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The association between resident physician work hour regulations and physician safety and health.

Weaver MD, Landrigan CP, Sullivan JP, O'Brien CS, Qadri S, Viyaran N, Wang W, Vetter C, Czeisler CA, Barger LK.

Am J Med. 2020 Feb 13. pii: S0002-9343(20)30116-9. doi: 10.1016/j.amjmed.2019.12.053. [Epub ahead of print]


Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure.

Rahman SA, Wright KP Jr, Lockley SW, Czeisler CA, Gronfier C.

Sci Rep. 2019 Dec 23;9(1):19720. doi: 10.1038/s41598-019-54806-7.


Irregular sleep and event schedules are associated with poorer self-reported well-being in US college students.

Fischer D, McHill AW, Sano A, Picard RW, Barger LK, Czeisler CA, Klerman EB, Phillips AJK.

Sleep. 2019 Dec 14. pii: zsz300. doi: 10.1093/sleep/zsz300. [Epub ahead of print]


Associations between shift work characteristics, shift work schedules, sleep and burnout in North American police officers: a cross-sectional study.

Peterson SA, Wolkow AP, Lockley SW, O'Brien CS, Qadri S, Sullivan JP, Czeisler CA, Rajaratnam SMW, Barger LK.

BMJ Open. 2019 Dec 1;9(11):e030302. doi: 10.1136/bmjopen-2019-030302.


Using a Single Daytime Performance Test to Identify Most Individuals at High-Risk for Performance Impairment during Extended Wake.

St Hilaire MA, Kristal BS, Rahman SA, Sullivan JP, Quackenbush J, Duffy JF, Barger LK, Gooley JJ, Czeisler CA, Lockley SW.

Sci Rep. 2019 Nov 13;9(1):16681. doi: 10.1038/s41598-019-52930-y.


Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio.

Grant LK, Gooley JJ, St Hilaire MA, Rajaratnam SMW, Brainard GC, Czeisler CA, Lockley SW, Rahman SA.

Sleep. 2020 Feb 13;43(2). pii: zsz227. doi: 10.1093/sleep/zsz227.


Employer-Mandated Obstructive Sleep Apnea Treatment and Healthcare Cost Savings among Truckers.

Burks SV, Anderson JE, Panda B, Haider R, Ginader T, Sandback N, Pokutnaya D, Toso D, Hughes N, Haider HS, Brockman R, Toll A, Solberg N, Eklund J, Cagle M, Hickman JS, Mabry E, Berger M, Czeisler CA, Kales SN.

Sleep. 2019 Oct 24. pii: zsz262. doi: 10.1093/sleep/zsz262. [Epub ahead of print]


Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Swanson CM, Kohrt WM, Wolfe P, Wright KP Jr, Shea SA, Cain SW, Munch M, Vujović N, Czeisler CA, Orwoll ES, Buxton OM.

Osteoporos Int. 2019 Dec;30(12):2485-2493. doi: 10.1007/s00198-019-05135-y. Epub 2019 Aug 24.


Classifying attentional vulnerability to total sleep deprivation using baseline features of Psychomotor Vigilance Test performance.

Chua EC, Sullivan JP, Duffy JF, Klerman EB, Lockley SW, Kristal BS, Czeisler CA, Gooley JJ.

Sci Rep. 2019 Aug 20;9(1):12102. doi: 10.1038/s41598-019-48280-4.


Endogenous Circadian Regulation of Female Reproductive Hormones.

Rahman SA, Grant LK, Gooley JJ, Rajaratnam SMW, Czeisler CA, Lockley SW.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6049-6059. doi: 10.1210/jc.2019-00803.


An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences.

Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB.

J Biol Rhythms. 2019 Aug 1:748730419862702. doi: 10.1177/0748730419862702. [Epub ahead of print]


Patient Safety under Flexible and Standard Duty-Hour Rules.

Landrigan CP, Czeisler CA.

N Engl J Med. 2019 Jun 13;380(24):2379-2380. doi: 10.1056/NEJMc1905064. No abstract available.


Associations between sleep disturbances, mental health outcomes and burnout in firefighters, and the mediating role of sleep during overnight work: A cross-sectional study.

Wolkow AP, Barger LK, O'Brien CS, Sullivan JP, Qadri S, Lockley SW, Czeisler CA, Rajaratnam SMW.

J Sleep Res. 2019 Dec;28(6):e12869. doi: 10.1111/jsr.12869. Epub 2019 May 26.


Effects on resident work hours, sleep duration, and work experience in a randomized order safety trial evaluating resident-physician schedules (ROSTERS).

Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA; ROSTERS Study Group.

Sleep. 2019 Aug 1;42(8). pii: zsz110. doi: 10.1093/sleep/zsz110.


Sleep myths: an expert-led study to identify false beliefs about sleep that impinge upon population sleep health practices.

Robbins R, Grandner MA, Buxton OM, Hale L, Buysse DJ, Knutson KL, Patel SR, Troxel WM, Youngstedt SD, Czeisler CA, Jean-Louis G.

