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Items: 1 to 50 of 199

1.

Precursor-Based Selective Methyl Labeling of Cell-Free Synthesized Proteins.

Lazarova M, Löhr F, Rues RB, Kleebach R, Dötsch V, Bernhard F.

ACS Chem Biol. 2018 Jun 22. doi: 10.1021/acschembio.8b00338. [Epub ahead of print]

PMID:
29894149
2.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

3.

CHK2 sets the stage for CK1 in oocyte quality control.

Kehrloesser S, Tuppi M, Dötsch V.

Cell Death Differ. 2018 Jun;25(6):1007-1009. doi: 10.1038/s41418-018-0107-6. No abstract available.

PMID:
29666471
4.

Protein labeling strategies for liquid-state NMR spectroscopy using cell-free synthesis.

Hoffmann B, Löhr F, Laguerre A, Bernhard F, Dötsch V.

Prog Nucl Magn Reson Spectrosc. 2018 Apr;105:1-22. doi: 10.1016/j.pnmrs.2017.11.004. Epub 2017 Dec 7. Review.

PMID:
29548364
5.

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.

Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Felici M, Behrends C, Klinger FG, Dötsch V.

Nat Struct Mol Biol. 2018 Mar;25(3):261-269. doi: 10.1038/s41594-018-0035-7. Epub 2018 Feb 26.

PMID:
29483652
6.

Systematic optimization of cell-free synthesized human endothelin B receptor folding.

Rues RB, Dong F, Dötsch V, Bernhard F.

Methods. 2018 Jan 31. pii: S1046-2023(17)30386-9. doi: 10.1016/j.ymeth.2018.01.012. [Epub ahead of print]

PMID:
29378315
7.

Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V.

Structure. 2018 Feb 6;26(2):249-258.e4. doi: 10.1016/j.str.2017.12.011. Epub 2018 Jan 18.

PMID:
29358025
8.

Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.

Russo C, Osterburg C, Sirico A, Antonini D, Ambrosio R, Würz JM, Rinnenthal J, Ferniani M, Kehrloesser S, Schäfer B, Güntert P, Sinha S, Dötsch V, Missero C.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E906-E915. doi: 10.1073/pnas.1713773115. Epub 2018 Jan 16.

9.

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.

Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O.

Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6.

10.

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.

Nemajerova A, Amelio I, Gebel J, Dötsch V, Melino G, Moll UM.

Cell Death Differ. 2018 Jan;25(1):144-153. doi: 10.1038/cdd.2017.178. Epub 2017 Oct 27. Review.

11.

Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy.

Peetz O, Henrich E, Laguerre A, Löhr F, Hein C, Dötsch V, Bernhard F, Morgner N.

Anal Chem. 2017 Nov 21;89(22):12314-12318. doi: 10.1021/acs.analchem.7b03309. Epub 2017 Oct 30.

PMID:
29039652
12.

The E. coli S30 lysate proteome: A prototype for cell-free protein production.

Foshag D, Henrich E, Hiller E, Schäfer M, Kerger C, Burger-Kentischer A, Diaz-Moreno I, García-Mauriño SM, Dötsch V, Rupp S, Bernhard F.

N Biotechnol. 2018 Jan 25;40(Pt B):245-260. doi: 10.1016/j.nbt.2017.09.005. Epub 2017 Sep 21.

PMID:
28943390
13.

Control mechanisms in germ cells mediated by p53 family proteins.

Gebel J, Tuppi M, Krauskopf K, Coutandin D, Pitzius S, Kehrloesser S, Osterburg C, Dötsch V.

J Cell Sci. 2017 Aug 9. pii: jcs.204859. doi: 10.1242/jcs.204859. [Epub ahead of print] Review.

PMID:
28794013
14.

Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.

Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A.

J Biol Chem. 2017 Sep 15;292(37):15340-15351. doi: 10.1074/jbc.M117.794255. Epub 2017 Aug 7.

PMID:
28784659
15.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27.

16.

From Gene to Function: Cell-Free Electrophysiological and Optical Analysis of Ion Pumps in Nanodiscs.

Henrich E, Sörmann J, Eberhardt P, Peetz O, Mezhyrova J, Morgner N, Fendler K, Dötsch V, Wachtveitl J, Bernhard F, Bamann C.

Biophys J. 2017 Sep 19;113(6):1331-1341. doi: 10.1016/j.bpj.2017.03.026. Epub 2017 Apr 24.

PMID:
28450130
17.

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I.

Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6.

18.

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2.

Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, Rajalingam K.

EMBO Rep. 2017 May;18(5):733-744. doi: 10.15252/embr.201643744. Epub 2017 Mar 23.

