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Structural snapshots of actively transcribing influenza polymerase.

Kouba T, Drncová P, Cusack S.

Nat Struct Mol Biol. 2019 Jun;26(6):460-470. doi: 10.1038/s41594-019-0232-z. Epub 2019 Jun 3.


Prospective Predictors of Sexual Revictimization Among College Students.

Cusack SE, Bourdon JL, Bountress K, Saunders TR, Kendler KS, Dick DM, Amstadter AB.

J Interpers Violence. 2019 May 26:886260519849680. doi: 10.1177/0886260519849680. [Epub ahead of print]


Alcohol consumption, interpersonal trauma, and drinking to cope with trauma-related distress: An auto-regressive, cross-lagged model.

Bountress KE, Cusack SE, Sheerin CM, Hawn S, Dick DM, Kendler KS, Amstadter AB.

Psychol Addict Behav. 2019 May;33(3):221-231. doi: 10.1037/adb0000457. Epub 2019 Mar 14.


RIP2 filament formation is required for NOD2 dependent NF-κB signalling.

Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S.

Nat Commun. 2018 Oct 2;9(1):4043. doi: 10.1038/s41467-018-06451-3.


Moderation of improvement in self-efficacy following group psychotherapy for PTSD.

Cusack SE, Coleman JA, Rappaport LM, Sheerin C.

Psychol Serv. 2018 Jul 2. doi: 10.1037/ser0000260. [Epub ahead of print]


Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S.

Sci Rep. 2018 Jun 25;8(1):9633. doi: 10.1038/s41598-018-27890-4.


Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S.

Nat Commun. 2018 May 31;9(1):2183. doi: 10.1038/s41467-018-04643-5.


Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K.

Nat Commun. 2018 May 8;9(1):1820. doi: 10.1038/s41467-018-04214-8.


Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S.

Nat Commun. 2018 Apr 27;9(1):1701. doi: 10.1038/s41467-018-04142-7. Erratum in: Nat Commun. 2018 May 31;9(1):2183.


Prevalence and predictors of PTSD among a college sample.

Cusack SE, Hicks TA, Bourdon J, Sheerin CM, Overstreet CM, Kendler KS, Dick DM, Amstadter AB.

J Am Coll Health. 2019 Feb-Mar;67(2):123-131. doi: 10.1080/07448481.2018.1462824. Epub 2018 Jun 19.


Editorial overview: Protein-nucleic acid interactions: An expanding universe.

Cusack S, Müller CW.

Curr Opin Struct Biol. 2017 Dec;47:iv-v. doi: 10.1016/ No abstract available.


Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.

Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze WM, Cusack S.

Nucleic Acids Res. 2018 Jan 25;46(2):956-971. doi: 10.1093/nar/gkx1210.


The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation.

Xu L, Gong W, Cusack SA, Wu H, Loovers HM, Zhang H, Perrett S, Jones GW.

Cell Mol Life Sci. 2018 Apr;75(8):1445-1459. doi: 10.1007/s00018-017-2698-3. Epub 2017 Nov 9. Update in: Prion. 2018;12(3-4):170-174.


Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.

Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj I.

J Mol Biol. 2018 Jan 5;430(1):1-16. doi: 10.1016/j.jmb.2017.10.024. Epub 2017 Oct 27.


Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

Schulze WM, Cusack S.

Nat Commun. 2017 Nov 3;8(1):1302. doi: 10.1038/s41467-017-01402-w.


Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S.

PLoS One. 2017 May 18;12(5):e0177161. doi: 10.1371/journal.pone.0177161. eCollection 2017.


Structural insights into reptarenavirus cap-snatching machinery.

Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S.

PLoS Pathog. 2017 May 15;13(5):e1006400. doi: 10.1371/journal.ppat.1006400. eCollection 2017 May.


A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.

Britten CD, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, Brisendine A, Anderton K, Cusack SL, Maines LW, Zhuang Y, Smith CD, Thomas MB.

Clin Cancer Res. 2017 Aug 15;23(16):4642-4650. doi: 10.1158/1078-0432.CCR-16-2363. Epub 2017 Apr 18.


Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA.

EMBO Mol Med. 2017 Mar;9(3):385-394. doi: 10.15252/emmm.201607370.


An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.

Reich S, Guilligay D, Cusack S.

Nucleic Acids Res. 2017 Apr 7;45(6):3353-3368. doi: 10.1093/nar/gkx043.


Structural insights into RNA synthesis by the influenza virus transcription-replication machine.

Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S.

Virus Res. 2017 Apr 15;234:103-117. doi: 10.1016/j.virusres.2017.01.013. Epub 2017 Jan 20. Review.


Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S.

Nature. 2017 Jan 5;541(7635):117-121. doi: 10.1038/nature20594. Epub 2016 Dec 21.


