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Attenuated Acceleration to Leukemia after Ezh2 Loss in Nup98-HoxD13 (NHD13) Myelodysplastic Syndrome.

Ling VY, Saw J, Tremblay CS, Sonderegger SE, Toulmin E, Boyle J, Chiu SK, Lane SW, Ting SB, Curtis DJ.

Hemasphere. 2019 Aug 7;3(4):e277. doi: 10.1097/HS9.0000000000000277. eCollection 2019 Aug.


Immunization Status at the Time of Liver Transplant in Children and Adolescents.

Feldman AG, Sundaram SS, Beaty BL, Torres R, Curtis DJ, Kempe A.

JAMA. 2019 Nov 12;322(18):1822-1824. doi: 10.1001/jama.2019.14386. No abstract available.


Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.

AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116. Epub 2019 Aug 22.


Under-immunization of pediatric transplant recipients: a call to action for the pediatric community.

Feldman AG, Curtis DJ, Moore SL, Kempe A.

Pediatr Res. 2019 Jul 22. doi: 10.1038/s41390-019-0507-4. [Epub ahead of print] Review.


Protocol for a scoping review study to identify and map treatments for dysphagia following moderate to severe acquired brain injury.

Eskildsen SJ, Jakobsen D, Riberholt CG, Poulsen I, Curtis DJ.

BMJ Open. 2019 Jul 17;9(7):e029061. doi: 10.1136/bmjopen-2019-029061.


Shared roles for Scl and Lyl1 in murine platelet production and function.

Chiu SK, Orive SL, Moon MJ, Saw J, Ellis S, Kile BT, Huang Y, Chacon D, Pimanda JE, Beck D, Hamilton JR, Tremblay CS, Curtis DJ.

Blood. 2019 Sep 5;134(10):826-835. doi: 10.1182/blood.2019896175. Epub 2019 Jul 12.


The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.

Shields BJ, Slape CI, Vo N, Jackson JT, Pliego-Zamora A, Ranasinghe H, Shi W, Curtis DJ, McCormack MP.

Leukemia. 2019 Aug;33(8):1868-1880. doi: 10.1038/s41375-018-0361-0. Epub 2019 Jan 30.


ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms.

Goossens S, Wang J, Tremblay CS, De Medts J, T'Sas S, Nguyen T, Saw J, Haigh K, Curtis DJ, Van Vlierberghe P, Berx G, Taghon T, Haigh JJ.

Haematologica. 2019 Aug;104(8):1608-1616. doi: 10.3324/haematol.2018.207837. Epub 2019 Jan 24.


Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation.

de Silva HD, Ffrench RA, Korem M, Orlowski E, Curtis DJ, Spencer A, Avery S, Patil S, Morrissey CO.

Clin Transl Immunology. 2018 Oct 5;7(10):e1040. doi: 10.1002/cti2.1040. eCollection 2018.


A novel role for Lyl1 in primitive erythropoiesis.

Chiu SK, Saw J, Huang Y, Sonderegger SE, Wong NC, Powell DR, Beck D, Pimanda JE, Tremblay CS, Curtis DJ.

Development. 2018 Oct 11;145(19). pii: dev162990. doi: 10.1242/dev.162990.


Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.

Tremblay CS, Saw J, Chiu SK, Wong NC, Tsyganov K, Ghotb S, Graham AN, Yan F, Guirguis AA, Sonderegger SE, Lee N, Kalitsis P, Reynolds J, Ting SB, Powell DR, Jane SM, Curtis DJ.

Nat Commun. 2018 Aug 30;9(1):3535. doi: 10.1038/s41467-018-06021-7.


Characterization of Tfrc-mutant mice with microcytic phenotypes.

Conway AJ, Brown FC, Rank G, Kile BT, Morton CJ, Jane SM, Curtis DJ.

Blood Adv. 2018 Aug 14;2(15):1914-1922. doi: 10.1182/bloodadvances.2018018820.


Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency.

Conway AJ, Brown FC, Hortle EJ, Burgio G, Foote SJ, Morton CJ, Jane SM, Curtis DJ.

Dis Model Mech. 2018 May 21;11(5). pii: dmm034678. doi: 10.1242/dmm.034678.


Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome.

