Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 635


Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9.

Stephens CJ, Lauron EJ, Kashentseva E, Lu ZH, Yokoyama WM, Curiel DT.

J Control Release. 2019 Mar 28;298:128-141. doi: 10.1016/j.jconrel.2019.02.009. Epub 2019 Feb 13.


Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents.

González-Pastor R, Ashshi AM, El-Shemi AG, Dmitriev IP, Kashentseva EA, Lu ZH, Goedegebuure SP, Podhajcer OL, Curiel DT.

J Ovarian Res. 2019 Feb 15;12(1):18. doi: 10.1186/s13048-019-0493-5.


Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer.

Mooney R, Majid AA, Batalla-Covello J, Machado D, Liu X, Gonzaga J, Tirughana R, Hammad M, Lesniak MS, Curiel DT, Aboody KS.

Mol Ther Oncolytics. 2018 Dec 13;12:79-92. doi: 10.1016/j.omto.2018.12.003. eCollection 2019 Mar 29.


Capsid-Incorporation Strategy To Display Antigens for an Alternative Adenoviral Vector Vaccine Approach.

van Winkel CAJ, Moreno A, Curiel DT.

Mol Pharm. 2018 Dec 3;15(12):5446-5453. doi: 10.1021/acs.molpharmaceut.8b00591. Epub 2018 Nov 6.


Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs.

Chondronasiou D, Eisden TTHD, Stam AGM, Matthews QL, Icyuz M, Hooijberg E, Dmitriev I, Curiel DT, de Gruijl TD, van de Ven R.

Vaccines (Basel). 2018 Jul 18;6(3). pii: E42. doi: 10.3390/vaccines6030042.


Inclusion of the murine IgGκ signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine.

Fonseca JA, McCaffery JN, Caceres J, Kashentseva E, Singh B, Dmitriev IP, Curiel DT, Moreno A.

Vaccine. 2018 May 11;36(20):2799-2808. doi: 10.1016/j.vaccine.2018.03.091. Epub 2018 Apr 12.


Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9.

Stephens CJ, Kashentseva E, Everett W, Kaliberova L, Curiel DT.

Gene Ther. 2018 Apr;25(2):139-156. doi: 10.1038/s41434-018-0003-1. Epub 2018 Mar 27.


Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer.

Kuroki LM, Jin X, Dmitriev IP, Kashentseva EA, Powell MA, Mutch DG, Dietz AB, Curiel DT, Hawkins WG, Spitzer D.

PLoS One. 2017 Dec 21;12(12):e0190125. doi: 10.1371/journal.pone.0190125. eCollection 2017.


Development of an adenovirus vector vaccine platform for targeting dendritic cells.

Sharma PK, Dmitriev IP, Kashentseva EA, Raes G, Li L, Kim SW, Lu ZH, Arbeit JM, Fleming TP, Kaliberov SA, Goedegebuure SP, Curiel DT, Gillanders WE.

Cancer Gene Ther. 2018 Feb;25(1-2):27-38. doi: 10.1038/s41417-017-0002-1. Epub 2017 Dec 15.


A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice.

Fonseca JA, McCaffery JN, Kashentseva E, Singh B, Dmitriev IP, Curiel DT, Moreno A.

Vaccine. 2017 May 31;35(24):3239-3248. doi: 10.1016/j.vaccine.2017.04.062. Epub 2017 May 5.


Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs.

Naoum GE, Zhu ZB, Buchsbaum DJ, Curiel DT, Arafat WO.

Clin Transl Med. 2017 Dec;6(1):11. doi: 10.1186/s40169-017-0140-y. Epub 2017 Mar 1.


A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector.

Lu ZH, Kaliberov S, Sohn RE, Kaliberova L, Du Y, Prior JL, Leib DJ, Chauchereau A, Sehn JK, Curiel DT, Arbeit JM.

Oncotarget. 2017 Feb 14;8(7):12272-12289. doi: 10.18632/oncotarget.14699.


COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells.

Prima V, Kaliberova LN, Kaliberov S, Curiel DT, Kusmartsev S.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1117-1122. doi: 10.1073/pnas.1612920114. Epub 2017 Jan 17.


CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter.

Bhatia S, O'Bryan SM, Rivera AA, Curiel DT, Mathis JM.

Oncolytic Virother. 2016 Nov 11;5:99-113. eCollection 2016.


Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome.

Wambach JA, Yang P, Wegner DJ, Heins HB, Kaliberova LN, Kaliberov SA, Curiel DT, White FV, Hamvas A, Hackett BP, Cole FS.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):716-721.


A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens.

Cabrera-Mora M, Fonseca JA, Singh B, Zhao C, Makarova N, Dmitriev I, Curiel DT, Blackwell J, Moreno A.

J Immunol. 2016 Oct 1;197(7):2748-61. doi: 10.4049/jimmunol.1501926. Epub 2016 Aug 29.


A One Health overview, facilitating advances in comparative medicine and translational research.

Stroud C, Dmitriev I, Kashentseva E, Bryan JN, Curiel DT, Rindt H, Reinero C, Henry CJ, Bergman PJ, Mason NJ, Gnanandarajah JS, Engiles JB, Gray F, Laughlin D, Gaurnier-Hausser A, Wallecha A, Huebner M, Paterson Y, O'Connor D, Treml LS, Stannard JP, Cook JL, Jacobs M, Wyckoff GJ, Likins L, Sabbagh U, Skaff A, Guloy AS, Hays HD, LeBlanc AK, Coates JR, Katz ML, Lyons LA, Johnson GC, Johnson GS, O'Brien DP, Duan D, Calvet JP, Gandolfi B, Baron DA, Weiss ML, Webster DA, Karanu FN, Robb EJ, Harman RJ.

Clin Transl Med. 2016 Aug;5(Suppl 1):26. doi: 10.1186/s40169-016-0107-4.


A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection.

Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S.

Clin Vaccine Immunol. 2016 Sep 6;23(9):774-84. doi: 10.1128/CVI.00730-15. Print 2016 Sep.


Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer.

Ashshi AM, El-Shemi AG, Dmitriev IP, Kashentseva EA, Curiel DT.

J Ovarian Res. 2016 Jun 27;9(1):38. doi: 10.1186/s13048-016-0248-5.


Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.

Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D.

Sci Rep. 2016 May 4;6:25217. doi: 10.1038/srep25217. No abstract available.


A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine.

Fonseca JA, Cabrera-Mora M, Kashentseva EA, Villegas JP, Fernandez A, Van Pelt A, Dmitriev IP, Curiel DT, Moreno A.

PLoS One. 2016 Apr 29;11(4):e0154819. doi: 10.1371/journal.pone.0154819. eCollection 2016.


Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.

Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D.

Sci Rep. 2016 Mar 3;6:22661. doi: 10.1038/srep22661. Erratum in: Sci Rep. 2016 May 04;6:25217.


Enhancing Adenoviral-Mediated Gene Transfer and Expression to Endometrial Cells.

Othman ER, Curiel DT, Hussein M, Abdelaal II, Fetih AN, Al-Hendy A.

Reprod Sci. 2016 Aug;23(8):1109-15. doi: 10.1177/1933719116630420. Epub 2016 Feb 10.


Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels.

Buggio M, Towe C, Annan A, Kaliberov S, Lu ZH, Stephens C, Arbeit JM, Curiel DT.

J Gene Med. 2016 Jan-Mar;18(1-3):38-44. doi: 10.1002/jgm.2874.


Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.


A Multi Targeting Conditionally Replicating Adenovirus Displays Enhanced Oncolysis while Maintaining Expression of Immunotherapeutic Agents.

Dobbins GC, Ugai H, Curiel DT, Gillespie GY.

