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Items: 1 to 50 of 51

1.

The MATH-BTB BPM3 and BPM5 subunits of Cullin3-RING E3 ubiquitin ligases target PP2CA and other clade A PP2Cs for degradation.

Julian J, Coego A, Lozano-Juste J, Lechner E, Wu Q, Zhang X, Merilo E, Belda-Palazon B, Park SY, Cutler SR, An C, Genschik P, Rodriguez PL.

Proc Natl Acad Sci U S A. 2019 Jul 15. pii: 201908677. doi: 10.1073/pnas.1908677116. [Epub ahead of print]

PMID:
31308219
2.

User-defined single pot mutagenesis using unamplified oligo pools.

Medina-Cucurella AV, Steiner PJ, Faber MS, Beltrán J, Borelli AN, Kirby MB, Cutler SR, Whitehead TA.

Protein Eng Des Sel. 2019 Jul 12. pii: gzz013. doi: 10.1093/protein/gzz013. [Epub ahead of print]

PMID:
31297523
3.

Tuning water-use efficiency and drought tolerance in wheat using abscisic acid receptors.

Mega R, Abe F, Kim JS, Tsuboi Y, Tanaka K, Kobayashi H, Sakata Y, Hanada K, Tsujimoto H, Kikuchi J, Cutler SR, Okamoto M.

Nat Plants. 2019 Feb;5(2):153-159. doi: 10.1038/s41477-019-0361-8. Epub 2019 Feb 8.

PMID:
30737511
4.

Optimized small-molecule pull-downs define MLBP1 as an acyl-lipid-binding protein.

Sterlin Y, Pri-Tal O, Zimran G, Park SY, Ben-Ari J, Kourelis J, Verstraeten I, Gal M, Cutler SR, Mosquna A.

Plant J. 2019 Jun;98(5):928-941. doi: 10.1111/tpj.14272. Epub 2019 Mar 19.

PMID:
30735592
5.

Defining and Exploiting Hypersensitivity Hotspots to Facilitate Abscisic Acid Agonist Optimization.

Elzinga D, Sternburg E, Sabbadin D, Bartsch M, Park SY, Vaidya A, Mosquna A, Kaundal A, Wendeborn S, Lachia M, Karginov FV, Cutler SR.

ACS Chem Biol. 2019 Mar 15;14(3):332-336. doi: 10.1021/acschembio.8b00955. Epub 2019 Jan 29.

PMID:
30668093
6.

Small Molecule Probes of ABA Biosynthesis and Signaling.

Dejonghe W, Okamoto M, Cutler SR.

Plant Cell Physiol. 2018 Aug 1;59(8):1490-1499. doi: 10.1093/pcp/pcy126. Review.

PMID:
29986078
7.

Where are the drought tolerant crops? An assessment of more than two decades of plant biotechnology effort in crop improvement.

Nuccio ML, Paul M, Bate NJ, Cohn J, Cutler SR.

Plant Sci. 2018 Aug;273:110-119. doi: 10.1016/j.plantsci.2018.01.020. Epub 2018 Feb 5. Review.

PMID:
29907303
8.

Chemical Control of ABA Receptors to Enable Plant Protection Against Water Stress.

Okamoto M, Cutler SR.

Methods Mol Biol. 2018;1795:127-141. doi: 10.1007/978-1-4939-7874-8_11.

PMID:
29846924
9.

A Rationally Designed Agonist Defines Subfamily IIIA Abscisic Acid Receptors As Critical Targets for Manipulating Transpiration.

Vaidya AS, Peterson FC, Yarmolinsky D, Merilo E, Verstraeten I, Park SY, Elzinga D, Kaundal A, Helander J, Lozano-Juste J, Otani M, Wu K, Jensen DR, Kollist H, Volkman BF, Cutler SR.

ACS Chem Biol. 2017 Nov 17;12(11):2842-2848. doi: 10.1021/acschembio.7b00650. Epub 2017 Oct 18.

PMID:
28949512
10.

Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana.

Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M.

Plant Cell Physiol. 2017 Jan 1;58(1):95-105. doi: 10.1093/pcp/pcw181.

PMID:
28011868
11.

Hormone signalling: ABA has a breakdown.

Lozano-Juste J, Cutler SR.

Nat Plants. 2016 Sep 6;2(9):16137. doi: 10.1038/nplants.2016.137. No abstract available.

PMID:
27595660
12.

Chemical manipulation of plant water use.

Helander JD, Vaidya AS, Cutler SR.

Bioorg Med Chem. 2016 Feb 1;24(3):493-500. doi: 10.1016/j.bmc.2015.11.010. Epub 2015 Nov 11. Review.

13.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

14.

Discovery of small molecule inhibitors of xyloglucan endotransglucosylase (XET) activity by high-throughput screening.

Chormova D, Franková L, Defries A, Cutler SR, Fry SC.

Phytochemistry. 2015 Sep;117:220-236. doi: 10.1016/j.phytochem.2015.06.016. Epub 2015 Jun 19.

15.

