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Best matches for Cutruzzolà F[au]:

Glucose Metabolism in the Progression of Prostate Cancer. Cutruzzolà F et al. Front Physiol. (2017)

Serine and glycine metabolism in cancer. Amelio I et al. Trends Biochem Sci. (2014)

Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases. Rinaldo S et al. Methods Mol Biol. (2017)

Search results

Items: 1 to 50 of 119

1.

R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Montioli R, Paiardini A, Giardina G, Zanzoni S, Cutruzzola F, Cellini B, Borri Voltattorni C.

FEBS J. 2019 Apr 8. doi: 10.1111/febs.14843. [Epub ahead of print]

PMID:
30957963
2.

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.

Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.

Nucleic Acids Res. 2019 Feb 27. pii: gkz129. doi: 10.1093/nar/gkz129. [Epub ahead of print]

3.

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties.

Tramonti A, Nardella C, di Salvo ML, Barile A, Cutruzzolà F, Contestabile R.

Biochemistry. 2018 Dec 26;57(51):6984-6996. doi: 10.1021/acs.biochem.8b01074. Epub 2018 Dec 7.

PMID:
30500180
4.

Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.

Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G.

FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7.

PMID:
30106221
5.

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.

Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, Cutruzzolà F, Rinaldo S.

Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8.

PMID:
30040157
6.

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.

Giardina G, Paone A, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7.

PMID:
30035852
7.

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.

Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F.

Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/j.abb.2018.07.001. Epub 2018 Jul 4.

PMID:
29991441
8.

Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms.

Rinaldo S, Giardina G, Mantoni F, Paone A, Cutruzzolà F.

FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny029.

PMID:
29401255
9.

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.

Giardina G, Paiardini A, Montioli R, Cellini B, Voltattorni CB, Cutruzzolà F.

Sci Rep. 2017 Sep 15;7(1):11704. doi: 10.1038/s41598-017-11948-w.

10.

Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.

Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, Cutruzzolà F.

Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32.

PMID:
28889312
11.

Glucose Metabolism in the Progression of Prostate Cancer.

Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.

Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.

12.

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo ML, Fiascarelli A, Giorgi A, Maras B, Cutruzzolà F, Contestabile R.

Biochim Biophys Acta. 2016 Nov;1864(11):1506-17. doi: 10.1016/j.bbapap.2016.08.010. Epub 2016 Aug 13.

PMID:
27530298
13.

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.

Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.

14.

Novel genetic tools to tackle c-di-GMP-dependent signalling in Pseudomonas aeruginosa.

Pawar SV, Messina M, Rinaldo S, Cutruzzolà F, Kaever V, Rampioni G, Leoni L.

J Appl Microbiol. 2016 Jan;120(1):205-17. doi: 10.1111/jam.12984.

15.

Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, Cutruzzolà F.

J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184. Epub 2015 Oct 12.

PMID:
26426545
16.

In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.

Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S.

J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15. Print 2016 Jan 1.

17.

Origin and Impact of Nitric Oxide in Pseudomonas aeruginosa Biofilms.

Cutruzzolà F, Frankenberg-Dinkel N.

J Bacteriol. 2016 Jan 1;198(1):55-65. Review.

18.

Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.

Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, Cutruzzolà F, Giardina G.

J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14. Epub 2015 Feb 17.

19.

Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.

ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10.

20.

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.

21.

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.

Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482.

22.

Nitrosylation of c heme in cd(1)-nitrite reductase is enhanced during catalysis.

Rinaldo S, Giardina G, Cutruzzolà F.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):449-54. doi: 10.1016/j.bbrc.2014.08.020. Epub 2014 Aug 10.

PMID:
25117445
23.

Distal-proximal crosstalk in the heme binding pocket of the NO sensor DNR.

Cutruzzolà F, Arcovito A, Giardina G, della Longa S, D'Angelo P, Rinaldo S.

Biometals. 2014 Aug;27(4):763-73. doi: 10.1007/s10534-014-9770-3. Epub 2014 Jul 10.

PMID:
25007853
24.

Serine and glycine metabolism in cancer.

Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G.

Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20. Review.

25.

The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets.

Paiardini A, Aducci P, Cervoni L, Cutruzzolà F, Di Lucente C, Janson G, Pascarella S, Rinaldo S, Visconti S, Camoni L.

