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Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1β and IL-18.

Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, Mancuso G, Midiri A, Di Paola R, Cuzzocrea S.

Biochem Pharmacol. 2018 Jun 28;155:150-161. doi: 10.1016/j.bcp.2018.06.029. [Epub ahead of print]


Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections.

Esposito E, Campolo M, Casili G, Lanza M, Franco D, Filippone A, Peritore AF, Cuzzocrea S.

Int J Mol Sci. 2018 Jun 22;19(7). pii: E1844. doi: 10.3390/ijms19071844.


Evaluation of the Effect of α-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property.

Mortazavi-Jahromi SS, Taeb M, Cuzzocrea S, Esposito E.

Recent Pat Inflamm Allergy Drug Discov. 2018 Jun 7. doi: 10.2174/1872213X12666180607121809. [Epub ahead of print]


Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study.

Ostardo E, Impellizzeri D, Cervigni M, Porru D, Sommariva M, Cordaro M, Siracusa R, Fusco R, Gugliandolo E, Crupi R, Schievano C, Inferrera A, Di Paola R, Cuzzocrea S; Urology Study Group.

Pharmacol Res. 2018 May 22;134:16-30. doi: 10.1016/j.phrs.2018.05.013. [Epub ahead of print]


A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-D-mannuronic acid in rheumatoid arthritis patients.

Ahmadi H, Jamshidi AR, Gharibdoost F, Mahmoudi M, Rastkari N, Mostafaei S, Fattahi MJ, Vojdanian M, Cuzzocrea S, Rehm BHA, Matsuo H, Hosseini M, Aghazadeh Z, Mortazavi-Jahromi SS, Mirshafiey A.

Inflammopharmacology. 2018 Jun;26(3):737-745. doi: 10.1007/s10787-018-0475-z. Epub 2018 Apr 25.


Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH).

Paterniti I, Campolo M, Cordaro M, Siracusa R, Filippone A, Esposito E, Cuzzocrea S.

Inflamm Res. 2018 Jul;67(7):617-626. doi: 10.1007/s00011-018-1152-9. Epub 2018 Apr 20.


2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.

Cordaro M, Siracusa R, Crupi R, Impellizzeri D, Peritore AF, D'Amico R, Gugliandolo E, Di Paola R, Cuzzocrea S.

Mol Neurobiol. 2018 Apr 14. doi: 10.1007/s12035-018-1064-2. [Epub ahead of print]


Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.

Front Pharmacol. 2018 Mar 20;9:249. doi: 10.3389/fphar.2018.00249. eCollection 2018.


N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.

Crupi R, Impellizzeri D, Cordaro M, Siracusa R, Casili G, Evangelista M, Cuzzocrea S.

Mol Neurobiol. 2018 Mar 19. doi: 10.1007/s12035-018-0959-2. [Epub ahead of print]


Involvement Of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammosome Activation, Against Pulmonary Infection with Pseudomosas Aeruginosa.

Gugliandolo E, Fusco R, Ginestra G, D'amico R, Bisignano C, Mandalari G, Cuzzocrea S, Di Paola R.

Shock. 2018 Mar 15. doi: 10.1097/SHK.0000000000001137. [Epub ahead of print]


Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis.

Fattahi MJ, Ahmadi H, Jafarnezhad-Ansariha F, Mortazavi-Jahromi SS, Rehm BHA, Cuzzocrea S, Matsuo H, Mirshafiey A.

Biomed Pharmacother. 2018 Apr;100:495-500. doi: 10.1016/j.biopha.2018.02.059. Epub 2018 Feb 23.


The Antioxidant Activity of Pistachios Reduces Cardiac Tissue Injury of Acute Ischemia/Reperfusion (I/R) in Diabetic Streptozotocin (STZ)-Induced Hyperglycaemic Rats.

Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Campolo M, Latteri S, Carughi A, Mandalari G, Cuzzocrea S.

Front Pharmacol. 2018 Feb 6;9:51. doi: 10.3389/fphar.2018.00051. eCollection 2018.


Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms.

Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V.

Immun Ageing. 2018 Feb 14;15:8. doi: 10.1186/s12979-017-0108-1. eCollection 2018. Review.


Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2 O2 -induced oxidative stress.

Akki R, Siracusa R, Morabito R, Remigante A, Campolo M, Errami M, La Spada G, Cuzzocrea S, Marino A.

Cell Biochem Funct. 2018 Mar;36(2):56-64. doi: 10.1002/cbf.3317. Epub 2018 Feb 12.


Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms.

Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D.

Pain. 2018 Jun;159(6):1025-1034. doi: 10.1097/j.pain.0000000000001177.


Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury.

Casili G, Campolo M, Paterniti I, Lanza M, Filippone A, Cuzzocrea S, Esposito E.

J Neurotrauma. 2018 Jul 1;35(13):1437-1451. doi: 10.1089/neu.2017.5260. Epub 2018 Apr 17.


Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study.

Mondello P, Steiner N, Willenbacher W, Cerchione C, Nappi D, Mauro E, Ferrero S, Cuzzocrea S, Mian M.

