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Identifying New Substrates and Functions for an Old Enzyme: Calcineurin.

Roy J, Cyert MS.

Cold Spring Harb Perspect Biol. 2019 Jul 15. pii: a035436. doi: 10.1101/cshperspect.a035436. [Epub ahead of print]


Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads.

Nguyen HQ, Roy J, Harink B, Damle NP, Latorraca NR, Baxter BC, Brower K, Longwell SA, Kortemme T, Thorn KS, Cyert MS, Fordyce PM.

Elife. 2019 Jul 8;8. pii: e40499. doi: 10.7554/eLife.40499.


The unique C terminus of the calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Ca2+ and calmodulin.

Bond R, Ly N, Cyert MS.

J Biol Chem. 2017 Oct 6;292(40):16709-16721. doi: 10.1074/jbc.M117.795146. Epub 2017 Aug 25.


Calcineurin, the Ca2+-dependent phosphatase, regulates Rga2, a Cdc42 GTPase-activating protein, to modulate pheromone signaling.

Ly N, Cyert MS.

Mol Biol Cell. 2017 Mar 1;28(5):576-586. doi: 10.1091/mbc.E16-06-0432. Epub 2017 Jan 11.


Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course-based undergraduate research experience in molecular and cell biology.

Hekmat-Scafe DS, Brownell SE, Seawell PC, Malladi S, Imam JF, Singla V, Bradon N, Cyert MS, Stearns T.

Biochem Mol Biol Educ. 2017 Mar 4;45(2):161-178. doi: 10.1002/bmb.21024. Epub 2016 Nov 22.


Short linear motifs - ex nihilo evolution of protein regulation.

Davey NE, Cyert MS, Moses AM.

Cell Commun Signal. 2015 Nov 21;13:43. doi: 10.1186/s12964-015-0120-z. Review.


Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation.

Arsenault HE, Roy J, Mapa CE, Cyert MS, Benanti JA.

Mol Biol Cell. 2015 Oct 15;26(20):3570-7. doi: 10.1091/mbc.E15-07-0469. Epub 2015 Aug 12. Erratum in: Mol Biol Cell. 2015 Dec 1;26(24):4520-1.


A high-enrollment course-based undergraduate research experience improves student conceptions of scientific thinking and ability to interpret data.

Brownell SE, Hekmat-Scafe DS, Singla V, Chandler Seawell P, Conklin Imam JF, Eddy SL, Stearns T, Cyert MS.

CBE Life Sci Educ. 2015 Summer;14(2):14:ar21. doi: 10.1187/cbe.14-05-0092. Epub 2015 Jun 1.


Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress.

Guiney EL, Goldman AR, Elias JE, Cyert MS.

Mol Biol Cell. 2015 Feb 15;26(4):769-85. doi: 10.1091/mbc.E14-05-1019. Epub 2014 Dec 17.


The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity.

Goldman A, Roy J, Bodenmiller B, Wanka S, Landry CR, Aebersold R, Cyert MS.

Mol Cell. 2014 Aug 7;55(3):422-435. doi: 10.1016/j.molcel.2014.05.012. Epub 2014 Jun 12.


Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.

Alvaro CG, O'Donnell AF, Prosser DC, Augustine AA, Goldman A, Brodsky JL, Cyert MS, Wendland B, Thorner J.

Mol Cell Biol. 2014 Jul;34(14):2660-81.


Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs.

Holmes KJ, Klass DM, Guiney EL, Cyert MS.

PLoS One. 2013 Dec 27;8(12):e84060. doi: 10.1371/journal.pone.0084060. eCollection 2013.


A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.

O'Donnell AF, Huang L, Thorner J, Cyert MS.

J Biol Chem. 2013 Aug 16;288(33):24063-80. doi: 10.1074/jbc.M113.478511. Epub 2013 Jul 3.


The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

Grigoriu S, Bond R, Cossio P, Chen JA, Ly N, Hummer G, Page R, Cyert MS, Peti W.

PLoS Biol. 2013;11(2):e1001492. doi: 10.1371/journal.pbio.1001492. Epub 2013 Feb 26.


