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Items: 1 to 50 of 183

1.

Palladium(II)-Mediated C-H Tritiation of Complex Pharmaceuticals.

Yang H, Dormer PG, Rivera NR, Hoover AJ.

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1883-1887. doi: 10.1002/anie.201711364. Epub 2018 Feb 1.

PMID:
29314462
2.

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin.

Peng F, Chen Y, Chen CY, Dormer PG, Kassim A, McLaughlin M, Reamer RA, Sherer EC, Song ZJ, Tan L, Tudge MT, Wan B, Chung JYL.

J Org Chem. 2017 Sep 1;82(17):9023-9029. doi: 10.1021/acs.joc.7b01467. Epub 2017 Aug 14.

3.

NMR-based approach to the analysis of radiopharmaceuticals: radiochemical purity, specific activity, and radioactive concentration values by proton and tritium NMR spectroscopy.

Schenk DJ, Dormer PG, Hesk D, Pollack SR, Lavey CF.

J Labelled Comp Radiopharm. 2015 Jun 15;58(7):291-8. doi: 10.1002/jlcr.3295. Epub 2015 May 26.

PMID:
26014438
4.

A soluble copper(I) source and stable salts of volatile ligands for copper-catalyzed C-X couplings.

Maligres PE, Krska SW, Dormer PG.

J Org Chem. 2012 Sep 7;77(17):7646-51. doi: 10.1021/jo300905w. Epub 2012 Aug 27.

PMID:
22881453
5.

Inversion of 1J(CC) correlations in 1,n-ADEQUATE spectra.

Martin GE, Williamson RT, Dormer PG, Bermel W.

Magn Reson Chem. 2012 Aug;50(8):563-8. doi: 10.1002/mrc.3840.

PMID:
22806686
6.

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Song ZJ, Tellers DM, Journet M, Kuethe JT, Lieberman D, Humphrey G, Zhang F, Peng Z, Waters MS, Zewge D, Nolting A, Zhao D, Reamer RA, Dormer PG, Belyk KM, Davies IW, Devine PN, Tschaen DM.

J Org Chem. 2011 Oct 7;76(19):7804-15. doi: 10.1021/jo2011494. Epub 2011 Aug 31. Erratum in: J Org Chem. 2011 Nov 18;76(22):9553.

PMID:
21838271
7.

Separation of triphenyl atropisomers of a pharmaceutical compound on a novel mixed mode stationary phase: a case study involving dynamic chromatography, dynamic NMR and molecular modeling.

Bu X, Skrdla PJ, Dormer PG, Bereznitski Y.

J Chromatogr A. 2010 Nov 12;1217(46):7255-64. doi: 10.1016/j.chroma.2010.09.042. Epub 2010 Sep 19.

PMID:
20947090
8.

Catalyst-controlled regioselective Suzuki couplings at both positions of dihaloimidazoles, dihalooxazoles, and dihalothiazoles.

Strotman NA, Chobanian HR, He J, Guo Y, Dormer PG, Jones CM, Steves JE.

J Org Chem. 2010 Mar 5;75(5):1733-9. doi: 10.1021/jo100148x.

PMID:
20141223
9.

A cascade approach to cyclic aminonitrones: reaction discovery, mechanism, and scope.

Sharma R, Bulger PG, McNevin M, Dormer PG, Ball RG, Streckfuss E, Cuff JF, Yin J, Chen CY.

Org Lett. 2009 Aug 6;11(15):3194-7. doi: 10.1021/ol9010147.

PMID:
19572567
10.

A general method for the synthesis of 3,5-diarylcyclopentenones via friedel-crafts acylation of vinyl chlorides.

Xu Y, McLaughlin M, Chen CY, Reamer RA, Dormer PG, Davies IW.

J Org Chem. 2009 Jul 17;74(14):5100-3. doi: 10.1021/jo900696k.

PMID:
19485346
11.

Efficient cross-coupling of secondary alkyltrifluoroborates with aryl chlorides--reaction discovery using parallel microscale experimentation.

Dreher SD, Dormer PG, Sandrock DL, Molander GA.

J Am Chem Soc. 2008 Jul 23;130(29):9257-9. doi: 10.1021/ja8031423. Epub 2008 Jun 27.

12.

Diastereoselective Friedel-Crafts alkylation of indoles with chiral alpha-phenyl benzylic cations. Asymmetric synthesis of anti-1,1,2-triarylalkanes.

Chung JY, Mancheno D, Dormer PG, Variankaval N, Ball RG, Tsou NN.

Org Lett. 2008 Jul 17;10(14):3037-40. doi: 10.1021/ol800858c. Epub 2008 Jun 19.

PMID:
18563906
13.

Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

Klapars A, Campos KR, Waldman JH, Zewge D, Dormer PG, Chen CY.

J Org Chem. 2008 Jul 4;73(13):4986-93. doi: 10.1021/jo8006804. Epub 2008 May 29.

PMID:
18507444
14.

Expanding the [1,2]-aryl migration to the synthesis of substituted indoles.

