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Items: 1 to 50 of 94

1.

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, Baumann T, Gerlach I, Schobel SA, Paz E, Smith AV, Bennett CF, Lane RM.

N Engl J Med. 2019 Jun 13;380(24):2307-2316. doi: 10.1056/NEJMoa1900907. Epub 2019 May 6.

PMID:
31059641
2.

Patients with autism spectrum disorders display reproducible functional connectivity alterations.

Holiga Š, Hipp JF, Chatham CH, Garces P, Spooren W, D'Ardhuy XL, Bertolino A, Bouquet C, Buitelaar JK, Bours C, Rausch A, Oldehinkel M, Bouvard M, Amestoy A, Caralp M, Gueguen S, Ly-Le Moal M, Houenou J, Beckmann CF, Loth E, Murphy D, Charman T, Tillmann J, Laidi C, Delorme R, Beggiato A, Gaman A, Scheid I, Leboyer M, d'Albis MA, Sevigny J, Czech C, Bolognani F, Honey GD, Dukart J.

Sci Transl Med. 2019 Feb 27;11(481). pii: eaat9223. doi: 10.1126/scitranslmed.aat9223.

PMID:
30814340
3.

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy.

Kletzl H, Marquet A, Günther A, Tang W, Heuberger J, Groeneveld GJ, Birkhoff W, Mercuri E, Lochmüller H, Wood C, Fischer D, Gerlach I, Heinig K, Bugawan T, Dziadek S, Kinch R, Czech C, Khwaja O.

Neuromuscul Disord. 2019 Jan;29(1):21-29. doi: 10.1016/j.nmd.2018.10.001. Epub 2018 Oct 30.

PMID:
30553700
4.

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.

Laidi C, Boisgontier J, de Pierrefeu A, Duchesnay E, Hotier S, d'Albis MA, Delorme R, Bolognani F, Czech C, Bouquet C, Amestoy A, Petit J, Holiga Š, Dukart J, Gaman A, Toledano E, Ly-Le Moal M, Scheid I, Leboyer M, Houenou J.

J Autism Dev Disord. 2019 Apr;49(4):1402-1409. doi: 10.1007/s10803-018-3807-3.

PMID:
30511125
5.

Local structural connectivity is associated with social cognition in autism spectrum disorder.

d'Albis MA, Guevara P, Guevara M, Laidi C, Boisgontier J, Sarrazin S, Duclap D, Delorme R, Bolognani F, Czech C, Bouquet C, Ly-Le Moal M, Holiga S, Amestoy A, Scheid I, Gaman A, Leboyer M, Poupon C, Mangin JF, Houenou J.

Brain. 2018 Dec 1;141(12):3472-3481. doi: 10.1093/brain/awy275.

PMID:
30423029
6.

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.

Sturm S, Günther A, Jaber B, Jordan P, Al Kotbi N, Parkar N, Cleary Y, Frances N, Bergauer T, Heinig K, Kletzl H, Marquet A, Ratni H, Poirier A, Müller L, Czech C, Khwaja O.

Br J Clin Pharmacol. 2019 Jan;85(1):181-193. doi: 10.1111/bcp.13786. Epub 2018 Nov 16.

PMID:
30302786
7.

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease.

Byrne LM, Rodrigues FB, Johnson EB, Wijeratne PA, De Vita E, Alexander DC, Palermo G, Czech C, Schobel S, Scahill RI, Heslegrave A, Zetterberg H, Wild EJ.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaat7108. doi: 10.1126/scitranslmed.aat7108.

PMID:
30209243
8.

Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial.

Lipsmeier F, Taylor KI, Kilchenmann T, Wolf D, Scotland A, Schjodt-Eriksen J, Cheng WY, Fernandez-Garcia I, Siebourg-Polster J, Jin L, Soto J, Verselis L, Boess F, Koller M, Grundman M, Monsch AU, Postuma RB, Ghosh A, Kremer T, Czech C, Gossens C, Lindemann M.

Mov Disord. 2018 Aug;33(8):1287-1297. doi: 10.1002/mds.27376. Epub 2018 Apr 27.

9.

An Objective and Child-friendly Assessment of Arm Function by Using a 3-D Sensor.

Chen X, Wolf D, Siebourg-Polster J, Czech C, Bonati U, Fischer D, Khwaja O, Strahm M.

J Vis Exp. 2018 Feb 12;(132). doi: 10.3791/57014.

10.

