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A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study.

Zhao X, Geng X, Srinivasasainagendra V, Chaudhary N, Judd S, Wadley V, Gutiérrez OM, Wang H, Lange EM, Lange LA, Woo D, Unverzagt FW, Safford M, Cushman M, Limdi N, Quarells R, Arnett DK, Irvin MR, Zhi D.

BMC Med Genomics. 2019 Jan 31;12(Suppl 1):26. doi: 10.1186/s12920-018-0462-7.


Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins.

Pommier Y, Cushman M, Doroshow JH.

Oncotarget. 2018 Dec 18;9(99):37286-37288. doi: 10.18632/oncotarget.26466. eCollection 2018 Dec 18. No abstract available.


Ideal cardiovascular health, glycaemic status and incident type 2 diabetes mellitus: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Joseph JJ, Bennett A, Echouffo Tcheugui JB, Effoe VS, Odei JB, Hidalgo B, Dulin A, Safford MM, Cummings DM, Cushman M, Carson AP.

Diabetologia. 2019 Mar;62(3):426-437. doi: 10.1007/s00125-018-4792-y. Epub 2019 Jan 15.


Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans.

Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Cushman M, McClure LA, Safford MM, Wadley VG.

Hypertension. 2019 Feb;73(2):310-318. doi: 10.1161/HYPERTENSIONAHA.118.12062.


Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.

Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X, Bartz TM, Martinez-Perez A, Germain M, de Haan HG, Ozel AB, Polasek O, Smith AV, Eicher JD, Reiner AP, Tang W, Davies NM, Stott DJ, Rotter JI, Tofler GH, Boerwinkle E, de Maat MPM, Kleber ME, Welsh P, Brody JA, Chen MH, Vaidya D, Soria JM, Suchon P, van Hylckama Vlieg A, Desch KC, Kolcic I, Joshi PK, Launer LJ, Harris TB, Campbell H, Rudan I, Becker DM, Li JZ, Rivadeneira F, Uitterlinden AG, Hofman A, Franco OH, Cushman M, Psaty BM, Morange PE, McKnight B, Chong MR, Fernandez-Cadenas I, Rosand J, Lindgren A; INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC), Gudnason V, Wilson JF, Hayward C, Ginsburg D, Fornage M, Rosendaal FR, Souto JC, Becker LC, Jenny NS, März W, Jukema JW, Dehghan A, Trégouët DA, Morrison AC, Johnson AD, O'Donnell CJ, Strachan DP, Lowenstein CJ, Smith NL.

Circulation. 2019 Jan 29;139(5):620-635. doi: 10.1161/CIRCULATIONAHA.118.034532.


Life's Simple 7 and Peripheral Artery Disease: The Multi-Ethnic Study of Atherosclerosis.

Unkart JT, Allison MA, Criqui MH, McDermott MM, Wood AC, Folsom AR, Lloyd-Jones D, Rasmussen-Torvik LJ, Allen N, Burke G, Szklo M, Cushman M, McClelland RL, Wassel CL.

Am J Prev Med. 2019 Feb;56(2):262-270. doi: 10.1016/j.amepre.2018.09.021. Epub 2018 Dec 13.


Sex and Race Differences in the Association of Incident Ischemic Stroke With Risk Factors.

Howard VJ, Madsen TE, Kleindorfer DO, Judd SE, Rhodes JD, Soliman EZ, Kissela BM, Safford MM, Moy CS, McClure LA, Howard G, Cushman M.

JAMA Neurol. 2018 Dec 10. doi: 10.1001/jamaneurol.2018.3862. [Epub ahead of print]


American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients.

Schünemann HJ, Cushman M, Burnett AE, Kahn SR, Beyer-Westendorf J, Spencer FA, Rezende SM, Zakai NA, Bauer KA, Dentali F, Lansing J, Balduzzi S, Darzi A, Morgano GP, Neumann I, Nieuwlaat R, Yepes-Nuñez JJ, Zhang Y, Wiercioch W.

