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A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX. Yang HH, et al. Theranostics. 2020 Mar 26;10(11):4749-4761. doi: 10.7150/thno.43108. eCollection 2020. Theranostics. 2020. PMID: 32308747 Free PMC article.
Results: Dysregulation of CYPs/COX-2 metabolism of ARA occurred in the lungs and in primary macrophages under the LPS challenge. Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs). ...
Results: Dysregulation of CYPs/COX-2 metabolism of ARA occurred in the lungs and in primary macrophages under the LPS challenge. Decrease mR …
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC. Qu W, et al. J Biol Chem. 2001 Jul 6;276(27):25467-79. doi: 10.1074/jbc.M100545200. Epub 2001 Apr 27. J Biol Chem. 2001. PMID: 11328810 Free article.
Microsomes of CYP2J9/CYPOR-transfected cells metabolize arachidonic acid to 19-hydroxyeicosatetraenoic acid (HETE) thus CYP2J9 is enzymologically distinct from other P450s. ...In situ hybridization of mouse brain sections with a CYP2J9-specific riboprobe and …
Microsomes of CYP2J9/CYPOR-transfected cells metabolize arachidonic acid to 19-hydroxyeicosatetraenoic acid (HETE) thus CYP2J9
Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.
Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Li H, House JS, Hoopes SL, Edin ML, Zeldin DC. Graves JP, et al. Drug Metab Dispos. 2015 Aug;43(8):1169-80. doi: 10.1124/dmd.115.064139. Epub 2015 May 20. Drug Metab Dispos. 2015. PMID: 25994032 Free PMC article.
Cyp2j8 was detected in various tissues, with highest expression found in the skin. Cyp2j9 was highly expressed in the brain, liver, and lung. Cyp2j12 was predominately expressed in the brain. ...Both qPCR methods detected similar suppression of Cyp2j6 and Cyp2j9 dur …
Cyp2j8 was detected in various tissues, with highest expression found in the skin. Cyp2j9 was highly expressed in the brain, liver, a …
Murine atrial HL-1 cell line is a reliable model to study drug metabolizing enzymes in the heart.
Elshenawy OH, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO. Elshenawy OH, et al. Vascul Pharmacol. 2013 Apr;58(4):326-33. doi: 10.1016/j.vph.2012.12.002. Epub 2012 Dec 23. Vascul Pharmacol. 2013. PMID: 23268359
Cyp2b19, Cyp2c29, Cyp2c38, Cyp2c40, and Cyp4f16 mRNA levels were higher in HL-1 cells compared to mice hearts. Cyp2b9, Cyp2c44, Cyp2j9, Cyp2j11, Cyp2j13, Cyp4f13, Cyp4f15 mRNA levels were expressed to the same extent to that of mice hearts. ...Moreover, 3-methylcholanthren …
Cyp2b19, Cyp2c29, Cyp2c38, Cyp2c40, and Cyp4f16 mRNA levels were higher in HL-1 cells compared to mice hearts. Cyp2b9, Cyp2c44, Cyp2j9
Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s.
Moran JH, Mitchell LA, Bradbury JA, Qu W, Zeldin DC, Schnellmann RG, Grant DF. Moran JH, et al. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):268-79. doi: 10.1006/taap.2000.9053. Toxicol Appl Pharmacol. 2000. PMID: 11042099
We then tested the cytotoxic properties of linoleic acid, linoleic acid monoepoxides, and corresponding diols in a rabbit renal proximal tubule model. CYP1A2, CYP2E1, CYP2J2, CYP2J3, CYP2J5, and CYP2J9 metabolized linoleic acid at rates comparable to arachidonic acid and p …
We then tested the cytotoxic properties of linoleic acid, linoleic acid monoepoxides, and corresponding diols in a rabbit renal proximal tub …
EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid.
Baragatti B, Schwartzman ML, Angeloni D, Scebba F, Ciofini E, Sodini D, Ottaviano V, Nencioni S, Paolicchi A, Graves JP, Zeldin DC, Gotlinger K, Luin S, Coceani F. Baragatti B, et al. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2161-8. doi: 10.1152/ajpheart.00576.2009. Epub 2009 Oct 2. Am J Physiol Heart Circ Physiol. 2009. PMID: 19801493 Free PMC article.
We did not detect transcripts of the mouse CYP2C subfamily in vessel, while CYP2J subfamily transcripts were expressed with CYP2J6 and CYP2J9. These CYP2J hemoproteins were also detected in the ductus by immunofluorescence microscopy, being colocalized with the endoplasmic …
We did not detect transcripts of the mouse CYP2C subfamily in vessel, while CYP2J subfamily transcripts were expressed with CYP2J6 and CY