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Items: 49


The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia.

Quinlan S, Merino-Serrais P, Di Grande A, Dussmann H, Prehn JHM, Ní Chonghaile T, Henshall DC, Jimenez-Mateos EM.

Front Immunol. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752. eCollection 2019.


ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

Walter F, O'Brien A, Concannon CG, Düssmann H, Prehn JHM.

J Biol Chem. 2018 Nov 23;293(47):18270-18284. doi: 10.1074/jbc.RA118.002121. Epub 2018 Oct 4.


Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.

Lucantoni F, Dussmann H, Prehn JHM.

Front Cell Dev Biol. 2018 Sep 11;6:113. doi: 10.3389/fcell.2018.00113. eCollection 2018.


BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.

Lucantoni F, Düssmann H, Llorente-Folch I, Prehn JHM.

Oncotarget. 2018 May 25;9(40):26046-26063. doi: 10.18632/oncotarget.25433. eCollection 2018 May 25.


Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.

Lucantoni F, Lindner AU, O'Donovan N, Düssmann H, Prehn JHM.

Cell Death Dis. 2018 Jan 19;9(2):42. doi: 10.1038/s41419-017-0039-y.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform.

Anilkumar U, Weisova P, Schmid J, Bernas T, Huber HJ, Düssmann H, Connolly NMC, Prehn JHM.

PLoS One. 2017 Nov 16;12(11):e0188343. doi: 10.1371/journal.pone.0188343. eCollection 2017.


Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release.

Düssmann H, Perez-Alvarez S, Anilkumar U, Papkovsky DB, Prehn JH.

Cell Death Dis. 2017 Jun 1;8(6):e2853. doi: 10.1038/cddis.2017.247.


Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

Schwamborn R, Düssmann H, König HG, Prehn JHM.

Mol Cell Neurosci. 2017 Apr;80:148-158. doi: 10.1016/j.mcn.2017.02.007. Epub 2017 Feb 24.


AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D.

Biochim Biophys Acta. 2016 Apr;1863(4):499-509. doi: 10.1016/j.bbamcr.2015.12.016. Epub 2015 Dec 22.


Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models.

Dmitriev RI, Borisov SM, Düssmann H, Sun S, Müller BJ, Prehn J, Baklaushev VP, Klimant I, Papkovsky DB.

ACS Nano. 2015 May 26;9(5):5275-88. doi: 10.1021/acsnano.5b00771. Epub 2015 Apr 15.


Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.

Walter F, Schmid J, Düssmann H, Concannon CG, Prehn JH.

Cell Death Differ. 2015 Sep;22(9):1502-16. doi: 10.1038/cdd.2014.241. Epub 2015 Jan 30.


Bax regulates neuronal Ca2+ homeostasis.

D'Orsi B, Kilbride SM, Chen G, Perez Alvarez S, Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH.

J Neurosci. 2015 Jan 28;35(4):1706-22. doi: 10.1523/JNEUROSCI.2453-14.2015.


BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.

Pfeiffer S, Halang L, Düssmann H, Byrne MM, Prehn J.

Cell Death Discov. 2015 Oct 5;1:15041. doi: 10.1038/cddiscovery.2015.41. eCollection 2015.


Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.

Connolly NM, Düssmann H, Anilkumar U, Huber HJ, Prehn JH.

J Neurosci. 2014 Jul 30;34(31):10192-205. doi: 10.1523/JNEUROSCI.3127-13.2014.


Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

Ramapathiran L, Bernas T, Walter F, Williams L, Düssmann H, Concannon CG, Prehn JH.

J Cell Sci. 2014 Feb 1;127(Pt 3):609-19. doi: 10.1242/jcs.137158. Epub 2013 Nov 27.


Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.

Weisová P, Alvarez SP, Kilbride SM, Anilkumar U, Baumann B, Jordán J, Bernas T, Huber HJ, Düssmann H, Prehn JH.

Transl Psychiatry. 2013 Oct 22;3:e317. doi: 10.1038/tp.2013.92.


AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH.

J Neurochem. 2013 Mar;124(5):721-34. doi: 10.1111/jnc.12108. Epub 2012 Dec 26.


Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

Schmid J, Dussmann H, Boukes GJ, Flanagan L, Lindner AU, O'Connor CL, Rehm M, Prehn JH, Huber HJ.

J Biol Chem. 2012 Nov 30;287(49):41546-59. doi: 10.1074/jbc.M112.411827. Epub 2012 Oct 4.


Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate.

Davila D, Connolly NM, Bonner H, Weisová P, Dussmann H, Concannon CG, Huber HJ, Prehn JH.

Cell Death Differ. 2012 Oct;19(10):1677-88. doi: 10.1038/cdd.2012.49. Epub 2012 Apr 27.


Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

Skorupa A, King MA, Aparicio IM, Dussmann H, Coughlan K, Breen B, Kieran D, Concannon CG, Marin P, Prehn JH.

J Neurosci. 2012 Apr 11;32(15):5024-38. doi: 10.1523/JNEUROSCI.6366-11.2012.


Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

D'Orsi B, Bonner H, Tuffy LP, Düssmann H, Woods I, Courtney MJ, Ward MW, Prehn JH.

J Neurosci. 2012 Feb 1;32(5):1847-58. doi: 10.1523/JNEUROSCI.2345-11.2012.


A structured approach to the study of metabolic control principles in intact and impaired mitochondria.

Huber HJ, Connolly NM, Dussmann H, Prehn JH.

Mol Biosyst. 2012 Mar;8(3):828-42. doi: 10.1039/c2mb05434e. Epub 2012 Jan 5.


Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH.

J Biol Chem. 2011 Jul 22;286(29):25719-28. doi: 10.1074/jbc.M110.215525. Epub 2011 May 31.


Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

Laussmann MA, Passante E, Düssmann H, Rauen JA, Würstle ML, Delgado ME, Devocelle M, Prehn JH, Rehm M.

Cell Death Differ. 2011 Oct;18(10):1584-97. doi: 10.1038/cdd.2011.27. Epub 2011 Apr 1.


Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.

Huber HJ, Dussmann H, Kilbride SM, Rehm M, Prehn JH.

Mol Syst Biol. 2011 Mar 1;7:470. doi: 10.1038/msb.2011.2.


INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.

Bonner C, Bacon S, Concannon CG, Rizvi SR, Baquié M, Farrelly AM, Kilbride SM, Dussmann H, Ward MW, Boulanger CM, Wollheim CB, Graf R, Byrne MM, Prehn JH.

Diabetes. 2010 Nov;59(11):2799-808. doi: 10.2337/db09-1478. Epub 2010 Aug 3.


ALISSA: an automated live-cell imaging system for signal transduction analyses.

Wenus J, Düssmann H, Paul P, Kalamatianos D, Rehm M, Wellstead P, Prehn J, Huber H.

Biotechniques. 2009 Dec;47(6):1033-40. doi: 10.2144/000113247.


Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Düssmann H, Rehm M, Concannon CG, Anguissola S, Würstle M, Kacmar S, Völler P, Huber HJ, Prehn JH.

Cell Death Differ. 2010 Feb;17(2):278-90. doi: 10.1038/cdd.2009.123. Epub 2009 Sep 11.


Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

Anguissola S, Köhler B, O'Byrne R, Düssmann H, Cannon MD, Murray FE, Concannon CG, Rehm M, Kögel D, Prehn JH.

Mol Pharmacol. 2009 Nov;76(5):998-1010. doi: 10.1124/mol.109.058156. Epub 2009 Aug 27.


Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

Rehm M, Huber HJ, Hellwig CT, Anguissola S, Dussmann H, Prehn JH.

Cell Death Differ. 2009 Apr;16(4):613-23. doi: 10.1038/cdd.2008.187. Epub 2009 Jan 9.


TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

Huber HJ, Plchut M, Weisová P, Düssmann H, Wenus J, Rehm M, Ward MW, Prehn JH.

J Neurosci Methods. 2009 Jan 30;176(2):270-5. doi: 10.1016/j.jneumeth.2008.09.003. Epub 2008 Sep 7.


Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein.

O'Connor CL, Anguissola S, Huber HJ, Dussmann H, Prehn JH, Rehm M.

Biochim Biophys Acta. 2008 Oct;1783(10):1903-13. doi: 10.1016/j.bbamcr.2008.05.025. Epub 2008 Jun 11.


Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation.

Hellwig CT, Kohler BF, Lehtivarjo AK, Dussmann H, Courtney MJ, Prehn JH, Rehm M.

J Biol Chem. 2008 Aug 1;283(31):21676-85. doi: 10.1074/jbc.M802889200. Epub 2008 Jun 3.


Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

Ward MW, Huber HJ, Weisová P, Düssmann H, Nicholls DG, Prehn JH.

J Neurosci. 2007 Aug 1;27(31):8238-49.


The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

van den Boom F, Düssmann H, Uhlenbrock K, Abouhamed M, Bähler M.

Mol Biol Cell. 2007 Apr;18(4):1507-18. Epub 2007 Feb 21.


APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

Huber HJ, Rehm M, Plchut M, Düssmann H, Prehn JH.

Bioinformatics. 2007 Mar 1;23(5):648-50. Epub 2007 Jan 19.


Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein.

Rehm M, Huber HJ, Dussmann H, Prehn JH.

EMBO J. 2006 Sep 20;25(18):4338-49. Epub 2006 Aug 24.


Real-time single cell analysis of Smac/DIABLO release during apoptosis.

Rehm M, Düssmann H, Prehn JH.

J Cell Biol. 2003 Sep 15;162(6):1031-43.


Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K.

J Med Chem. 2003 Jul 17;46(15):3382-94.


Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis.

Düssmann H, Kögel D, Rehm M, Prehn JH.

J Biol Chem. 2003 Apr 11;278(15):12645-9. Epub 2003 Jan 30.


The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.

Kögel D, Reimertz C, Düssmann H, Mech P, Scheidtmann KH, Prehn JH.

Eur J Cancer. 2003 Jan;39(2):249-56. Erratum in: Eur J Cancer. 2003 Jul;39(10):1466-8.


Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1).

Kulms D, Düssmann H, Pöppelmann B, Ständer S, Schwarz A, Schwarz T.

Cell Death Differ. 2002 Jun;9(6):598-608.


Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

Rehm M, Dussmann H, Janicke RU, Tavare JM, Kogel D, Prehn JH.

J Biol Chem. 2002 Jul 5;277(27):24506-14. Epub 2002 Apr 18.


Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells.

Glunde K, Düssmann H, Juretschke HP, Leibfritz D.

J Neurochem. 2002 Jan;80(1):36-44.


Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

Wobser H, Düssmann H, Kögel D, Wang H, Reimertz C, Wollheim CB, Byrne MM, Prehn JH.

J Biol Chem. 2002 Feb 22;277(8):6413-21. Epub 2001 Nov 27.


Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.

Luetjens CM, Kögel D, Reimertz C, Düssmann H, Renz A, Schulze-Osthoff K, Nieminen AL, Poppe M, Prehn JH.

Mol Pharmacol. 2001 Nov;60(5):1008-19.


Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis.

Poppe M, Reimertz C, Düssmann H, Krohn AJ, Luetjens CM, Böckelmann D, Nieminen AL, Kögel D, Prehn JH.

J Neurosci. 2001 Jul 1;21(13):4551-63.

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