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Astrocytes: Role and Functions in Brain Pathologies.

Siracusa R, Fusco R, Cuzzocrea S.

Front Pharmacol. 2019 Sep 27;10:1114. doi: 10.3389/fphar.2019.01114. eCollection 2019. Review.


N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway.

Fusco R, Scuto M, Cordaro M, D'Amico R, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Int J Mol Sci. 2019 Sep 29;20(19). pii: E4845. doi: 10.3390/ijms20194845.


STAT6 activation correlates with cerebrospinal fluid IL-4 and IL-10 and poor prognosis in Primary Central Nervous System Lymphoma.

Mondello P, Cuzzocrea S, Arrigo C, Pitini V, Mian M, Bertoni F.

Hematol Oncol. 2019 Sep 16. doi: 10.1002/hon.2679. [Epub ahead of print]


Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets.

Peritore AF, Siracusa R, Crupi R, Cuzzocrea S.

Nutrients. 2019 Sep 11;11(9). pii: E2175. doi: 10.3390/nu11092175.


The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice.

Impellizzeri D, Peritore AF, Cordaro M, Gugliandolo E, Siracusa R, Crupi R, D'Amico R, Fusco R, Evangelista M, Cuzzocrea S, Di Paola R.

FASEB J. 2019 Oct;33(10):11364-11380. doi: 10.1096/fj.201900538R. Epub 2019 Jul 25.


Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations.

Lunardelli ML, Crupi R, Siracusa R, Cocuzza G, Cordaro M, Martini E, Impellizzeri D, Di Paola R, Cuzzocrea S.

CNS Neurol Disord Drug Targets. 2019 Jun 17. doi: 10.2174/1871527318666190617162041. [Epub ahead of print]


Interferon Alpha Has a Strong Anti-tumor Effect in Philadelphia-negative Myeloproliferative Neoplasms.

Mondello P, Di Mirto C, Cuzzocrea S, Arrigo C, Mian M, Pitini V.

Clin Lymphoma Myeloma Leuk. 2019 Aug;19(8):e489-e495. doi: 10.1016/j.clml.2019.03.027. Epub 2019 Apr 1.


Susceptibility of erythrocytes from different sources to xenobiotics-induced lysis.

Crupi R, Morabito R, Remigante A, Gugliandolo E, Britti D, Cuzzocrea S, Marino A.

Comp Biochem Physiol C Toxicol Pharmacol. 2019 Jul;221:68-72. doi: 10.1016/j.cbpc.2019.03.008. Epub 2019 Mar 26.


Correction to "Potential Eye Drop Based on a Calix[4]arene Nanoassembly for Curcumin Delivery: Enhanced Drug Solubility, Stability, and Anti-Inflammatory Effect.

Granata G, Paterniti I, Geraci C, Cunsolo F, Esposito E, Cordaro M, Blanco AR, Cuzzocrea S, Consoli GML.

Mol Pharm. 2019 Apr 1;16(4):1788. doi: 10.1021/acs.molpharmaceut.9b00299. Epub 2019 Mar 21. No abstract available.


A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2).

Kashefi S, Omranipour R, Mahmoodzadeh H, Ahmadi H, Alikhassi A, Hosseini M, Cuzzocrea S, Rehm BHA, Matsuo H, Mirshafiey A.

Clin Exp Pharmacol Physiol. 2019 Jun;46(6):527-532. doi: 10.1111/1440-1681.13086.


Role of Metabotropic Glutamate Receptors in Neurological Disorders.

Crupi R, Impellizzeri D, Cuzzocrea S.

Front Mol Neurosci. 2019 Feb 8;12:20. doi: 10.3389/fnmol.2019.00020. eCollection 2019.


Formyl peptide receptor 1 signalling promotes experimental colitis in mice.

Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Cordaro M, Impellizzeri D, Perretti M, Cuzzocrea S.

Pharmacol Res. 2019 Mar;141:591-601. doi: 10.1016/j.phrs.2019.01.041. Epub 2019 Jan 31.


Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats.

