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Items: 1 to 50 of 65

1.

Strategies and analytical workflows to extend the dynamic range in quantitative LC-MS/MS analysis.

Ediage EN, Aerts T, Lubin A, Cuyckens F, Dillen L, Verhaeghe T.

Bioanalysis. 2019 Jun;11(12):1189-1206. doi: 10.4155/bio-2018-0309. Epub 2019 Jun 17.

PMID:
31204858
2.

Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC).

Koppen V, Van Looveren C, François I, Cuyckens F.

J Chromatogr A. 2019 Sep 13;1601:164-170. doi: 10.1016/j.chroma.2019.04.064. Epub 2019 Apr 24.

PMID:
31047660
3.

Ion mobility mass spectrometry: Small molecule applications.

Cuyckens F.

Rapid Commun Mass Spectrom. 2019 Mar 20. doi: 10.1002/rcm.8443. [Epub ahead of print] No abstract available.

PMID:
30892747
4.

Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry.

Hadavi D, de Lange E, Jordens J, Mengerink Y, Cuyckens F, Honing M.

Rapid Commun Mass Spectrom. 2019 Feb 27. doi: 10.1002/rcm.8419. [Epub ahead of print]

PMID:
30811738
5.

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.

de Vries R, Jacobs F, Mannens G, Snoeys J, Cuyckens F, Chien C, Ward P.

Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517. Epub 2019 Feb 20.

PMID:
30787101
6.

High-Resolution Mass Spectrometry Quantification: Impact of Differences in Data Processing of Centroid and Continuum Data.

Vereyken L, Dillen L, Vreeken RJ, Cuyckens F.

J Am Soc Mass Spectrom. 2019 Feb;30(2):203-212. doi: 10.1007/s13361-018-2101-0. Epub 2018 Dec 17.

PMID:
30560541
7.

Optimization of flow splitting and make-up flow conditions in liquid chromatography/electrospray ionization mass spectrometry.

Liigand J, de Vries R, Cuyckens F.

Rapid Commun Mass Spectrom. 2019 Feb 15;33(3):314-322. doi: 10.1002/rcm.8352.

PMID:
30440111
8.

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease.

Flinders B, Huizing LRS, van Heerden M, Cuyckens F, Neumann UP, van der Laan LJW, Olde Damink SWM, Heeren RMA, Schaap FG, Vreeken RJ.

Anal Chem. 2018 Oct 16;90(20):11835-11846. doi: 10.1021/acs.analchem.8b01378. Epub 2018 Oct 4.

9.

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept.

Liigand P, Liigand J, Cuyckens F, Vreeken RJ, Kruve A.

Anal Chim Acta. 2018 Nov 22;1032:68-74. doi: 10.1016/j.aca.2018.05.072. Epub 2018 May 31.

PMID:
30143223
10.

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations.

Dening TJ, Thomas N, Rao S, van Looveren C, Cuyckens F, Holm R, Prestidge CA.

Mol Pharm. 2018 Sep 4;15(9):4148-4160. doi: 10.1021/acs.molpharmaceut.8b00555. Epub 2018 Aug 14.

PMID:
30067372
11.

Mass spectrometry in drug metabolism and pharmacokinetics: Current trends and future perspectives.

Cuyckens F.

Rapid Commun Mass Spectrom. 2019 Jul;33 Suppl 3:90-95. doi: 10.1002/rcm.8235. Epub 2018 Sep 4.

PMID:
30019507
12.

Translational safety biomarkers of colonic barrier integrity in the rat.

Erkens T, Bueters R, van Heerden M, Cuyckens F, Vreeken R, Goeminne N, Lammens L.

J Appl Toxicol. 2018 Oct;38(10):1282-1292. doi: 10.1002/jat.3639. Epub 2018 May 20.

PMID:
29781175
13.

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Dubbelman AC, Cuyckens F, Dillen L, Gross G, Vreeken RJ, Hankemeier T.

Anal Chim Acta. 2018 Aug 22;1020:62-75. doi: 10.1016/j.aca.2018.02.055. Epub 2018 Mar 3.

14.

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation.

De Vijlder T, Valkenborg D, Lemière F, Romijn EP, Laukens K, Cuyckens F.

Mass Spectrom Rev. 2018 Sep;37(5):607-629. doi: 10.1002/mas.21551. Epub 2017 Nov 9. Review.

