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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005.


Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D'Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT.

Nat Med. 2018 Nov 12. doi: 10.1038/s41591-018-0233-1. [Epub ahead of print]


Influence of Mediterranean Diet on Blood Pressure.

De Pergola G, D'Alessandro A.

Nutrients. 2018 Nov 7;10(11). pii: E1700. doi: 10.3390/nu10111700. Review.


The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.

Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE.

Nat Commun. 2018 Oct 26;9(1):4462. doi: 10.1038/s41467-018-06929-0.


Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2018 Oct 24. doi: 10.1111/trf.14979. [Epub ahead of print]


Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Sep 28. pii: S2212-8778(18)30835-4. doi: 10.1016/j.molmet.2018.09.008. [Epub ahead of print]


Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.

Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A.

Transfusion. 2018 Oct 12. doi: 10.1111/trf.14936. [Epub ahead of print]


Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport.

Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A.

Expert Rev Proteomics. 2018 Nov;15(11):855-864. doi: 10.1080/14789450.2018.1531710. Epub 2018 Oct 14.


Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.

Culp-Hill R, Srinivasan AJ, Gehrke S, Kamyszek R, Ansari A, Shah N, Welsby I, D'Alessandro A.

Transfusion. 2018 Sep 28. doi: 10.1111/trf.14931. [Epub ahead of print]


The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.

Karafin MS, Fu X, D'Alessandro A, Thomas T, Hod EA, Zimring JC, Field JJ, Francis RO.

Curr Opin Hematol. 2018 Nov;25(6):494-499. doi: 10.1097/MOH.0000000000000455.


Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.

Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK.

Mol Cancer Res. 2018 Sep 13. doi: 10.1158/1541-7786.MCR-18-0246. [Epub ahead of print]


Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Stevens BM, Khan N, D'Alessandro A, Nemkov T, Winters A, Jones CL, Zhang W, Pollyea DA, Jordan CT.

Nat Commun. 2018 Sep 12;9(1):3694. doi: 10.1038/s41467-018-05984-x.


Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis.

Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaas9822. doi: 10.1126/sciimmunol.aas9822.


A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma.

Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK.

Mol Cancer Res. 2018 Aug 24. doi: 10.1158/1541-7786.MCR-18-0362. [Epub ahead of print]


KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.

Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA.

Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3.


Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.


Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding.

Paukovich N, Xue M, Elder JR, Redzic JS, Blue A, Pike H, Miller BG, Pitts TM, Pollock DD, Hansen K, D'Alessandro A, Eisenmesser EZ.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3234-3250. doi: 10.1016/j.jmb.2018.06.015. Epub 2018 Jun 20.


Technological attempts at producing cheese from donkey milk.

Faccia M, Gambacorta G, Martemucci G, Natrella G, D'Alessandro AG.

J Dairy Res. 2018 Aug;85(3):327-330. doi: 10.1017/S0022029918000420. Epub 2018 Jun 20.


Effect of PCM on the Hydration Process of Cement-Based Mixtures: A Novel Thermo-Mechanical Investigation.

Fabiani C, Pisello AL, D'Alessandro A, Ubertini F, Cabeza LF, Cotana F.

Materials (Basel). 2018 May 23;11(6). pii: E871. doi: 10.3390/ma11060871.


Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment.

Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA.

J Proteome Res. 2018 Jul 6;17(7):2421-2427. doi: 10.1021/acs.jproteome.8b00169. Epub 2018 Jun 19.


Vaccination knowledge and acceptability among pregnant women in Italy.

D'Alessandro A, Napolitano F, D'Ambrosio A, Angelillo IF.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1573-1579. doi: 10.1080/21645515.2018.1483809. Epub 2018 Jun 20.


Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):479-489. doi: 10.1165/rcmb.2018-0095OC.


Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.

Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ.

J Biol Chem. 2018 Jul 6;293(27):10731-10743. doi: 10.1074/jbc.RA117.001298. Epub 2018 May 18.


Endoscopic submucosal dissection versus endoscopic mucosal resection for type 0-II superficial gastric lesions larger than 20 mm.

Gambitta P, Iannuzzi F, Ballerini A, D'Alessandro A, Vertemati M, Bareggi E, Pallotta S, Fontana P, Aseni P.

Ann Gastroenterol. 2018 May-Jun;31(3):338-343. doi: 10.20524/aog.2018.0237. Epub 2018 Feb 8.


Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.

Gehrke S, Srinivasan AJ, Culp-Hill R, Reisz JA, Ansari A, Gray A, Landrigan M, Welsby I, D'Alessandro A.

Transfusion. 2018 Aug;58(8):1980-1991. doi: 10.1111/trf.14623. Epub 2018 Apr 24.


Retrospective Comparison of Single-Port Sleeve Gastrectomy Versus Three-Port Laparoscopic Sleeve Gastrectomy: a Propensity Score Adjustment Analysis.

Mauriello C, Chouillard E, d'alessandro A, Marte G, Papadimitriou A, Chahine E, Kassir R.

Obes Surg. 2018 Jul;28(7):2105-2112. doi: 10.1007/s11695-018-3244-6.


Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.

El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ.

Nat Commun. 2018 Apr 11;9(1):1393. doi: 10.1038/s41467-018-03764-1.


Investigating Italian parents' vaccine hesitancy: A cross-sectional survey.

Napolitano F, D'Alessandro A, Angelillo IF.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1558-1565. doi: 10.1080/21645515.2018.1463943. Epub 2018 May 14.


Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells.

D'Alessandro A, Reisz JA, Culp-Hill R, Korsten H, van Bruggen R, de Korte D.

Transfusion. 2018 Aug;58(8):1992-2002. doi: 10.1111/trf.14620. Epub 2018 Apr 6.


HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia.

Sarnelli G, Seguella L, Pesce M, Lu J, Gigli S, Bruzzese E, Lattanzi R, D'Alessandro A, Cuomo R, Steardo L, Esposito G.

J Neuroinflammation. 2018 Mar 24;15(1):94. doi: 10.1186/s12974-018-1126-4.


A randomized, open-label, comparative, crossover trial on preference, efficacy, and safety profiles of lispro insulin u-100 versus concentrated lispro insulin u-200 in patients with type 2 diabetes mellitus: a possible contribution to greater treatment adherence.

Gentile S, Fusco A, Colarusso S, Piscopo M, Improta MR, Corigliano M, Martedi E, Oliva D, Santorelli A, Simonetti R, Giammarco A, Colella C, Miretto L, D'Alessandro A, Russo V, Guarino G, Marino G, Corigliano G, Strollo F.

Expert Opin Drug Saf. 2018 May;17(5):445-450. doi: 10.1080/14740338.2018.1453495. Epub 2018 Apr 18.


Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.

Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K.

J Trauma Acute Care Surg. 2018 Jun;84(6):929-938. doi: 10.1097/TA.0000000000001878.


Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.

Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC.

J Biol Chem. 2018 May 4;293(18):6659-6671. doi: 10.1074/jbc.RA117.000470. Epub 2018 Mar 14.


When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies.

Reisz JA, Barrett AS, Nemkov T, Hansen KC, D'Alessandro A.

Expert Rev Proteomics. 2018 Apr;15(4):293-309. doi: 10.1080/14789450.2018.1453362. Epub 2018 Mar 21.


An Experimental Study on Static and Dynamic Strain Sensitivity of Embeddable Smart Concrete Sensors Doped with Carbon Nanotubes for SHM of Large Structures.

Meoni A, D'Alessandro A, Downey A, García-Macías E, Rallini M, Materazzi AL, Torre L, Laflamme S, Castro-Triguero R, Ubertini F.

Sensors (Basel). 2018 Mar 9;18(3). pii: E831. doi: 10.3390/s18030831.


Preliminary experience with umbilical stoma in transumbilical single-port colorectal surgery.

d'Alessandro A, Kari N, Alameh A, Pasquier N, Tarhini A, Vinson Bonnet B, Noun R, Chouillard E.

Tech Coloproctol. 2018 Apr;22(4):301-304. doi: 10.1007/s10151-018-1767-4. Epub 2018 Mar 6.


Correction: An autonomous metabolic role for Spen.

Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T.

PLoS Genet. 2018 Mar 6;14(3):e1007266. doi: 10.1371/journal.pgen.1007266. eCollection 2018 Mar.


Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.

Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR.

Hepatol Commun. 2018 Jan 22;2(3):313-328. doi: 10.1002/hep4.1139. eCollection 2018 Mar.


Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.

Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC.

JCI Insight. 2018 Feb 8;3(3). pii: 96805. doi: 10.1172/jci.insight.96805. [Epub ahead of print]


OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.


Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors.

Reisz JA, Tzounakas VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH.

Front Med (Lausanne). 2018 Jan 11;4:248. doi: 10.3389/fmed.2017.00248. eCollection 2017.


The Mediterranean Diet: its definition and evaluation of a priori dietary indexes in primary cardiovascular prevention.

D'Alessandro A, De Pergola G.

Int J Food Sci Nutr. 2018 Sep;69(6):647-659. doi: 10.1080/09637486.2017.1417978. Epub 2018 Jan 18. Review.


Echocolor Doppler morpho-functional study of the jugulo-subclavian confluence in chronic cerebro-spinal venous insufficiency and multiple sclerosis patients.

Mandolesi S, d'Alessandro A, Desogus AI, Ciccone MM, Zito A, Stammegna I, Niglio T, Orsini A, Mandolesi D, d'Alessandro A, Revelli L.

Ann Ital Chir. 2017;88:546-552.


The impact of kidney donor profile index on delayed graft function and transplant outcomes: A single-center analysis.

Zens TJ, Danobeitia JS, Leverson G, Chlebeck PJ, Zitur LJ, Redfield RR, D'Alessandro AM, Odorico S, Kaufman DB, Fernandez LA.

Clin Transplant. 2018 Mar;32(3):e13190. doi: 10.1111/ctr.13190.


Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging.

Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A.

Blood Adv. 2017 Dec 21;1(27):2776-2780. doi: 10.1182/bloodadvances.2017011957. eCollection 2017 Dec 26.


Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats.

Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A.

Blood Adv. 2017 Jul 14;1(17):1296-1305. doi: 10.1182/bloodadvances.2017007187. eCollection 2017 Jul 25.


The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers.

Di Emidio G, Rossi G, Bonomo I, Alonso GL, Sferra R, Vetuschi A, Artini PG, Provenzani A, Falone S, Carta G, D'Alessandro AM, Amicarelli F, Tatone C.

Oxid Med Cell Longev. 2017;2017:8928604. doi: 10.1155/2017/8928604. Epub 2017 Nov 15.


Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia.

Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL.

PLoS One. 2017 Dec 18;12(12):e0189536. doi: 10.1371/journal.pone.0189536. eCollection 2017.


Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.

Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM.

Transfusion. 2018 Jan;58(1):255-266. doi: 10.1111/trf.14435. Epub 2017 Dec 15.


Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells.

Gigli S, Seguella L, Pesce M, Bruzzese E, D'Alessandro A, Cuomo R, Steardo L, Sarnelli G, Esposito G.

United European Gastroenterol J. 2017 Dec;5(8):1108-1115. doi: 10.1177/2050640617698622. Epub 2017 Mar 13.

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