphys.2012.00451. eCollection 2012.


Cellular ERK phospho-form profiles with conserved preference for a switch-like pattern.

Hahn B, D'Alessandro LA, Depner S, Waldow K, Boehm ME, Bachmann J, Schilling M, Klingmüller U, Lehmann WD.

J Proteome Res. 2013 Feb 1;12(2):637-46. doi: 10.1021/pr3007232. Epub 2012 Dec 26.


The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.

J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883.

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