Agrochemical control of plant water use using engineered abscisic acid receptors.

Park SY, Peterson FC, Mosquna A, Yao J, Volkman BF, Cutler SR.

Nature. 2015 Apr 23;520(7548):545-8. doi: 10.1038/nature14123. Epub 2015 Feb 4.

PMID:
25652827
16.

Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance.

González-Guzmán M, Rodríguez L, Lorenzo-Orts L, Pons C, Sarrión-Perdigones A, Fernández MA, Peirats-Llobet M, Forment J, Moreno-Alvero M, Cutler SR, Albert A, Granell A, Rodríguez PL.

J Exp Bot. 2014 Aug;65(15):4451-64. doi: 10.1093/jxb/eru219. Epub 2014 May 26.

17.

A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis.

Lumba S, Toh S, Handfield LF, Swan M, Liu R, Youn JY, Cutler SR, Subramaniam R, Provart N, Moses A, Desveaux D, McCourt P.

Dev Cell. 2014 May 12;29(3):360-72. doi: 10.1016/j.devcel.2014.04.004.

18.

Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions.

Takeuchi J, Okamoto M, Akiyama T, Muto T, Yajima S, Sue M, Seo M, Kanno Y, Kamo T, Endo A, Nambara E, Hirai N, Ohnishi T, Cutler SR, Todoroki Y.

Nat Chem Biol. 2014 Jun;10(6):477-82. doi: 10.1038/nchembio.1524. Epub 2014 May 4.

PMID:
24792952
19.

Plant genome engineering in full bloom.

Lozano-Juste J, Cutler SR.

Trends Plant Sci. 2014 May;19(5):284-7. doi: 10.1016/j.tplants.2014.02.014. Epub 2014 Mar 24.

PMID:
24674878
20.

Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance.

Okamoto M, Peterson FC, Defries A, Park SY, Endo A, Nambara E, Volkman BF, Cutler SR.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12132-7. doi: 10.1073/pnas.1305919110. Epub 2013 Jul 1.

21.

Glutamate signalling via a MEKK1 kinase-dependent pathway induces changes in Arabidopsis root architecture.

Forde BG, Cutler SR, Zaman N, Krysan PJ.

Plant J. 2013 Jul;75(1):1-10. doi: 10.1111/tpj.12201. Epub 2013 May 6.

22.

Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana.

Dinh TT, O'Leary M, Won SY, Li S, Arroyo L, Liu X, Defries A, Zheng B, Cutler SR, Chen X.

Silence. 2013 Apr 5;4(1):1. doi: 10.1186/1758-907X-4-1.

23.

Potent and selective activation of abscisic acid receptors in vivo by mutational stabilization of their agonist-bound conformation.

Mosquna A, Peterson FC, Park SY, Lozano-Juste J, Volkman BF, Cutler SR.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20838-43. doi: 10.1073/pnas.1112838108. Epub 2011 Dec 2.

24.

A thermodynamic switch modulates abscisic acid receptor sensitivity.

Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL, Márquez JA.

EMBO J. 2011 Aug 16;30(20):4171-84. doi: 10.1038/emboj.2011.294.

25.

Inducible gene expression in mammals: plants add to the menu.

Cutler SR.

Sci Signal. 2011 Mar 15;4(164):pe13. doi: 10.1126/scisignal.2001875. Review.

PMID:
21406689
26.

Modulation of abscisic acid signaling in vivo by an engineered receptor-insensitive protein phosphatase type 2C allele.

Dupeux F, Antoni R, Betz K, Santiago J, Gonzalez-Guzman M, Rodriguez L, Rubio S, Park SY, Cutler SR, Rodriguez PL, Márquez JA.

Plant Physiol. 2011 May;156(1):106-16. doi: 10.1104/pp.110.170894. Epub 2011 Feb 28.

27.

Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues.

Rosado A, Hicks GR, Norambuena L, Rogachev I, Meir S, Pourcel L, Zouhar J, Brown MQ, Boirsdore MP, Puckrin RS, Cutler SR, Rojo E, Aharoni A, Raikhel NV.

Chem Biol. 2011 Feb 25;18(2):187-97. doi: 10.1016/j.chembiol.2010.11.015.

28.

Structural and functional insights into core ABA signaling.

Weiner JJ, Peterson FC, Volkman BF, Cutler SR.

Curr Opin Plant Biol. 2010 Oct;13(5):495-502. doi: 10.1016/j.pbi.2010.09.007. Epub 2010 Oct 9. Review.

29.

Identification and mechanism of ABA receptor antagonism.

Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Chinnusamy V, Suino-Powell KM, Kovach A, Tham FS, Cutler SR, Li J, Yong EL, Zhu JK, Xu HE.

Nat Struct Mol Biol. 2010 Sep;17(9):1102-8. doi: 10.1038/nsmb.1887. Epub 2010 Aug 22.

30.

Structural basis for selective activation of ABA receptors.

Peterson FC, Burgie ES, Park SY, Jensen DR, Weiner JJ, Bingman CA, Chang CE, Cutler SR, Phillips GN Jr, Volkman BF.

