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Items: 40

1.

Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat.

Meloni BP, South SM, Gill DA, Marriott AL, Déziel RA, Jacques A, Blacker DJ, Knuckey NW.

J Neuropathol Exp Neurol. 2019 May 1;78(5):426-435. doi: 10.1093/jnen/nlz014.

PMID:
30888409
2.

Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat.

Déziel RA, Tasker RA.

Acta Neuropsychiatr. 2018 Jun;30(3):181-186. doi: 10.1017/neu.2017.32. Epub 2017 Dec 5.

PMID:
29202895
3.

Effects of endothelin-induced prefrontal cortical lesions on delay discounting in the rat.

Déziel RA, Tasker RA.

Behav Neurosci. 2017 Feb;131(1):11-19. doi: 10.1037/bne0000179. Epub 2016 Dec 22.

PMID:
28004949
4.

Prefrontal Ischemia in the Rat Leads to Secondary Damage and Inflammation in Remote Gray and White Matter Regions.

Weishaupt N, Zhang A, Deziel RA, Tasker RA, Whitehead SN.

Front Neurosci. 2016 Mar 2;10:81. doi: 10.3389/fnins.2016.00081. eCollection 2016.

5.

Ischemic lesions localized to the medial prefrontal cortex produce selective deficits in measures of executive function in rats.

Déziel RA, Ryan CL, Tasker RA.

Behav Brain Res. 2015 Oct 15;293:54-61. doi: 10.1016/j.bbr.2015.07.003. Epub 2015 Jul 9.

PMID:
26166190
6.

Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.

Therrien E, Larouche G, Nguyen N, Rahil J, Lemieux AM, Li Z, Fournel M, Yan TP, Landry AJ, Lefebvre S, Wang JJ, MacBeth K, Heise C, Nguyen A, Besterman JM, Déziel R, Wahhab A.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2514-8. doi: 10.1016/j.bmcl.2015.04.068. Epub 2015 Apr 28.

PMID:
25971769
7.

Identification of a novel series of potent RON receptor tyrosine kinase inhibitors.

Raeppel S, Gaudette F, Mannion M, Claridge S, Saavedra O, Isakovic L, Déziel R, Beaulieu N, Beaulieu C, Dupont I, Nguyen H, Wang J, Macleod AR, Maroun C, Besterman JM, Vaisburg A.

Bioorg Med Chem Lett. 2010 May 1;20(9):2745-9. doi: 10.1016/j.bmcl.2010.03.073. Epub 2010 Mar 19.

PMID:
20363625
8.

N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases.

Saavedra O, Claridge S, Zhan L, Raeppel F, Granger MC, Raeppel S, Mannion M, Gaudette F, Zhou N, Isakovic L, Bernstein N, Déziel R, Nguyen H, Beaulieu N, Beaulieu C, Dupont I, Wang J, Macleod AR, Besterman JM, Vaisburg A.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6836-9. doi: 10.1016/j.bmcl.2009.10.095. Epub 2009 Oct 25.

PMID:
19896842
9.

N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Mannion M, Raeppel S, Claridge S, Zhou N, Saavedra O, Isakovic L, Zhan L, Gaudette F, Raeppel F, Déziel R, Beaulieu N, Nguyen H, Chute I, Beaulieu C, Dupont I, Robert MF, Lefebvre S, Dubay M, Rahil J, Wang J, Ste-Croix H, Robert Macleod A, Besterman JM, Vaisburg A.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6552-6. doi: 10.1016/j.bmcl.2009.10.040. Epub 2009 Oct 13.

PMID:
19854051
10.

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

Tessier P, Smil DV, Wahhab A, Leit S, Rahil J, Li Z, Déziel R, Besterman JM.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. doi: 10.1016/j.bmcl.2009.08.010. Epub 2009 Aug 7.

PMID:
19699639
11.

Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.

Manku S, Allan M, Nguyen N, Ajamian A, Rodrigue J, Therrien E, Wang J, Guo T, Rahil J, Petschner AJ, Nicolescu A, Lefebvre S, Li Z, Fournel M, Besterman JM, Déziel R, Wahhab A.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1866-70. doi: 10.1016/j.bmcl.2009.02.075. Epub 2009 Feb 23.

PMID:
19272776
12.

N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Raeppel S, Claridge S, Saavedra O, Gaudette F, Zhan L, Mannion M, Zhou N, Raeppel F, Granger MC, Isakovic L, Déziel R, Nguyen H, Beaulieu N, Beaulieu C, Dupont I, Robert MF, Lefebvre S, Dubay M, Rahil J, Wang J, Ste-Croix H, Robert Macleod A, Besterman J, Vaisburg A.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1323-8. doi: 10.1016/j.bmcl.2009.01.068. Epub 2009 Jan 27.

PMID:
19211249
13.

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).

