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Items: 1 to 50 of 63

1.

Quantification of the capacity for cold-induced thermogenesis in young men with and without obesity.

Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood RP, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY.

J Clin Endocrinol Metab. 2019 May 31. pii: jc.2019-00728. doi: 10.1210/jc.2019-00728. [Epub ahead of print]

PMID:
31150063
2.

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT.

Kim K, Huang S, Fletcher LA, O'Mara AE, Tal I, Brychta RJ, Cypess AM, Chen KY, Leitner BP.

J Vis Exp. 2019 Apr 1;(146). doi: 10.3791/58469.

PMID:
30985755
3.

TGF-β receptor 1 regulates progenitors that promote browning of white fat.

Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, Chen W, Kulkarni AB, McCoy JP, Finkel T, Cypess AM, Rane SG.

Mol Metab. 2018 Oct;16:160-171. doi: 10.1016/j.molmet.2018.07.008. Epub 2018 Jul 27.

4.

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.

Lynes MD, Shamsi F, Sustarsic EG, Leiria LO, Wang CH, Su SC, Huang TL, Gao F, Narain NR, Chen EY, Cypess AM, Schulz TJ, Gerhart-Hines Z, Kiebish MA, Tseng YH.

Cell Rep. 2018 Jul 17;24(3):781-790. doi: 10.1016/j.celrep.2018.06.073.

5.

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist.

Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM.

Diabetes. 2018 Oct;67(10):2113-2125. doi: 10.2337/db18-0462. Epub 2018 Jul 6.

6.

Kinetics of human brown adipose tissue activation and deactivation.

Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM.

Int J Obes (Lond). 2019 Mar;43(3):633-637. doi: 10.1038/s41366-018-0104-3. Epub 2018 May 24.

7.

Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis.

Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D.

Mol Psychiatry. 2018 Mar 9. doi: 10.1038/s41380-018-0045-1. [Epub ahead of print]

8.

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384b.

9.

PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28.

Ran C, Albrecht DS, Bredella MA, Yang J, Yang J, Liang SH, Cypess AM, Loggia ML, Atassi N, Moore A.

Mol Imaging Biol. 2018 Apr;20(2):188-193. doi: 10.1007/s11307-017-1129-z.

10.

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.

Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NZ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T.

Nat Cell Biol. 2017 Sep;19(9):1081-1092. doi: 10.1038/ncb3590. Epub 2017 Aug 14.

11.

Mapping of human brown adipose tissue in lean and obese young men.

Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8649-8654. doi: 10.1073/pnas.1705287114. Epub 2017 Jul 24.

12.

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.

Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M.

Sci Rep. 2017 May 3;7(1):1383. doi: 10.1038/s41598-017-00291-9.

13.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

14.

Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status.

Gavrila A, Hasselgren PO, Glasgow A, Doyle AN, Lee AJ, Fox P, Gautam S, Hennessey JV, Kolodny GM, Cypess AM.

Thyroid. 2017 Jan;27(1):1-10. doi: 10.1089/thy.2015.0646. Epub 2016 Nov 29.

15.

Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits.

Fried PJ, Schilberg L, Brem AK, Saxena S, Wong B, Cypess AM, Horton ES, Pascual-Leone A.

J Alzheimers Dis. 2017;55(1):89-100.

16.

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE.

Cell Metab. 2016 Sep 13;24(3):420-433. doi: 10.1016/j.cmet.2016.08.005.

17.

Correction: Effect of Chronic Athletic Activity on Brown Fat in Young Women.

Singhal V, Maffazioli GD, Ackerman KE, Lee H, Elia EF, Woolley R, Kolodny G, Cypess AM, Misra M.

PLoS One. 2016 Aug 10;11(8):e0160129. doi: 10.1371/journal.pone.0160129. eCollection 2016.

18.

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.

Chen KY, Cypess AM, Laughlin MR, Haft CR, Hu HH, Bredella MA, Enerbäck S, Kinahan PE, Lichtenbelt Wv, Lin FI, Sunderland JJ, Virtanen KA, Wahl RL.

