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Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury.

Park MJ, D'Alecy LG, Anderson MA, Basrur V, Feng Y, Brady GF, Kim DI, Wu J, Nesvizhskii AI, Lahann J, Lukacs NW, Fontana RJ, Omary MB.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9125-9134. doi: 10.1073/pnas.1822173116. Epub 2019 Apr 12.


Differential impact of type-1 and type-2 diabetes on control of heart rate in mice.

Stables CL, Auerbach DS, Whitesall SE, D'Alecy LG, Feldman EL.

Auton Neurosci. 2016 Jan;194:17-25. doi: 10.1016/j.autneu.2015.12.006. Epub 2015 Dec 17.


Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress.

Maitra D, Elenbaas JS, Whitesall SE, Basrur V, D'Alecy LG, Omary MB.

J Biol Chem. 2015 Sep 25;290(39):23711-24. doi: 10.1074/jbc.M114.636001. Epub 2015 Jul 23.


Packed red blood cells are an abundant and proximate potential source of nitric oxide synthase inhibition.

Zwemer CF, Davenport RD, Gomez-Espina J, Blanco-Gonzalez E, Whitesall SE, D'Alecy LG.

PLoS One. 2015 Mar 20;10(3):e0119991. doi: 10.1371/journal.pone.0119991. eCollection 2015.


Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model.

English SJ, Piert MR, Diaz JA, Gordon D, Ghosh A, DʼAlecy LG, Whitesall SE, Sharma AK, DeRoo EP, Watt T, Su G, Henke PK, Eliason JL, Ailawadi G, Upchurch GR Jr.

Ann Surg. 2015 Feb;261(2):395-404. doi: 10.1097/SLA.0000000000000602.


Potential treatment influences and mechanisms related to asymmetric dimethylarginine control in heart failure.

Billecke SS, D'Alecy LG, Marcovitz PA.

J Am Coll Cardiol. 2012 Sep 4;60(10):948-9; author reply 949. doi: 10.1016/j.jacc.2012.04.044. No abstract available.


Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.

Northcott CA, Billecke S, Craig T, Hinojosa-Laborde C, Patel KP, Chen AF, D'Alecy LG, Haywood JR.

Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2276-84. doi: 10.1152/ajpheart.00562.2011. Epub 2012 Mar 23.


Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.

von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D'Alecy LG, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S, Sydow K.

Circulation. 2011 Dec 13;124(24):2735-45. doi: 10.1161/CIRCULATIONAHA.111.060541. Epub 2011 Nov 14.


Secretin is not necessary for exocrine pancreatic development and growth in mice.

Sans MD, Sabbatini ME, Ernst SA, D'Alecy LG, Nishijima I, Williams JA.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G791-8. doi: 10.1152/ajpgi.00245.2011. Epub 2011 Aug 18.


Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

Adams GN, LaRusch GA, Stavrou E, Zhou Y, Nieman MT, Jacobs GH, Cui Y, Lu Y, Jain MK, Mahdi F, Shariat-Madar Z, Okada Y, D'Alecy LG, Schmaier AH.

Blood. 2011 Apr 7;117(14):3929-37. doi: 10.1182/blood-2010-11-318527. Epub 2011 Feb 4.


Massive quantities of asymmetric dimethylarginine (ADMA) are incorporated in red blood cell proteins and may be released by proteolysis following hemolytic stress.

D'Alecy LG, Billecke SS.

Blood Cells Mol Dis. 2010 Jun 15;45(1):40. doi: 10.1016/j.bcmd.2010.03.004. Epub 2010 Apr 8. No abstract available.


Molecular mechanisms of pancreatic dysfunction induced by protein malnutrition.

Crozier SJ, D'Alecy LG, Ernst SA, Ginsburg LE, Williams JA.

Gastroenterology. 2009 Sep;137(3):1093-101, 1101.e1-3. doi: 10.1053/j.gastro.2009.04.058. Epub 2009 May 7.


Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension.

Chang L, Villacorta L, Zhang J, Garcia-Barrio MT, Yang K, Hamblin M, Whitesall SE, D'Alecy LG, Chen YE.

Circulation. 2009 Apr 28;119(16):2161-9. doi: 10.1161/CIRCULATIONAHA.108.815803. Epub 2009 Apr 13.


Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo.

Palpant NJ, D'Alecy LG, Metzger JM.

FASEB J. 2009 May;23(5):1529-40. doi: 10.1096/fj.08-121996. Epub 2009 Jan 13.


Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.

Billecke SS, D'Alecy LG, Platel R, Whitesall SE, Jamerson KA, Perlman RL, Gadegbeku CA.

Nephrol Dial Transplant. 2009 Feb;24(2):489-96. doi: 10.1093/ndt/gfn500. Epub 2008 Sep 15.


Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo.

Fomicheva EV, Turner II, Edwards TG, Hoff J, Arden E, D'Alecy LG, Metzger JM.

Mol Ther. 2008 Sep;16(9):1594-601. doi: 10.1038/mt.2008.136. Epub 2008 Jun 24.


Vascular dysfunction in the alpha-galactosidase A-knockout mouse is an endothelial cell-, plasma membrane-based defect.

Park JL, Whitesall SE, D'Alecy LG, Shu L, Shayman JA.

Clin Exp Pharmacol Physiol. 2008 Oct;35(10):1156-63. doi: 10.1111/j.1440-1681.2008.04984.x. Epub 2008 Jun 18.


CCK-induced pancreatic growth is not limited by mitogenic capacity in mice.

Crozier SJ, Sans MD, Lang CH, D'Alecy LG, Ernst SA, Williams JA.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1148-57. doi: 10.1152/ajpgi.00426.2007. Epub 2008 Mar 20.


