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Natural history of neurological improvement following complete (AIS A) thoracic spinal cord injury across three registries to guide acute clinical trial design and interpretation.

Aimetti AA, Kirshblum S, Curt A, Mobley J, Grossman RG, Guest JD.

Spinal Cord. 2019 Jun 10. doi: 10.1038/s41393-019-0299-8. [Epub ahead of print]


RE-CODE DCM (REsearch Objectives and Common Data Elements for Degenerative Cervical Myelopathy): A Consensus Process to Improve Research Efficiency in DCM, Through Establishment of a Standardized Dataset for Clinical Research and the Definition of the Research Priorities.

Davies BM, Khan DZ, Mowforth OD, McNair AGK, Gronlund T, Kolias AG, Tetreault L, Starkey ML, Sadler I, Sarewitz E, Houlton D, Carter J, Kalsi-Ryan S, Aarabi B, Kwon BK, Kurpad SN, Harrop J, Wilson JR, Grossman R, Curt A, Fehlings MG, Kotter MRN.

Global Spine J. 2019 May;9(1 Suppl):65S-76S. doi: 10.1177/2192568219832855. Epub 2019 May 8.


Segmental differences of cervical spinal cord motion: advancing from confounders to a diagnostic tool.

Hupp M, Vallotton K, Brockmann C, Huwyler S, Rosner J, Sutter R, Klarhoefer M, Freund P, Farshad M, Curt A.

Sci Rep. 2019 May 15;9(1):7415. doi: 10.1038/s41598-019-43908-x.


Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury.

Vallotton K, Huber E, Sutter R, Curt A, Hupp M, Freund P.

Neurology. 2019 Jun 11;92(24):e2793-e2802. doi: 10.1212/WNL.0000000000007642. Epub 2019 May 15.


Repeated assessment of key clinical walking measures can induce confounding practice effects.

Meyer C, Killeen T, Lörincz L, Curt A, Bolliger M, Linnebank M, Zörner B, Filli L.

Mult Scler. 2019 May 13:1352458519845839. doi: 10.1177/1352458519845839. [Epub ahead of print]


The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury.

Blight AR, Hsieh J, Curt A, Fawcett JW, Guest JD, Kleitman N, Kurpad SN, Kwon BK, Lammertse DP, Weidner N, Steeves JD.

Spinal Cord. 2019 May;57(5):348-359. doi: 10.1038/s41393-019-0276-2. Epub 2019 Apr 8. Review.


Perseverance is required!

Curt A.

Spinal Cord. 2019 May;57(5):347. doi: 10.1038/s41393-019-0277-1. Epub 2019 Apr 8. No abstract available.


Familiarization with treadmill walking: How much is enough?

Meyer C, Killeen T, Easthope CS, Curt A, Bolliger M, Linnebank M, Zörner B, Filli L.

Sci Rep. 2019 Mar 26;9(1):5232. doi: 10.1038/s41598-019-41721-0.


Probing Corticospinal Control During Different Locomotor Tasks Using Detailed Time-Frequency Analysis of Electromyograms.

Filli L, Meyer C, Killeen T, Lörincz L, Göpfert B, Linnebank M, von Tscharner V, Curt A, Bolliger M, Zörner B.

Front Neurol. 2019 Jan 29;10:17. doi: 10.3389/fneur.2019.00017. eCollection 2019.


MR Spectroscopy of the Cervical Spinal Cord in Chronic Spinal Cord Injury.

Wyss PO, Huber E, Curt A, Kollias S, Freund P, Henning A.

Radiology. 2019 Apr;291(1):131-138. doi: 10.1148/radiol.2018181037. Epub 2019 Jan 29.


Sensorimotor plasticity after spinal cord injury: a longitudinal and translational study.

Jutzeler CR, Streijger F, Aguilar J, Shortt K, Manouchehri N, Okon E, Hupp M, Curt A, Kwon BK, Kramer JLK.

Ann Clin Transl Neurol. 2018 Dec 1;6(1):68-82. doi: 10.1002/acn3.679. eCollection 2019 Jan.


Not Hot, but Sharp: Dissociation of Pinprick and Heat Perception in Snake Eye Appearance Myelopathy.

Rosner J, Hubli M, Hostettler P, Jutzeler CR, Kramer JLK, Curt A.

Front Neurol. 2018 Dec 21;9:1144. doi: 10.3389/fneur.2018.01144. eCollection 2018.


Reliability of Wearable-Sensor-Derived Measures of Physical Activity in Wheelchair-Dependent Spinal Cord Injured Patients.

Schneider S, Popp WL, Brogioli M, Albisser U, Demkó L, Debecker I, Velstra IM, Gassert R, Curt A.