Cell Metab. 2016 Aug 9;24(2):210-22. doi: 10.1016/j.cmet.2016.07.014. Review.

19.

Imaging of Brown Adipose Tissue: State of the Art.

Sampath SC, Sampath SC, Bredella MA, Cypess AM, Torriani M.

Radiology. 2016 Jul;280(1):4-19. doi: 10.1148/radiol.2016150390. Review.

20.

Effect of Chronic Athletic Activity on Brown Fat in Young Women.

Singhal V, Maffazioli GD, Ackerman KE, Lee H, Elia EF, Woolley R, Kolodny G, Cypess AM, Misra M.

PLoS One. 2016 May 31;11(5):e0156353. doi: 10.1371/journal.pone.0156353. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0160129.

21.

Factors associated with overweight and obesity in schizophrenia, schizoaffective and bipolar disorders.

Chouinard VA, Pingali SM, Chouinard G, Henderson DC, Mallya SG, Cypess AM, Cohen BM, Öngür D.

Psychiatry Res. 2016 Mar 30;237:304-10. doi: 10.1016/j.psychres.2016.01.024. Epub 2016 Jan 14.

PMID:
26805561
22.

Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients.

Torriani M, Srinivasa S, Fitch KV, Thomou T, Wong K, Petrow E, Kahn CR, Cypess AM, Grinspoon SK.

J Clin Endocrinol Metab. 2016 Mar;101(3):1225-34. doi: 10.1210/jc.2015-3993. Epub 2016 Jan 12.

23.

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH.

EMBO Rep. 2015 Oct;16(10):1378-93. doi: 10.15252/embr.201540837. Epub 2015 Aug 24.

24.

Contrast-Enhanced Ultrasound: A Novel Noninvasive, Nonionizing Method for the Detection of Brown Adipose Tissue in Humans.

Flynn A, Li Q, Panagia M, Abdelbaky A, MacNabb M, Samir A, Cypess AM, Weyman AE, Tawakol A, Scherrer-Crosbie M.

J Am Soc Echocardiogr. 2015 Oct;28(10):1247-54. doi: 10.1016/j.echo.2015.06.014. Epub 2015 Aug 5.

25.

Diet-induced obesity causes insulin resistance in mouse brown adipose tissue.

Roberts-Toler C, O'Neill BT, Cypess AM.

Obesity (Silver Spring). 2015 Sep;23(9):1765-70. doi: 10.1002/oby.21134. Epub 2015 Aug 3.

26.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH.

Nat Med. 2015 Jul;21(7):760-8. doi: 10.1038/nm.3881. Epub 2015 Jun 15.

27.

Genetic and functional characterization of clonally derived adult human brown adipocytes.

Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S.

Nat Med. 2015 Apr;21(4):389-94. doi: 10.1038/nm.3819. Epub 2015 Mar 16.

28.

Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM.

Cell Metab. 2015 Jan 6;21(1):33-8. doi: 10.1016/j.cmet.2014.12.009.

29.

Brown fat in humans: consensus points and experimental guidelines.

Cypess AM, Haft CR, Laughlin MR, Hu HH.

Cell Metab. 2014 Sep 2;20(3):408-15. doi: 10.1016/j.cmet.2014.07.025.

30.

Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome.

Srinivasa S, Wong K, Fitch KV, Wei J, Petrow E, Cypess AM, Torriani M, Grinspoon SK.

Clin Endocrinol (Oxf). 2015 May;82(5):678-85. doi: 10.1111/cen.12582. Epub 2014 Oct 8.

31.

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR.

Sci Transl Med. 2014 Jul 30;6(247):247ra103. doi: 10.1126/scitranslmed.3008490.

32.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED.

Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.

33.

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.

Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR.

J Clin Invest. 2014 Aug;124(8):3339-51. doi: 10.1172/JCI73468. Epub 2014 Jul 1.

34.

The prevalence and predictors of active brown adipose tissue in Chinese adults.