15.

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range.

Lubin A, Sheng S, Cabooter D, Augustijns P, Cuyckens F.

J Chromatogr A. 2017 Nov 17;1524:101-107. doi: 10.1016/j.chroma.2017.09.053. Epub 2017 Sep 27.

PMID:
28989028
16.

High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity.

de Vries R, Vereyken L, François I, Dillen L, Vreeken RJ, Cuyckens F.

Anal Chim Acta. 2017 Oct 9;989:104-111. doi: 10.1016/j.aca.2017.07.067. Epub 2017 Aug 4.

PMID:
28915936
17.
18.

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

Lubin A, De Vries R, Cabooter D, Augustijns P, Cuyckens F.

J Pharm Biomed Anal. 2017 Aug 5;142:225-231. doi: 10.1016/j.jpba.2017.05.003. Epub 2017 May 4.

PMID:
28521276
19.

Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites.

Martens J, Koppen V, Berden G, Cuyckens F, Oomens J.

Anal Chem. 2017 Apr 18;89(8):4359-4362. doi: 10.1021/acs.analchem.7b00577. Epub 2017 Apr 3.

20.

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry.

Li S, Klencsár B, Balcaen L, Cuyckens F, Lynen F, Vanhaecke F.

Anal Chem. 2017 Feb 7;89(3):1907-1915. doi: 10.1021/acs.analchem.6b04388. Epub 2017 Jan 13.

PMID:
28050907
21.

High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects.

Van Acker T, Van Malderen SJ, Van Heerden M, McDuffie JE, Cuyckens F, Vanhaecke F.

Anal Chim Acta. 2016 Nov 16;945:23-30. doi: 10.1016/j.aca.2016.10.014. Epub 2016 Oct 14.

PMID:
27968712
22.

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

Lubin A, Bajic S, Cabooter D, Augustijns P, Cuyckens F.

J Am Soc Mass Spectrom. 2017 Feb;28(2):286-293. doi: 10.1007/s13361-016-1537-3. Epub 2016 Nov 28.

PMID:
27896698
23.

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J.

Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20.

24.

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

Lubin A, Geerinckx S, Bajic S, Cabooter D, Augustijns P, Cuyckens F, Vreeken RJ.

J Chromatogr A. 2016 Apr 1;1440:260-265. doi: 10.1016/j.chroma.2016.02.055. Epub 2016 Feb 22.

PMID:
26948759
25.

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

Klencsár B, Bolea-Fernandez E, Flórez MR, Balcaen L, Cuyckens F, Lynen F, Vanhaecke F.

J Pharm Biomed Anal. 2016 May 30;124:112-119. doi: 10.1016/j.jpba.2016.02.019. Epub 2016 Feb 24.

PMID:
26942335
26.

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections.

Bruinen AL, van Oevelen C, Eijkel GB, Van Heerden M, Cuyckens F, Heeren RM.

J Am Soc Mass Spectrom. 2016 Jan;27(1):117-23. doi: 10.1007/s13361-015-1254-3. Epub 2015 Sep 18.

27.

One drop chemical derivatization--DESI-MS analysis for metabolite structure identification.

Lubin A, Cabooter D, Augustijns P, Cuyckens F.

J Mass Spectrom. 2015 Jul;50(7):871-8. doi: 10.1002/jms.3604.

PMID:
26349641
28.

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K.

AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25.

29.

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G.

Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8.

PMID:
25488930
30.

High volume injections of biological samples for sensitive metabolite profiling and quantitation.

Koppen V, Jones R, Bockx M, Cuyckens F.

J Chromatogr A. 2014 Dec 12;1372C:102-109. doi: 10.1016/j.chroma.2014.10.087. Epub 2014 Nov 1.

PMID:
25465008
31.

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

Dubbelman AC, Cuyckens F, Dillen L, Gross G, Hankemeier T, Vreeken RJ.

J Chromatogr A. 2014 Dec 29;1374:122-133. doi: 10.1016/j.chroma.2014.11.037. Epub 2014 Nov 20.

PMID:
25435462
32.

Characterization of polar organosulfates in secondary organic aerosol from the green leaf volatile 3-Z-hexenal.

Shalamzari MS, Kahnt A, Vermeylen R, Kleindienst TE, Lewandowski M, Cuyckens F, Maenhaut W, Claeys M.

