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Epac1 null mice have nephrogenic diabetes insipidus with deficient cortico-papillary osmotic gradient and weaker collecting duct tight junctions.

Åsrud KS, Bjørnstad R, Kopperud R, Pedersen L, van der Hoeven B, Karlsen TV, Rygh CB, Curry FR, Bakke M, Reed RK, Tenstad O, Døskeland SO.

Acta Physiol (Oxf). 2020 Jan 13. doi: 10.1111/apha.13442. [Epub ahead of print]


Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.

Sivertsen Åsrud K, Pedersen L, Aesoy R, Muwonge H, Aasebø E, Nitschke Pettersen IK, Herfindal L, Dobie R, Jenkins S, Berge RK, Henderson NC, Selheim F, Døskeland SO, Bakke M.

Sci Rep. 2019 Sep 24;9(1):13789. doi: 10.1038/s41598-019-50219-8.


Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis.

Guček A, Gandasi NR, Omar-Hmeadi M, Bakke M, Døskeland SO, Tengholm A, Barg S.

Elife. 2019 May 20;8. pii: e41711. doi: 10.7554/eLife.41711.


A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.

Bjørnstad R, Aesoy R, Bruserud Ø, Brenner AK, Giraud F, Dowling TH, Gausdal G, Moreau P, Døskeland SO, Anizon F, Herfindal L.

Mol Cancer Ther. 2019 Mar;18(3):567-578. doi: 10.1158/1535-7163.MCT-17-1234. Epub 2019 Jan 24.


Epac1-/- mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights.

Curry FE, Taxt T, Rygh CB, Pavlin T, Bjønrstad R, Døskeland SO, Reed RK.

Acta Physiol (Oxf). 2019 Mar;225(3):e13199. doi: 10.1111/apha.13199. Epub 2018 Nov 2.


Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice.

Aesoy R, Muwonge H, Asrud KS, Sabir M, Witsoe SL, Bjornstad R, Kopperud RK, Hoivik EA, Doskeland SO, Bakke M.

PLoS One. 2018 Jul 26;13(7):e0200935. doi: 10.1371/journal.pone.0200935. eCollection 2018.


Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets.

Kleppe R, Jonassen I, Døskeland SO, Selheim F.

Int J Mol Sci. 2018 Feb 19;19(2). pii: E612. doi: 10.3390/ijms19020612.


Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome.

Wangen R, Aasebø E, Trentani A, Døskeland SO, Bruserud Ø, Selheim F, Hernandez-Valladares M.

Int J Mol Sci. 2018 Jan 19;19(1). pii: E296. doi: 10.3390/ijms19010296.


Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles.

Prandina A, Herfindal L, Radix S, Rongved P, Døskeland SO, Le Borgne M, Perret F.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):370-375. doi: 10.1080/14756366.2017.1421638.


Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression.

Nygaard G, Herfindal L, Asrud KS, Bjørnstad R, Kopperud RK, Oveland E, Berven FS, Myhren L, Hoivik EA, Lunde THF, Bakke M, Døskeland SO, Selheim F.

Sci Rep. 2017 Aug 18;7(1):8725. doi: 10.1038/s41598-017-08975-y.


Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives.

Viktorsson EÖ, Melling Grøthe B, Aesoy R, Sabir M, Snellingen S, Prandina A, Høgmoen Åstrand OA, Bonge-Hansen T, Døskeland SO, Herfindal L, Rongved P.

Bioorg Med Chem. 2017 Apr 1;25(7):2285-2293. doi: 10.1016/j.bmc.2017.02.058. Epub 2017 Feb 28.


Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling.

Edland F, Wergeland A, Kopperud R, Åsrud KS, Hoivik EA, Witsø SL, Æsøy R, Madsen L, Kristiansen K, Bakke M, Døskeland SO, Jonassen AK.

Nutr Metab (Lond). 2016 Nov 28;13:87. eCollection 2016.


Increased microvascular permeability in mice lacking Epac1 (Rapgef3).

Kopperud RK, Rygh CB, Karlsen TV, Krakstad C, Kleppe R, Hoivik EA, Bakke M, Tenstad O, Selheim F, Lidén Å, Madsen L, Pavlin T, Taxt T, Kristiansen K, Curry FE, Reed RK, Døskeland SO.

Acta Physiol (Oxf). 2017 Feb;219(2):441-452. doi: 10.1111/apha.12697. Epub 2016 May 17.


Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells.

Giraud F, Bourhis M, Ebrahimi E, Herfindal L, Choudhury RR, Bjørnstad R, Døskeland SO, Anizon F, Moreau P.

Bioorg Med Chem. 2015 Nov 15;23(22):7313-23. doi: 10.1016/j.bmc.2015.10.031. Epub 2015 Oct 24.


Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.

Kleppe R, Herfindal L, Døskeland SO.

Mar Drugs. 2015 Oct 22;13(10):6505-20. doi: 10.3390/md13106505. Review.


B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.