Social cognition in autism is associated with the neurodevelopment of the posterior superior temporal sulcus.

Hotier S, Leroy F, Boisgontier J, Laidi C, Mangin JF, Delorme R, Bolognani F, Czech C, Bouquet C, Toledano E, Bouvard M, Petit J, Mishchenko M, d'Albis MA, Gras D, Gaman A, Scheid I, Leboyer M, Zalla T, Houenou J.

Acta Psychiatr Scand. 2017 Nov;136(5):517-525. doi: 10.1111/acps.12814. Epub 2017 Sep 22.

PMID:
28940401
11.

Cerebellar anatomical alterations and attention to eyes in autism.

Laidi C, Boisgontier J, Chakravarty MM, Hotier S, d'Albis MA, Mangin JF, Devenyi GA, Delorme R, Bolognani F, Czech C, Bouquet C, Toledano E, Bouvard M, Gras D, Petit J, Mishchenko M, Gaman A, Scheid I, Leboyer M, Zalla T, Houenou J.

Sci Rep. 2017 Sep 20;7(1):12008. doi: 10.1038/s41598-017-11883-w.

12.

Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results.

Youssef EA, Berry-Kravis E, Czech C, Hagerman RJ, Hessl D, Wong CY, Rabbia M, Deptula D, John A, Kinch R, Drewitt P, Lindemann L, Marcinowski M, Langland R, Horn C, Fontoura P, Santarelli L, Quiroz JA; FragXis Study Group.

Neuropsychopharmacology. 2018 Feb;43(3):503-512. doi: 10.1038/npp.2017.177. Epub 2017 Aug 17.

13.

Local structure and stacking disorder of chloro(phthalocyaninato)aluminium.

Czech C, Kalinowsky L, Schmidt MU.

Acta Crystallogr B Struct Sci Cryst Eng Mater. 2017 Aug 1;73(Pt 4):744-755. doi: 10.1107/S2052520617005017. Epub 2017 Jul 25.

PMID:
28762984
14.

Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease.

Vandesquille M, Li T, Po C, Ganneau C, Lenormand P, Dudeffant C, Czech C, Grueninger F, Duyckaerts C, Delatour B, Dhenain M, Lafaye P, Bay S.

MAbs. 2017 Aug/Sep;9(6):1016-1027. doi: 10.1080/19420862.2017.1342914. Epub 2017 Jun 28.

15.

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E.

J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12.

PMID:
28654263
16.

Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti-NMDA-receptor autoantibody.

Gréa H, Scheid I, Gaman A, Rogemond V, Gillet S, Honnorat J, Bolognani F, Czech C, Bouquet C, Toledano E, Bouvard M, Delorme R, Groc L, Leboyer M.

Dialogues Clin Neurosci. 2017 Mar;19(1):65-70.

17.

Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).

Nave S, Doody RS, Boada M, Grimmer T, Savola JM, Delmar P, Pauly-Evers M, Nikolcheva T, Czech C, Borroni E, Ricci B, Dukart J, Mannino M, Carey T, Moran E, Gilaberte I, Muelhardt NM, Gerlach I, Santarelli L, Ostrowitzki S, Fontoura P.

J Alzheimers Dis. 2017;58(4):1217-1228. doi: 10.3233/JAD-161309.

18.

Longitudinal characterization of biomarkers for spinal muscular atrophy.

Bonati U, Holiga Š, Hellbach N, Risterucci C, Bergauer T, Tang W, Hafner P, Thoeni A, Bieri O, Gerlach I, Marquet A, Khwaja O, Sambataro F, Bertolino A, Dukart J, Fischmann A, Fischer D, Czech C.

Ann Clin Transl Neurol. 2017 Apr 11;4(5):292-304. doi: 10.1002/acn3.406. eCollection 2017 May.

19.

Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis.

Lugert S, Kremer T, Jagasia R, Herrmann A, Aigner S, Giachino C, Mendez-David I, Gardier AM, Carralot JP, Meistermann H, Augustin A, Saxe MD, Lamerz J, Duran-Pacheco G, Ducret A, Taylor V, David DJ, Czech C.

Sci Rep. 2017 Apr 25;7:46543. doi: 10.1038/srep46543.

20.

Feasibility of Using Microsoft Kinect to Assess Upper Limb Movement in Type III Spinal Muscular Atrophy Patients.

Chen X, Siebourg-Polster J, Wolf D, Czech C, Bonati U, Fischer D, Khwaja O, Strahm M.