Pei T, Chen CY, Dormer PG, Davies IW.

Angew Chem Int Ed Engl. 2008;47(22):4231-3. doi: 10.1002/anie.200705804. No abstract available.

PMID:
18442144
15.

A novel crystallization-induced diastereomeric transformation based on a reversible carbon-sulfur bond formation. Application to the synthesis of a gamma-secretase inhibitor.

Davies AJ, Scott JP, Bishop BC, Brands KM, Brewer SE, Dasilva JO, Dormer PG, Dolling UH, Gibb AD, Hammond DC, Lieberman DR, Palucki M, Payack JF.

J Org Chem. 2007 Jun 22;72(13):4864-71. Epub 2007 May 24.

PMID:
17521199
16.

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

Zewge D, Chen CY, Deer C, Dormer PG, Hughes DL.

J Org Chem. 2007 May 25;72(11):4276-9. Epub 2007 Apr 26.

PMID:
17458997
17.

Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid.

Chen AM, Ellison ME, Peresypkin A, Wenslow RM, Variankaval N, Savarin CG, Natishan TK, Mathre DJ, Dormer PG, Euler DH, Ball RG, Ye Z, Wang Y, Santos I.

Chem Commun (Camb). 2007 Jan 28;(4):419-21. Epub 2006 Nov 1.

PMID:
17220990
18.

Stereoselective preparation of a cyclopentane-based NK1 receptor antagonist bearing an unsymmetrically substituted sec-sec ether.

Kuethe JT, Marcoux JF, Wong A, Wu J, Hillier MC, Dormer PG, Davies IW, Hughes DL.

J Org Chem. 2006 Sep 15;71(19):7378-90.

PMID:
16958533
19.

Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine.

Campos KR, Klapars A, Waldman JH, Dormer PG, Chen CY.

J Am Chem Soc. 2006 Mar 22;128(11):3538-9.

PMID:
16536525
20.

Efficient synthesis of a trisubstituted 1,6-naphthyridone from acetonedicarboxylate and regioselective Suzuki arylation.

Chung JY, Cai C, McWilliams JC, Reamer RA, Dormer PG, Cvetovich RJ.

J Org Chem. 2005 Dec 9;70(25):10342-7.

PMID:
16323843
21.

Detection and elimination of product inhibition from the asymmetric catalytic hydrogenation of enamines.

Hansen KB, Rosner T, Kubryk M, Dormer PG, Armstrong JD 3rd.

Org Lett. 2005 Oct 27;7(22):4935-8.

PMID:
16235926
22.

Synthesis of benzo[b]furans via CuI-catalyzed ring closure.

Chen CY, Dormer PG.

J Org Chem. 2005 Aug 19;70(17):6964-7.

PMID:
16095327
23.

Asymmetric hydrogenation of N-sulfonylated-alpha-dehydroamino acids: toward the synthesis of an anthrax lethal factor inhibitor.

Shultz CS, Dreher SD, Ikemoto N, Williams JM, Grabowski EJ, Krska SW, Sun Y, Dormer PG, Dimichele L.

Org Lett. 2005 Aug 4;7(16):3405-8.

PMID:
16048303
24.

Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.

Jensen MS, Hoerrner RS, Li W, Nelson DP, Javadi GJ, Dormer PG, Cai D, Larsen RD.

J Org Chem. 2005 Jul 22;70(15):6034-9.

PMID:
16018700
25.
26.

Improved carbonylation of heterocyclic chlorides and electronically challenging aryl bromides.

Albaneze-Walker J, Bazaral C, Leavey T, Dormer PG, Murry JA.

Org Lett. 2004 Jun 24;6(13):2097-100.

PMID:
15200294
27.
28.

An efficient synthesis of an alphavbeta3 antagonist.

Yasuda N, Hsiao Y, Jensen MS, Rivera NR, Yang C, Wells KM, Yau J, Palucki M, Tan L, Dormer PG, Volante RP, Hughes DL, Reider PJ.

J Org Chem. 2004 Mar 19;69(6):1959-66.

PMID:
15058940
29.

Demonstrating the synergy of synthetic, mechanistic, and computational studies in a regioselective aniline synthesis.

Davies IW, Marcoux JF, Kuethe JT, Lankshear MD, Taylor JD, Tsou N, Dormer PG, Hughes DL, Houk KN, Guner V.

J Org Chem. 2004 Feb 20;69(4):1298-308.

PMID:
14961684
30.

Synthesis of 3-aminopyrazinone mediated by 2-pyridylthioimidate-ZnCl2 complexes. Development of an efficient route to a thrombin inhibitor.

Chung JY, Cvetovich RJ, Tsay FR, Dormer PG, DiMichele L, Mathre DJ, Chilenski JR, Mao B, Wenslow R.

J Org Chem. 2003 Nov 14;68(23):8838-46.

PMID:
14604352
31.

Efficient and general protocol for the copper-free sonogashira coupling of aryl bromides at room temperature.