Houge G, Haesen D, Vissers LE, Mehta S, Parker MJ, Wright M, Vogt J, McKee S, Tolmie JL, Cordeiro N, Kleefstra T, Willemsen MH, Reijnders MR, Berland S, Hayman E, Lahat E, Brilstra EH, van Gassen KL, Zonneveld-Huijssoon E, de Bie CI, Hoischen A, Eichler EE, Holdhus R, Steen VM, Døskeland SO, Hurles ME, FitzPatrick DR, Janssens V.

J Clin Invest. 2015 Aug 3;125(8):3051-62. doi: 10.1172/JCI79860. Epub 2015 Jul 13.


New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.

Giraud F, Bourhis M, Nauton L, Théry V, Herfindal L, Døskeland SO, Anizon F, Moreau P.

Bioorg Chem. 2014 Dec;57:108-115. doi: 10.1016/j.bioorg.2014.09.004. Epub 2014 Sep 26.


4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

Liu L, Jokela J, Herfindal L, Wahlsten M, Sinkkonen J, Permi P, Fewer DP, Døskeland SO, Sivonen K.

ACS Chem Biol. 2014 Nov 21;9(11):2646-55. doi: 10.1021/cb500436p. Epub 2014 Sep 25.


Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines.

Aasebø E, Vaudel M, Mjaavatten O, Gausdal G, Van der Burgh A, Gjertsen BT, Døskeland SO, Bruserud O, Berven FS, Selheim F.

Proteomics. 2014 Sep;14(17-18):1971-6. doi: 10.1002/pmic.201300448. Epub 2014 Aug 8. Erratum in: Proteomics. 2016 Aug;16(15-16):2302.


Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.

Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Døskeland SO, Kleppe R, Selheim F.

Biochem Biophys Res Commun. 2014 Jul 4;449(3):357-63. doi: 10.1016/j.bbrc.2014.05.032. Epub 2014 May 17.


Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.

Myhren L, Nilssen IM, Nicolas V, Døskeland SO, Barratt G, Herfindal L.

Eur J Pharm Biopharm. 2014 Sep;88(1):186-93. doi: 10.1016/j.ejpb.2014.04.002. Epub 2014 Apr 18.


Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

Herfindal L, Krakstad C, Myhren L, Hagland H, Kopperud R, Teigen K, Schwede F, Kleppe R, Døskeland SO.

PLoS One. 2014 Apr 16;9(4):e94926. doi: 10.1371/journal.pone.0094926. eCollection 2014.


Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Liu L, Herfindal L, Jokela J, Shishido TK, Wahlsten M, Døskeland SO, Sivonen K.

Mar Drugs. 2014 Apr 3;12(4):2036-53. doi: 10.3390/md12042036.


Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.

Bouaziz Z, Issa S, Gentili J, Gratz A, Bollacke A, Kassack M, Jose J, Herfindal L, Gausdal G, Døskeland SO, Mullié C, Sonnet P, Desgrouas C, Taudon N, Valdameri G, Di Pietro A, Baitiche M, Le Borgne M.

J Enzyme Inhib Med Chem. 2015 Apr;30(2):180-8. doi: 10.3109/14756366.2014.899594. Epub 2014 Apr 3.


Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.

Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjærvik E, Zahlsen K, Brunsvik A, Nygaard G, Aachmann FL, Ellingsen TE, Døskeland SO, Zotchev SB.

Appl Microbiol Biotechnol. 2014 Jan;98(2):603-10. doi: 10.1007/s00253-013-5320-0. Epub 2013 Oct 26.


DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.

Hoivik EA, Witsoe SL, Bergheim IR, Xu Y, Jakobsson I, Tengholm A, Doskeland SO, Bakke M.

PLoS One. 2013 Jul 4;8(7):e67925. doi: 10.1371/journal.pone.0067925. Print 2013.


Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.

Herfindal L, Nygaard G, Kopperud R, Krakstad C, Døskeland SO, Selheim F.

Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8. doi: 10.1016/j.bbrc.2013.07.007. Epub 2013 Jul 12.


Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen.

Herfindal L, Myhren L, Gjertsen BT, Døskeland SO, Gausdal G.

BMC Cancer. 2013 Jul 11;13:341. doi: 10.1186/1471-2407-13-341.


Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells.

Nguyen E, Gausdal G, Varennes J, Pendino F, Lanotte M, Døskeland SO, Ségal-Bendirdjian E.

Mol Pharmacol. 2013 May;83(5):1057-65. doi: 10.1124/mol.112.081034. Epub 2013 Mar 1.


Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO.

Cell Death Dis. 2013 Feb 28;4:e516. doi: 10.1038/cddis.2013.39.


Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells.

Myhren LE, Nygaard G, Gausdal G, Sletta H, Teigen K, Degnes KF, Zahlsen K, Brunsvik A, Bruserud Ø, Døskeland SO, Selheim F, Herfindal L.

Mar Drugs. 2013 Jan 30;11(2):332-49. doi: 10.3390/md11020332.


The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.

Oftedal L, Myhren L, Jokela J, Gausdal G, Sivonen K, Døskeland SO, Herfindal L.