Sleep Health. 2019 Aug;5(4):409-417. doi: 10.1016/j.sleh.2019.02.002. Epub 2019 Apr 17.


Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.

Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R.

Sci Rep. 2019 Mar 29;9(1):5350. doi: 10.1038/s41598-019-41712-1.


Design and recruitment of the randomized order safety trial evaluating resident-physician schedules (ROSTERS) study.

Blackwell T, Kriesel DR, Vittinghoff E, O'Brien CS, Sullivan JP, Viyaran NC, Rahman SA, Lockley SW, Barger LK, Halbower AC, Poynter SE, Wright KP Jr, Yu PL, Zee PC, Landrigan CP, Czeisler CA, Stone KL; ROSTERS Study Group.

Contemp Clin Trials. 2019 May;80:22-33. doi: 10.1016/j.cct.2019.03.005. Epub 2019 Mar 15.


Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults.

McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EB.

Nutrients. 2019 Mar 11;11(3). pii: E587. doi: 10.3390/nu11030587.


Brief (<4 hr) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts.

St Hilaire MA, Anderson C, Anwar J, Sullivan JP, Cade BE, Flynn-Evans EE, Czeisler CA, Lockley SW; Harvard Work Hours Health and Safety Group.

Sleep. 2019 May 1;42(5). pii: zsz041. doi: 10.1093/sleep/zsz041.


Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy.

Rahman SA, Bibbo C, Olcese J, Czeisler CA, Robinson JN, Klerman EB.

J Pineal Res. 2019 May;66(4):e12566. doi: 10.1111/jpi.12566. Epub 2019 Mar 10.


Chronic sleep restriction greatly magnifies performance decrements immediately after awakening.

McHill AW, Hull JT, Cohen DA, Wang W, Czeisler CA, Klerman EB.

Sleep. 2019 May 1;42(5). pii: zsz032. doi: 10.1093/sleep/zsz032.


Light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-image-forming photoreception.

Vandewalle G, van Ackeren MJ, Daneault V, Hull JT, Albouy G, Lepore F, Doyon J, Czeisler CA, Dumont M, Carrier J, Lockley SW, Collignon O.

Sci Rep. 2018 Nov 16;8(1):16968. doi: 10.1038/s41598-018-35400-9.


Human Resting Energy Expenditure Varies with Circadian Phase.

Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF.

Curr Biol. 2018 Nov 19;28(22):3685-3690.e3. doi: 10.1016/j.cub.2018.10.005. Epub 2018 Nov 8.


Association of DAT1 genetic variants with habitual sleep duration in the UK Biobank.

Rhodes JA, Lane JM, Vlasac IM, Rutter MK, Czeisler CA, Saxena R.

Sleep. 2019 Jan 1;42(1). doi: 10.1093/sleep/zsy193.


Cross-sectional analysis of sleep-promoting and wake-promoting drug use on health, fatigue-related error, and near-crashes in police officers.

Ogeil RP, Barger LK, Lockley SW, O'Brien CS, Sullivan JP, Qadri S, Lubman DI, Czeisler CA, Rajaratnam SMW.

BMJ Open. 2018 Sep 19;8(9):e022041. doi: 10.1136/bmjopen-2018-022041.


Sleep disorders, depression and anxiety are associated with adverse safety outcomes in healthcare workers: A prospective cohort study.

Weaver MD, Vetter C, Rajaratnam SMW, O'Brien CS, Qadri S, Benca RM, Rogers AE, Leary EB, Walsh JK, Czeisler CA, Barger LK.

J Sleep Res. 2018 Dec;27(6):e12722. doi: 10.1111/jsr.12722. Epub 2018 Aug 1.


Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults.

Zitting KM, Münch MY, Cain SW, Wang W, Wong A, Ronda JM, Aeschbach D, Czeisler CA, Duffy JF.

Sci Rep. 2018 Jul 23;8(1):11052. doi: 10.1038/s41598-018-29358-x.


Sleep Education for College Students: The Time Is Now.

Quan SF, Ziporyn PS, Czeisler CA.

J Clin Sleep Med. 2018 Jul 15;14(7):1269. doi: 10.5664/jcsm.7246. No abstract available.


Housing Immigrant Children - The Inhumanity of Constant Illumination.

Czeisler CA.

N Engl J Med. 2018 Jul 12;379(2):e3. doi: 10.1056/NEJMp1808450. Epub 2018 Jun 22. No abstract available.


Resident physician extended work hours and burnout.

McHill AW, Czeisler CA, Shea SA.

Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy112. No abstract available.


Unrestricted evening use of light-emitting tablet computers delays self-selected bedtime and disrupts circadian timing and alertness.

Chinoy ED, Duffy JF, Czeisler CA.

Physiol Rep. 2018 May;6(10):e13692. doi: 10.14814/phy2.13692.


Increased vulnerability to attentional failure during acute sleep deprivation in women depends on menstrual phase.

Vidafar P, Gooley JJ, Burns AC, Rajaratnam SMW, Rueger M, Van Reen E, Czeisler CA, Lockley SW, Cain SW.

Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy098.