Oncologist. 2018 Apr;23(4):454-460. doi: 10.1634/theoncologist.2017-0037. Epub 2018 Jan 9.


Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma.

Cuzzocrea S, Doyle T, Campolo M, Paterniti I, Esposito E, Farr SA, Salvemini D.

J Neurotrauma. 2018 Jul 1;35(13):1452-1466. doi: 10.1089/neu.2017.5391. Epub 2018 Apr 17.


Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats.

Gugliandolo E, Fusco R, D'Amico R, Militi A, Oteri G, Wallace JL, Di Paola R, Cuzzocrea S.

Pharmacol Res. 2018 Jun;132:220-231. doi: 10.1016/j.phrs.2017.12.022. Epub 2017 Dec 26.


Middle Cerebral Artery Occlusion by an Intraluminal Suture Method.

Crupi R, Di Paola R, Esposito E, Cuzzocrea S.

Methods Mol Biol. 2018;1727:393-401. doi: 10.1007/978-1-4939-7571-6_31.


A Controlled Cortical Impact Preclinical Model of Traumatic Brain Injury.

Campolo M, Esposito E, Cuzzocrea S.

Methods Mol Biol. 2018;1727:385-391. doi: 10.1007/978-1-4939-7571-6_30.


An In Vivo Compression Model of Spinal Cord Injury.

Paterniti I, Esposito E, Cuzzocrea S.

Methods Mol Biol. 2018;1727:379-384. doi: 10.1007/978-1-4939-7571-6_29.


Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial.

Fattahi MJ, Jamshidi AR, Mahmoudi M, Vojdanian M, Yekaninejad MS, Jafarnezhad-Ansariha F, Ahmadi H, Rehm BHA, Matsuo H, Cuzzocrea S, Hosseini M, Hashemi SN, Aghazadeh Z, Mirshafiey A.

Int Immunopharmacol. 2018 Jan;54:112-117. doi: 10.1016/j.intimp.2017.11.003. Epub 2017 Nov 8.


Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis.

Calabrese V, Santoro A, Monti D, Crupi R, Di Paola R, Latteri S, Cuzzocrea S, Zappia M, Giordano J, Calabrese EJ, Franceschi C.

Free Radic Biol Med. 2018 Feb 1;115:80-91. doi: 10.1016/j.freeradbiomed.2017.10.379. Epub 2017 Nov 25. Review.


Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells.

Campolo M, Casili G, Lanza M, Filippone A, Paterniti I, Cuzzocrea S, Esposito E.

J Cell Mol Med. 2018 Feb;22(2):1081-1094. doi: 10.1111/jcmm.13358. Epub 2017 Oct 9.


Modulation of Dkk-3 and claudin-5 as new therapeutic strategy in the treatment of meningiomas.

Caffo M, Esposito E, Barresi V, Caruso G, Cardali SM, Rinaldi M, Mallamace R, Campolo M, Casili G, Conti A, Germanò A, Cuzzocrea S, Minutoli L.

Oncotarget. 2017 Aug 7;8(40):68280-68290. doi: 10.18632/oncotarget.20047. eCollection 2017 Sep 15.


Introduction of β-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression.

Mirshafiey A, Taeb M, Mortazavi-Jahromi SS, Jafarnezhad-Ansariha F, Rehm BHA, Esposito E, Cuzzocrea S, Matsuo H.

Pharmacol Rep. 2017 Oct;69(5):1067-1072. doi: 10.1016/j.pharep.2017.04.015. Epub 2017 Apr 25.


The Anti-Inflammatory and Antioxidant Potential of Pistachios (Pistacia vera L.) In Vitro and In Vivo.

Paterniti I, Impellizzeri D, Cordaro M, Siracusa R, Bisignano C, Gugliandolo E, Carughi A, Esposito E, Mandalari G, Cuzzocrea S.

Nutrients. 2017 Aug 22;9(8). pii: E915. doi: 10.3390/nu9080915.


The effects of β-D-mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line.

Jafarnezhad-Ansariha F, Yekaninejad MS, Jamshidi AR, Mansouri R, Vojdanian M, Mahmoudi M, Fattahi MJ, Hashemi SN, Rehm BHA, Matsuo H, Esposito E, Cuzzocrea S, Mirshafiey A.

Inflammopharmacology. 2018 Apr;26(2):375-384. doi: 10.1007/s10787-017-0386-4. Epub 2017 Aug 17.


A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models.

Britti D, Crupi R, Impellizzeri D, Gugliandolo E, Fusco R, Schievano C, Morittu VM, Evangelista M, Di Paola R, Cuzzocrea S.

BMC Vet Res. 2017 Aug 2;13(1):229. doi: 10.1186/s12917-017-1151-z.


Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

Gugliandolo E, Fusco R, Biundo F, D'Amico R, Benedetto F, Di Paola R, Cuzzocrea S.

Pharmacol Res. 2017 Sep;123:83-92. doi: 10.1016/j.phrs.2017.06.014. Epub 2017 Jul 1.


Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia.

Adesso S, Magnus T, Cuzzocrea S, Campolo M, Rissiek B, Paciello O, Autore G, Pinto A, Marzocco S.

Front Pharmacol. 2017 Jun 12;8:370. doi: 10.3389/fphar.2017.00370. eCollection 2017.


AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis.

Cross J, Stenton GR, Harwig C, Szabo C, Genovese T, Di Paola R, Esposito E, Cuzzocrea S, Mackenzie LF.

Br J Pharmacol. 2017 Sep;174(18):3045-3057. doi: 10.1111/bph.13934. Epub 2017 Aug 11.


Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia.

Siracusa R, Impellizzeri D, Cordaro M, Crupi R, Esposito E, Petrosino S, Cuzzocrea S.

Front Neurol. 2017 Jun 6;8:233. doi: 10.3389/fneur.2017.00233. eCollection 2017.


2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation.

Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S.

Front Pharmacol. 2017 May 30;8:308. doi: 10.3389/fphar.2017.00308. eCollection 2017.


Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia.

Cordaro M, Impellizzeri D, Siracusa R, Gugliandolo E, Fusco R, Inferrera A, Esposito E, Di Paola R, Cuzzocrea S.

Toxicol Appl Pharmacol. 2017 Aug 15;329:231-240. doi: 10.1016/j.taap.2017.06.005. Epub 2017 Jun 10.


Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.

Fusco R, Gugliandolo E, Campolo M, Evangelista M, Di Paola R, Cuzzocrea S.

PLoS One. 2017 Jun 8;12(6):e0178553. doi: 10.1371/journal.pone.0178553. eCollection 2017.


Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy.

Fusco R, Gugliandolo E, Biundo F, Campolo M, Di Paola R, Cuzzocrea S.

FASEB J. 2017 Aug;31(8):3497-3511. doi: 10.1096/fj.201601349R. Epub 2017 May 1.


Potential Eye Drop Based on a Calix[4]arene Nanoassembly for Curcumin Delivery: Enhanced Drug Solubility, Stability, and Anti-Inflammatory Effect.

Granata G, Paterniti I, Geraci C, Cunsolo F, Esposito E, Cordaro M, Blanco AR, Cuzzocrea S, Consoli GML.

Mol Pharm. 2017 May 1;14(5):1610-1622. doi: 10.1021/acs.molpharmaceut.6b01066. Epub 2017 Apr 10.


Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease.

Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, Navarra M, Cuzzocrea S, Esposito E.

PLoS One. 2017 Apr 3;12(4):e0174470. doi: 10.1371/journal.pone.0174470. eCollection 2017.


Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson's Disease.

Siracusa R, Paterniti I, Cordaro M, Crupi R, Bruschetta G, Campolo M, Cuzzocrea S, Esposito E.

Mol Neurobiol. 2018 Mar;55(3):2403-2419. doi: 10.1007/s12035-017-0496-4. Epub 2017 Mar 29.


The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis.

Ahmadi H, Jamshidi AR, Mahmoudi M, Cuzzocrea S, Fattahi MJ, Barati A, Rehm BHA, Matsuo H, Mirshafiey A.

Curr Drug Discov Technol. 2017;14(3):206-214. doi: 10.2174/1570163814666170321113059.


FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.

Bruschetta G, Impellizzeri D, Campolo M, Casili G, Di Paola R, Paterniti I, Esposito E, Cuzzocrea S.

Front Neurosci. 2017 Feb 7;11:6. doi: 10.3389/fnins.2017.00006. eCollection 2017.


Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.


Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.


Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.

Mondello P, Cuzzocrea S, Navarra M, Mian M.

Oncotarget. 2017 Mar 21;8(12):20394-20409. doi: 10.18632/oncotarget.14610. Review.


N-Palmitoylethanolamine-Oxazoline as a New Therapeutic Strategy to Control Neuroinflammation: Neuroprotective Effects in Experimental Models of Spinal Cord and Brain Injury.

Impellizzeri D, Cordaro M, Bruschetta G, Siracusa R, Crupi R, Esposito E, Cuzzocrea S.

J Neurotrauma. 2017 Sep 15;34(18):2609-2623. doi: 10.1089/neu.2016.4808. Epub 2017 Aug 24.


The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2.

Campolo M, Casili G, Biundo F, Crupi R, Cordaro M, Cuzzocrea S, Esposito E.

Antioxid Redox Signal. 2017 Sep 10;27(8):453-471. doi: 10.1089/ars.2016.6800. Epub 2017 Jan 27.


Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats.

Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S.

Arthritis Res Ther. 2016 Dec 12;18(1):291.


Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state.

Calabrese V, Giordano J, Crupi R, Di Paola R, Ruggieri M, Bianchini R, Ontario ML, Cuzzocrea S, Calabrese EJ.

J Neurosci Res. 2017 May;95(5):1182-1193. doi: 10.1002/jnr.23967. Epub 2016 Nov 29. Review.


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