Gugliandolo E, Fusco R, D'Amico R, Peditto M, Oteri G, Di Paola R, Cuzzocrea S, Navarra M.

Front Pharmacol. 2019 Jan 17;9:1563. doi: 10.3389/fphar.2018.01563. eCollection 2018.


TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas.

Casili G, Caffo M, Campolo M, Barresi V, Caruso G, Cardali SM, Lanza M, Mallamace R, Filippone A, Conti A, Germanò A, Cuzzocrea S, Esposito E.

Oncotarget. 2018 Dec 25;9(101):37564-37580. doi: 10.18632/oncotarget.26500. eCollection 2018 Dec 25.


Effects of a new compound containing Palmitoylethanolamide and Baicalein in myocardial ischaemia/reperfusion injury in vivo.

D'amico R, Fusco R, Gugliandolo E, Cordaro M, Siracusa R, Impellizzeri D, Peritore AF, Crupi R, Cuzzocrea S, Di Paola R.

Phytomedicine. 2019 Feb 15;54:27-42. doi: 10.1016/j.phymed.2018.09.191. Epub 2018 Sep 19.


N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion.

Impellizzeri D, Siracusa R, Cordaro M, Crupi R, Peritore AF, Gugliandolo E, D'Amico R, Petrosino S, Evangelista M, Di Paola R, Cuzzocrea S.

Neurobiol Dis. 2019 May;125:77-91. doi: 10.1016/j.nbd.2019.01.007. Epub 2019 Jan 17.


Multidisciplinary approach to prostatitis.

Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, Giuberti R, Granatieri CM, Latino MA, Larganà G, Leli C, Maierna G, Marchese V, Massa E, Matteelli A, Montanari E, Morgia G, Naber KG, Papadouli V, Perletti G, Rekleiti N, Russo GI, Sensini A, Stamatiou K, Trinchieri A, Wagenlehner FME.

Arch Ital Urol Androl. 2019 Jan 18;90(4):227-248. doi: 10.4081/aiua.2018.4.227.


The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice.

Campolo M, Siracusa R, Cordaro M, Filippone A, Gugliandolo E, Peritore AF, Impellizzeri D, Crupi R, Paterniti I, Cuzzocrea S.

PLoS One. 2019 Jan 17;14(1):e0208730. doi: 10.1371/journal.pone.0208730. eCollection 2019.


Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.

Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M, Nourshargh S.

J Pathol. 2019 May;248(1):88-102. doi: 10.1002/path.5234. Epub 2019 Mar 22.


International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.

Rezaieyazdi Z, Farooqi A, Soleymani-Salehabadi H, Ahmadzadeh A, Aslani M, Omidian S, Sadoughi A, Vahidi Z, Khodashahi M, Zamurrad S, Mortazavi-Jahromi SS, Fallahzadeh H, Hosseini M, Aghazadeh Z, Ekhtiari P, Matsuo H, Rehm BHA, Cuzzocrea S, D'Aniello A, Mirshafiey A.

Inflammopharmacology. 2019 Oct;27(5):911-921. doi: 10.1007/s10787-018-00557-2. Epub 2019 Jan 2.


Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease.

Gentili M, Ronchetti S, Ricci E, Di Paola R, Gugliandolo E, Cuzzocrea S, Bereshchenko O, Migliorati G, Riccardi C.

Pharmacol Res. 2019 Mar;141:21-31. doi: 10.1016/j.phrs.2018.12.005. Epub 2018 Dec 12.


TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.

Campolo M, Paterniti I, Siracusa R, Filippone A, Esposito E, Cuzzocrea S.

Brain Behav Immun. 2019 Feb;76:236-247. doi: 10.1016/j.bbi.2018.12.003. Epub 2018 Dec 11.


Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.


Pharmacodynamical effects of orally administered exenatide nanoparticles embedded in gastro-resistant microparticles.

Soudry-Kochavi L, Naraykin N, Di Paola R, Gugliandolo E, Peritore A, Cuzzocrea S, Ziv E, Nassar T, Benita S.