Allan M, Manku S, Therrien E, Nguyen N, Styhler S, Robert MF, Goulet AC, Petschner AJ, Rahil G, Robert Macleod A, Déziel R, Besterman JM, Nguyen H, Wahhab A.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1218-23. doi: 10.1016/j.bmcl.2008.12.075. Epub 2008 Dec 24.

PMID:
19131248
14.

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

Smil DV, Manku S, Chantigny YA, Leit S, Wahhab A, Yan TP, Fournel M, Maroun C, Li Z, Lemieux AM, Nicolescu A, Rahil J, Lefebvre S, Panetta A, Besterman JM, Déziel R.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92. doi: 10.1016/j.bmcl.2008.12.045. Epub 2008 Dec 14.

PMID:
19111466
15.

Sulfamides as novel histone deacetylase inhibitors.

Wahhab A, Smil D, Ajamian A, Allan M, Chantigny Y, Therrien E, Nguyen N, Manku S, Leit S, Rahil J, Petschner AJ, Lu AH, Nicolescu A, Lefebvre S, Montcalm S, Fournel M, Yan TP, Li Z, Besterman JM, Déziel R.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. doi: 10.1016/j.bmcl.2008.11.081. Epub 2008 Nov 27.

PMID:
19084395
16.

Efficient parallel synthesis of macrocyclic peptidomimetics.

Marsault E, Hoveyda HR, Gagnon R, Peterson ML, Vézina M, Saint-Louis C, Landry A, Pinault JF, Ouellet L, Beauchemin S, Beaubien S, Mathieu A, Benakli K, Wang Z, Brassard M, Lonergan D, Bilodeau F, Ramaseshan M, Fortin N, Lan R, Li S, Galaud F, Plourde V, Champagne M, Doucet A, Bhérer P, Gauthier M, Olsen G, Villeneuve G, Bhat S, Foucher L, Fortin D, Peng X, Bernard S, Drouin A, Déziel R, Berthiaume G, Dory YL, Fraser GL, Deslongchamps P.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4731-5. doi: 10.1016/j.bmcl.2008.06.085. Epub 2008 Jun 28.

PMID:
18640834
17.

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.

Claridge S, Raeppel F, Granger MC, Bernstein N, Saavedra O, Zhan L, Llewellyn D, Wahhab A, Deziel R, Rahil J, Beaulieu N, Nguyen H, Dupont I, Barsalou A, Beaulieu C, Chute I, Gravel S, Robert MF, Lefebvre S, Dubay M, Pascal R, Gillespie J, Jin Z, Wang J, Besterman JM, MacLeod AR, Vaisburg A.

Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8. doi: 10.1016/j.bmcl.2008.04.009. Epub 2008 Apr 9.

PMID:
18434145
18.

Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.

Marsault E, Benakli K, Beaubien S, Saint-Louis C, Déziel R, Fraser G.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4187-90. Epub 2007 May 18.

PMID:
17533127
19.

Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.

Goudreau N, Cameron DR, Déziel R, Haché B, Jakalian A, Malenfant E, Naud J, Ogilvie WW, O'meara J, White PW, Yoakim C.

Bioorg Med Chem. 2007 Apr 1;15(7):2690-700. Epub 2007 Jan 24.

PMID:
17306550
20.

Discovery of a new class of macrocyclic antagonists to the human motilin receptor.

Marsault E, Hoveyda HR, Peterson ML, Saint-Louis C, Landry A, Vézina M, Ouellet L, Wang Z, Ramaseshan M, Beaubien S, Benakli K, Beauchemin S, Déziel R, Peeters T, Fraser GL.

J Med Chem. 2006 Nov 30;49(24):7190-7.

PMID:
17125271
21.

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

O'Meara JA, Yoakim C, Bonneau PR, Bös M, Cordingley MG, Déziel R, Doyon L, Duan J, Garneau M, Guse I, Landry S, Malenfant E, Naud J, Ogilvie WW, Thavonekham B, Simoneau B.

J Med Chem. 2005 Aug 25;48(17):5580-8.

PMID:
16107158
22.

Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives.

Yoakim C, Bonneau PR, Déziel R, Doyon L, Duan J, Guse I, Landry S, Malenfant E, Naud J, Ogilvie WW, O'Meara JA, Plante R, Simoneau B, Thavonekham B, Bös M, Cordingley MG.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):739-42.

PMID:
14741280
23.

A rational approach towards successful crystallization and crystal treatment of human cytomegalovirus protease and its inhibitor complex.

Qian C, Lagacé L, Massariol MJ, Chabot C, Yoakim C, Déziel R, Tong L.

Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):175-80.

PMID:
10666597
24.

Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease.

Ogilvie WW, Yoakim C, Dô F, Haché B, Lagacé L, Naud J, O'Meara JA, Déziel R.

Bioorg Med Chem. 1999 Aug;7(8):1521-31.

PMID:
10482444
25.

Potent beta-lactam inhibitors of human cytomegalovirus protease.