PLoS One. 2015 Dec 21;10(12):e0145272. doi: 10.1371/journal.pone.0145272. eCollection 2015.


A Genetically Modified Adenoviral Vector with a Phage Display-Derived Peptide Incorporated into Fiber Fibritin Chimera Prolongs Survival in Experimental Glioma.

Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Morshed RA, Miska J, Ahmed AU, Balyasnikova IV, Han Y, Zhang L, Curiel DT, Lesniak MS.

Hum Gene Ther. 2015 Sep;26(9):635-46. doi: 10.1089/hum.2015.008. Epub 2015 Aug 11.


Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.

Beatty MS, Timares L, Curiel DT.

Cancer Gene Ther. 2015 Mar;22(4):222. doi: 10.1038/cgt.2015.13.


The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.

Ghisays F, Brace CS, Yackly SM, Kwon HJ, Mills KF, Kashentseva E, Dmitriev IP, Curiel DT, Imai SI, Ellenberger T.

Cell Rep. 2015 Mar 17;10(10):1665-1673. doi: 10.1016/j.celrep.2015.02.036. Epub 2015 Mar 12.


Gene therapy for radioprotection.

Everett WH, Curiel DT.

Cancer Gene Ther. 2015 Mar;22(4):172-80. doi: 10.1038/cgt.2015.8. Epub 2015 Feb 27. Review.


A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models.

Weber HL, Gidekel M, Werbajh S, Salvatierra E, Rotondaro C, Sganga L, Haab GA, Curiel DT, Cafferata EG, Podhajcer OL.

Clin Cancer Res. 2015 Apr 1;21(7):1665-74. doi: 10.1158/1078-0432.CCR-14-2316. Epub 2015 Jan 8.


Retargeted oncolytic adenovirus displaying a single variable domain of camelid heavy-chain-only antibody in a fiber protein.

van Erp EA, Kaliberova LN, Kaliberov SA, Curiel DT.

Mol Ther Oncolytics. 2015 Feb 18;2:15001. doi: 10.1038/mto.2015.1. eCollection 2015.


Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157:H7 against fatal systemic intoxication.

Sheoran AS, Dmitriev IP, Kashentseva EA, Cohen O, Mukherjee J, Debatis M, Shearer J, Tremblay JM, Beamer G, Curiel DT, Shoemaker CB, Tzipori S.

Infect Immun. 2015 Jan;83(1):286-91. doi: 10.1128/IAI.02360-14. Epub 2014 Nov 3.


Monitoring of biodistribution and persistence of conditionally replicative adenovirus in a murine model of ovarian cancer using capsid-incorporated mCherry and expression of human somatostatin receptor subtype 2 gene.

Dmitriev IP, Kashentseva EA, Kim KH, Matthews QL, Krieger SS, Parry JJ, Nguyen KN, Akers WJ, Achilefu S, Rogers BE, Alvarez RD, Curiel DT.

Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00024.


Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer.

Kawamura YI, Adachi Y, Curiel DT, Kawashima R, Kannagi R, Nishimoto N, Dohi T.

Cancer Gene Ther. 2014 Oct;21(10):427-33. doi: 10.1038/cgt.2014.46. Epub 2014 Sep 12.


Fiber-modified adenovirus for central nervous system Parkinson's disease gene therapy.

Lewis TB, Glasgow JN, Harms AS, Standaert DG, Curiel DT.

Viruses. 2014 Aug 21;6(8):3293-310. doi: 10.3390/v6083293.


Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.

Mukherjee J, Dmitriev I, Debatis M, Tremblay JM, Beamer G, Kashentseva EA, Curiel DT, Shoemaker CB.

PLoS One. 2014 Aug 29;9(8):e106422. doi: 10.1371/journal.pone.0106422. eCollection 2014.


Construction and radiolabeling of adenovirus variants that incorporate human metallothionein into protein IX for analysis of biodistribution.

Liu L, Rogers BE, Aladyshkina N, Cheng B, Lokitz SJ, Curiel DT, Mathis JM.