Biochim Biophys Acta. 2012 Dec;1818(12):3000-9. doi: 10.1016/j.bbamem.2012.07.015. Epub 2012 Jul 25.


Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.

Jokela J, Oftedal L, Herfindal L, Permi P, Wahlsten M, Døskeland SO, Sivonen K.

PLoS One. 2012;7(7):e41222. doi: 10.1371/journal.pone.0041222. Epub 2012 Jul 19.


Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells.

Jia B, Madsen L, Petersen RK, Techer N, Kopperud R, Ma T, Døskeland SO, Ailhaud G, Wang J, Amri EZ, Kristiansen K.

PLoS One. 2012;7(3):e34114. doi: 10.1371/journal.pone.0034114. Epub 2012 Mar 27.


Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.

Huseby S, Gausdal G, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser HG, Kleppe R, Døskeland SO.

Cell Death Dis. 2011 Dec 8;2:e237. doi: 10.1038/cddis.2011.124.


The 14-3-3 proteins in regulation of cellular metabolism.

Kleppe R, Martinez A, Døskeland SO, Haavik J.

Semin Cell Dev Biol. 2011 Sep;22(7):713-9. doi: 10.1016/j.semcdb.2011.08.008. Epub 2011 Aug 22. Review.


The cAMP-dependent protein kinase pathway as therapeutic target: possibilities and pitfalls.

Kleppe R, Krakstad C, Selheim F, Kopperud R, Døskeland SO.

Curr Top Med Chem. 2011;11(11):1393-405. Review.


The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.

Dao KK, Pey AL, Gjerde AU, Teigen K, Byeon IJ, Døskeland SO, Gronenborn AM, Martinez A.

PLoS One. 2011 Mar 4;6(3):e17602. doi: 10.1371/journal.pone.0017602.


Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.

Herfindal L, Myhren L, Kleppe R, Krakstad C, Selheim F, Jokela J, Sivonen K, Døskeland SO.

Mol Pharm. 2011 Apr 4;8(2):360-7. doi: 10.1021/mp1002224. Epub 2011 Jan 24.


Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.

Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO, Herfindal L.

Mar Drugs. 2010 Oct 14;8(10):2659-72. doi: 10.3390/md8102659.


Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change.

Jensen BO, Kleppe R, Kopperud R, Nygaard G, Døskeland SO, Holmsen H, Selheim F.

Platelets. 2011;22(1):8-19. doi: 10.3109/09537104.2010.517581. Epub 2010 Oct 19.


The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity.

Oftedal L, Skjærven KH, Coyne RT, Edvardsen B, Rohrlack T, Skulberg OM, Døskeland SO, Herfindal L.

J Ind Microbiol Biotechnol. 2011 Apr;38(4):489-501. doi: 10.1007/s10295-010-0791-9. Epub 2010 Aug 6.


UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.

Madsen L, Pedersen LM, Lillefosse HH, Fjaere E, Bronstad I, Hao Q, Petersen RK, Hallenborg P, Ma T, De Matteis R, Araujo P, Mercader J, Bonet ML, Hansen JB, Cannon B, Nedergaard J, Wang J, Cinti S, Voshol P, Døskeland SO, Kristiansen K.

PLoS One. 2010 Jun 30;5(6):e11391. doi: 10.1371/journal.pone.0011391.


A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins.

Jokela J, Herfindal L, Wahlsten M, Permi P, Selheim F, Vasconçelos V, Døskeland SO, Sivonen K.

Chembiochem. 2010 Jul 26;11(11):1594-9. doi: 10.1002/cbic.201000179.


Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR.

Byeon IJ, Dao KK, Jung J, Keen J, Leiros I, Døskeland SO, Martinez A, Gronenborn AM.

J Biol Chem. 2010 Apr 30;285(18):14062-70. doi: 10.1074/jbc.M110.106666. Epub 2010 Mar 2.


Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity.

Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, Døskeland SO, Herfindal L.

Mar Drugs. 2009 Nov 18;7(4):605-23. doi: 10.3390/md7040605.


Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.

Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB.

Chem Biol. 2009 Oct 30;16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014.


Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells.

Herfindal L, Kasprzykowski F, Schwede F, Łankiewicz L, Fladmark KE, Łukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO.

J Med Chem. 2009 Sep 24;52(18):5758-62. doi: 10.1021/jm900502e.


POSTMan (POST-translational modification analysis), a software application for PTM discovery.

Arntzen MØ, Osland CL, Raa CR, Kopperud R, Døskeland SO, Lewis AE, D'Santos CS.

Proteomics. 2009 Mar;9(5):1400-6. doi: 10.1002/pmic.200800500.


Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes.

Madsen L, Petersen RK, Steffensen KR, Pedersen LM, Hallenborg P, Ma T, Frøyland L, Døskeland SO, Gustafsson JA, Kristiansen K.

J Biol Chem. 2008 Aug 15;283(33):22723-36. doi: 10.1074/jbc.M800720200. Epub 2008 May 16.

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