Direct monitoring pressure overload predicts cardiac hypertrophy in mice.

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM.

Physiol Meas. 2007 Nov;28(11):1329-39. Epub 2007 Oct 5.


Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality.

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC 3rd, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM.

J Clin Invest. 2007 Mar;117(3):812-22. Epub 2007 Feb 15.


Acute and conditioned hypoxic tolerance augmented by endothelial nitric oxide synthase inhibition in mice.

Song MY, Zwemer CF, Whitesall SE, D'Alecy LG.

J Appl Physiol (1985). 2007 Feb;102(2):610-5. Epub 2006 Oct 26.


Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR.

Mol Cell Biol. 2006 Sep;26(18):6870-9.


Strain differences in response to acute hypoxia: CD-1 versus C57BL/6J mice.

Zwemer CF, Song MY, Carello KA, D'Alecy LG.

J Appl Physiol (1985). 2007 Jan;102(1):286-93. Epub 2006 Aug 17.


Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin.

Sans MD, Tashiro M, Vogel NL, Kimball SR, D'Alecy LG, Williams JA.

J Nutr. 2006 Jul;136(7):1792-9.


Contribution of whole blood to the control of plasma asymmetrical dimethylarginine.

Billecke SS, Kitzmiller LA, Northrup JJ, Whitesall SE, Kimoto M, Hinz AV, D'Alecy LG.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1788-96. Epub 2006 Apr 21.


Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice.

Crozier SJ, Sans MD, Guo L, D'Alecy LG, Williams JA.

J Physiol. 2006 Jun 15;573(Pt 3):775-86. Epub 2006 Apr 13.


Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR.

Circ Res. 2006 Mar 17;98(5):659-66. Epub 2006 Feb 2.


Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.

Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM.

Nat Med. 2006 Feb;12(2):181-9. Epub 2006 Jan 22.


Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.

Linder AE, Weber DS, Whitesall SE, D'Alecy LG, Webb RC.

J Cardiovasc Pharmacol. 2005 Oct;46(4):438-44.


Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats.

Carello KA, Whitesall SE, Lloyd MC, Billecke SS, D'Alecy LG.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H209-16. Epub 2005 Aug 19.


Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine.

Dvonch JT, Brook RD, Keeler GJ, Rajagopalan S, D'Alecy LG, Marsik FJ, Morishita M, Yip FY, Brook JR, Timm EJ, Wagner JG, Harkema JR.

Inhal Toxicol. 2004 Jun;16(6-7):473-80.


Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA.

Sans MD, Lee SH, D'Alecy LG, Williams JA.

Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G667-75. Epub 2004 Apr 29.


Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods.

Whitesall SE, Hoff JB, Vollmer AP, D'Alecy LG.

Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2408-15. Epub 2004 Feb 12.


Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.

Saran R, Novak JE, Desai A, Abdulhayoglu E, Warren JS, Bustami R, Handelman GJ, Barbato D, Weitzel W, D'Alecy LG, Rajagopalan S.

Nephrol Dial Transplant. 2003 Nov;18(11):2415-20.


Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease.

Rajagopalan S, Pfenninger D, Kehrer C, Chakrabarti A, Somers E, Pavlic R, Mukherjee D, Brook R, D'Alecy LG, Kaplan MJ.

Arthritis Rheum. 2003 Jul;48(7):1992-2000.


Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.

Sans MD, DiMagno MJ, D'Alecy LG, Williams JA.

Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G517-28. Epub 2003 May 28.


Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms.

Knipp BS, Peterson DA, Rajagopalan S, Kehrer C, Ford JW, D'Alecy LG, Whitesall SE, Eagleton MJ, Wakefield TW, Henke PK, Jacobs LA, Greenfield LJ, Stanley JC, Upchurch GR Jr.

J Vasc Surg. 2002 Feb;35(2):363-7.


Thyroid hormone in neural rescue.

D'Alecy LG.

Thyroid. 1997 Feb;7(1):115-24.


Gender differences in 24-hour outcome following resuscitation after 9 minutes of cardiac arrest in dogs.

Zwemer CF, O'Connor EM, Whitesall SE, D'Alecy LG.

Crit Care Med. 1997 Feb;25(2):330-8.


Acute administration of T3 or rT3 failed to improve outcome following resuscitation from cardiac arrest in dogs.

Whitesall SE, Mayor GH, Nachreiner RF, Zwemer CF, D'Alecy LG.

Resuscitation. 1996 Nov;33(1):53-62.


High resolution magnetic resonance imaging of the rat spinal cord.

LeMay DR, Fechner KP, Zelenock GB, Sun JK, Zee CS, D'Alecy LG.

Neurol Res. 1996 Oct;18(5):471-4.


Infrarenal aortic clamp hypertension is exacerbated by baroreceptor blockade.

Giglia JS, Zelenock GB, D'Alecy LG.

J Surg Res. 1996 Aug;64(2):112-5.


Alkaloid delta agonist BW373U86 increases hypoxic tolerance.

Bofetiado DM, Mayfield KP, D'Alecy LG.

Anesth Analg. 1996 Jun;82(6):1237-41.


Calcium channel activity increased by plasma from ischemic hindlimbs of rats: role of an endogenous NO synthase inhibitor.

Jin JS, Wilde DW, Webb RC, D'Alecy LG.

Am J Physiol. 1996 Apr;270(4 Pt 2):H1484-92.


Inhibition of vascular nitric oxide-cGMP pathway by plasma from ischemic hindlimb of rats.

Jin JS, Webb RC, D'Alecy LG.

Am J Physiol. 1995 Jul;269(1 Pt 2):H254-61.


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