Regulation of cation balance in Saccharomyces cerevisiae.

Cyert MS, Philpott CC.

Genetics. 2013 Mar;193(3):677-713. doi: 10.1534/genetics.112.147207. Review.


Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Minear S, O'Donnell AF, Ballew A, Giaever G, Nislow C, Stearns T, Cyert MS.

Eukaryot Cell. 2011 Nov;10(11):1574-81. doi: 10.1128/EC.05163-11. Epub 2011 Sep 9.


Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.

Piña FJ, O'Donnell AF, Pagant S, Piao HL, Miller JP, Fields S, Miller EA, Cyert MS.

Eukaryot Cell. 2011 Jan;10(1):63-71. doi: 10.1128/EC.00241-10. Epub 2010 Nov 19.


Alpha-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling.

O'Donnell AF, Apffel A, Gardner RG, Cyert MS.

Mol Biol Cell. 2010 Oct 15;21(20):3552-66. doi: 10.1091/mbc.E10-07-0636. Epub 2010 Aug 25.


Cracking the phosphatase code: docking interactions determine substrate specificity.

Roy J, Cyert MS.

Sci Signal. 2009 Dec 8;2(100):re9. doi: 10.1126/scisignal.2100re9. Review.


A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.

Rodríguez A, Roy J, Martínez-Martínez S, López-Maderuelo MD, Niño-Moreno P, Ortí L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM.

Mol Cell. 2009 Mar 13;33(5):616-26. doi: 10.1016/j.molcel.2009.01.030.


Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X.

FASEB J. 2007 Oct;21(12):3023-8. Epub 2007 Jun 26. No abstract available.


Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Bultynck G, Heath VL, Majeed AP, Galan JM, Haguenauer-Tsapis R, Cyert MS.

Mol Cell Biol. 2006 Jun;26(12):4729-45.


Mapping pathways and phenotypes by systematic gene overexpression.

Sopko R, Huang D, Preston N, Chua G, Papp B, Kafadar K, Snyder M, Oliver SG, Cyert M, Hughes TR, Boone C, Andrews B.

Mol Cell. 2006 Feb 3;21(3):319-30.


Genomic and proteomic comparisons between bacterial and archaeal genomes and related comparisons with the yeast and fly genomes.

Karlin S, Brocchieri L, Campbell A, Cyert M, Mrázek J.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7309-14. Epub 2005 May 9.


Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.

Cyert MS.

Biochem Biophys Res Commun. 2003 Nov 28;311(4):1143-50. Review.


Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I.

Kafadar KA, Zhu H, Snyder M, Cyert MS.

Genes Dev. 2003 Nov 1;17(21):2698-708.


Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae.

Yoshimoto H, Saltsman K, Gasch AP, Li HX, Ogawa N, Botstein D, Brown PO, Cyert MS.

J Biol Chem. 2002 Aug 23;277(34):31079-88. Epub 2002 Jun 10.


Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae.

Cyert MS.

Annu Rev Genet. 2001;35:647-72. Review.


Regulation of nuclear localization during signaling.

Cyert MS.

J Biol Chem. 2001 Jun 15;276(24):20805-8. Epub 2001 Apr 12. Review. No abstract available.


Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

Stathopoulos-Gerontides A, Guo JJ, Cyert MS.

Genes Dev. 1999 Apr 1;13(7):798-803.


Importance of phenylalanine residues of yeast calmodulin for target binding and activation.

Okano H, Cyert MS, Ohya Y.

J Biol Chem. 1998 Oct 9;273(41):26375-82.


Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin.

Zhao C, Jung US, Garrett-Engele P, Roe T, Cyert MS, Levin DE.

Mol Cell Biol. 1998 Feb;18(2):1013-22.


An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.

Withee JL, Mulholland J, Jeng R, Cyert MS.

Mol Biol Cell. 1997 Feb;8(2):263-77.


Immunosuppressants hit the target.

Cyert MS.

Curr Biol. 1992 Jan;2(1):18-20. No abstract available.


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