Front Neurol. 2018 Dec 10;9:1039. doi: 10.3389/fneur.2018.01039. eCollection 2018.


Cold evoked potentials: Acquisition from cervical dermatomes.

Rosner J, Rinert J, Ernst M, Curt A, Hubli M.

Neurophysiol Clin. 2019 Feb;49(1):49-57. doi: 10.1016/j.neucli.2018.11.003. Epub 2018 Dec 11.


Author response: Progressive neurodegeneration following spinal cord injury: Implications for clinical trials.

Freund P, Thompson A, Curt A, Hupp M, Weiskopf N, Grabher P, Altmann D, Friston K, Ashburner J, Ziegler G.

Neurology. 2018 Nov 20;91(21):985. doi: 10.1212/WNL.0000000000006540. No abstract available.


Overground walking patterns after chronic incomplete spinal cord injury show distinct response patterns to unloading.

Easthope CS, Traini LR, Awai L, Franz M, Rauter G, Curt A, Bolliger M.

J Neuroeng Rehabil. 2018 Nov 12;15(1):102. doi: 10.1186/s12984-018-0436-1.


Progression of Neuropathic Pain after Acute Spinal Cord Injury: A Meta-Analysis and Framework for Clinical Trials.

Warner FM, Cragg JJ, Jutzeler CR, Finnerup NB, Werhagen L, Weidner N, Maier D, Kalke YB, Curt A, Kramer JLK.

J Neurotrauma. 2019 May 1;36(9):1461-1468. doi: 10.1089/neu.2018.5960. Epub 2018 Dec 18.


Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury.

Seif M, Curt A, Thompson AJ, Grabher P, Weiskopf N, Freund P.

Neuroimage Clin. 2018 Aug 19;20:556-563. doi: 10.1016/j.nicl.2018.08.026. eCollection 2018.


Arm swing asymmetry in overground walking.

Killeen T, Elshehabi M, Filli L, Hobert MA, Hansen C, Rieger D, Brockmann K, Nussbaum S, Zörner B, Bolliger M, Curt A, Berg D, Maetzler W.

Sci Rep. 2018 Aug 24;8(1):12803. doi: 10.1038/s41598-018-31151-9.


Normative data of contact heat evoked potentials from the lower extremities.

Rosner J, Hostettler P, Scheuren PS, Sirucek L, Rinert J, Curt A, Kramer JLK, Jutzeler CR, Hubli M.

Sci Rep. 2018 Jul 20;8(1):11003. doi: 10.1038/s41598-018-29145-8.


Estimation of Energy Expenditure in Wheelchair-Bound Spinal Cord Injured Individuals Using Inertial Measurement Units.

Popp WL, Richner L, Brogioli M, Wilms B, Spengler CM, Curt AEP, Starkey ML, Gassert R.

Front Neurol. 2018 Jul 3;9:478. doi: 10.3389/fneur.2018.00478. eCollection 2018.


Early urological care of patients with spinal cord injury.

Welk B, Schneider MP, Thavaseelan J, Traini LR, Curt A, Kessler TM.

World J Urol. 2018 Oct;36(10):1537-1544. doi: 10.1007/s00345-018-2367-7. Epub 2018 Jun 9. Review.


Raising awareness for spinal cord injury research.

Schwab JM, Maas AIR, Hsieh JTC, Curt A.

Lancet Neurol. 2018 Jul;17(7):581-582. doi: 10.1016/S1474-4422(18)30206-0. No abstract available.


First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury.

Kucher K, Johns D, Maier D, Abel R, Badke A, Baron H, Thietje R, Casha S, Meindl R, Gomez-Mancilla B, Pfister C, Rupp R, Weidner N, Mir A, Schwab ME, Curt A.

Neurorehabil Neural Repair. 2018 Jun;32(6-7):578-589. doi: 10.1177/1545968318776371. Epub 2018 Jun 5.


Early neurological care of patients with spinal cord injury.

Kessler TM, Traini LR, Welk B, Schneider MP, Thavaseelan J, Curt A.

World J Urol. 2018 Oct;36(10):1529-1536. doi: 10.1007/s00345-018-2343-2. Epub 2018 May 28. Review.


Lower extremity outcome measures: considerations for clinical trials in spinal cord injury.

Bolliger M, Blight AR, Field-Fote EC, Musselman K, Rossignol S, Barthélemy D, Bouyer L, Popovic MR, Schwab JM, Boninger ML, Tansey KE, Scivoletto G, Kleitman N, Jones LAT, Gagnon DH, Nadeau S, Haupt D, Awai L, Easthope CS, Zörner B, Rupp R, Lammertse D, Curt A, Steeves J.