Mol Imaging. 2014 Sep;13(7). doi: 10.2310/7290.2014.00022.


The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting.

Lu ZH, Kaliberov S, Zhang J, Muz B, Azab AK, Sohn RE, Kaliberova L, Du Y, Curiel DT, Arbeit JM.

Lab Invest. 2014 Aug;94(8):881-92. doi: 10.1038/labinvest.2014.78. Epub 2014 Jun 23.


Adenoviral targeting using genetically incorporated camelid single variable domains.

Kaliberov SA, Kaliberova LN, Buggio M, Tremblay JM, Shoemaker CB, Curiel DT.

Lab Invest. 2014 Aug;94(8):893-905. doi: 10.1038/labinvest.2014.82. Epub 2014 Jun 16.


Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus.

Kaliberov SA, Kaliberova LN, Buchsbaum DJ, Curiel DT.

Cancer Gene Ther. 2014 Jul;21(7):264-74. doi: 10.1038/cgt.2014.26. Epub 2014 Jun 6.


Characterization of the canine mda-7 gene, transcripts and expression patterns.

Sandey M, Bird RC, Das SK, Sarkar D, Curiel DT, Fisher PB, Smith BF.

Gene. 2014 Aug 15;547(1):23-33. doi: 10.1016/j.gene.2014.05.054. Epub 2014 May 24.


Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes.

Uchino J, Curiel DT, Ugai H.

PLoS One. 2014 Feb 4;9(2):e87342. doi: 10.1371/journal.pone.0087342. eCollection 2014.


Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice.

Lu ZH, Kaliberov S, Sohn RE, Kaliberova L, Curiel DT, Arbeit JM.

PLoS One. 2013 Dec 23;8(12):e83933. doi: 10.1371/journal.pone.0083933. eCollection 2013.


Retargeting of gene expression using endothelium specific hexon modified adenoviral vector.

Kaliberov SA, Kaliberova LN, Hong Lu Z, Preuss MA, Barnes JA, Stockard CR, Grizzle WE, Arbeit JM, Curiel DT.

Virology. 2013 Dec;447(1-2):312-25. doi: 10.1016/j.virol.2013.09.020. Epub 2013 Oct 15.


Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.

Beatty MS, Timares L, Curiel DT.

Cancer Gene Ther. 2013 Aug;20(8):445-52. doi: 10.1038/cgt.2013.39. Epub 2013 Aug 9. Erratum in: Cancer Gene Ther. 2015 Mar;22(4):222. Timares, L [added].


Towards gene therapy of postoperative adhesions: fiber and transcriptional modifications enhance adenovirus targeting towards human adhesion cells.

Nair S, Saed GM, Atta HM, Rajaratnam V, Diamond MP, Curiel DT, Al-Hendy A.

Gynecol Obstet Invest. 2013;76(2):119-24. doi: 10.1159/000353426. Epub 2013 Aug 6.


Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV).

Azab BM, Dash R, Das SK, Bhutia SK, Sarkar S, Shen XN, Quinn BA, Dent P, Dmitriev IP, Wang XY, Curiel DT, Pellecchia M, Reed JC, Sarkar D, Fisher PB.

J Cell Physiol. 2014 Jan;229(1):34-43. doi: 10.1002/jcp.24408.


Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas.

Nair S, Curiel DT, Rajaratnam V, Thota C, Al-Hendy A.

Hum Reprod. 2013 Sep;28(9):2398-406. doi: 10.1093/humrep/det275. Epub 2013 Jul 2.


A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer.

Kim KH, Dmitriev IP, Saddekni S, Kashentseva EA, Harris RD, Aurigemma R, Bae S, Singh KP, Siegal GP, Curiel DT, Alvarez RD.

Gynecol Oncol. 2013 Sep;130(3):518-24. doi: 10.1016/j.ygyno.2013.06.003. Epub 2013 Jun 10.

Supplemental Content

Loading ...
Support Center