PLoS One. 2017 Jan 25;12(1):e0170472. doi: 10.1371/journal.pone.0170472. eCollection 2017.

21.

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.

Li T, Vandesquille M, Koukouli F, Dudeffant C, Youssef I, Lenormand P, Ganneau C, Maskos U, Czech C, Grueninger F, Duyckaerts C, Dhenain M, Bay S, Delatour B, Lafaye P.

J Control Release. 2016 Dec 10;243:1-10. doi: 10.1016/j.jconrel.2016.09.019. Epub 2016 Oct 6.

22.

Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls.

Czech C, Tang W, Bugawan T, Mano C, Horn C, Iglesias VA, Fröhner S, Zaworski PG, Paushkin S, Chen K, Kremer T.

PLoS One. 2015 Oct 15;10(10):e0139950. doi: 10.1371/journal.pone.0139950. eCollection 2015.

23.

Cheek Tooth Extraction Via a Minimally Invasive Transbuccal Approach and Intradental Screw Placement in 54 Equids.

Langeneckert F, Witte T, Schellenberger F, Czech C, Aebischer D, Vidondo B, Koch C.

Vet Surg. 2015 Nov;44(8):1012-20. doi: 10.1111/vsu.12409. Epub 2015 Oct 12.

PMID:
26455833
24.

Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells.

Halevy T, Czech C, Benvenisty N.

Stem Cell Reports. 2015 Jan 13;4(1):37-46. doi: 10.1016/j.stemcr.2014.10.015. Epub 2014 Dec 4.

25.

Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis.

Micotti E, Paladini A, Balducci C, Tolomeo D, Frasca A, Marizzoni M, Filibian M, Caroli A, Valbusa G, Dix S, O'Neill M, Ozmen L, Czech C, Richardson JC, Frisoni GB, Forloni G.

Neurobiol Aging. 2015 Feb;36(2):776-88. doi: 10.1016/j.neurobiolaging.2014.10.027. Epub 2014 Oct 25.

PMID:
25433456
26.

Anaplasma phagocytophilum infection in a horse from Switzerland with severe neurological symptoms.

Gussmann K, Czech C, Hermann M, Schaarschmidt-Kiener D, von Loewenich FD.

Schweiz Arch Tierheilkd. 2014 Jul;156(7):345-8. doi: 10.1024/0036-7281/a000605.

27.

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

Boländer A, Kieser D, Scholz C, Heyny-von Haußen R, Mall G, Goetschy V, Czech C, Schmidt B.

Neurodegener Dis. 2014;13(4):209-13. doi: 10.1159/000351436. Epub 2013 Sep 25.

PMID:
24080522
28.

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

Anumala UR, Gu J, Lo Monte F, Kramer T, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Schön C, Mall G, Hilger I, Czech C, Herms J, Schmidt B.

Bioorg Med Chem. 2013 Sep 1;21(17):5139-44. doi: 10.1016/j.bmc.2013.06.039. Epub 2013 Jun 27.

PMID:
23859773
29.

Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain.

Kremer T, Jagasia R, Herrmann A, Matile H, Borroni E, Francis F, Kuhn HG, Czech C.

PLoS One. 2013 May 14;8(5):e59269. doi: 10.1371/journal.pone.0059269. Print 2013.

30.

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

Gu J, Anumala UR, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Mall G, Hilger I, Czech C, Schmidt B.

ChemMedChem. 2013 Jun;8(6):891-7. doi: 10.1002/cmdc.201300090. Epub 2013 Apr 16.

PMID:
23592568
31.

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.

Gu J, Anumala UR, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, Goetschy-Meyer V, Mall G, Hilger I, Czech C, Schmidt B.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7667-71. doi: 10.1016/j.bmcl.2012.09.109. Epub 2012 Oct 6.

PMID:
23127889
32.

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.

Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, Bittner T, Hölzer J, Heyny-von Haußen R, Mall G, Goetschy V, Czech C, Knust H, Berger R, Herms J, Hilger I, Schmidt B.

J Med Chem. 2012 Nov 8;55(21):9170-80. doi: 10.1021/jm300653b. Epub 2012 Aug 31.

PMID:
22913544
33.

Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes.

Leuner K, Schulz K, Schütt T, Pantel J, Prvulovic D, Rhein V, Savaskan E, Czech C, Eckert A, Müller WE.

