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SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.

Di Emidio G, Santini SJ, D'Alessandro AM, Vetuschi A, Sferra R, Artini PG, Carta G, Falone S, Amicarelli F, Tatone C.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 13. pii: S0925-4439(19)30063-8. doi: 10.1016/j.bbadis.2019.02.011. [Epub ahead of print]


Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2019 Feb 11;35(2):333-335. doi: 10.1016/j.ccell.2019.01.013. No abstract available.


Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product utilisation.

Moore HB, D'alessandro A, Moore EE, Wither M, Lawson PJ, Huebner BR, Hansen K, Choudhury R, Nydam TL.

Blood Transfus. 2019 Feb 4:1-9. doi: 10.2450/2019.0205-18. [Epub ahead of print]


Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.

Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'alessandro A, Moore HB.

Blood Transfus. 2018 Dec 13:1-13. doi: 10.2450/2018.0188-18. [Epub ahead of print]


Massive Gastrointestinal Bleeding Due to Splenic Artery Erosion by a PigTail Drain in a Post Sleeve Gastrectomy Leak: a Case Report.

Chahine E, D'Alessandro A, Elhajjam M, Moryoussef F, Vitte RL, Carlier R, Alsabah S, Chouillard E.

Obes Surg. 2019 Feb 12. doi: 10.1007/s11695-019-03765-z. [Epub ahead of print] No abstract available.


Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.

Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S.

Kidney Int. 2019 Jan 29. pii: S0085-2538(18)30821-4. doi: 10.1016/j.kint.2018.10.020. [Epub ahead of print]


High Throughput Metabolomics in Clinical Studies: Review and New Applications to Remote Ischemic Preconditioning.

Clendenen N, D'Alessandro A.

Curr Top Med Chem. 2018;18(25):2143-2153. doi: 10.2174/1568026619666181130140937.


From omics technologies to personalized transfusion medicine.

D'Alessandro A.

Expert Rev Proteomics. 2019 Jan 18:1-11. doi: 10.1080/14789450.2019.1571917. [Epub ahead of print]


Red blood cell storage lesion: causes and potential clinical consequences.

Yoshida T, Prudent M, D'alessandro A.

Blood Transfus. 2019 Jan;17(1):27-52. doi: 10.2450/2019.0217-18. Review.


Crystal structure of E. coli PRPP synthetase.

Zhou W, Tsai A, Dattmore DA, Stives DP, Chitrakar I, D'alessandro AM, Patil S, Hicks KA, French JB.

BMC Struct Biol. 2019 Jan 15;19(1):1. doi: 10.1186/s12900-019-0100-4.


Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention.

Festuccia C, Colapietro A, Mancini A, D'alessandro A.

Anticancer Agents Med Chem. 2018 Dec 30. doi: 10.2174/1871520619666181231112453. [Epub ahead of print]


p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.

Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP 4th, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C.

Cell. 2019 Jan 24;176(3):564-580.e19. doi: 10.1016/j.cell.2018.11.011. Epub 2018 Dec 20.


Urinary Metabolic Signature of Primary Aldosteronism: Gender and Subtype-Specific Alterations.

Lana A, Alexander K, Castagna A, D'Alessandro A, Morandini F, Pizzolo F, Zorzi F, Mulatero P, Zolla L, Olivieri O.

Proteomics Clin Appl. 2018 Dec 23:e1800049. doi: 10.1002/prca.201800049. [Epub ahead of print]


Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.

Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer GM, Cook A, Ernst M, Prakash J, Terng M, Towfighi P, Doctor R, Said A, Joens MS, Fitzpatrick JAJ, Hanna G, Lin X, Reisz JA, Nemkov T, D'Alessandro A, Doctor A.

PLoS One. 2018 Dec 21;13(12):e0209201. doi: 10.1371/journal.pone.0209201. eCollection 2018.


Dietary effect of lemon verbena extract on selected blood parameters and on plasma oxidative profile in Avelignese horses.

Palazzo M, Vizzarri F, Cinone M, D'Alessandro AG, Martemucci G, Casamassima D.