Kraakman MJ, Kammoun HL, Dragoljevic D, Al-Sharea A, Lee MKS, Flynn MC, Stolz CJ, Guirguis AA, Lancaster GI, Chin-Dusting J, Curtis DJ, Murphy AJ.

Haematologica. 2018 Apr;103(4):597-606. doi: 10.3324/haematol.2017.181958. Epub 2018 Jan 25.


Control of collagen gel mechanical properties through manipulation of gelation conditions near the sol-gel transition.

Holder AJ, Badiei N, Hawkins K, Wright C, Williams PR, Curtis DJ.

Soft Matter. 2018 Jan 24;14(4):574-580. doi: 10.1039/c7sm01933e.


Local dynamic stability during treadmill walking can detect children with developmental coordination disorder.

Speedtsberg MB, Christensen SB, Stenum J, Kallemose T, Bencke J, Curtis DJ, Jensen BR.

Gait Posture. 2018 Jan;59:99-103. doi: 10.1016/j.gaitpost.2017.09.035. Epub 2017 Oct 5.


The Reliability of the Segmental Assessment of Trunk Control (SATCo) in Children with Cerebral Palsy.

Hansen L, Erhardsen KT, Bencke J, Magnusson SP, Curtis DJ.

Phys Occup Ther Pediatr. 2018 Aug;38(3):291-304. doi: 10.1080/01942638.2017.1337662. Epub 2017 Jul 27.


Specification of neurotransmitter identity by Tal1 in thalamic nuclei.

Lee B, Lee M, Song S, Loi LD, Lam DT, Yoon J, Baek K, Curtis DJ, Jeong Y.

Dev Dyn. 2017 Oct;246(10):749-758. doi: 10.1002/dvdy.24546. Epub 2017 Aug 30.


A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.

Conway AJ, Brown FC, Fullinfaw RO, Kile BT, Jane SM, Curtis DJ.

Dis Model Mech. 2017 Aug 1;10(8):1005-1013. doi: 10.1242/dmm.029116. Epub 2017 Jun 9.


Recommendations for Methicillin-Resistant Staphylococcus aureus Prevention in Adult ICUs: A Cost-Effectiveness Analysis.

Whittington MD, Atherly AJ, Curtis DJ, Lindrooth RC, Bradley CJ, Campbell JD.

Crit Care Med. 2017 Aug;45(8):1304-1310. doi: 10.1097/CCM.0000000000002484.


Loss of Dynamin 2 GTPase function results in microcytic anaemia.

Brown FC, Collett M, Tremblay CS, Rank G, De Camilli P, Booth CJ, Bitoun M, Robinson PJ, Kile BT, Jane SM, Curtis DJ.

Br J Haematol. 2017 Aug;178(4):616-628. doi: 10.1111/bjh.14709. Epub 2017 May 3.


Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma.

Nair AP, Walker P, Kalff A, Bergin K, Hocking J, Avery S, Curtis DJ, Patil S, Das T, Klarica D, Morgan S, Muirhead J, Gorniak M, Reynolds J, Spencer A.

Bone Marrow Transplant. 2017 Jun;52(6):839-845. doi: 10.1038/bmt.2017.37. Epub 2017 Mar 20.


Targeted therapies for T-cell acute lymphoblastic leukaemia (T-ALL): what makes T-ALL TYK?

Curtis DJ.

Br J Haematol. 2017 Apr;177(2):169-170. doi: 10.1111/bjh.14559. Epub 2017 Feb 17. No abstract available.


Screening test recommendations for methicillin-resistant Staphylococcus aureus surveillance practices: A cost-minimization analysis.

Whittington MD, Curtis DJ, Atherly AJ, Bradley CJ, Lindrooth RC, Campbell JD.

Am J Infect Control. 2017 Jul 1;45(7):704-708. doi: 10.1016/j.ajic.2016.12.014. Epub 2017 Jan 23.


Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.

Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ.

Blood. 2017 Feb 23;129(8):981-990. doi: 10.1182/blood-2016-06-721191. Epub 2017 Jan 9.


The functional effect of segmental trunk and head control training in moderate-to-severe cerebral palsy: A randomized controlled trial.

Curtis DJ, Woollacott M, Bencke J, Lauridsen HB, Saavedra S, Bandholm T, Sonne-Holm S.

Dev Neurorehabil. 2018 Feb;21(2):91-100. doi: 10.1080/17518423.2016.1265603. Epub 2017 Jan 3.


