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Items: 45


Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death.

Bastea LI, Hollant LMA, Döppler HR, Reid EM, Storz P.

Sci Rep. 2019 Nov 12;9(1):16588. doi: 10.1038/s41598-019-53223-0.


The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast.

Durand N, Borges S, Hall T, Bastea L, Döppler H, Edenfield BH, Thompson EA, Geiger X, Storz P.

Oncotarget. 2018 Nov 20;9(91):36358-36370. doi: 10.18632/oncotarget.26357. eCollection 2018 Nov 20.


Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion.

Durand N, Bastea LI, Döppler H, Eiseler T, Storz P.

Sci Rep. 2017 Aug 25;7(1):9524. doi: 10.1038/s41598-017-10210-7.


The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis.

Liou GY, Bastea L, Fleming A, Döppler H, Edenfield BH, Dawson DW, Zhang L, Bardeesy N, Storz P.

Cell Rep. 2017 May 16;19(7):1322-1333. doi: 10.1016/j.celrep.2017.04.052.


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer.

Döppler H, Storz P.

Front Oncol. 2017 Mar 15;7:41. doi: 10.3389/fonc.2017.00041. eCollection 2017. Review.


Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ.

Durand N, Bastea LI, Long J, Döppler H, Ling K, Storz P.

Sci Rep. 2016 Oct 24;6:35963. doi: 10.1038/srep35963.


The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer.

Döppler H, Panayiotou R, Reid EM, Maimo W, Bastea L, Storz P.

Sci Rep. 2016 Sep 21;6:33758. doi: 10.1038/srep33758.


Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P.

Cell Rep. 2016 Mar 15;14(10):2325-36. doi: 10.1016/j.celrep.2016.02.029. Epub 2016 Mar 3.


Differences in Metabolic Programming Define the Site of Breast Cancer Cell Metastasis.

Döppler H, Storz P.

Cell Metab. 2015 Oct 6;22(4):536-7. doi: 10.1016/j.cmet.2015.09.022.


The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.

Döppler H, Bastea L, Borges S, Geiger X, Storz P.

Oncotarget. 2015 Oct 6;6(30):29740-52. doi: 10.18632/oncotarget.4965.


Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.


Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.

Liou GY, Döppler H, Necela B, Edenfield B, Zhang L, Dawson DW, Storz P.

Cancer Discov. 2015 Jan;5(1):52-63. doi: 10.1158/2159-8290.CD-14-0474. Epub 2014 Oct 31.


Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.

Döppler H, Bastea LI, Borges S, Spratley SJ, Pearce SE, Storz P.

PLoS One. 2014 May 19;9(5):e98090. doi: 10.1371/journal.pone.0098090. eCollection 2014.


A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.

Borges S, Döppler HR, Storz P.

Breast Cancer Res Treat. 2014 Feb;144(1):79-91. doi: 10.1007/s10549-014-2857-2. Epub 2014 Feb 8.


Regulation of VASP by phosphorylation: consequences for cell migration.

Döppler H, Storz P.

Cell Adh Migr. 2013 Nov-Dec;7(6):482-6. doi: 10.4161/cam.27351. Epub 2013 Dec 5.


Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.

Borges S, Döppler H, Perez EA, Andorfer CA, Sun Z, Anastasiadis PZ, Thompson E, Geiger XJ, Storz P.

Breast Cancer Res. 2013 Aug 23;15(2):R66. doi: 10.1186/bcr3460.


Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.

Liou GY, Döppler H, Necela B, Krishna M, Crawford HC, Raimondo M, Storz P.

J Cell Biol. 2013 Aug 5;202(3):563-77. doi: 10.1083/jcb.201301001.


Protein kinase D1-mediated phosphorylations regulate vasodilator-stimulated phosphoprotein (VASP) localization and cell migration.

Döppler HR, Bastea LI, Lewis-Tuffin LJ, Anastasiadis PZ, Storz P.

J Biol Chem. 2013 Aug 23;288(34):24382-93. doi: 10.1074/jbc.M113.474676. Epub 2013 Jul 11.


Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4.

Bastea LI, Döppler H, Pearce SE, Durand N, Spratley SJ, Storz P.

Biochem J. 2013 Oct 15;455(2):251-60. doi: 10.1042/BJ20130281.


Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity.