Blood Adv. 2018 Nov 27;2(22):3198-3225. doi: 10.1182/bloodadvances.2018022954. Review.


Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

Elsayed MSA, Nielsen JJ, Park S, Park J, Liu Q, Kim CH, Pommier Y, Agama K, Low PS, Cushman M.

J Med Chem. 2018 Nov 21. doi: 10.1021/acs.jmedchem.8b00510. [Epub ahead of print]


Association Between Inflammatory Markers and Myocardial Fibrosis.

Marques MD, Nauffal V, Ambale-Venkatesh B, Vasconcellos HD, Wu C, Bahrami H, Tracy RP, Cushman M, Bluemke DA, Lima JAC.

Hypertension. 2018 Oct;72(4):902-908. doi: 10.1161/HYPERTENSIONAHA.118.11463.


Diversity and inclusion in a new medical journal: Advancing science in the 21st century.

Cushman M.

Res Pract Thromb Haemost. 2018 Oct 10;2(4):620-621. doi: 10.1002/rth2.12154. eCollection 2018 Oct. No abstract available.


Adiposity and Incident Heart Failure and its Subtypes: MESA (Multi-Ethnic Study of Atherosclerosis).

Rao VN, Zhao D, Allison MA, Guallar E, Sharma K, Criqui MH, Cushman M, Blumenthal RS, Michos ED.

JACC Heart Fail. 2018 Dec;6(12):999-1007. doi: 10.1016/j.jchf.2018.07.009. Epub 2018 Oct 10.


The prognostic value of interleukin 6 in multiple chronic diseases and all-cause death: The Multi-Ethnic Study of Atherosclerosis (MESA).

Cainzos-Achirica M, Enjuanes C, Greenland P, McEvoy JW, Cushman M, Dardari Z, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Miedema MD, Blumenthal RS, Comin-Colet J, Blaha MJ.

Atherosclerosis. 2018 Nov;278:217-225. doi: 10.1016/j.atherosclerosis.2018.09.034. Epub 2018 Oct 4.


Associations of Sedentary Behavior and Abdominal Muscle Density: The Multi-Ethnic Study of Atherosclerosis.

Vella CA, Michos ED, Sears DD, Cushman M, Van Hollebeke RB, Wiest MM, Allison MA.

J Phys Act Health. 2018 Nov 1;15(11):827-833. doi: 10.1123/jpah.2018-0028. Epub 2018 Oct 9.


Prospective Study of Endogenous Hormones and Incidence of Venous Thromboembolism: The Atherosclerosis Risk in Communities Study.

Roetker NS, MacLehose RF, Hoogeveen RC, Ballantyne CM, Basu S, Cushman M, Folsom AR.

Thromb Haemost. 2018 Nov;118(11):1940-1950. doi: 10.1055/s-0038-1673613. Epub 2018 Oct 8.


Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.

Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A.

PLoS One. 2018 Oct 5;13(10):e0204352. doi: 10.1371/journal.pone.0204352. eCollection 2018.


Association of Clinical and Social Factors With Excess Hypertension Risk in Black Compared With White US Adults.

Howard G, Cushman M, Moy CS, Oparil S, Muntner P, Lackland DT, Manly JJ, Flaherty ML, Judd SE, Wadley VG, Long DL, Howard VJ.

JAMA. 2018 Oct 2;320(13):1338-1348. doi: 10.1001/jama.2018.13467.


Dietary Oxidative Balance Scores and Biomarkers of Inflammation among Individuals with and without Chronic Kidney Disease.

Marks KJ, Hartman TJ, Judd SE, Ilori TO, Cheung KL, Warnock DG, Gutiérrez OM, Goodman M, Cushman M, McClellan WM.

Nephron Extra. 2018 Aug 21;8(2):11-23. doi: 10.1159/000490499. eCollection 2018 May-Aug.


Pulmonary Embolism for the Cardiologist: Emphasis on Diagnosis.

Halevy J, Cushman M.

Curr Cardiol Rep. 2018 Sep 26;20(11):120. doi: 10.1007/s11886-018-1060-1. Review.


Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study.

Dubin RF, Judd S, Scherzer R, Shlipak M, Warnock DG, Cushman M, Sarnak M, Parikh C, Bennett M, Powe N, Peralta CA.

Kidney Int Rep. 2018 Jun 20;3(5):1183-1192. doi: 10.1016/j.ekir.2018.05.013. eCollection 2018 Sep.


The role of scientific publishing in the development of early career investigators.

Cuker A, Ay C, Cushman M.

Res Pract Thromb Haemost. 2017 Dec 27;2(1):6-7. doi: 10.1002/rth2.12072. eCollection 2018 Jan. No abstract available.


Ability of the Khorana score to predict recurrent thromboembolism in cancer patients with ischemic stroke.

Murthy SB, Cushman M, Bobrow D, Kamel H, Merkler AE, Elkind MSV, DeAngelis LM, Navi BB.

J Clin Neurosci. 2018 Nov;57:111-115. doi: 10.1016/j.jocn.2018.08.018. Epub 2018 Aug 23.


Striving for Ideal Cardiovascular and Brain Health: It Is Never Too Early or Too Late.

Saver JL, Cushman M.

JAMA. 2018 Aug 21;320(7):645-647. doi: 10.1001/jama.2018.11002. No abstract available.


Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome.

Lee HM, Clark EP, Kuijer MB, Cushman M, Pommier Y, Philpot BD.

Mol Autism. 2018 Aug 17;9:45. doi: 10.1186/s13229-018-0228-2. eCollection 2018.


Comparison of Frequency of Atherosclerotic Cardiovascular and Safety Events With Systolic Blood Pressure <120mm Hg Versus 135-139mm Hg in a Systolic Blood Pressure Intervention Trial Primary Prevention Subgroup.

Plante TB, Juraschek SP, Miller ER 3rd, Appel LJ, Cushman M, Littenberg B.

Am J Cardiol. 2018 Oct 1;122(7):1185-1190. doi: 10.1016/j.amjcard.2018.06.041. Epub 2018 Jul 4.


Activity of Aromathecins against African Trypanosomes.

Nenortas NP, Cinelli MA, Morrell AE, Cushman M, Shapiro TA.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00786-18. doi: 10.1128/AAC.00786-18. Print 2018 Nov.


Synthesis of Benzo[1,6]naphthyridinones Using the Catellani Reaction.

Elsayed MSA, Griggs B, Cushman M.

Org Lett. 2018 Sep 7;20(17):5228-5232. doi: 10.1021/acs.orglett.8b02171. Epub 2018 Aug 13.


Venous thromboembolism, factor VIII and chronic kidney disease.

Cheung KL, Bouchard BA, Cushman M.

Thromb Res. 2018 Oct;170:10-19. doi: 10.1016/j.thromres.2018.07.029. Epub 2018 Jul 31. Review.


Illustrated review article: A new format for disseminating scientific progress.

Wolberg AS, Cushman M.

Res Pract Thromb Haemost. 2018 Jun 10;2(3):405-406. doi: 10.1002/rth2.12124. eCollection 2018 Jul. No abstract available.


Biomarkers, menopausal hormone therapy and risk of venous thrombosis: The Women's Health Initiative.

Cushman M, Larson JC, Rosendaal FR, Heckbert SR, Curb JD, Phillips LS, Baird AE, Eaton CB, Stafford RS.

Res Pract Thromb Haemost. 2018 Apr 17;2(2):310-319. doi: 10.1002/rth2.12100. eCollection 2018 Apr.


Search engine optimization: What is it and why should we care?

Cushman M.

Res Pract Thromb Haemost. 2018 Apr 15;2(2):180-181. doi: 10.1002/rth2.12098. eCollection 2018 Apr. No abstract available.


Indexing for a new journal: Research and Practice in Thrombosis and Haemostasis.

Cushman M, Brink E.

Res Pract Thromb Haemost. 2017 Oct 9;1(2):148-149. doi: 10.1002/rth2.12047. eCollection 2017 Oct. No abstract available.