Anim Sci J. 2019 Feb;90(2):222-228. doi: 10.1111/asj.13057. Epub 2018 Dec 16.


Macrovascular venous invasion of pancreatic neuroendocrine tumours: impact on surgical outcomes and survival.

Addeo P, d'Alessandro A, Averous G, Imperiale A, Faitot F, Goichot B, Bachellier P.

HPB (Oxford). 2018 Dec 3. pii: S1365-182X(18)34507-6. doi: 10.1016/j.hpb.2018.10.010. [Epub ahead of print]


Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate.

Sheridan RM, Fong N, D'Alessandro A, Bentley DL.

Mol Cell. 2019 Jan 3;73(1):107-118.e4. doi: 10.1016/j.molcel.2018.10.031. Epub 2018 Nov 29.


Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005. Erratum in: Cancer Cell. 2019 Feb 11;35(2):333-335.


Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D'Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT.

Nat Med. 2018 Dec;24(12):1859-1866. doi: 10.1038/s41591-018-0233-1. Epub 2018 Nov 12.


Influence of Mediterranean Diet on Blood Pressure.

De Pergola G, D'Alessandro A.

Nutrients. 2018 Nov 7;10(11). pii: E1700. doi: 10.3390/nu10111700. Review.


The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.

Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE.

Nat Commun. 2018 Oct 26;9(1):4462. doi: 10.1038/s41467-018-06929-0.


Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2019 Jan;59(1):89-100. doi: 10.1111/trf.14979. Epub 2018 Oct 24.


Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28.


Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.

Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A.

Transfusion. 2018 Dec;58(12):2978-2991. doi: 10.1111/trf.14936. Epub 2018 Oct 12.


Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport.

Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A.

Expert Rev Proteomics. 2018 Nov;15(11):855-864. doi: 10.1080/14789450.2018.1531710. Epub 2018 Oct 14.


Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.

Culp-Hill R, Srinivasan AJ, Gehrke S, Kamyszek R, Ansari A, Shah N, Welsby I, D'Alessandro A.

Transfusion. 2018 Dec;58(12):2797-2806. doi: 10.1111/trf.14931. Epub 2018 Sep 28.


The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.

Karafin MS, Fu X, D'Alessandro A, Thomas T, Hod EA, Zimring JC, Field JJ, Francis RO.

Curr Opin Hematol. 2018 Nov;25(6):494-499. doi: 10.1097/MOH.0000000000000455.


Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.

Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK.

Mol Cancer Res. 2019 Jan;17(1):30-41. doi: 10.1158/1541-7786.MCR-18-0246. Epub 2018 Sep 13.


Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Stevens BM, Khan N, D'Alessandro A, Nemkov T, Winters A, Jones CL, Zhang W, Pollyea DA, Jordan CT.

Nat Commun. 2018 Sep 12;9(1):3694. doi: 10.1038/s41467-018-05984-x.


Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis.

Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaas9822. doi: 10.1126/sciimmunol.aas9822.


A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma.

Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK.

Mol Cancer Res. 2019 Jan;17(1):131-139. doi: 10.1158/1541-7786.MCR-18-0362. Epub 2018 Aug 24.


KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.

Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA.

Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3.


Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.


Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding.

Paukovich N, Xue M, Elder JR, Redzic JS, Blue A, Pike H, Miller BG, Pitts TM, Pollock DD, Hansen K, D'Alessandro A, Eisenmesser EZ.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3234-3250. doi: 10.1016/j.jmb.2018.06.015. Epub 2018 Jun 20.


Technological attempts at producing cheese from donkey milk.

Faccia M, Gambacorta G, Martemucci G, Natrella G, D'Alessandro AG.

J Dairy Res. 2018 Aug;85(3):327-330. doi: 10.1017/S0022029918000420. Epub 2018 Jun 20.


Effect of PCM on the Hydration Process of Cement-Based Mixtures: A Novel Thermo-Mechanical Investigation.