IUBMB Life. 2014 Jan;66(1):52-62. doi: 10.1002/iub.1239. Epub 2014 Jan 10.

26.

p73 keeps metabolic control in balance.

Cutruzzolà F, Avigliano L, Candi E.

Cell Cycle. 2014;13(2):179-80. doi: 10.4161/cc.27301. Epub 2013 Nov 22. No abstract available.

27.

Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain.

Giardina G, Paiardini A, Fernicola S, Franceschini S, Rinaldo S, Stelitano V, Cutruzzolà F.

PLoS One. 2013 Nov 22;8(11):e81324. doi: 10.1371/journal.pone.0081324. eCollection 2013.

28.

C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG.

Stelitano V, Giardina G, Paiardini A, Castiglione N, Cutruzzolà F, Rinaldo S.

PLoS One. 2013 Sep 16;8(9):e74920. doi: 10.1371/journal.pone.0074920. eCollection 2013.

29.

The mitochondrial Italian Human Proteome Project initiative (mt-HPP).

Urbani A, De Canio M, Palmieri F, Sechi S, Bini L, Castagnola M, Fasano M, Modesti A, Roncada P, Timperio AM, Bonizzi L, Brunori M, Cutruzzolà F, De Pinto V, Di Ilio C, Federici G, Folli F, Foti S, Gelfi C, Lauro D, Lucacchini A, Magni F, Messana I, Pandolfi PP, Papa S, Pucci P, Sacchetta P; Italian Mt-Hpp Study Group-Italian Proteomics Association (www.itpa.it).

Mol Biosyst. 2013 Aug;9(8):1984-92. doi: 10.1039/c3mb70065h. Epub 2013 May 28.

PMID:
23712443
30.

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability.

Antoniani D, Rossi E, Rinaldo S, Bocci P, Lolicato M, Paiardini A, Raffaelli N, Cutruzzolà F, Landini P.

Appl Microbiol Biotechnol. 2013 Aug;97(16):7325-36. doi: 10.1007/s00253-013-4875-0. Epub 2013 Apr 14.

PMID:
23584245
31.

Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy.

Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzolà F.

Nucleic Acids Res. 2013 Apr;41(7):e79. doi: 10.1093/nar/gkt028. Epub 2013 Jan 28.

32.

Solvent accessibility in the distal heme pocket of the nitrosyl d(1)-heme complex of Pseudomonas stutzeri cd(1) nitrite reductase.

Radoul M, Barak Y, Rinaldo S, Cutruzzolà F, Pecht I, Goldfarb D.

Biochemistry. 2012 Nov 13;51(45):9192-201. doi: 10.1021/bi3011237. Epub 2012 Nov 2.

PMID:
23072349
33.

Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding.

Chi CN, Haq SR, Rinaldo S, Dogan J, Cutruzzolà F, Engström Å, Gianni S, Lundström P, Jemth P.

Biochemistry. 2012 Nov 6;51(44):8971-9. doi: 10.1021/bi300792h. Epub 2012 Oct 23.

PMID:
23046383
34.

Unusual heme binding properties of the dissimilative nitrate respiration regulator, a bacterial nitric oxide sensor.

Rinaldo S, Castiglione N, Giardina G, Caruso M, Arcovito A, Longa SD, D'Angelo P, Cutruzzolà F.

Antioxid Redox Signal. 2012 Nov 1;17(9):1178-89. doi: 10.1089/ars.2011.4226. Epub 2012 Apr 27.

PMID:
22424265
35.

Nitrite and nitrite reductases: from molecular mechanisms to significance in human health and disease.

Castiglione N, Rinaldo S, Giardina G, Stelitano V, Cutruzzolà F.

Antioxid Redox Signal. 2012 Aug 15;17(4):684-716. doi: 10.1089/ars.2011.4196. Epub 2012 Mar 16. Review.

PMID:
22304560
36.

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20514-9. doi: 10.1073/pnas.1111456108. Epub 2011 Dec 5.

37.

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed.

Daidone F, Florio R, Rinaldo S, Contestabile R, di Salvo ML, Cutruzzolà F, Bossa F, Paiardini A.

Eur J Med Chem. 2011 May;46(5):1616-21. doi: 10.1016/j.ejmech.2011.02.009. Epub 2011 Mar 2.