Hello Research and Practice in Thrombosis and Haemostasis.

Cushman M.

Res Pract Thromb Haemost. 2017 Jul 8;1(1):5. doi: 10.1002/rth2.12022. eCollection 2017 Jul. No abstract available.


The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF.

Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, Kizer JR, Sarma A, Blaha MJ, Gansevoort RT, Gardin JM, Hillege HL, Ji F, Kop WJ, Lau ES, Lee DS, Sadreyev R, van Gilst WH, Wang TJ, Zanni MV, Vasan RS, Allen NB, Psaty BM, van der Harst P, Levy D, Larson M, Shah SJ, de Boer RA, Gottdiener JS, Ho JE.

JACC Heart Fail. 2018 Aug;6(8):701-709. doi: 10.1016/j.jchf.2018.05.018. Epub 2018 Jul 11.


Longitudinal increases in blood biomarkers of inflammation or cardiovascular disease and the incidence of venous thromboembolism.

Folsom AR, Lutsey PL, Heckbert SR, Poudel K, Basu S, Hoogeveen RC, Cushman M, Ballantyne CM.

J Thromb Haemost. 2018 Oct;16(10):1964-1972. doi: 10.1111/jth.14241. Epub 2018 Aug 11.


Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu FC, Nho K, Hofer E, Hagenaars SP, Nyquist PA, Mishra A, Adams HHH, Li S, Teumer A, Zhao W, Freedman BI, Saba Y, Yanek LR, Chauhan G, van Buchem MA, Cushman M, Royle NA, Bryan RN, Niessen WJ, Windham BG, DeStefano AL, Habes M, Heckbert SR, Palmer ND, Lewis CE, Eiriksdottir G, Maillard P, Mathias RA, Homuth G, Valdés-Hernández MDC, Divers J, Beiser AS, Langner S, Rice KM, Bastin ME, Yang Q, Maldjian JA, Starr JM, Sidney S, Risacher SL, Uitterlinden AG, Gudnason VG, Nauck M, Rotter JI, Schreiner PJ, Boerwinkle E, van Duijn CM, Mazoyer B, von Sarnowski B, Gottesman RF, Levy D, Sigurdsson S, Vernooij MW, Turner ST, Schmidt R, Wardlaw JM, Psaty BM, Mosley TH, DeCarli CS, Saykin AJ, Bowden DW, Becker DM, Deary IJ, Schmidt H, Kardia SLR, Ikram MA, Debette S, Grabe HJ, Longstreth WT Jr, Seshadri S, Launer LJ, Fornage M; neuroCHARGE Working Group.

Stroke. 2018 Aug;49(8):1812-1819. doi: 10.1161/STROKEAHA.118.020689.


Mechanisms and mitigating factors for venous thromboembolism in chronic kidney disease: the REGARDS study.

Cheung KL, Zakai NA, Callas PW, Howard G, Mahmoodi BK, Peralta CA, Judd SE, Kurella Tamura M, Cushman M.

J Thromb Haemost. 2018 Sep;16(9):1743-1752. doi: 10.1111/jth.14235. Epub 2018 Aug 9.


Urinary cadmium concentration and the risk of ischemic stroke.

Chen C, Xun P, Tsinovoi C, McClure LA, Brockman J, MacDonald L, Cushman M, Cai J, Kamendulis L, Mackey J, He K.

Neurology. 2018 Jul 24;91(4):e382-e391. doi: 10.1212/WNL.0000000000005856. Epub 2018 Jun 22.


Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables.

Weng LC, Guan W, Steffen LM, Pankow JS, Pankratz N, Chen MH, Cushman M, Basu S, Folsom AR, Tang W.

Thromb Res. 2018 Aug;168:53-59. doi: 10.1016/j.thromres.2018.05.032. Epub 2018 Jun 1.


APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.

Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA.

Circ Genom Precis Med. 2018 Jun;11(6):e002098. doi: 10.1161/CIRCGEN.117.002098.