A Study of the Patients Admitted to the Clinical Decision Unit over One Year.

O'Shea E, Cusack S, O'Sullivan I.

Ir Med J. 2016 Jun 10;109(6):424.


Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J.

Nat Commun. 2016 Oct 7;7:12928. doi: 10.1038/ncomms12928.


Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.


Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.


Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.

Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S.

PLoS Pathog. 2016 Jun 15;12(6):e1005636. doi: 10.1371/journal.ppat.1005636. eCollection 2016 Jun.


Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein.

Fernández-García Y, Reguera J, Busch C, Witte G, Sánchez-Ramos O, Betzel C, Cusack S, Günther S, Reindl S.

PLoS Pathog. 2016 Jun 14;12(6):e1005635. doi: 10.1371/journal.ppat.1005635. eCollection 2016 Jun.


Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.


Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.

Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S.

Mol Cell. 2016 May 19;62(4):586-602. doi: 10.1016/j.molcel.2016.04.021.


Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate.

Aleksandrov A, Palencia A, Cusack S, Field M.

J Phys Chem B. 2016 May 19;120(19):4388-98. doi: 10.1021/acs.jpcb.6b02387. Epub 2016 May 10.


Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T.

Sci Rep. 2016 Apr 20;6:24727. doi: 10.1038/srep24727.


Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.

Avilov S, Magnus J, Cusack S, Naffakh N.

PLoS One. 2016 Mar 15;11(3):e0149986. doi: 10.1371/journal.pone.0149986. eCollection 2016.


Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases.

Reguera J, Gerlach P, Cusack S.

Curr Opin Struct Biol. 2016 Feb;36:75-84. doi: 10.1016/ Epub 2016 Jan 27. Review.


Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S.

Mol Cell. 2016 Jan 7;61(1):125-37. doi: 10.1016/j.molcel.2015.11.016. Epub 2015 Dec 17.


Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E.

Nature. 2015 Nov 5;527(7576):114-7. doi: 10.1038/nature15525. Epub 2015 Oct 26.


An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex.

Roch FF, Hinterkörner G, Menke J, Tang GQ, Cusack S, Butzendobler B, Buschmann H, Datta K, Wolkerstorfer A.

Assay Drug Dev Technol. 2015 Oct;13(8):488-506. doi: 10.1089/adt.2015.668.


Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.

Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D.

BMC Biol. 2015 Jul 28;13:54. doi: 10.1186/s12915-015-0166-9.


Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S.

ACS Chem Biol. 2015 Oct 16;10(10):2277-85. doi: 10.1021/acschembio.5b00291. Epub 2015 Jul 31.


Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.

Gerlach P, Malet H, Cusack S, Reguera J.

Cell. 2015 Jun 4;161(6):1267-79. doi: 10.1016/j.cell.2015.05.006. Epub 2015 May 21.


Maxillofacial Injury-Not Always a Difficult Airway.

Glasheen J, Hennelly D, Cusack S.

Prehosp Disaster Med. 2015 Aug;30(4):421-4. doi: 10.1017/S1049023X15004744. Epub 2015 May 21.


Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S.

Nature. 2014 Dec 18;516(7531):361-6. doi: 10.1038/nature14009. Epub 2014 Nov 19.


Structure of influenza A polymerase bound to the viral RNA promoter.

Pflug A, Guilligay D, Reich S, Cusack S.

Nature. 2014 Dec 18;516(7531):355-60. doi: 10.1038/nature14008. Epub 2014 Nov 19.


Diet-microbiota-health interactions in older subjects: implications for healthy aging.

Lynch DB, Jeffery IB, Cusack S, O'Connor EM, O'Toole PW.

Interdiscip Top Gerontol. 2015;40:141-54. doi: 10.1159/000364976. Epub 2014 Oct 13. Review.


Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S.

RNA. 2014 Dec;20(12):1955-62. doi: 10.1261/rna.047209.114. Epub 2014 Oct 21.


RIG-I self-oligomerization is either dispensable or very transient for signal transduction.

Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D.

PLoS One. 2014 Sep 26;9(9):e108770. doi: 10.1371/journal.pone.0108770. eCollection 2014.


The physiological target for LeuRS translational quality control is norvaline.

Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I.

EMBO J. 2014 Aug 1;33(15):1639-53. doi: 10.15252/embj.201488199. Epub 2014 Jun 16.


RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts.

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS.

Cell. 2014 Jun 19;157(7):1698-711. doi: 10.1016/j.cell.2014.05.018. Epub 2014 Jun 5.


Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.

Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A.

Genes Dev. 2014 May 1;28(9):929-42. doi: 10.1101/gad.240200.114.


Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity.

Hasin N, Cusack SA, Ali SS, Fitzpatrick DA, Jones GW.

BMC Genomics. 2014 Mar 14;15:194. doi: 10.1186/1471-2164-15-194.

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