Environ Sci Technol. 2014 Nov 4;48(21):12671-8. doi: 10.1021/es503226b. Epub 2014 Oct 17.

PMID:
25271849
33.

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K.

Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22.

PMID:
25048637
34.

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK.

Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25.

PMID:
24568888
35.

High-resolution MS: first choice for peptide quantification?

Dillen L, Cuyckens F.

Bioanalysis. 2013 May;5(10):1145-8. doi: 10.4155/bio.13.90. No abstract available.

PMID:
23721436
36.

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background.

Cuyckens F, Dillen L, Cools W, Bockx M, Vereyken L, de Vries R, Mortishire-Smith RJ.

Bioanalysis. 2012 Mar;4(5):595-604. doi: 10.4155/bio.11.333.

PMID:
22409556
37.

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides.

Dillen L, Cools W, Vereyken L, Lorreyne W, Huybrechts T, de Vries R, Ghobarah H, Cuyckens F.

Bioanalysis. 2012 Mar;4(5):565-79. doi: 10.4155/bio.12.3.

PMID:
22409554
38.

HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies.

Meermann B, Hulstaert A, Laenen A, Van Looveren C, Vliegen M, Cuyckens F, Vanhaecke F.

Anal Chem. 2012 Mar 6;84(5):2395-401. doi: 10.1021/ac203165p. Epub 2012 Feb 22.

PMID:
22304524
39.

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards.

Cuyckens F, Pauwels N, Koppen V, Leclercq L.

Bioanalysis. 2012 Jan;4(2):143-56. doi: 10.4155/bio.11.302. Erratum in: Bioanalysis. 2012 Oct;4(20):2544.

PMID:
22250797
40.

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites.

Cuyckens F, Wassvik C, Mortishire-Smith RJ, Tresadern G, Campuzano I, Claereboudt J.

Rapid Commun Mass Spectrom. 2011 Dec 15;25(23):3497-503. doi: 10.1002/rcm.5258.

PMID:
22095497
41.

Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution.

Meermann B, Bockx M, Laenen A, Van Looveren C, Cuyckens F, Vanhaecke F.

Anal Bioanal Chem. 2012 Jan;402(1):439-48. doi: 10.1007/s00216-011-5339-y. Epub 2011 Aug 30.

PMID:
21877185
42.

Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata.

Foubert K, Cuyckens F, Matheeussen A, Vlietinck A, Apers S, Maes L, Pieters L.

Phytochemistry. 2011 Aug;72(11-12):1414-23. doi: 10.1016/j.phytochem.2011.04.009. Epub 2011 May 23.

PMID:
21601896
43.

Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.

Foubert K, Cuyckens F, Vleeschouwer K, Theunis M, Vlietinck A, Pieters L, Apers S.

Talanta. 2010 Jun 15;81(4-5):1258-63. doi: 10.1016/j.talanta.2010.02.018. Epub 2010 Feb 13.

PMID:
20441893
44.

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Vermeir M, Hemeryck A, Cuyckens F, Francesch A, Bockx M, Van Houdt J, Steemans K, Mannens G, Avilés P, De Coster R.

Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020. Epub 2009 Mar 10.

PMID:
19426702
45.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE.

J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r.

PMID:
19388676
46.

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC.

Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Review.

PMID:
19183054
47.

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.

Vermeir M, Lachau-Durand S, Mannens G, Cuyckens F, van Hoof B, Raoof A.

Drug Metab Dispos. 2009 Apr;37(4):809-20. doi: 10.1124/dmd.108.024109. Epub 2009 Jan 8.

PMID:
19131522
48.

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

Cuyckens F, Hurkmans R, Castro-Perez JM, Leclercq L, Mortishire-Smith RJ.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):327-32. doi: 10.1002/rcm.3881.

PMID:
19089853
49.

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

Leclercq L, Mortishire-Smith RJ, Huisman M, Cuyckens F, Hartshorn MJ, Hill A.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):39-50. doi: 10.1002/rcm.3854.

PMID:
19051234
50.

Improved liquid chromatography-Online radioactivity detection for metabolite profiling.

Cuyckens F, Koppen V, Kembuegler R, Leclercq L.

J Chromatogr A. 2008 Oct 31;1209(1-2):128-35. doi: 10.1016/j.chroma.2008.09.002. Epub 2008 Sep 5.

PMID:
18817918

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