Soheili A, Albaneze-Walker J, Murry JA, Dormer PG, Hughes DL.

Org Lett. 2003 Oct 30;5(22):4191-4.

PMID:
14572282
32.

A convenient one-pot synthesis of 1,8-naphthyridones.

Springfield SA, Marcantonio K, Ceglia S, Albaneze-Walker J, Dormer PG, Nelson TD, Murry JA.

J Org Chem. 2003 May 30;68(11):4598-9.

PMID:
12762782
33.

Intramolecular aromatic 1,5-hydrogen transfer in free radical reactions III. Reactivity of diaryl ketones, ethers, thioethers, sulfoxydes, and sulfones. An experimental and theoretical study.

Karady S, Cummins JM, Dannenberg JJ, del Rio E, Dormer PG, Marcune BF, Reamer RA, Sordo TL.

Org Lett. 2003 Apr 17;5(8):1175-8.

PMID:
12688712
34.

Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation.

Brands KM, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ.

J Am Chem Soc. 2003 Feb 26;125(8):2129-35.

PMID:
12590540
35.

Highly regioselective Friedländer annulations with unmodified ketones employing novel amine catalysts: syntheses of 2-substituted quinolines, 1,8-naphthyridines, and related heterocycles.

Dormer PG, Eng KK, Farr RN, Humphrey GR, McWilliams JC, Reider PJ, Sager JW, Volante RP.

J Org Chem. 2003 Jan 24;68(2):467-77.

PMID:
12530873
36.

Asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes as key components of substance p antagonists.

Kuethe JT, Wong A, Wu J, Davies IW, Dormer PG, Welch CJ, Hillier MC, Hughes DL, Reider PJ.

J Org Chem. 2002 Aug 23;67(17):5993-6000.

PMID:
12182634
37.

Development of a new and practical route to chiral 3,4-disubstituted cyclopentanones: asymmetric alkylation and intramolecular cyclopropanation as key C-C bond-forming steps.

Palucki M, Um JM, Yasuda N, Conlon DA, Tsay FR, Hartner FW, Hsiao Y, Marcune B, Karady S, Hughes DL, Dormer PG, Reider PJ.

J Org Chem. 2002 Aug 9;67(16):5508-16.

PMID:
12153248
38.
39.

Ullmann diaryl ether synthesis: rate acceleration by 2,2,6,6-tetramethylheptane-3,5-dione.

Buck E, Song ZJ, Tschaen D, Dormer PG, Volante RP, Reider PJ.

Org Lett. 2002 May 2;4(9):1623-6.

PMID:
11975644
40.

An unexpected [1,5]-h shift in the synthesis of nitroanilines.

Davies IW, Marcoux JF, Taylor JD, Dormer PG, Deeth RJ, Marcotte FA, Hughes DL, Reider PJ.

Org Lett. 2002 Feb 7;4(3):439-41. Erratum in: Org Lett. 2002 Aug 22;4(17):3017.

PMID:
11820899
41.

Synthesis of 5-pyridyl-2-furaldehydes via palladium-catalyzed cross-coupling with triorganozincates.

Gauthier DR Jr, Szumigala RH Jr, Dormer PG, Armstrong JD 3rd, Volante RP, Reider PJ.

Org Lett. 2002 Feb 7;4(3):375-8.

PMID:
11820883
42.

Preparation and novel reduction reactions of vinamidinium salts.

Davies IW, Taylor M, Marcoux JF, Wu J, Dormer PG, Hughes D, Reider PJ.

J Org Chem. 2001 Jan 12;66(1):251-5.

PMID:
11429907
43.

A general preparation of pyridines and pyridones via the annulation of ketones and esters.

Marcoux JF, Marcotte FA, Wu J, Dormer PG, Davies IW, Hughes D, Reider PJ.

J Org Chem. 2001 Jun 15;66(12):4194-9.

PMID:
11397153
44.

A practical synthesis of a COX-2-specific inhibitor.

Davies IW, Marcoux JF, Corley EG, Journet M, Cai DW, Palucki M, Wu J, Larsen RD, Rossen K, Pye PJ, DiMichele L, Dormer P, Reider PJ.

J Org Chem. 2000 Dec 15;65(25):8415-20.

PMID:
11112557
45.

Factors associated with fatigue in a family medicine clinic in the United Arab Emirates.

McIlvenny S, DeGlume A, Elewa M, Fernandez O, Dormer P.

Fam Pract. 2000 Oct;17(5):408-13.

PMID:
11021901
46.

An efficient preparation of vinamidinium hexafluorophosphate salts.

Davies IW, Marcoux JF, Wu J, Palucki M, Corley EG, Robbins MA, Tsou N, Ball RG, Dormer P, Larsen RD, Reider PJ.

J Org Chem. 2000 Jul 28;65(15):4571-4.

PMID:
10959861
47.
48.
49.

VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells.

Oostendorp RA, Dörmer P.

Leuk Lymphoma. 1997 Feb;24(5-6):423-35. Review.

PMID:
9086434
50.

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