19.

Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins.

Johansen T, Birgisdottir ÅB, Huber J, Kniss A, Dötsch V, Kirkin V, Rogov VV.

Methods Enzymol. 2017;587:143-169. doi: 10.1016/bs.mie.2016.10.023. Epub 2017 Jan 12.

PMID:
28253953
20.

Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology.

Henrich E, Peetz O, Hein C, Laguerre A, Hoffmann B, Hoffmann J, Dötsch V, Bernhard F, Morgner N.

Elife. 2017 Jan 9;6. pii: e20954. doi: 10.7554/eLife.20954.

21.

Acceleration of protein backbone NMR assignment by combinatorial labeling: Application to a small molecule binding study.

Hein C, Löhr F, Schwarz D, Dötsch V.

Biopolymers. 2017 May;107(5). doi: 10.1002/bip.23013.

PMID:
28035667
22.

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I.

EMBO J. 2017 Feb 15;36(4):549-564. doi: 10.15252/embj.201695063. Epub 2016 Dec 27.

23.

The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2.

Waberer L, Henrich E, Peetz O, Morgner N, Dötsch V, Bernhard F, Volknandt W.

J Neurochem. 2017 Jan;140(2):280-293. doi: 10.1111/jnc.13886. Epub 2016 Dec 5.

24.

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.

Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V.

Cell Death Differ. 2016 Dec;23(12):1930-1940. doi: 10.1038/cdd.2016.83. Epub 2016 Oct 7.

25.

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.

Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Dötsch V.

Structure. 2016 Oct 4;24(10):1830-1841. doi: 10.1016/j.str.2016.07.017. Epub 2016 Sep 15.

26.

Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.

Kehrloesser S, Osterburg C, Tuppi M, Schäfer B, Vousden KH, Dötsch V.

Cell Death Differ. 2016 Dec;23(12):1952-1960. doi: 10.1038/cdd.2016.75. Epub 2016 Jul 22.

27.

Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression.

Focke PJ, Hein C, Hoffmann B, Matulef K, Bernhard F, Dötsch V, Valiyaveetil FI.

Biochemistry. 2016 Aug 2;55(30):4212-9. doi: 10.1021/acs.biochem.6b00488. Epub 2016 Jul 21.

28.

The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation.

von Delbrück M, Kniss A, Rogov VV, Pluska L, Bagola K, Löhr F, Güntert P, Sommer T, Dötsch V.

Mol Cell. 2016 Jun 16;62(6):918-928. doi: 10.1016/j.molcel.2016.04.031. Epub 2016 Jun 2.

29.

Structural Evolution and Dynamics of the p53 Proteins.

Chillemi G, Kehrloesser S, Bernassola F, Desideri A, Dötsch V, Levine AJ, Melino G.

Cold Spring Harb Perspect Med. 2017 Apr 3;7(4). pii: a028308. doi: 10.1101/cshperspect.a028308. Review.

PMID:
27091942
30.

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.

Coutandin D, Osterburg C, Srivastav RK, Sumyk M, Kehrloesser S, Gebel J, Tuppi M, Hannewald J, Schäfer B, Salah E, Mathea S, Müller-Kuller U, Doutch J, Grez M, Knapp S, Dötsch V.

Elife. 2016 Mar 14;5. pii: e13909. doi: 10.7554/eLife.13909.

31.

Co-translational formation and pharmacological characterization of beta1-adrenergic receptor/nanodisc complexes with different lipid environments.

Rues RB, Dötsch V, Bernhard F.

Biochim Biophys Acta. 2016 Jun;1858(6):1306-16. doi: 10.1016/j.bbamem.2016.02.031. Epub 2016 Feb 26.

32.

Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway.

Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F.

J Biol Chem. 2016 Jan 29;291(5):2535-46. doi: 10.1074/jbc.M115.664292. Epub 2015 Nov 30.

33.

Labeling of membrane proteins by cell-free expression.

LaGuerre A, Löhr F, Bernhard F, Dötsch V.

Methods Enzymol. 2015;565:367-88. doi: 10.1016/bs.mie.2015.06.001. Epub 2015 Jul 2.

PMID:
26577739
34.

Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.

Heering J, Jonker HR, Löhr F, Schwalbe H, Dötsch V.

Protein Sci. 2016 Feb;25(2):410-22. doi: 10.1002/pro.2830. Epub 2015 Nov 25.

35.

Probing metallo-β-lactamases with molecular fragments identified by consensus docking.

Klingler FM, Moser D, Büttner D, Wichelhaus TA, Löhr F, Dötsch V, Proschak E.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5243-6. doi: 10.1016/j.bmcl.2015.09.056. Epub 2015 Sep 28.