Eur J Pharm Biopharm. 2018 Dec;133:214-223. doi: 10.1016/j.ejpb.2018.10.013. Epub 2018 Oct 18.


AST-120 Reduces Neuroinflammation Induced by Indoxyl Sulfate in Glial Cells.

Adesso S, Paterniti I, Cuzzocrea S, Fujioka M, Autore G, Magnus T, Pinto A, Marzocco S.

J Clin Med. 2018 Oct 17;7(10). pii: E365. doi: 10.3390/jcm7100365.


Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.

Esposito E, Campolo M, Casili G, Lanza M, Filippone A, Peritore AF, Cuzzocrea S.

Future Microbiol. 2018 Sep;13:1375-1382. doi: 10.2217/fmb-2018-0102. Epub 2018 Sep 26.


Sodium Butyrate Exerts Neuroprotective Effects in Spinal Cord Injury.

Lanza M, Campolo M, Casili G, Filippone A, Paterniti I, Cuzzocrea S, Esposito E.

Mol Neurobiol. 2019 Jun;56(6):3937-3947. doi: 10.1007/s12035-018-1347-7. Epub 2018 Sep 18.


Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush.

Gugliandolo E, D'amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

J Neuroinflammation. 2018 Sep 14;15(1):264. doi: 10.1186/s12974-018-1303-5.


Topical Application of Adelmidrol + Trans-Traumatic Acid Enhances Skin Wound Healing in a Streptozotocin-Induced Diabetic Mouse Model.

Siracusa R, Impellizzeri D, Cordaro M, Gugliandolo E, Peritore AF, Di Paola R, Cuzzocrea S.

Front Pharmacol. 2018 Aug 23;9:871. doi: 10.3389/fphar.2018.00871. eCollection 2018.


Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis.

Fusco R, D'amico R, Cordaro M, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Oncotarget. 2018 Jul 31;9(59):31355-31366. doi: 10.18632/oncotarget.25823. eCollection 2018 Jul 31.


Micronized palmitoylethanolamide reduces joint pain and glial cell activation.

Bartolucci ML, Marini I, Bortolotti F, Impellizzeri D, Di Paola R, Bruschetta G, Crupi R, Portelli M, Militi A, Oteri G, Esposito E, Cuzzocrea S.

Inflamm Res. 2018 Oct;67(10):891-901. doi: 10.1007/s00011-018-1179-y. Epub 2018 Aug 18.


Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury.

Gugliandolo E, D'Amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

Front Neurol. 2018 Jul 31;9:590. doi: 10.3389/fneur.2018.00590. eCollection 2018.


Correction: Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.

Fusco R, Gugliandolo E, Campolo M, Evangelista M, Di Paola R, Cuzzocrea S.

PLoS One. 2018 Jul 25;13(7):e0201501. doi: 10.1371/journal.pone.0201501. eCollection 2018.


Lung resident mesenchymal cells isolated from patients with the Bronchiolitis Obliterans Syndrome display a deregulated epigenetic profile.

Vella S, Conaldi PG, Cova E, Meloni F, Liotta R, Cuzzocrea S, Martino L, Bertani A, Luca A, Vitulo P.

Sci Rep. 2018 Jul 24;8(1):11167. doi: 10.1038/s41598-018-29504-5.


Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1β and IL-18.

Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, Mancuso G, Midiri A, Di Paola R, Cuzzocrea S.

Biochem Pharmacol. 2018 Sep;155:150-161. doi: 10.1016/j.bcp.2018.06.029. Epub 2018 Jun 28.


Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections.

Esposito E, Campolo M, Casili G, Lanza M, Franco D, Filippone A, Peritore AF, Cuzzocrea S.

Int J Mol Sci. 2018 Jun 22;19(7). pii: E1844. doi: 10.3390/ijms19071844.


Evaluation of the Effect of α-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property.

Mirshafiey A, Mortazavi-Jahromi SS, Taeb M, Cuzzocrea S, Esposito E.

Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):162-168. doi: 10.2174/1872213X12666180607121809.


Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study.

