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Items: 23


Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.

Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170072. doi: 10.1098/rstb.2017.0072.


SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.

Gribling-Burrer AS, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer-Charlier N, Cura V, Barkats M, Cavarelli J, Massenet S, Allmang C.

Nucleic Acids Res. 2017 May 19;45(9):5399-5413. doi: 10.1093/nar/gkx031.


Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J.

FEBS J. 2017 Jan;284(1):77-96. doi: 10.1111/febs.13953. Epub 2016 Nov 23.


TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J.

Sci Rep. 2016 Jan 27;6:19725. doi: 10.1038/srep19725.


Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.

Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianférani S, Cavarelli J.

J Struct Biol. 2015 Aug;191(2):175-83. doi: 10.1016/j.jsb.2015.06.017. Epub 2015 Jun 18.


Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.

Cura V, Troffer-Charlier N, Wurtz JM, Bonnefond L, Cavarelli J.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2401-12. doi: 10.1107/S1399004714014278. Epub 2014 Aug 29.


Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.

Cura V, Troffer-Charlier N, Lambert MA, Bonnefond L, Cavarelli J.

Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):80-6. doi: 10.1107/S2053230X13032871. Epub 2013 Dec 24.


Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C.

PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26.


Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, Poussin-Courmontagne P, Cura V, Brimer N, Babah KO, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Travé G.

Science. 2013 Feb 8;339(6120):694-8. doi: 10.1126/science.1229934.


Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G.

J Med Chem. 2012 Nov 26;55(22):9875-90. doi: 10.1021/jm301097p. Epub 2012 Nov 2.


Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.

Osz J, Brélivet Y, Peluso-Iltis C, Cura V, Eiler S, Ruff M, Bourguet W, Rochel N, Moras D.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E588-94. doi: 10.1073/pnas.1118192109. Epub 2012 Feb 21.


Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Schüle R, Bedford MT, Sippl W, Jung M.

Bioorg Med Chem. 2011 Jun 15;19(12):3717-31. doi: 10.1016/j.bmc.2011.02.032. Epub 2011 Feb 27.


The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.

Diebold ML, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, Romier C.

EMBO J. 2010 Dec 1;29(23):3979-91. doi: 10.1038/emboj.2010.272. Epub 2010 Nov 5.


Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.

Kainov DE, Cura V, Vitorino M, Nierengarten H, Poussin P, Kieffer B, Cavarelli J, Poterszman A.

Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):745-55. doi: 10.1107/S0907444910009844. Epub 2010 Jun 19.


Cleaved thioredoxin fusion protein enables the crystallization of poorly soluble ERalpha in complex with synthetic ligands.

Cura V, Gangloff M, Eiler S, Moras D, Ruff M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):54-7. Epub 2007 Dec 20.


Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains.

Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J.

EMBO J. 2007 Oct 17;26(20):4391-401. Epub 2007 Sep 20.


Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1.

Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):330-3. Epub 2007 Mar 30.


Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetase.

Cura V, Olieric N, Guichard A, Wang ED, Moras D, Eriani G, Cavarelli J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):899-901. Epub 2005 Sep 13.


Study of the different types of actuators and mechanisms for upper limb prostheses.

Cura VO, Cunha FL, Aguiar ML, Cliquet A Jr.

Artif Organs. 2003 Jun;27(6):507-16. Review.


Crystallisation of the glycyl-tRNA synthetase from Thermus thermophilus and initial crystallographic data.

Logan DT, Cura V, Touzel JP, Kern D, Moras D.

J Mol Biol. 1994 Sep 2;241(5):732-5.


Heavy-atom refinement against solvent-flattened phases.

Cura V, Krishnaswamy S, Podjarny AD.

Acta Crystallogr A. 1992 Sep 1;48 ( Pt 5):756-64.


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