Fabiani C, Pisello AL, D'Alessandro A, Ubertini F, Cabeza LF, Cotana F.

Materials (Basel). 2018 May 23;11(6). pii: E871. doi: 10.3390/ma11060871.


Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment.

Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA.

J Proteome Res. 2018 Jul 6;17(7):2421-2427. doi: 10.1021/acs.jproteome.8b00169. Epub 2018 Jun 19.


Vaccination knowledge and acceptability among pregnant women in Italy.

D'Alessandro A, Napolitano F, D'Ambrosio A, Angelillo IF.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1573-1579. doi: 10.1080/21645515.2018.1483809. Epub 2018 Jun 20.


Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):479-489. doi: 10.1165/rcmb.2018-0095OC.


Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.

Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ.

J Biol Chem. 2018 Jul 6;293(27):10731-10743. doi: 10.1074/jbc.RA117.001298. Epub 2018 May 18.


Endoscopic submucosal dissection versus endoscopic mucosal resection for type 0-II superficial gastric lesions larger than 20 mm.

Gambitta P, Iannuzzi F, Ballerini A, D'Alessandro A, Vertemati M, Bareggi E, Pallotta S, Fontana P, Aseni P.

Ann Gastroenterol. 2018 May-Jun;31(3):338-343. doi: 10.20524/aog.2018.0237. Epub 2018 Feb 8.


Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.

Gehrke S, Srinivasan AJ, Culp-Hill R, Reisz JA, Ansari A, Gray A, Landrigan M, Welsby I, D'Alessandro A.

Transfusion. 2018 Aug;58(8):1980-1991. doi: 10.1111/trf.14623. Epub 2018 Apr 24.


Retrospective Comparison of Single-Port Sleeve Gastrectomy Versus Three-Port Laparoscopic Sleeve Gastrectomy: a Propensity Score Adjustment Analysis.

Mauriello C, Chouillard E, d'alessandro A, Marte G, Papadimitriou A, Chahine E, Kassir R.

Obes Surg. 2018 Jul;28(7):2105-2112. doi: 10.1007/s11695-018-3244-6.


Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.

El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ.

Nat Commun. 2018 Apr 11;9(1):1393. doi: 10.1038/s41467-018-03764-1.


Investigating Italian parents' vaccine hesitancy: A cross-sectional survey.

Napolitano F, D'Alessandro A, Angelillo IF.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1558-1565. doi: 10.1080/21645515.2018.1463943. Epub 2018 May 14.


Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells.

D'Alessandro A, Reisz JA, Culp-Hill R, Korsten H, van Bruggen R, de Korte D.

Transfusion. 2018 Aug;58(8):1992-2002. doi: 10.1111/trf.14620. Epub 2018 Apr 6.


HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia.

Sarnelli G, Seguella L, Pesce M, Lu J, Gigli S, Bruzzese E, Lattanzi R, D'Alessandro A, Cuomo R, Steardo L, Esposito G.

J Neuroinflammation. 2018 Mar 24;15(1):94. doi: 10.1186/s12974-018-1126-4.


A randomized, open-label, comparative, crossover trial on preference, efficacy, and safety profiles of lispro insulin u-100 versus concentrated lispro insulin u-200 in patients with type 2 diabetes mellitus: a possible contribution to greater treatment adherence.

Gentile S, Fusco A, Colarusso S, Piscopo M, Improta MR, Corigliano M, Martedi E, Oliva D, Santorelli A, Simonetti R, Giammarco A, Colella C, Miretto L, D'Alessandro A, Russo V, Guarino G, Marino G, Corigliano G, Strollo F.

Expert Opin Drug Saf. 2018 May;17(5):445-450. doi: 10.1080/14740338.2018.1453495. Epub 2018 Apr 18.


Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.

Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K.

J Trauma Acute Care Surg. 2018 Jun;84(6):929-938. doi: 10.1097/TA.0000000000001878.


Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.

Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC.

J Biol Chem. 2018 May 4;293(18):6659-6671. doi: 10.1074/jbc.RA117.000470. Epub 2018 Mar 14.


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