Spinal Cord. 2018 Jul;56(7):628-642. doi: 10.1038/s41393-018-0097-8. Epub 2018 Apr 27. Review.


Prediction of autonomic dysreflexia during urodynamics: a prospective cohort study.

Walter M, Knüpfer SC, Cragg JJ, Leitner L, Schneider MP, Mehnert U, Krassioukov AV, Schubert M, Curt A, Kessler TM.

BMC Med. 2018 Apr 13;16(1):53. doi: 10.1186/s12916-018-1040-8.


Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time.

Filli L, Sutter T, Easthope CS, Killeen T, Meyer C, Reuter K, Lörincz L, Bolliger M, Weller M, Curt A, Straumann D, Linnebank M, Zörner B.

Sci Rep. 2018 Mar 21;8(1):4984. doi: 10.1038/s41598-018-22676-0.


Progressive neurodegeneration following spinal cord injury: Implications for clinical trials.

Ziegler G, Grabher P, Thompson A, Altmann D, Hupp M, Ashburner J, Friston K, Weiskopf N, Curt A, Freund P.

Neurology. 2018 Apr 3;90(14):e1257-e1266. doi: 10.1212/WNL.0000000000005258. Epub 2018 Mar 7.


In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study.

Wolf K, Hupp M, Friedl S, Sutter R, Klarhöfer M, Grabher P, Freund P, Curt A.

Spinal Cord. 2018 Aug;56(8):769-776. doi: 10.1038/s41393-018-0075-1. Epub 2018 Mar 1.


Prediction of bladder outcomes after ischemic spinal cord injury: A longitudinal cohort study from the European multicenter study about spinal cord injury.

Scivoletto G, Pavese C, Bachmann LM, Schubert M, Curt A, Finazzi Agro E, Kessels AG, Kessler TM.

Neurourol Urodyn. 2018 Jun;37(5):1779-1784. doi: 10.1002/nau.23521. Epub 2018 Feb 21.


Contact heat evoked potentials: Reliable acquisition from lower extremities.

Rosner J, Hubli M, Hostettler P, Scheuren PS, Rinert J, Kramer JLK, Hupp M, Curt A, Jutzeler CR.

Clin Neurophysiol. 2018 Mar;129(3):584-591. doi: 10.1016/j.clinph.2017.12.034. Epub 2018 Jan 7.


The Spinal Cord Ability Ruler (SCAR) complements the Spinal Cord Independence Measure (SCIM).

Steeves J, Curt A, Mehra M, Rupp R, Blight A, Maier D, Jones L, Lammertse D, Abel R, Kirshblum S, Weidner N.

Spinal Cord. 2018 May;56(5):525-526. doi: 10.1038/s41393-018-0064-4. Epub 2018 Jan 31. No abstract available.


Considerations and recommendations for selection and utilization of upper extremity clinical outcome assessments in human spinal cord injury trials.

Jones LAT, Bryden A, Wheeler TL, Tansey KE, Anderson KD, Beattie MS, Blight A, Curt A, Field-Fote E, Guest JD, Hseih J, Jakeman LB, Kalsi-Ryan S, Krisa L, Lammertse DP, Leiby B, Marino R, Schwab JM, Scivoletto G, Tulsky DS, Wirth E, Zariffa J, Kleitman N, Mulcahey MJ, Steeves JD.

Spinal Cord. 2018 May;56(5):414-425. doi: 10.1038/s41393-017-0015-5. Epub 2017 Dec 28. Review.


Home-Based Virtual Reality-Augmented Training Improves Lower Limb Muscle Strength, Balance, and Functional Mobility following Chronic Incomplete Spinal Cord Injury.

Villiger M, Liviero J, Awai L, Stoop R, Pyk P, Clijsen R, Curt A, Eng K, Bolliger M.

Front Neurol. 2017 Nov 28;8:635. doi: 10.3389/fneur.2017.00635. eCollection 2017.


The Graded and Redefined Assessment of Strength, Sensibility, and Prehension Version 2 Provides Interval Measure Properties.

Velstra IM, Fellinghauer C, Abel R, Kalsi-Ryan S, Rupp R, Curt A.

J Neurotrauma. 2018 Mar 15;35(6):854-863. doi: 10.1089/neu.2017.5195. Epub 2018 Jan 16.


Physical therapy is targeted and adjusted over time for the rehabilitation of locomotor function in acute spinal cord injury interventions in physical and sports therapy.

Franz M, Richner L, Wirz M, von Reumont A, Bergner U, Herzog T, Popp W, Bach K, Weidner N, Curt A.

Spinal Cord. 2018 Feb;56(2):158-167. doi: 10.1038/s41393-017-0007-5. Epub 2017 Oct 23.


