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Year Number of Results
2010 1
2011 1
2012 4
2013 1
2015 2
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2017 6
2018 2
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2020 2
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2023 3
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33 results

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Page 1
CWC22-Mediated Alternative Splicing of Spp1 Regulates Nociception in Inflammatory Pain.
Song Y, Wang ZY, Luo J, Han WC, Wang XY, Yin C, Zhao WN, Hu SW, Zhang Q, Li YQ, Cao JL. Song Y, et al. Neuroscience. 2023 Dec 15;535:50-62. doi: 10.1016/j.neuroscience.2023.10.006. Epub 2023 Oct 12. Neuroscience. 2023. PMID: 37838283
Knockdown of spinal CWC22 by lentivirus transfection (lenti-shCwc22) reversed CFA-induced thermal hyperalgesia and mechanical allodynia, whereas upregulation of spinal CWC22 (lenti-Cwc22) in naive mice precipitated pain. ...Blocking CWC22 or CWC22 …
Knockdown of spinal CWC22 by lentivirus transfection (lenti-shCwc22) reversed CFA-induced thermal hyperalgesia and mechanical allodyn …
CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.
Steckelberg AL, Altmueller J, Dieterich C, Gehring NH. Steckelberg AL, et al. Nucleic Acids Res. 2015 May 19;43(9):4687-700. doi: 10.1093/nar/gkv320. Epub 2015 Apr 13. Nucleic Acids Res. 2015. PMID: 25870412 Free PMC article.
Here we analyze the mechanisms, by which CWC22 co-regulates pre-mRNA splicing and EJC assembly. We show that the core of CWC22 is sufficient to mediate both pre-mRNA splicing and EJC assembly. Nonetheless, both processes can be functionally uncoupled with an eIF4A3- …
Here we analyze the mechanisms, by which CWC22 co-regulates pre-mRNA splicing and EJC assembly. We show that the core of CWC22 …
CWC22 connects pre-mRNA splicing and exon junction complex assembly.
Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH. Steckelberg AL, et al. Cell Rep. 2012 Sep 27;2(3):454-61. doi: 10.1016/j.celrep.2012.08.017. Epub 2012 Sep 6. Cell Rep. 2012. PMID: 22959432 Free article.
In CWC22-depleted cells, pre-mRNA splicing is impaired but is rescued by a central fragment of CWC22. We show that the MIF4G domain of CWC22 initiates EJC assembly via a direct interaction with the EJC core protein eIF4A3, and we characterize mutations in eIF …
In CWC22-depleted cells, pre-mRNA splicing is impaired but is rescued by a central fragment of CWC22. We show that the MIF4G d …
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.
Barbosa I, Haque N, Fiorini F, Barrandon C, Tomasetto C, Blanchette M, Le Hir H. Barbosa I, et al. Nat Struct Mol Biol. 2012 Oct;19(10):983-90. doi: 10.1038/nsmb.2380. Epub 2012 Sep 9. Nat Struct Mol Biol. 2012. PMID: 22961380
Sequence-independent binding of the EJC core to RNA is ensured by the DEAD-box helicase eIF4AIII. Here, we identified the splicing factor CWC22 as a new eIF4AIII partner in flies and humans. CWC22 coexists with eIF4AIII in large protein complexes distinct from EJCs. …
Sequence-independent binding of the EJC core to RNA is ensured by the DEAD-box helicase eIF4AIII. Here, we identified the splicing factor …
The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.
Monies D, Abouelhoda M, AlSayed M, Alhassnan Z, Alotaibi M, Kayyali H, Al-Owain M, Shah A, Rahbeeni Z, Al-Muhaizea MA, Alzaidan HI, Cupler E, Bohlega S, Faqeih E, Faden M, Alyounes B, Jaroudi D, Goljan E, Elbardisy H, Akilan A, Albar R, Aldhalaan H, Gulab S, Chedrawi A, Al Saud BK, Kurdi W, Makhseed N, Alqasim T, El Khashab HY, Al-Mousa H, Alhashem A, Kanaan I, Algoufi T, Alsaleem K, Basha TA, Al-Murshedi F, Khan S, Al-Kindy A, Alnemer M, Al-Hajjar S, Alyamani S, Aldhekri H, Al-Mehaidib A, Arnaout R, Dabbagh O, Shagrani M, Broering D, Tulbah M, Alqassmi A, Almugbel M, AlQuaiz M, Alsaman A, Al-Thihli K, Sulaiman RA, Al-Dekhail W, Alsaegh A, Bashiri FA, Qari A, Alhomadi S, Alkuraya H, Alsebayel M, Hamad MH, Szonyi L, Abaalkhail F, Al-Mayouf SM, Almojalli H, Alqadi KS, Elsiesy H, Shuaib TM, Seidahmed MZ, Abosoudah I, Akleh H, AlGhonaium A, Alkharfy TM, Al Mutairi F, Eyaid W, Alshanbary A, Sheikh FR, Alsohaibani FI, Alsonbul A, Al Tala S, Balkhy S, Bassiouni R, Alenizi AS, Hussein MH, Hassan S, Khalil M, Tabarki B, Alshahwan S, Oshi A, Sabr Y, Alsaadoun S, Salih MA, Mohamed S, Sultana H, Tamim A, El-Haj M, Alshahrani S, Bubshait DK, Alfadhel M, Faquih T, El-Kalioby M, Subhani S, Shah … See abstract for full author list ➔ Monies D, et al. Hum Genet. 2017 Aug;136(8):921-939. doi: 10.1007/s00439-017-1821-8. Epub 2017 Jun 9. Hum Genet. 2017. PMID: 28600779 Free PMC article.
Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CABP1, CCDC186, CCP110, CLSTN2, CNTN3, CNTN5, CTNNA2, CWC22, DMAP1, DMKN, DMXL1, DSCAM, DVL2, ECI1, EP400, EPB41L5, FBXL22, GAP43, GEMI …
Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CA …
Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.
Busetto V, Barbosa I, Basquin J, Marquenet É, Hocq R, Hennion M, Paternina JA, Namane A, Conti E, Bensaude O, Le Hir H. Busetto V, et al. Nucleic Acids Res. 2020 Jun 4;48(10):5670-5683. doi: 10.1093/nar/gkaa267. Nucleic Acids Res. 2020. PMID: 32329775 Free PMC article.
Human CWC27 is an uncharacterized splicing factor and mutations in its gene are linked to retinal degeneration and other developmental defects. We identify the splicing factor CWC22 as the major CWC27 partner. Both CWC27 and CWC22 are present in published Bact splic …
Human CWC27 is an uncharacterized splicing factor and mutations in its gene are linked to retinal degeneration and other developmental defec …
Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway.
Yeh TC, Liu HL, Chung CS, Wu NY, Liu YC, Cheng SC. Yeh TC, et al. Mol Cell Biol. 2011 Jan;31(1):43-53. doi: 10.1128/MCB.00801-10. Epub 2010 Oct 18. Mol Cell Biol. 2011. PMID: 20956557 Free PMC article.
Cwc22 is associated with the spliceosome prior to catalytic steps and remains associated throughout the reaction. The stable association of Cwc22 with the spliceosome requires the presence of the NTC but is independent of Prp2. ...
Cwc22 is associated with the spliceosome prior to catalytic steps and remains associated throughout the reaction. The stable associat …
Diabetic Polyneuropathy: New Strategies to Target Sensory Neurons in Dorsal Root Ganglia.
Miyashita A, Kobayashi M, Yokota T, Zochodne DW. Miyashita A, et al. Int J Mol Sci. 2023 Mar 22;24(6):5977. doi: 10.3390/ijms24065977. Int J Mol Sci. 2023. PMID: 36983051 Free PMC article. Review.
In this context, we discuss the role for DRG-targeting gene delivery, specifically oligonucleotide therapeutics for DPN. Molecules including insulin, GLP-1, PTEN, HSP27, RAGE, CWC22, and DUSP1 that impact neurotrophic signal transduction (for example, phosphatidylinositol- …
In this context, we discuss the role for DRG-targeting gene delivery, specifically oligonucleotide therapeutics for DPN. Molecules including …
Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22.
Sharma A, Heinze SD, Wu Y, Kohlbrenner T, Morilla I, Brunner C, Wimmer EA, van de Zande L, Robinson MD, Beukeboom LW, Bopp D. Sharma A, et al. Science. 2017 May 12;356(6338):642-645. doi: 10.1126/science.aam5498. Science. 2017. PMID: 28495751
Mdmd originated from a duplication of the spliceosomal factor gene CWC22 (nucampholin). Targeted Mdmd disruption results in complete sex reversal to fertile females because of a shift from male to female expression of the downstream genes transformer and doublesex The pres …
Mdmd originated from a duplication of the spliceosomal factor gene CWC22 (nucampholin). Targeted Mdmd disruption results in complete …
Pinocytotic engulfment of lipoproteins by macrophages.
Miyazaki T. Miyazaki T. Front Cardiovasc Med. 2022 Aug 29;9:957897. doi: 10.3389/fcvm.2022.957897. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36105534 Free PMC article. Review.
33 results