Nat Struct Mol Biol. 2010 Sep;17(9):1109-13. doi: 10.1038/nsmb.1898. Epub 2010 Aug 22.

31.

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ.

Nat Chem Biol. 2010 Jul;6(7):549-57. doi: 10.1038/nchembio.380. Epub 2010 May 30.

PMID:
20512140
32.

Abscisic acid: emergence of a core signaling network.

Cutler SR, Rodriguez PL, Finkelstein RR, Abrams SR.

Annu Rev Plant Biol. 2010;61:651-79. doi: 10.1146/annurev-arplant-042809-112122. Review.

PMID:
20192755
33.

Structural mechanism of abscisic acid binding and signaling by dimeric PYR1.

Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED.

Science. 2009 Dec 4;326(5958):1373-9. doi: 10.1126/science.1181829. Epub 2009 Oct 22.

34.

In vitro reconstitution of an abscisic acid signalling pathway.

Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park SY, Cutler SR, Sheen J, Rodriguez PL, Zhu JK.

Nature. 2009 Dec 3;462(7273):660-4. doi: 10.1038/nature08599. Epub 2009 Nov 18.

35.

The abscisic acid receptor PYR1 in complex with abscisic acid.

Santiago J, Dupeux F, Round A, Antoni R, Park SY, Jamin M, Cutler SR, Rodriguez PL, Márquez JA.

Nature. 2009 Dec 3;462(7273):665-8. doi: 10.1038/nature08591. Epub 2009 Nov 8.

PMID:
19898494
36.

A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.

Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE.

Nature. 2009 Dec 3;462(7273):602-8. doi: 10.1038/nature08613.

37.

PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis.

Nishimura N, Sarkeshik A, Nito K, Park SY, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI.

Plant J. 2010 Jan;61(2):290-9. doi: 10.1111/j.1365-313X.2009.04054.x. Epub 2009 Oct 26.

38.

Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.

Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Márquez JA, Cutler SR, Rodriguez PL.

Plant J. 2009 Nov;60(4):575-88. doi: 10.1111/j.1365-313X.2009.03981.x. Epub 2009 Jul 16.

39.

Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.

Park SY, Fung P, Nishimura N, Jensen DR, Fujii H, Zhao Y, Lumba S, Santiago J, Rodrigues A, Chow TF, Alfred SE, Bonetta D, Finkelstein R, Provart NJ, Desveaux D, Rodriguez PL, McCourt P, Zhu JK, Schroeder JI, Volkman BF, Cutler SR.

Science. 2009 May 22;324(5930):1068-71. doi: 10.1126/science.1173041. Epub 2009 Apr 30.

40.

Elucidating the germination transcriptional program using small molecules.

Bassel GW, Fung P, Chow TF, Foong JA, Provart NJ, Cutler SR.

Plant Physiol. 2008 May;147(1):143-55. doi: 10.1104/pp.107.110841. Epub 2008 Mar 21.

41.

Arabidopsis P-glycoprotein19 participates in the inhibition of gravitropism by gravacin.

Rojas-Pierce M, Titapiwatanakun B, Sohn EJ, Fang F, Larive CK, Blakeslee J, Cheng Y, Cutler SR, Peer WA, Murphy AS, Raikhel NV.

Chem Biol. 2007 Dec;14(12):1366-76. Erratum in: Chem Biol. 2008 Jan;15(1):87. Cuttler, Sean [corrected to Cutler, Sean R].

42.

Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated.

Zhao Y, Chow TF, Puckrin RS, Alfred SE, Korir AK, Larive CK, Cutler SR.

Nat Chem Biol. 2007 Nov;3(11):716-21. Epub 2007 Sep 23.

PMID:
17891152
44.

High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.

Burns AR, Kwok TC, Howard A, Houston E, Johanson K, Chan A, Cutler SR, McCourt P, Roy PJ.

Nat Protoc. 2006;1(4):1906-14.

PMID:
17487175
45.

Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement.

DeBolt S, Gutierrez R, Ehrhardt DW, Melo CV, Ross L, Cutler SR, Somerville C, Bonetta D.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5854-9. Epub 2007 Mar 27.

46.

A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Kwok TC, Ricker N, Fraser R, Chan AW, Burns A, Stanley EF, McCourt P, Cutler SR, Roy PJ.

Nature. 2006 May 4;441(7089):91-5.

PMID:
16672971
47.
48.

Polarized cytokinesis in vacuolate cells of Arabidopsis.

Cutler SR, Ehrhardt DW.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2812-7.

49.

Random GFP::cDNA fusions enable visualization of subcellular structures in cells of Arabidopsis at a high frequency.

Cutler SR, Ehrhardt DW, Griffitts JS, Somerville CR.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3718-23.

50.

Effect of ionizing radiation on the heart: a prospective study of 65 patients.

Nanivadekar S, Pinto JM, Karnik AM, Cutler SR, Badami SG.

Indian Heart J. 1977 Nov-Dec;29(6):308-14. No abstract available.

PMID:
612520

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