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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.

Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP.

Nat Neurosci. 2019 May;22(5):719-728. doi: 10.1038/s41593-019-0372-9. Epub 2019 Apr 1.


Uric acid enhances longevity and endurance and protects the brain against ischemia.

Cutler RG, Camandola S, Feldman NH, Yoon JS, Haran JB, Arguelles S, Mattson MP.

Neurobiol Aging. 2019 Mar;75:159-168. doi: 10.1016/j.neurobiolaging.2018.10.031. Epub 2018 Dec 12.


Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.

de Mello-Coelho V, Cutler RG, Bunbury A, Tammara A, Mattson MP, Taub DD.

Mech Ageing Dev. 2017 Oct;167:46-55. doi: 10.1016/j.mad.2017.08.015. Epub 2017 Sep 1.


Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

McGee-Lawrence ME, Wenger KH, Misra S, Davis CL, Pollock NK, Elsalanty M, Ding K, Isales CM, Hamrick MW, Wosiski-Kuhn M, Arounleut P, Mattson MP, Cutler RG, Yu JC, Stranahan AM.

Endocrinology. 2017 May 1;158(5):1160-1171. doi: 10.1210/en.2016-1250.


Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.

Liu Y, Yang Y, Dong H, Cutler RG, Strong R, Mattson MP.

Exp Neurol. 2016 Jan;275 Pt 1:126-32. doi: 10.1016/j.expneurol.2015.10.002. Epub 2015 Oct 22.


The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.

Cutler RG, Camandola S, Malott KF, Edelhauser MA, Mattson MP.

Curr Top Med Chem. 2015;15(21):2233-8. Review.


The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation.

Liu D, Zhang Y, Gharavi R, Park HR, Lee J, Siddiqui S, Telljohann R, Nassar MR, Cutler RG, Becker KG, Mattson MP.

J Neurochem. 2015 Aug;134(4):677-92. doi: 10.1111/jnc.13176. Epub 2015 Jun 19.


Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans.

Cutler RG, Thompson KW, Camandola S, Mack KT, Mattson MP.

Mech Ageing Dev. 2014 Dec 15;143-144:9-18. doi: 10.1016/j.mad.2014.11.002. Epub 2014 Nov 28.


TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes.

Kawamoto EM, Cutler RG, Rothman SM, Mattson MP, Camandola S.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):731-7. doi: 10.1016/j.bbrc.2013.12.039. Epub 2013 Dec 14.


Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions.

Argüelles S, Camandola S, Cutler RG, Ayala A, Mattson MP.

Free Radic Biol Med. 2014 Feb;67:131-8. doi: 10.1016/j.freeradbiomed.2013.10.015. Epub 2013 Oct 17.


The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women.

Harvie M, Wright C, Pegington M, McMullan D, Mitchell E, Martin B, Cutler RG, Evans G, Whiteside S, Maudsley S, Camandola S, Wang R, Carlson OD, Egan JM, Mattson MP, Howell A.

Br J Nutr. 2013 Oct;110(8):1534-47. doi: 10.1017/S0007114513000792. Epub 2013 Apr 16.


Impulsivity is associated with uric acid: evidence from humans and mice.

Sutin AR, Cutler RG, Camandola S, Uda M, Feldman NH, Cucca F, Zonderman AB, Mattson MP, Ferrucci L, Schlessinger D, Terracciano A.

Biol Psychiatry. 2014 Jan 1;75(1):31-7. doi: 10.1016/j.biopsych.2013.02.024. Epub 2013 Apr 10.


Molecular control of the amount, subcellular location, and activity state of translation elongation factor 2 in neurons experiencing stress.

Argüelles S, Camandola S, Hutchison ER, Cutler RG, Ayala A, Mattson MP.

Free Radic Biol Med. 2013 Aug;61:61-71. doi: 10.1016/j.freeradbiomed.2013.03.016. Epub 2013 Mar 29.


Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress.

Stranahan AM, Cutler RG, Button C, Telljohann R, Mattson MP.

J Neurochem. 2011 Aug;118(4):611-5. doi: 10.1111/j.1471-4159.2011.07351.x. Epub 2011 Jul 1.


The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women.

Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, Son TG, Maudsley S, Carlson OD, Egan JM, Flyvbjerg A, Howell A.

Int J Obes (Lond). 2011 May;35(5):714-27. doi: 10.1038/ijo.2010.171. Epub 2010 Oct 5.


The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Liu D, Pitta M, Lee JH, Ray B, Lahiri DK, Furukawa K, Mughal M, Jiang H, Villarreal J, Cutler RG, Greig NH, Mattson MP.

J Alzheimers Dis. 2010;22(2):443-57. doi: 10.3233/JAD-2010-101017.


Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells.

Wu T, Tian J, Cutler RG, Telljohann RS, Bernlohr DA, Mattson MP, Handa JT.

Lab Invest. 2010 Jun;90(6):963-5. doi: 10.1038/labinvest.2010.87. No abstract available.


Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms.

Norman E, Cutler RG, Flannery R, Wang Y, Mattson MP.

J Neurochem. 2010 Jul;114(2):430-9. doi: 10.1111/j.1471-4159.2010.06779.x. Epub 2010 Apr 29.


Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.

Son TG, Camandola S, Arumugam TV, Cutler RG, Telljohann RS, Mughal MR, Moore TA, Luo W, Yu QS, Johnson DA, Johnson JA, Greig NH, Mattson MP.

J Neurochem. 2010 Mar;112(5):1316-26. doi: 10.1111/j.1471-4159.2009.06552.x. Epub 2009 Dec 17.


Comparison of biomarkers of oxidative stress and cardiovascular disease in humans and chimpanzees (Pan troglodytes).

Videan EN, Heward CB, Chowdhury K, Plummer J, Su Y, Cutler RG.

Comp Med. 2009 Jun;59(3):287-96.


Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells.

Wu T, Tian J, Cutler RG, Telljohann RS, Bernlohr DA, Mattson MP, Handa JT.

Lab Invest. 2010 Jun;90(6):906-14. doi: 10.1038/labinvest.2009.33. Epub 2009 May 11. Erratum in: Lab Invest. 2010 Jun;90(6):963-5.


Decline in daily running distance presages disease onset in a mouse model of ALS.

Bruestle DA, Cutler RG, Telljohann RS, Mattson MP.

Neuromolecular Med. 2009;11(2):58-62. doi: 10.1007/s12017-009-8064-3. Epub 2009 May 6.


Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice.

Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, Mattson MP.

Hippocampus. 2009 Oct;19(10):951-61. doi: 10.1002/hipo.20577. Erratum in: Hippocampus. 2009 Nov;19(11):1151.


Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice.

Stranahan AM, Lee K, Becker KG, Zhang Y, Maudsley S, Martin B, Cutler RG, Mattson MP.

Neurobiol Aging. 2010 Nov;31(11):1937-49. doi: 10.1016/j.neurobiolaging.2008.10.016. Epub 2008 Dec 12.


Iron-deficiency anaemia enhances red blood cell oxidative stress.

Nagababu E, Gulyani S, Earley CJ, Cutler RG, Mattson MP, Rifkind JM.

Free Radic Res. 2008 Sep;42(9):824-9. doi: 10.1080/10715760802459879.


The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acids, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity.

Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, Spate VL, Helzlsouer KJ.

Am J Epidemiol. 2008 Oct 1;168(7):831-40. doi: 10.1093/aje/kwn328.


Effect of dietary restriction on serum antioxidant capacity in rats.

Cao G, Prior RL, Cutler RG, Yu BP.

Arch Gerontol Geriatr. 1997 Nov-Dec;25(3):245-53.


Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP.

Hippocampus. 2008;18(11):1085-8. doi: 10.1002/hipo.20470.


Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons.

Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP.

Nat Neurosci. 2008 Mar;11(3):309-17. doi: 10.1038/nn2055. Epub 2008 Feb 17.


Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells.

Yamada Y, Tian J, Yang Y, Cutler RG, Wu T, Telljohann RS, Mattson MP, Handa JT.

J Neurochem. 2008 May;105(4):1187-97. doi: 10.1111/j.1471-4159.2008.05211.x. Epub 2008 Jan 7.


Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.