Factor VIII, Protein C and Cardiovascular Disease Risk: The REasons for Geographic and Racial Differences in Stroke Study (REGARDS).

Zakai NA, Judd SE, Kissela B, Howard G, Safford MM, Cushman M.

Thromb Haemost. 2018 Jul;118(7):1305-1315. doi: 10.1055/s-0038-1655766. Epub 2018 Jun 11.


Associations of Abdominal Muscle Area and Radiodensity with Adiponectin and Leptin: The Multiethnic Study of Atherosclerosis.

Vella CA, Cushman M, Van Hollebeke RB, Allison MA.

Obesity (Silver Spring). 2018 Jul;26(7):1234-1241. doi: 10.1002/oby.22208. Epub 2018 Jun 7.


Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (from the Reasons for Geographic and Racial Differences in Stroke Study).

Wettersten N, Cushman M, Howard VJ, Hartmann O, Filippatos G, Beri N, Clopton P, Howard G, Safford MM, Judd SE, Bergmann A, Struck J, Maisel AS.

Am J Cardiol. 2018 Jul 1;122(1):26-32. doi: 10.1016/j.amjcard.2018.03.009. Epub 2018 Mar 28.


Clinical Performance Measures for Adults Hospitalized With Intracerebral Hemorrhage: Performance Measures for Healthcare Professionals From the American Heart Association/American Stroke Association.

Hemphill JC 3rd, Adeoye OM, Alexander DN, Alexandrov AW, Amin-Hanjani S, Cushman M, George MG, LeRoux PD, Mayer SA, Qureshi AI, Saver JL, Schwamm LH, Sheth KN, Tirschwell D; AHA/ASA Stroke Performance Oversight Committee.

Stroke. 2018 Jul;49(7):e243-e261. doi: 10.1161/STR.0000000000000171. Epub 2018 May 21. Review. No abstract available.


The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after >10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA).

Cainzos-Achirica M, Miedema MD, McEvoy JW, Cushman M, Dardari Z, Greenland P, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Blumenthal RS, Comin-Colet J, Blaha MJ.

Int J Cardiol. 2018 Aug 1;264:158-164. doi: 10.1016/j.ijcard.2018.02.027.


Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites.

Venkatraman A, Callas P, McClure LA, Unverzagt F, Arora G, Howard V, Wadley VG, Cushman M, Arora P.

Alzheimers Dement (N Y). 2018 Apr 26;4:165-172. doi: 10.1016/j.trci.2018.03.006. eCollection 2018.


Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.

Marzi L, Agama K, Murai J, Difilippantonio S, James A, Peer CJ, Figg WD, Beck D, Elsayed MSA, Cushman M, Pommier Y.

Mol Cancer Ther. 2018 Aug;17(8):1694-1704. doi: 10.1158/1535-7163.MCT-18-0028. Epub 2018 May 10.


Serum mercury concentration and the risk of ischemic stroke: The REasons for Geographic and Racial Differences in Stroke Trace Element Study.

Chen C, Xun P, McClure LA, Brockman J, MacDonald L, Cushman M, Cai J, Kamendulis L, Mackey J, He K.

Environ Int. 2018 Aug;117:125-131. doi: 10.1016/j.envint.2018.05.001. Epub 2018 May 5.


Hemostasis biomarkers and incident cognitive impairment: the REGARDS study.

Gillett SR, McClure LA, Callas PW, Thacker EL, Unverzagt FW, Wadley VG, Letter AJ, Cushman M.

J Thromb Haemost. 2018 Jul;16(7):1259-1267. doi: 10.1111/jth.14138. Epub 2018 Jun 6.


New diagnosis of cancer and the risk of subsequent cerebrovascular events.

Navi BB, Howard G, Howard VJ, Zhao H, Judd SE, Elkind MSV, Iadecola C, DeAngelis LM, Kamel H, Okin PM, Gilchrist S, Soliman EZ, Cushman M, Muntner P.

Neurology. 2018 Jun 5;90(23):e2025-e2033. doi: 10.1212/WNL.0000000000005636. Epub 2018 May 4.


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