Döppler H, Liou GY, Storz P.

PLoS One. 2013;8(1):e53676. doi: 10.1371/journal.pone.0053676. Epub 2013 Jan 3.


Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein.

Döppler H, Bastea LI, Eiseler T, Storz P.

J Biol Chem. 2013 Jan 4;288(1):455-65. doi: 10.1074/jbc.M112.397448. Epub 2012 Nov 12.


Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.

Marlow LA, von Roemeling CA, Cooper SJ, Zhang Y, Rohl SD, Arora S, Gonzales IM, Azorsa DO, Reddi HV, Tun HW, Döppler HR, Storz P, Smallridge RC, Copland JA.

J Cell Sci. 2012 Sep 15;125(Pt 18):4253-63. doi: 10.1242/jcs.097428. Epub 2012 Jun 20.


Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.

Bastea LI, Döppler H, Balogun B, Storz P.

PLoS One. 2012;7(1):e30459. doi: 10.1371/journal.pone.0030459. Epub 2012 Jan 20.


Protein kinase D regulates cofilin activity through p21-activated kinase 4.

Spratley SJ, Bastea LI, Döppler H, Mizuno K, Storz P.

J Biol Chem. 2011 Sep 30;286(39):34254-61. doi: 10.1074/jbc.M111.259424. Epub 2011 Aug 9.


FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

Storz P, Döppler H, Copland JA, Simpson KJ, Toker A.

Mol Cell Biol. 2009 Sep;29(18):4906-17. doi: 10.1128/MCB.00077-09. Epub 2009 Jun 29.


Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot.

Eiseler T, Döppler H, Yan IK, Kitatani K, Mizuno K, Storz P.

Nat Cell Biol. 2009 May;11(5):545-56. doi: 10.1038/ncb1861. Epub 2009 Mar 29.


Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling.

Cowell CF, Döppler H, Yan IK, Hausser A, Umezawa Y, Storz P.

J Cell Sci. 2009 Apr 1;122(Pt 7):919-28. doi: 10.1242/jcs.041061. Epub 2009 Mar 3.


Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.

Eiseler T, Döppler H, Yan IK, Goodison S, Storz P.

Breast Cancer Res. 2009;11(1):R13. doi: 10.1186/bcr2232. Epub 2009 Feb 25.


Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1.

Cowell CF, Yan IK, Eiseler T, Leightner AC, Döppler H, Storz P.

J Cell Biochem. 2009 Mar 1;106(4):714-28. doi: 10.1002/jcb.22067.


A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation.

Döppler H, Storz P.

J Biol Chem. 2007 Nov 2;282(44):31873-81. Epub 2007 Sep 5.


A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

Döppler H, Storz P, Li J, Comb MJ, Toker A.

J Biol Chem. 2005 Apr 15;280(15):15013-9. Epub 2005 Feb 22.


Functional dichotomy of A20 in apoptotic and necrotic cell death.

Storz P, Döppler H, Ferran C, Grey ST, Toker A.

Biochem J. 2005 Apr 1;387(Pt 1):47-55.


Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

Storz P, Döppler H, Toker A.

Mol Pharmacol. 2004 Oct;66(4):870-9. Epub 2004 Jun 29.


Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.

Storz P, Döppler H, Johannes FJ, Toker A.

J Biol Chem. 2003 May 16;278(20):17969-76. Epub 2003 Mar 11.


Regulation of novel protein kinase C epsilon by phosphorylation.

Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A.

Biochem J. 2002 May 1;363(Pt 3):537-45.


A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression.

Storz P, Döppler H, Horn-Müller J, Groner B, Pfizenmaier K, Müller G.

Anal Biochem. 1999 Dec 1;276(1):97-104.


TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28.

Storz P, Döppler H, Wernig A, Pfizenmaier K, Müller G.

FEBS Lett. 1998 Nov 27;440(1-2):41-5.


Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells.

Bourteele S, Hausser A, Döppler H, Horn-Müller J, Röpke C, Schwarzmann G, Pfizenmaier K, Müller G.

J Biol Chem. 1998 Nov 20;273(47):31245-51.


Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.

Müller G, Storz P, Bourteele S, Döppler H, Pfizenmaier K, Mischak H, Philipp A, Kaiser C, Kolch W.

EMBO J. 1998 Feb 2;17(3):732-42.

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