Haberman F, Tang SC, Arumugam TV, Hyun DH, Yu QS, Cutler RG, Guo Z, Holloway HW, Greig NH, Mattson MP.

Neuromolecular Med. 2007;9(4):315-23. Epub 2007 Aug 10.


Associative and predictive biomarkers of dementia in HIV-1-infected patients.

Bandaru VV, McArthur JC, Sacktor N, Cutler RG, Knapp EL, Mattson MP, Haughey NJ.

Neurology. 2007 May 1;68(18):1481-7.


Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.

Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP.

Neurobiol Dis. 2007 Apr;26(1):212-20. Epub 2007 Jan 13.


Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.

Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Telljohann R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP.

Free Radic Biol Med. 2007 Mar 1;42(5):665-74. Epub 2006 Dec 14. Erratum in: Free Radic Biol Med. 2007 Nov 1;43(9):1348. Tellejohan, Richard [corrected to Telljohann, Richard].


Neuroprotective actions of a histidine analogue in models of ischemic stroke.

Tang SC, Arumugam TV, Cutler RG, Jo DG, Magnus T, Chan SL, Mughal MR, Telljohann RS, Nassar M, Ouyang X, Calderan A, Ruzza P, Guiotto A, Mattson MP.

J Neurochem. 2007 May;101(3):729-36. Epub 2007 Jan 24.


Differential response induced by exposure to low-dose ionizing radiation in SHSY-5Y and normal human fibroblast cells.

McLachlan-Burgess A, McCarthy S, Griffin C, Richer J, Cutler RG, Pandey S.

Appl Biochem Biotechnol. 2006 Nov;135(2):159-78.


Energy intake and amyotrophic lateral sclerosis.

Mattson MP, Cutler RG, Camandola S.

Neuromolecular Med. 2007;9(1):17-20.


The adversities of aging.

Cutler RG, Mattson MP.

Ageing Res Rev. 2006 Aug;5(3):221-38. Epub 2006 Sep 6. Review.


Oxidative stress profiling: part II. Theory, technology, and practice.

Cutler RG, Plummer J, Chowdhury K, Heward C.

Ann N Y Acad Sci. 2005 Dec;1055:136-58. Review.


Alzheimer peptides perturb lipid-regulating enzymes.

Mattson MP, Cutler RG, Jo DG.

Nat Cell Biol. 2005 Nov;7(11):1045-7. No abstract available.


Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.

McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH Jr.

Hum Mol Genet. 2005 Nov 15;14(22):3507-21. Epub 2005 Oct 6.


Oxidative stress and aging: catalase is a longevity determinant enzyme.

Cutler RG.

Rejuvenation Res. 2005 Fall;8(3):138-40. Review.


Folate deficiency inhibits proliferation of adult hippocampal progenitors.

Kruman II, Mouton PR, Emokpae R Jr, Cutler RG, Mattson MP.

Neuroreport. 2005 Jul 13;16(10):1055-9.


Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB.

Camandola S, Cutler RG, Gary DS, Milhavet O, Mattson MP.

J Biol Chem. 2005 Jun 10;280(23):22287-96. Epub 2005 Apr 6.


Role of dietary iron restriction in a mouse model of Parkinson's disease.

Levenson CW, Cutler RG, Ladenheim B, Cadet JL, Hare J, Mattson MP.

Exp Neurol. 2004 Dec;190(2):506-14.


Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia.

Cutler RG, Haughey NJ, Tammara A, McArthur JC, Nath A, Reid R, Vargas DL, Pardo CA, Mattson MP.

Neurology. 2004 Aug 24;63(4):626-30.


Suppression of uracil-DNA glycosylase induces neuronal apoptosis.

Kruman II, Schwartz E, Kruman Y, Cutler RG, Zhu X, Greig NH, Mattson MP.

J Biol Chem. 2004 Oct 15;279(42):43952-60. Epub 2004 Aug 5.


Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease.

Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2070-5. Epub 2004 Feb 15.


Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia.

Haughey NJ, Cutler RG, Tamara A, McArthur JC, Vargas DL, Pardo CA, Turchan J, Nath A, Mattson MP.

Ann Neurol. 2004 Feb;55(2):257-67.


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