Ostardo E, Impellizzeri D, Cervigni M, Porru D, Sommariva M, Cordaro M, Siracusa R, Fusco R, Gugliandolo E, Crupi R, Schievano C, Inferrera A, Di Paola R, Cuzzocrea S; Urology Study Group.

Pharmacol Res. 2018 Aug;134:16-30. doi: 10.1016/j.phrs.2018.05.013. Epub 2018 May 22.


A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-D-mannuronic acid in rheumatoid arthritis patients.

Ahmadi H, Jamshidi AR, Gharibdoost F, Mahmoudi M, Rastkari N, Mostafaei S, Fattahi MJ, Vojdanian M, Cuzzocrea S, Rehm BHA, Matsuo H, Hosseini M, Aghazadeh Z, Mortazavi-Jahromi SS, Mirshafiey A.

Inflammopharmacology. 2018 Jun;26(3):737-745. doi: 10.1007/s10787-018-0475-z. Epub 2018 Apr 25.


Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH).

Paterniti I, Campolo M, Cordaro M, Siracusa R, Filippone A, Esposito E, Cuzzocrea S.

Inflamm Res. 2018 Jul;67(7):617-626. doi: 10.1007/s00011-018-1152-9. Epub 2018 Apr 20.


2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.

Cordaro M, Siracusa R, Crupi R, Impellizzeri D, Peritore AF, D'Amico R, Gugliandolo E, Di Paola R, Cuzzocrea S.

Mol Neurobiol. 2018 Dec;55(12):9251-9266. doi: 10.1007/s12035-018-1064-2. Epub 2018 Apr 14.


Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.

Front Pharmacol. 2018 Mar 20;9:249. doi: 10.3389/fphar.2018.00249. eCollection 2018.


N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.

Crupi R, Impellizzeri D, Cordaro M, Siracusa R, Casili G, Evangelista M, Cuzzocrea S.

Mol Neurobiol. 2018 Nov;55(11):8455-8472. doi: 10.1007/s12035-018-0959-2. Epub 2018 Mar 19.


Involvement of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa.

Gugliandolo E, Fusco R, Ginestra G, D'amico R, Bisignano C, Mandalari G, Cuzzocrea S, Di Paola R.

Shock. 2019 Feb;51(2):221-227. doi: 10.1097/SHK.0000000000001137.


Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis.

Fattahi MJ, Ahmadi H, Jafarnezhad-Ansariha F, Mortazavi-Jahromi SS, Rehm BHA, Cuzzocrea S, Matsuo H, Mirshafiey A.

Biomed Pharmacother. 2018 Apr;100:495-500. doi: 10.1016/j.biopha.2018.02.059. Epub 2018 Feb 23.


The Antioxidant Activity of Pistachios Reduces Cardiac Tissue Injury of Acute Ischemia/Reperfusion (I/R) in Diabetic Streptozotocin (STZ)-Induced Hyperglycaemic Rats.

Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Campolo M, Latteri S, Carughi A, Mandalari G, Cuzzocrea S.

Front Pharmacol. 2018 Feb 6;9:51. doi: 10.3389/fphar.2018.00051. eCollection 2018.


Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms.

Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V.

Immun Ageing. 2018 Feb 14;15:8. doi: 10.1186/s12979-017-0108-1. eCollection 2018. Review.


Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2 O2 -induced oxidative stress.

Akki R, Siracusa R, Morabito R, Remigante A, Campolo M, Errami M, La Spada G, Cuzzocrea S, Marino A.

Cell Biochem Funct. 2018 Mar;36(2):56-64. doi: 10.1002/cbf.3317. Epub 2018 Feb 12.


Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms.

Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D.

Pain. 2018 Jun;159(6):1025-1034. doi: 10.1097/j.pain.0000000000001177.


Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury.

Casili G, Campolo M, Paterniti I, Lanza M, Filippone A, Cuzzocrea S, Esposito E.

J Neurotrauma. 2018 Jul 1;35(13):1437-1451. doi: 10.1089/neu.2017.5260. Epub 2018 Apr 17.


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