Zhang Z, Cypess AM, Miao Q, Ye H, Liew CW, Zhang Q, Xue R, Zhang S, Zuo C, Xu Z, Tang Q, Hu R, Guan Y, Li Y.

Eur J Endocrinol. 2014 Feb 4;170(3):359-66. doi: 10.1530/EJE-13-0712. Print 2014 Mar.

35.

Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT.

Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL 3rd, Kolodny GM.

J Nucl Med. 2013 Nov;54(11):1896-901. doi: 10.2967/jnumed.113.121012. Epub 2013 Sep 26.

36.

Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging.

Chen YC, Cypess AM, Chen YC, Palmer M, Kolodny G, Kahn CR, Kwong KK.

J Nucl Med. 2013 Sep;54(9):1584-7. doi: 10.2967/jnumed.112.117275. Epub 2013 Jul 18.

37.

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH.

Nat Med. 2013 May;19(5):635-9. doi: 10.1038/nm.3112. Epub 2013 Apr 21.

38.

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH.

Nature. 2013 Mar 21;495(7441):379-83. doi: 10.1038/nature11943. Epub 2013 Mar 13.

39.

Increased FDG uptake in association with reduced extremity fat in HIV patients.

Torriani M, Zanni MV, Fitch K, Stavrou E, Bredella MA, Lim R, Cypess AM, Grinspoon S.

Antivir Ther. 2013;18(2):243-8. doi: 10.3851/IMP2420. Epub 2012 Oct 5.

40.

Cold but not sympathomimetics activates human brown adipose tissue in vivo.

Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM, Kahn CR.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10001-5. doi: 10.1073/pnas.1207911109. Epub 2012 Jun 4.

41.

Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging.

Chen YI, Cypess AM, Sass CA, Brownell AL, Jokivarsi KT, Kahn CR, Kwong KK.

Obesity (Silver Spring). 2012 Jul;20(7):1519-26. doi: 10.1038/oby.2012.22. Epub 2012 Feb 20.

42.

Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome.

Torriani M, Fitch K, Stavrou E, Bredella MA, Lim R, Sass CA, Cypess AM, Grinspoon S.

J Clin Endocrinol Metab. 2012 Apr;97(4):E602-7. doi: 10.1210/jc.2011-2951. Epub 2012 Jan 18.

43.

Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.

Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH.

Endocrinology. 2011 Oct;152(10):3680-9. doi: 10.1210/en.2011-1229. Epub 2011 Aug 23.

44.

Pediatric brown adipose tissue: detection, epidemiology, and differences from adults.

Drubach LA, Palmer EL 3rd, Connolly LP, Baker A, Zurakowski D, Cypess AM.

J Pediatr. 2011 Dec;159(6):939-44. doi: 10.1016/j.jpeds.2011.06.028. Epub 2011 Aug 11.

PMID:
21839465
45.

A new connection between muscle and brown fat.

Cypess AM.

J Pediatr. 2011 May;158(5):696-8. doi: 10.1016/j.jpeds.2011.01.001. Epub 2011 Feb 24. No abstract available.

46.

Cellular bioenergetics as a target for obesity therapy.

Tseng YH, Cypess AM, Kahn CR.

Nat Rev Drug Discov. 2010 Jun;9(6):465-82. doi: 10.1038/nrd3138. Review.

47.

The role and importance of brown adipose tissue in energy homeostasis.

Cypess AM, Kahn CR.

Curr Opin Pediatr. 2010 Aug;22(4):478-84. doi: 10.1097/MOP.0b013e32833a8d6e. Review.

48.

Insulin enhances glucose-stimulated insulin secretion in healthy humans.

Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4770-5. doi: 10.1073/pnas.1000002107. Epub 2010 Feb 22.

49.

Brown fat as a therapy for obesity and diabetes.

Cypess AM, Kahn CR.

Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):143-9. doi: 10.1097/MED.0b013e328337a81f. Review.

50.

Identification and importance of brown adipose tissue in adult humans.

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR.

N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.

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