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Items: 1 to 50 of 317

1.

Mechanisms of insulin resistance related to white, beige, and brown adipocytes.

Czech MP.

Mol Metab. 2020 Apr;34:27-42. doi: 10.1016/j.molmet.2019.12.014. Epub 2020 Jan 7. Review.

2.

Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat.

Fitzgibbons TP, Lee N, Tran KV, Nicoloro S, Kelly M, Tam SK, Czech MP.

JCI Insight. 2019 Oct 17;4(20). pii: 124859. doi: 10.1172/jci.insight.124859.

3.

The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium.

Li Q, Nirala NK, Chen HJ, Nie Y, Wang W, Zhang B, Czech MP, Wang Q, Xu L, Mao J, Ip YT.

J Cell Physiol. 2019 Dec;234(12):21925-21936. doi: 10.1002/jcp.28756. Epub 2019 May 1.

PMID:
31042012
4.

Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism.

Blaszczak AM, Wright VP, Anandani K, Liu J, Jalilvand A, Bergin S, Nicoloro SM, Czech MP, Lafuse W, Deng T, Bradley D, Hsueh WA.

J Immunol. 2019 Apr 15;202(8):2451-2459. doi: 10.4049/jimmunol.1801470. Epub 2019 Mar 8.

PMID:
30850480
5.

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus.

Guilherme A, Henriques F, Bedard AH, Czech MP.

Nat Rev Endocrinol. 2019 Apr;15(4):207-225. doi: 10.1038/s41574-019-0165-y. Review.

6.

CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.

Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP.

J Biol Chem. 2018 Nov 2;293(44):17291-17305. doi: 10.1074/jbc.RA118.004554. Epub 2018 Sep 6.

7.

Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis.

Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP.

Mol Metab. 2018 Oct;16:116-125. doi: 10.1016/j.molmet.2018.06.014. Epub 2018 Jun 27.

8.

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.

Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I.

Nature. 2018 Mar 29;555(7698):673-677. doi: 10.1038/nature26138. Epub 2018 Mar 21.

9.

Macrophages dispose of catecholamines in adipose tissue.

Czech MP.

Nat Med. 2017 Nov 7;23(11):1255-1257. doi: 10.1038/nm.4440. No abstract available.

PMID:
29117176
10.

Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice.

Jourdan T, Nicoloro SM, Zhou Z, Shen Y, Liu J, Coffey NJ, Cinar R, Godlewski G, Gao B, Aouadi M, Czech MP, Kunos G.

Mol Metab. 2017 Nov;6(11):1517-1528. doi: 10.1016/j.molmet.2017.08.011. Epub 2017 Sep 1.

11.

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.

Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP.

Mol Metab. 2017 May 31;6(8):781-796. doi: 10.1016/j.molmet.2017.05.012. eCollection 2017 Aug.

12.

Insulin action and resistance in obesity and type 2 diabetes.

Czech MP.

Nat Med. 2017 Jul 11;23(7):804-814. doi: 10.1038/nm.4350. Review.

13.

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.

Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD.

Cardiovasc Diabetol. 2017 Jul 7;16(1):87. doi: 10.1186/s12933-017-0567-x.

14.

Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.

Roth Flach RJ, DiStefano MT, Danai LV, Senol-Cosar O, Yawe JC, Kelly M, Garcia Menendez L, Czech MP.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E303-E313. doi: 10.1152/ajpendo.00037.2017. Epub 2017 Jun 13.

15.

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes.

Jourdan T, Szanda G, Cinar R, Godlewski G, Holovac DJ, Park JK, Nicoloro S, Shen Y, Liu J, Rosenberg AZ, Liu Z, Czech MP, Kunos G.

Diabetes. 2017 Apr;66(4):994-1007. doi: 10.2337/db16-1199. Epub 2017 Jan 12.

16.

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP.

Mol Metab. 2016 Sep 28;5(12):1149-1161. doi: 10.1016/j.molmet.2016.09.009. eCollection 2016 Dec.

17.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.

J Biol Chem. 2016 Jul 29;291(31):16221-30. doi: 10.1074/jbc.M116.718932. Epub 2016 May 20.

18.

Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.

Virbasius JV, Czech MP.

Trends Endocrinol Metab. 2016 Jul;27(7):484-492. doi: 10.1016/j.tem.2016.04.006. Epub 2016 May 6. Review.

19.

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.

Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP.

Mol Cell Biol. 2016 May 31;36(12):1740-9. doi: 10.1128/MCB.01121-15. Print 2016 Jun 15.

20.

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S.

J Clin Invest. 2016 May 2;126(5):1704-16. doi: 10.1172/JCI83532. Epub 2016 Mar 28.

21.

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP.

Nat Commun. 2016 Feb 16;7:10686. doi: 10.1038/ncomms10686.

22.

Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance.

Fitzgibbons TP, Czech MP.

J Mol Med (Berl). 2016 Mar;94(3):267-75. doi: 10.1007/s00109-016-1385-4. Epub 2016 Feb 4. Review.

23.

Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA.

Cohen JL, Shen Y, Aouadi M, Vangala P, Tencerova M, Amano SU, Nicoloro SM, Yawe JC, Czech MP.

Mol Pharm. 2016 Mar 7;13(3):964-978. doi: 10.1021/acs.molpharmaceut.5b00831. Epub 2016 Feb 11.

24.

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.

Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP.

Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995.

25.

NETs and traps delay wound healing in diabetes.

Roth Flach RJ, Czech MP.

Trends Endocrinol Metab. 2015 Sep;26(9):451-2. doi: 10.1016/j.tem.2015.07.004. Epub 2015 Jul 31. Review.