PMID:
21371789
38.

Dynamic hydrogen-bonding network in the distal pocket of the nitrosyl complex of Pseudomonas aeruginosa cd1 nitrite reductase.

Radoul M, Bykov D, Rinaldo S, Cutruzzolà F, Neese F, Goldfarb D.

J Am Chem Soc. 2011 Mar 9;133(9):3043-55. doi: 10.1021/ja109688w. Epub 2011 Feb 10.

PMID:
21309511
39.

The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms.

Giardina G, Castiglione N, Caruso M, Cutruzzolà F, Rinaldo S.

Biochem Soc Trans. 2011 Jan;39(1):294-8. doi: 10.1042/BST0390294.

PMID:
21265791
40.

The catalytic mechanism of Pseudomonas aeruginosa cd1 nitrite reductase.

Rinaldo S, Giardina G, Castiglione N, Stelitano V, Cutruzzolà F.

Biochem Soc Trans. 2011 Jan;39(1):195-200. doi: 10.1042/BST0390195.

PMID:
21265772
41.

Observation of fast release of NO from ferrous d₁ haem allows formulation of a unified reaction mechanism for cytochrome cd₁ nitrite reductases.

Rinaldo S, Sam KA, Castiglione N, Stelitano V, Arcovito A, Brunori M, Allen JW, Ferguson SJ, Cutruzzolà F.

Biochem J. 2011 Apr 1;435(1):217-25. doi: 10.1042/BJ20101615.

PMID:
21244362
42.

Nitrite reduction: a ubiquitous function from a pre-aerobic past.

Cutruzzolà F, Rinaldo S, Castiglione N, Giardina G, Pecht I, Brunori M.

Bioessays. 2009 Aug;31(8):885-91. doi: 10.1002/bies.200800235. Review.

PMID:
19554608
43.

The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli.

Castiglione N, Rinaldo S, Giardina G, Cutruzzolà F.

Microbiology. 2009 Sep;155(Pt 9):2838-44. doi: 10.1099/mic.0.028027-0. Epub 2009 May 28.

PMID:
19477902
44.

A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR.

Giardina G, Rinaldo S, Castiglione N, Caruso M, Cutruzzolà F.

Proteins. 2009 Oct;77(1):174-80. doi: 10.1002/prot.22428.

PMID:
19415759
45.

Intramolecular electron transfer in Pseudomonas aeruginosa cd(1) nitrite reductase: thermodynamics and kinetics.

Farver O, Brunori M, Cutruzzolà F, Rinaldo S, Wherland S, Pecht I.

Biophys J. 2009 Apr 8;96(7):2849-56. doi: 10.1016/j.bpj.2008.12.3937.

46.

Heme d1 nitrosyl complex of cd1 nitrite reductase studied by high-field-pulse electron paramagnetic resonance spectroscopy.

Radoul M, Centola F, Rinaldo S, Cutruzzolà F, Pecht I, Goldfarb D.

Inorg Chem. 2009 May 4;48(9):3913-5. doi: 10.1021/ic802355y.

PMID:
19348457
47.

New insights into the activity of Pseudomonas aeruginosa cd1 nitrite reductase.

Rinaldo S, Arcovito A, Giardina G, Castiglione N, Brunori M, Cutruzzolà F.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1155-9. doi: 10.1042/BST0361155. Review.

PMID:
19021515
48.

NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR.

Giardina G, Rinaldo S, Johnson KA, Di Matteo A, Brunori M, Cutruzzolà F.

J Mol Biol. 2008 May 16;378(5):1002-15. doi: 10.1016/j.jmb.2008.03.013. Epub 2008 Mar 14.

PMID:
18420222
49.

Ancient hemes for ancient catalysts.

Rinaldo S, Brunori M, Cutruzzolà F.

Plant Signal Behav. 2008 Feb;3(2):135-6.

50.

Tyrosine as a redox-active center in electron transfer to ferryl heme in globins.

Reeder BJ, Cutruzzola F, Bigotti MG, Hider RC, Wilson MT.

Free Radic Biol Med. 2008 Feb 1;44(3):274-83. doi: 10.1016/j.freeradbiomed.2007.06.030. Epub 2007 Aug 22.

PMID:
18215736

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