Yoakim C, Ogilvie WW, Cameron DR, Chabot C, Grand-Maître C, Guse I, Haché B, Kawai S, Naud J, O'Meara JA, Plante R, Déziel R.

Antivir Chem Chemother. 1998 Sep;9(5):379-87.

PMID:
9875391
26.

Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.

Llinàs-Brunet M, Bailey M, Déziel R, Fazal G, Gorys V, Goulet S, Halmos T, Maurice R, Poirier M, Poupart MA, Rancourt J, Thibeault D, Wernic D, Lamarre D.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2719-24.

PMID:
9873610
27.

Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.

Déziel R, Malenfant E.

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1437-42.

PMID:
9871780
28.

The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease.

LaPlante SR, Cameron DR, Aubry N, Bonneau PR, Déziel R, Grand-Maître C, Ogilvie WW, Kawai SH.

Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2729-2732. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2729::AID-ANIE2729>3.0.CO;2-4.

PMID:
29711617
29.

Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.

Tong L, Qian C, Massariol MJ, Déziel R, Yoakim C, Lagacé L.

Nat Struct Biol. 1998 Sep;5(9):819-26.

PMID:
9731777
30.

beta-Lactam derivatives as inhibitors of human cytomegalovirus protease.

Yoakim C, Ogilvie WW, Cameron DR, Chabot C, Guse I, Haché B, Naud J, O'Meara JA, Plante R, Déziel R.

J Med Chem. 1998 Jul 16;41(15):2882-91.

PMID:
9667976
31.

Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo.

Duan J, Liuzzi M, Paris W, Lambert M, Lawetz C, Moss N, Jaramillo J, Gauthier J, Déziel R, Cordingley MG.

Antimicrob Agents Chemother. 1998 Jul;42(7):1629-35.

32.

Peptidomimetic inhibitors of the human cytomegalovirus protease.

Ogilvie W, Bailey M, Poupart MA, Abraham A, Bhavsar A, Bonneau P, Bordeleau J, Bousquet Y, Chabot C, Duceppe JS, Fazal G, Goulet S, Grand-Maître C, Guse I, Halmos T, Lavallée P, Leach M, Malenfant E, O'Meara J, Plante R, Plouffe C, Poirier M, Soucy F, Yoakim C, Déziel R.

J Med Chem. 1997 Dec 5;40(25):4113-35.

PMID:
9406601
33.

Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity.

Moss N, Beaulieu P, Duceppe JS, Ferland JM, Garneau M, Gauthier J, Ghiro E, Goulet S, Guse I, Jaramillo J, Llinas-Brunet M, Malenfant E, Plante R, Poirier M, Soucy F, Wernic D, Yoakim C, Déziel R.

J Med Chem. 1996 Oct 11;39(21):4173-80.

PMID:
8863795
34.

Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation.

Moss N, Beaulieu P, Duceppe JS, Ferland JM, Gauthier J, Ghiro E, Goulet S, Guse I, Llinàs-Brunet M, Plante R, Plamondon L, Wernic D, Déziel R.

J Med Chem. 1996 May 24;39(11):2178-87.

PMID:
8667361
35.

Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease.

Brandt CR, Spencer B, Imesch P, Garneau M, Déziel R.

Antimicrob Agents Chemother. 1996 May;40(5):1078-84.

36.

A Practical and Diastereoselective Synthesis of Ketomethylene Dipeptide Isosteres of the Type AAPsi[COCH(2)]Asp.

Déziel R, Plante R, Caron V, Grenier L, Llinas-Brunet M, Duceppe JS, Malenfant E, Moss N.

J Org Chem. 1996 Apr 19;61(8):2901-2903. No abstract available.

PMID:
11667134
37.

Practical Synthesis of (R,R)- and (S,S)-Bis[2,6-bis(1-ethoxyethyl)phenyl] Diselenide.

Déziel R, Malenfant E, Bélanger G.

J Org Chem. 1996 Mar 8;61(5):1875-1876. No abstract available.

PMID:
11667068
38.

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo.

Liuzzi M, Déziel R, Moss N, Beaulieu P, Bonneau AM, Bousquet C, Chafouleas JG, Garneau M, Jaramillo J, Krogsrud RL, et al.

Nature. 1994 Dec 15;372(6507):695-8.

PMID:
7990963
39.

Herpes simplex virus ribonucleotide reductase subunit association inhibitors: the effect and conformation of beta-alkylated aspartic acid derivatives.

Moss N, Déziel R, Ferland JM, Goulet S, Jones PJ, Leonard SF, Pitner TP, Plante R.

Bioorg Med Chem. 1994 Sep;2(9):959-70.

PMID:
7712131
40.

Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.

Moss N, Déziel R, Adams J, Aubry N, Bailey M, Baillet M, Beaulieu P, DiMaio J, Duceppe JS, Ferland JM, et al.

J Med Chem. 1993 Oct 1;36(20):3005-9.

PMID:
8411018

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