26.

A major role of insulin in promoting obesity-associated adipose tissue inflammation.

Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP.

Mol Metab. 2015 May 1;4(7):507-18. doi: 10.1016/j.molmet.2015.04.003. eCollection 2015 Jul.

27.

The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.

DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP.

J Biol Chem. 2015 Jun 12;290(24):15175-84. doi: 10.1074/jbc.M115.650184. Epub 2015 Apr 28.

28.

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues.

Danai LV, Flach RJ, Virbasius JV, Menendez LG, Jung DY, Kim JH, Kim JK, Czech MP.

Mol Cell Biol. 2015 Jul;35(13):2356-65.

29.

Activated Kupffer cells inhibit insulin sensitivity in obese mice.

Tencerova M, Aouadi M, Vangala P, Nicoloro SM, Yawe JC, Cohen JL, Shen Y, Garcia-Menendez L, Pedersen DJ, Gallagher-Dorval K, Perugini RA, Gupta OT, Czech MP.

FASEB J. 2015 Jul;29(7):2959-69. doi: 10.1096/fj.15-270496. Epub 2015 Mar 24.

30.

The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT.

Dev Cell. 2014 Nov 10;31(3):291-304. doi: 10.1016/j.devcel.2014.09.012. Epub 2014 Nov 10.

31.

IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis.

Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP.

PLoS One. 2014 Sep 12;9(9):e107265. doi: 10.1371/journal.pone.0107265. eCollection 2014.

32.

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance.

Aouadi M, Vangala P, Yawe JC, Tencerova M, Nicoloro SM, Cohen JL, Shen Y, Czech MP.

Am J Physiol Endocrinol Metab. 2014 Aug 15;307(4):E374-83. doi: 10.1152/ajpendo.00187.2014. Epub 2014 Jul 1.

33.

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction.

Sun K, Park J, Gupta OT, Holland WL, Auerbach P, Zhang N, Goncalves Marangoni R, Nicoloro SM, Czech MP, Varga J, Ploug T, An Z, Scherer PE.

Nat Commun. 2014 Mar 19;5:3485. doi: 10.1038/ncomms4485.

34.

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations.

Fitzgibbons TP, Czech MP.

J Am Heart Assoc. 2014 Mar 4;3(2):e000582. doi: 10.1161/JAHA.113.000582. Review. No abstract available.

35.

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M.

Cell Metab. 2014 Jan 7;19(1):162-171. doi: 10.1016/j.cmet.2013.11.017. Epub 2013 Dec 26.

36.

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G.

Nat Med. 2013 Sep;19(9):1132-40. doi: 10.1038/nm.3265. Epub 2013 Aug 18.

37.

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.

Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP.

J Lipid Res. 2013 Oct;54(10):2697-707. doi: 10.1194/jlr.M038802. Epub 2013 Aug 7.

38.

Obesity Notches up fatty liver.

Czech MP.

Nat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. No abstract available.

PMID:
23921741
39.

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.

Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8278-83. doi: 10.1073/pnas.1300492110. Epub 2013 Apr 29.

40.

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.

Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E951-63. doi: 10.1152/ajpendo.00514.2012. Epub 2013 Mar 12.

41.

Insulin signalling mechanisms for triacylglycerol storage.

Czech MP, Tencerova M, Pedersen DJ, Aouadi M.

Diabetologia. 2013 May;56(5):949-64. doi: 10.1007/s00125-013-2869-1. Epub 2013 Feb 27. Review.

42.

β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.

Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP.

J Biol Chem. 2013 Jan 25;288(4):2882-92. doi: 10.1074/jbc.M112.412346. Epub 2012 Dec 12.

43.

Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.

Wang M, Amano SU, Flach RJ, Chawla A, Aouadi M, Czech MP.

Mol Cell Biol. 2013 Feb;33(4):678-87. doi: 10.1128/MCB.00618-12. Epub 2012 Dec 3.

44.

Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.

Sartorius T, Staiger H, Ketterer C, Heni M, Machicao F, Guilherme A, Grallert H, Schulze MB, Boeing H, Stefan N, Fritsche A, Czech MP, Häring HU.

PLoS One. 2012;7(10):e47647. doi: 10.1371/journal.pone.0047647. Epub 2012 Oct 18.

45.

What causes the insulin resistance underlying obesity?

Hardy OT, Czech MP, Corvera S.

Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):81-7. doi: 10.1097/MED.0b013e3283514e13. Review.

46.

CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone.

Young JL, Mora A, Cerny A, Czech MP, Woda B, Kurt-Jones EA, Finberg RW, Corvera S.

PLoS One. 2012;7(1):e29688. doi: 10.1371/journal.pone.0029688. Epub 2012 Jan 13.

47.

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY.

Cell Metab. 2011 Sep 7;14(3):378-89. doi: 10.1016/j.cmet.2011.06.015.

48.

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation.

Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1425-37. doi: 10.1152/ajpheart.00376.2011. Epub 2011 Jul 15.

49.

Tensions rise and blood flows over dysfunctional fat.

Corvera S, Czech MP.

Circulation. 2011 Jul 5;124(1):13-6. doi: 10.1161/CIRCULATIONAHA.111.037804. No abstract available.

50.

RNAi-based therapeutic strategies for metabolic disease.

Czech MP, Aouadi M, Tesz GJ.

Nat Rev Endocrinol. 2011 Apr 19;7(8):473-84. doi: 10.1038/nrendo.2011.57. Review.

PMID:
21502982

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