Chronic sleep curtailment, even without extended (>16-h) wakefulness, degrades human vigilance performance.

McHill AW, Hull JT, Wang W, Czeisler CA, Klerman EB.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):6070-6075. doi: 10.1073/pnas.1706694115. Epub 2018 May 21.


Functional decoupling of melatonin suppression and circadian phase resetting in humans.

Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW.

J Physiol. 2018 Jun;596(11):2147-2157. doi: 10.1113/JP275501. Epub 2018 Apr 29.


Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light: Clinical Characteristics.

Hull JT, Czeisler CA, Lockley SW.

Ophthalmology. 2018 Aug;125(8):1160-1171. doi: 10.1016/j.ophtha.2018.01.036. Epub 2018 Apr 4.


Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study.

Gottlieb DJ, Ellenbogen JM, Bianchi MT, Czeisler CA.

BMC Med. 2018 Mar 20;16(1):44. doi: 10.1186/s12916-018-1025-7.


Data and methods for studying commercial motor vehicle driver fatigue, highway safety and long-term driver health.

Stern HS, Blower D, Cohen ML, Czeisler CA, Dinges DF, Greenhouse JB, Guo F, Hanowski RJ, Hartenbaum NP, Krueger GP, Mallis MM, Pain RF, Rizzo M, Sinha E, Small DS, Stuart EA, Wegman DH.

Accid Anal Prev. 2019 May;126:37-42. doi: 10.1016/j.aap.2018.02.021. Epub 2018 Mar 9. Review.


Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion.

Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ.

TH Open. 2018 Jan 30;2(1):e49-e53. doi: 10.1055/s-0038-1624565. eCollection 2018 Jan.


Self-reported Drowsiness and Safety Outcomes While Driving After an Extended Duration Work Shift in Trainee Physicians.

Anderson C, Ftouni S, Ronda JM, Rajaratnam SMW, Czeisler CA, Lockley SW.

Sleep. 2018 Feb 1;41(2). pii: zsx195. doi: 10.1093/sleep/zsx195.


Prediction of drowsiness events in night shift workers during morning driving.

Liang Y, Horrey WJ, Howard ME, Lee ML, Anderson C, Shreeve MS, O'Brien CS, Czeisler CA.

Accid Anal Prev. 2019 May;126:105-114. doi: 10.1016/j.aap.2017.11.004. Epub 2017 Nov 7.


Short Sleep Duration, Obstructive Sleep Apnea, Shiftwork, and the Risk of Adverse Cardiovascular Events in Patients After an Acute Coronary Syndrome.

Barger LK, Rajaratnam SMW, Cannon CP, Lukas MA, Im K, Goodrich EL, Czeisler CA, O'Donoghue ML.

J Am Heart Assoc. 2017 Oct 10;6(10). pii: e006959. doi: 10.1161/JAHA.117.006959.


Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans.

Swanson CM, Shea SA, Wolfe P, Cain SW, Munch M, Vujovic N, Czeisler CA, Buxton OM, Orwoll ES.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3722-3730. doi: 10.1210/jc.2017-01147.


Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele.

Grant LK, Cain SW, Chang AM, Saxena R, Czeisler CA, Anderson C.

Behav Brain Res. 2018 Feb 15;338:51-55. doi: 10.1016/j.bbr.2017.09.025. Epub 2017 Sep 22.


Later circadian timing of food intake is associated with increased body fat.

McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB.

Am J Clin Nutr. 2017 Nov;106(5):1213-1219. doi: 10.3945/ajcn.117.161588. Epub 2017 Sep 6.


Soluble interleukin-13rα1: a circulating regulator of glucose.

Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E663-E671. doi: 10.1152/ajpendo.00168.2017. Epub 2017 Sep 5.


24-hour profile of serum sclerostin and its association with bone biomarkers in men.

Swanson C, Shea SA, Wolfe P, Markwardt S, Cain SW, Munch M, Czeisler CA, Orwoll ES, Buxton OM.

Osteoporos Int. 2017 Nov;28(11):3205-3213. doi: 10.1007/s00198-017-4162-5. Epub 2017 Jul 26.


Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing.

Phillips AJK, Clerx WM, O'Brien CS, Sano A, Barger LK, Picard RW, Lockley SW, Klerman EB, Czeisler CA.

Sci Rep. 2017 Jun 12;7(1):3216. doi: 10.1038/s41598-017-03171-4.


Circadian phase resetting by a single short-duration light exposure.

Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB.

JCI Insight. 2017 Apr 6;2(7):e89494. doi: 10.1172/jci.insight.89494.


Randomized, Prospective Study of the Impact of a Sleep Health Program on Firefighter Injury and Disability.

Sullivan JP, O'Brien CS, Barger LK, Rajaratnam SM, Czeisler CA, Lockley SW; Harvard Work Hours, Health and Safety Group.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw001.


Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and Women.

Cain SW, Chang AM, Vlasac I, Tare A, Anderson C, Czeisler CA, Saxena R.

J Biol Rhythms. 2017 Feb;32(1):75-82. doi: 10.1177/0748730417693124. Epub 2017 Feb 20.


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