In-situ synthesis of magnetic iron-oxide nanoparticle-nanofibre composites using electrospinning.

Burke L, Mortimer CJ, Curtis DJ, Lewis AR, Williams R, Hawkins K, Maffeis TG, Wright CJ.

Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):512-519. doi: 10.1016/j.msec.2016.09.014. Epub 2016 Sep 7.


Impaired postural control in children with developmental coordination disorder is related to less efficient central as well as peripheral control.

Speedtsberg MB, Christensen SB, Andersen KK, Bencke J, Jensen BR, Curtis DJ.

Gait Posture. 2017 Jan;51:1-6. doi: 10.1016/j.gaitpost.2016.09.019. Epub 2016 Sep 24.


Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza.

Rao S, Messacar K, Torok MR, Rick AM, Holzberg J, Montano A, Bagdure D, Curtis DJ, Oberste MS, Nix WA, de Masellis G, Robinson CC, Dominguez SR.

Pediatr Crit Care Med. 2016 Nov;17(11):1023-1031.


Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.

Tremblay CS, Brown FC, Collett M, Saw J, Chiu SK, Sonderegger SE, Lucas SE, Alserihi R, Chau N, Toribio ML, McCormack MP, Chircop M, Robinson PJ, Jane SM, Curtis DJ.

Leukemia. 2016 Oct;30(10):1993-2001. doi: 10.1038/leu.2016.100. Epub 2016 Apr 27.


West Nile infections in pediatric solid organ transplant recipients.

Levi ME, Curtis DJ.

Pediatr Transplant. 2016 Sep;20(6):744-6. doi: 10.1111/petr.12710. Epub 2016 Apr 19. No abstract available.


PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.

Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ.

Cell Death Differ. 2016 Jun;23(6):1049-59. doi: 10.1038/cdd.2015.159. Epub 2016 Jan 8.


Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.

Brown FC, Conway AJ, Cerruti L, Collinge JE, McLean C, Wiley JS, Kile BT, Jane SM, Curtis DJ.

Blood. 2015 Dec 24;126(26):2863-70. doi: 10.1182/blood-2014-10-609362. Epub 2015 Oct 8.


The Effects of Temperature on Clot Microstructure and Strength in Healthy Volunteers.

Lawrence MJ, Marsden N, Mothukuri R, Morris RH, Davies G, Hawkins K, Curtis DJ, Brown MR, Williams PR, Evans PA.

Anesth Analg. 2016 Jan;122(1):21-6. doi: 10.1213/ANE.0000000000000992.


A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era.

Rao S, Torok MR, Bagdure D, Cunningham MA, Williams JT, Curtis DJ, Wilson K, Dominguez SR.

J Clin Virol. 2015 Oct;71:44-50. doi: 10.1016/j.jcv.2015.07.308. Epub 2015 Jul 29.


Monosomal karyotype predicts inferior survival independently of a complex karyotype in patients with myelodysplastic syndromes.

McQuilten ZK, Sundararajan V, Andrianopoulos N, Curtis DJ, Wood EM, Campbell LJ, Wall M.

Cancer. 2015 Sep 1;121(17):2892-9. doi: 10.1002/cncr.29396. Epub 2015 Jun 4.


Transcriptomic Analysis of Yersinia enterocolitica Biovar 1B Infecting Murine Macrophages Reveals New Mechanisms of Extracellular and Intracellular Survival.

Bent ZW, Poorey K, Brazel DM, LaBauve AE, Sinha A, Curtis DJ, House SE, Tew KE, Hamblin RY, Williams KP, Branda SS, Young GM, Meagher RJ.

Infect Immun. 2015 Jul;83(7):2672-85. doi: 10.1128/IAI.02922-14. Epub 2015 Apr 20.


Characterization of functional antibody and memory B-cell responses to pH1N1 monovalent vaccine in HIV-infected children and youth.

Curtis DJ, Muresan P, Nachman S, Fenton T, Richardson KM, Dominguez T, Flynn PM, Spector SA, Cunningham CK, Bloom A, Weinberg A.

PLoS One. 2015 Mar 18;10(3):e0118567. doi: 10.1371/journal.pone.0118567. eCollection 2015.


Measuring postural sway in sitting: a new segmental approach.