Mol Neurobiol. 2012 Aug;46(1):194-204. doi: 10.1007/s12035-012-8300-y. Epub 2012 Jul 22. Review.

PMID:
22821186
34.

Metabolite profiling of Alzheimer's disease cerebrospinal fluid.

Czech C, Berndt P, Busch K, Schmitz O, Wiemer J, Most V, Hampel H, Kastler J, Senn H.

PLoS One. 2012;7(2):e31501. doi: 10.1371/journal.pone.0031501. Epub 2012 Feb 16.

35.

Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

Grueninger F, Bohrmann B, Christensen K, Graf M, Roth D, Czech C.

Mol Cell Biochem. 2011 Nov;357(1-2):199-207. doi: 10.1007/s11010-011-0890-6. Epub 2011 Jun 3.

PMID:
21638028
36.

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Dröse S, Brandt U, Savaskan E, Czech C, Götz J, Eckert A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20057-62. doi: 10.1073/pnas.0905529106. Epub 2009 Nov 6.

37.

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

Grueninger F, Bohrmann B, Czech C, Ballard TM, Frey JR, Weidensteiner C, von Kienlin M, Ozmen L.

Neurobiol Dis. 2010 Feb;37(2):294-306. doi: 10.1016/j.nbd.2009.09.004. Epub 2009 Sep 23.

PMID:
19781645
38.

Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

Ozmen L, Albientz A, Czech C, Jacobsen H.

Neurodegener Dis. 2009;6(1-2):29-36. doi: 10.1159/000170884. Epub 2008 Nov 5.

PMID:
19066434
39.

Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

Kitas EA, Galley G, Jakob-Roetne R, Flohr A, Wostl W, Mauser H, Alker AM, Czech C, Ozmen L, David-Pierson P, Reinhardt D, Jacobsen H.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):304-8. Epub 2007 Nov 5.

PMID:
17983746
40.

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.

Peters JU, Galley G, Jacobsen H, Czech C, David-Pierson P, Kitas EA, Ozmen L.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5918-23. Epub 2007 Aug 22.

PMID:
17869099
41.

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

Narlawar R, Baumann K, Czech C, Schmidt B.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5428-31. Epub 2007 Aug 6.

PMID:
17723298
42.

Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase.

Czech C, Burns MP, Vardanian L, Augustin A, Jacobsen H, Baumann K, Rebeck GW.

J Neurochem. 2007 May;101(4):929-36.

43.

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

Ozmen L, Woolley M, Albientz A, Miss MT, Nelboeck P, Malherbe P, Czech C, Gruninger-Leitch F, Brockhaus M, Ballard T, Jacobsen H.

Neurodegener Dis. 2005;2(6):284-98.

PMID:
16909011
44.

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.

Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M.

EMBO Rep. 2006 Sep;7(9):940-6. Epub 2006 Aug 11.

45.

A 13 kDa carboxy-terminal fragment of ApoE stabilizes Abeta hexamers.

Wellnitz S, Friedlein A, Bonanni C, Anquez V, Goepfert F, Loetscher H, Adessi C, Czech C.

J Neurochem. 2005 Sep;94(5):1351-60. Epub 2005 Jul 11.

46.

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.

Schuessel K, Schäfer S, Bayer TA, Czech C, Pradier L, Müller-Spahn F, Müller WE, Eckert A.

Neurobiol Dis. 2005 Feb;18(1):89-99.

PMID:
15649699
47.

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.

Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Müller-Spahn F, Haass C, Czech C, Pradier L, Müller WE, Eckert A.

J Biol Chem. 2004 Nov 26;279(48):50310-20. Epub 2004 Sep 14.

48.

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.

Schmitz C, Rutten BP, Pielen A, Schäfer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Rezaie P, Korr H, Steinbusch HW, Pradier L, Bayer TA.

Am J Pathol. 2004 Apr;164(4):1495-502.

49.

Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease.

Schindowski K, Kratzsch T, Peters J, Steiner B, Leutner S, Touchet N, Maurer K, Czech C, Pradier L, Frölich L, Müller WE, Eckert A.

Neuromolecular Med. 2003;4(3):161-78.

PMID:
14716024
50.

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice.

Blanchard V, Moussaoui S, Czech C, Touchet N, Bonici B, Planche M, Canton T, Jedidi I, Gohin M, Wirths O, Bayer TA, Langui D, Duyckaerts C, Tremp G, Pradier L.

Exp Neurol. 2003 Nov;184(1):247-63.

PMID:
14637096

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