PMID:
26463134
36.

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.

Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C.

Mol Cell. 2015 Oct 1;60(1):89-104. doi: 10.1016/j.molcel.2015.09.010.

37.

Assembling a Correctly Folded and Functional Heptahelical Membrane Protein by Protein Trans-splicing.

Mehler M, Eckert CE, Busche A, Kulhei J, Michaelis J, Becker-Baldus J, Wachtveitl J, Dötsch V, Glaubitz C.

J Biol Chem. 2015 Nov 13;290(46):27712-22. doi: 10.1074/jbc.M115.681205. Epub 2015 Sep 24.

38.

Biosynthesis of membrane dependent proteins in insect cell lysates: identification of limiting parameters for folding and processing.

Merk H, Rues RB, Gless C, Beyer K, Dong F, Dötsch V, Gerrits M, Bernhard F.

Biol Chem. 2015 Sep;396(9-10):1097-107. doi: 10.1515/hsz-2015-0105.

PMID:
25999328
39.

Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.

Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV, Dötsch V, Osiewacz HD, Sreeramulu S, Schwalbe H.

J Biol Chem. 2015 Jun 26;290(26):16415-30. doi: 10.1074/jbc.M115.660829. Epub 2015 May 15.

40.

An extended combinatorial 15N, 13Cα, and 13C' labeling approach to protein backbone resonance assignment.

Löhr F, Tumulka F, Bock C, Abele R, Dötsch V.

J Biomol NMR. 2015 Jul;62(3):263-79. doi: 10.1007/s10858-015-9941-8. Epub 2015 May 8.

PMID:
25953311
41.

Membrane protein production in Escherichia coli cell-free lysates.

Henrich E, Hein C, Dötsch V, Bernhard F.

FEBS Lett. 2015 Jul 8;589(15):1713-22. doi: 10.1016/j.febslet.2015.04.045. Epub 2015 May 1. Review.

42.

Screening for lipid requirements of membrane proteins by combining cell-free expression with nanodiscs.

Henrich E, Dötsch V, Bernhard F.

Methods Enzymol. 2015;556:351-69. doi: 10.1016/bs.mie.2014.12.016. Epub 2015 Mar 20.

PMID:
25857790
43.

FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.

Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo KM, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M.

Int J Cancer. 2015 Sep 15;137(6):1318-29. doi: 10.1002/ijc.29498. Epub 2015 Mar 12.

44.

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.

Mol Cell. 2015 Mar 19;57(6):995-1010. doi: 10.1016/j.molcel.2014.12.040. Epub 2015 Feb 12.

45.

Cell-free expression of G-protein-coupled receptors.

Orbán E, Proverbio D, Haberstock S, Dötsch V, Bernhard F.

Methods Mol Biol. 2015;1261:171-95. doi: 10.1007/978-1-4939-2230-7_10.

PMID:
25502200
46.

Co-translational stabilization of insoluble proteins in cell-free expression systems.

Kai L, Orbán E, Henrich E, Proverbio D, Dötsch V, Bernhard F.

Methods Mol Biol. 2015;1258:125-43. doi: 10.1007/978-1-4939-2205-5_7. Review.

PMID:
25447862
47.

Time-shared experiments for efficient assignment of triple-selectively labeled proteins.

Löhr F, Laguerre A, Bock C, Reckel S, Connolly PJ, Abdul-Manan N, Tumulka F, Abele R, Moore JM, Dötsch V.

J Magn Reson. 2014 Nov;248:81-95. doi: 10.1016/j.jmr.2014.09.014. Epub 2014 Sep 30.

48.

Functional interplay between MDM2, p63/p73 and mutant p53.

Stindt MH, Muller PA, Ludwig RL, Kehrloesser S, Dötsch V, Vousden KH.

Oncogene. 2015 Aug 13;34(33):4300-10. doi: 10.1038/onc.2014.359. Epub 2014 Nov 24.

49.

Cell-free expression of G-protein coupled receptors: new pipelines for challenging targets.

Rues RB, Orbán E, Dötsch V, Bernhard F.

Biol Chem. 2014 Dec;395(12):1425-34. doi: 10.1515/hsz-2014-0217. Review.

PMID:
25178907
50.

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase.

Schröder M, Häfner AK, Hofmann B, Rådmark O, Tumulka F, Abele R, Dötsch V, Steinhilber D.

Biochim Biophys Acta. 2014 Oct;1842(10):1538-47. doi: 10.1016/j.bbalip.2014.07.022. Epub 2014 Aug 8.

PMID:
25107828

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