Curtis DJ, Hansen L, Luun M, Løberg R, Woollacott M, Saavedra S, Sonne-Holm S, Berggreen S, Bencke J.

J Mot Behav. 2015;47(5):427-35. doi: 10.1080/00222895.2014.1003782. Epub 2015 Mar 2.


Effects of unidirectional flow shear stresses on the formation, fractal microstructure and rigidity of incipient whole blood clots and fibrin gels.

Badiei N, Sowedan AM, Curtis DJ, Brown MR, Lawrence MJ, Campbell AI, Sabra A, Evans PA, Weisel JW, Chernysh IN, Nagaswami C, Williams PR, Hawkins K.

Clin Hemorheol Microcirc. 2015;60(4):451-64. doi: 10.3233/CH-151924.


ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ.

Nat Commun. 2015 Jan 7;6:5794. doi: 10.1038/ncomms6794.


The central role of trunk control in the gross motor function of children with cerebral palsy: a retrospective cross-sectional study.

Curtis DJ, Butler P, Saavedra S, Bencke J, Kallemose T, Sonne-Holm S, Woollacott M.

Dev Med Child Neurol. 2015 Apr;57(4):351-7. doi: 10.1111/dmcn.12641. Epub 2014 Nov 20.


A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism.

Lawrence MJ, Sabra A, Mills G, Pillai SG, Abdullah W, Hawkins K, Morris RH, Davidson SJ, D'Silva LA, Curtis DJ, Brown MR, Weisel JW, Williams PR, Evans PA.

Br J Haematol. 2015 Feb;168(4):571-5. doi: 10.1111/bjh.13173. Epub 2014 Oct 10.


The effect of training in an interactive dynamic stander on ankle dorsiflexion and gross motor function in children with cerebral palsy.

Curtis DJ, Bencke J, Mygind B.

Dev Neurorehabil. 2014 Dec;17(6):393-7. doi: 10.3109/17518423.2013.844738. Epub 2014 May 27.


The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia.

Tremblay CS, Curtis DJ.

Curr Opin Hematol. 2014 Jul;21(4):320-5. doi: 10.1097/MOH.0000000000000058. Review.


Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions.

Curtis DJ, Sood A, Phillips TJ, Leinster VH, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, Cornes L, Giugliano M, Barone RA, Matsusaki M, Akashi M, Tanaka HY, Kano M, McGarvey J, Halemani ND, Simon K, Keehan R, Ind W, Masters T, Grant S, Athwal S, Collett G, Tannetta D, Sargent IL, Scull-Brown E, Liu X, Aquilina K, Cohen N, Lane JD, Thoresen M, Hanley J, Randall A, Case CP.

Exp Neurol. 2014 Nov;261:386-95. doi: 10.1016/j.expneurol.2014.05.003. Epub 2014 May 10.


Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population-based data linkage study.

McQuilten ZK, Wood EM, Polizzotto MN, Campbell LJ, Wall M, Curtis DJ, Farrugia H, McNeil JJ, Sundararajan V.

Cancer. 2014 Jun 1;120(11):1686-94. doi: 10.1002/cncr.28641. Epub 2014 Mar 18.


Vaccine strain varicella-zoster virus-induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency.

Sabry A, Hauk PJ, Jing H, Su HC, Stence NV, Mirsky DM, Nagel MA, Abbott JK, Dragone LL, Armstrong-Wells J, Curtis DJ, Cohrs R, Schmid DS, Gilden D, Gelfand EW.

J Allergy Clin Immunol. 2014 Apr;133(4):1225-1227. doi: 10.1016/j.jaci.2013.11.031. Epub 2014 Jan 11. No abstract available.


The fusion partner specifies the oncogenic potential of NUP98 fusion proteins.

Saw J, Curtis DJ, Hussey DJ, Dobrovic A, Aplan PD, Slape CI.

Leuk Res. 2013 Dec;37(12):1668-73. doi: 10.1016/j.leukres.2013.09.013. Epub 2013 Sep 21.


Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.

McCormack MP, Shields BJ, Jackson JT, Nasa C, Shi W, Slater NJ, Tremblay CS, Rabbitts TH, Curtis DJ.

Blood. 2013 Sep 19;122(12):2093-103. doi: 10.1182/blood-2012-09-458570. Epub 2013 Aug 7.


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