Ten Meters Walking Speed in Spinal Cord-Injured Patients: Does Speed Predict Who Walks and Who Rolls?

van Silfhout L, Hosman AJF, Bartels RHMA, Edwards MJR, Abel R, Curt A, van de Meent H; EM-SCI Study Group.

Neurorehabil Neural Repair. 2017 Sep;31(9):842-850. doi: 10.1177/1545968317723751. Epub 2017 Aug 8.


A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury.

Mignardot JB, Le Goff CG, van den Brand R, Capogrosso M, Fumeaux N, Vallery H, Anil S, Lanini J, Fodor I, Eberle G, Ijspeert A, Schurch B, Curt A, Carda S, Bloch J, von Zitzewitz J, Courtine G.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaah3621. doi: 10.1126/scitranslmed.aah3621.


Assessing structure and function of myelin in cervical spondylotic myelopathy: Evidence of demyelination.

Liu H, MacMillian EL, Jutzeler CR, Ljungberg E, MacKay AL, Kolind SH, Mädler B, Li DKB, Dvorak MF, Curt A, Laule C, Kramer JLK.

Neurology. 2017 Aug 8;89(6):602-610. doi: 10.1212/WNL.0000000000004197. Epub 2017 Jul 12. Erratum in: Neurology. 2018 Jan 23;90(4):200.


Emerging Safety of Intramedullary Transplantation of Human Neural Stem Cells in Chronic Cervical and Thoracic Spinal Cord Injury.

Levi AD, Okonkwo DO, Park P, Jenkins AL 3rd, Kurpad SN, Parr AM, Ganju A, Aarabi B, Kim D, Casha S, Fehlings MG, Harrop JS, Anderson KD, Gage A, Hsieh J, Huhn S, Curt A, Guzman R.

Neurosurgery. 2018 Apr 1;82(4):562-575. doi: 10.1093/neuros/nyx250.


Definitions of traumatic conus medullaris and cauda equina syndrome: a systematic literature review.

Brouwers E, van de Meent H, Curt A, Starremans B, Hosman A, Bartels R.

Spinal Cord. 2017 Oct;55(10):886-890. doi: 10.1038/sc.2017.54. Epub 2017 May 23. Review.


Minimum toe clearance: probing the neural control of locomotion.

Killeen T, Easthope CS, Demkó L, Filli L, Lőrincz L, Linnebank M, Curt A, Zörner B, Bolliger M.

Sci Rep. 2017 May 15;7(1):1922. doi: 10.1038/s41598-017-02189-y.


Traumatic spinal cord injury.

Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, Fehlings MG.

Nat Rev Dis Primers. 2017 Apr 27;3:17018. doi: 10.1038/nrdp.2017.18. Review.


Challenges to Translation and the Hippocratic Oath by Premature Termination of Spinal Cord Stem Cell-Based Trials.

Curt A, Levi AD, Schwab JM.

JAMA Neurol. 2017 Jun 1;74(6):635-636. doi: 10.1001/jamaneurol.2017.0318. No abstract available. Erratum in: JAMA Neurol. 2017 Jun 1;74(6):747.


Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?

Huber E, Lachappelle P, Sutter R, Curt A, Freund P.

Ann Neurol. 2017 May;81(5):740-748. doi: 10.1002/ana.24932.


Preserved gait kinematics during controlled body unloading.

Awai L, Franz M, Easthope CS, Vallery H, Curt A, Bolliger M.

J Neuroeng Rehabil. 2017 Apr 4;14(1):25. doi: 10.1186/s12984-017-0239-9.


Spinal cord ability ruler: an interval scale to measure volitional performance after spinal cord injury.

Reed R, Mehra M, Kirshblum S, Maier D, Lammertse D, Blight A, Rupp R, Jones L, Abel R, Weidner N; EMSCI Study Group; SCOPE, Curt A, Steeves J.

Spinal Cord. 2017 Aug;55(8):730-738. doi: 10.1038/sc.2017.1. Epub 2017 Mar 21.


Increasing cognitive load attenuates right arm swing in healthy human walking.

Killeen T, Easthope CS, Filli L, Lőrincz L, Schrafl-Altermatt M, Brugger P, Linnebank M, Curt A, Zörner B, Bolliger M.

R Soc Open Sci. 2017 Jan 25;4(1):160993. doi: 10.1098/rsos.160993. eCollection 2017 Jan.


Improved Diagnosis of Cervical Spondylotic Myelopathy with Contact Heat Evoked Potentials.

Jutzeler CR, Ulrich A, Huber B, Rosner J, Kramer JLK, Curt A.

J Neurotrauma. 2017 Jun 15;34(12):2045-2053. doi: 10.1089/neu.2016.4891. Epub 2017 Apr 7.

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