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Items: 15


Design, Synthesis, and Biological Evaluation of MEK PROTACs.

Vollmer S, Cunoosamy D, Lv H, Feng H, Li X, Nan Z, Yang W, Perry MWD.

J Med Chem. 2020 Jan 9;63(1):157-162. doi: 10.1021/acs.jmedchem.9b00810. Epub 2019 Dec 20.


Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus.

Jubrail J, Africano-Gomez K, Herit F, Mularski A, Bourdoncle P, Oberg L, Israelsson E, Burgel PR, Mayer G, Cunoosamy DM, Kurian N, Niedergang F.

EMBO Rep. 2020 Jan 7;21(1):e47963. doi: 10.15252/embr.201947963. Epub 2019 Nov 13.


Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies.

Watson A, Spalluto CM, McCrae C, Cellura D, Burke H, Cunoosamy D, Freeman A, Hicks A, Hühn M, Ostridge K, Staples KJ, Vaarala O, Wilkinson T.

Am J Respir Crit Care Med. 2020 Jan 1;201(1):83-94. doi: 10.1164/rccm.201901-0214OC.


Use of precision cut lung slices as a translational model for the study of lung biology.

Liu G, Betts C, Cunoosamy DM, Åberg PM, Hornberg JJ, Sivars KB, Cohen TS.

Respir Res. 2019 Jul 19;20(1):162. doi: 10.1186/s12931-019-1131-x. Review.


MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling.

Baturcam E, Vollmer S, Schlüter H, Maciewicz RA, Kurian N, Vaarala O, Ludwig S, Cunoosamy DM.

Cell Commun Signal. 2019 Jul 18;17(1):78. doi: 10.1186/s12964-019-0378-7.


The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.


HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger.

Jubrail J, Africano-Gomez K, Herit F, Baturcam E, Mayer G, Cunoosamy DM, Kurian N, Niedergang F.

Front Immunol. 2018 Dec 18;9:2908. doi: 10.3389/fimmu.2018.02908. eCollection 2018.


A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.

Wang X, Polverino F, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 Jun 4. doi: 10.1164/rccm.201711-2300OC. [Epub ahead of print]


A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.

Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC.


Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells.

Higham A, Karur P, Jackson N, Cunoosamy DM, Jansson P, Singh D.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 19;13:1279-1288. doi: 10.2147/COPD.S159936. eCollection 2018.


The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.

Patel NR, Cunoosamy DM, Fagerås M, Taib Z, Asimus S, Hegelund-Myrbäck T, Lundin S, Pardali K, Kurian N, Ersdal E, Kristensson C, Korsback K, Palmér R, Brown MN, Greenaway S, Siew L, Clarke GW, Rennard SI, Make BJ, Wise RA, Jansson P.

Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019. doi: 10.2147/COPD.S150576. eCollection 2018.


AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure.

Pehrson R, Hegelund-Myrbäck T, Cunoosamy D, Asimus S, Jansson P, Patel N, Borde A, Lundin S.

J Pharmacol Exp Ther. 2018 Jun;365(3):567-572. doi: 10.1124/jpet.117.246132. Epub 2018 Mar 16.


Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.

Igoe N, Bayle ED, Tallant C, Fedorov O, Meier JC, Savitsky P, Rogers C, Morias Y, Scholze S, Boyd H, Cunoosamy D, Andrews DM, Cheasty A, Brennan PE, Müller S, Knapp S, Fish PV.

J Med Chem. 2017 Aug 24;60(16):6998-7011. doi: 10.1021/acs.jmedchem.7b00611. Epub 2017 Aug 10.


Role of B Cell-Activating Factor in Chronic Obstructive Pulmonary Disease.

Seys LJ, Verhamme FM, Schinwald A, Hammad H, Cunoosamy DM, Bantsimba-Malanda C, Sabirsh A, McCall E, Flavell L, Herbst R, Provoost S, Lambrecht BN, Joos GF, Brusselle GG, Bracke KR.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):706-18. doi: 10.1164/rccm.201501-0103OC.


Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease.

Bracke KR, Verhamme FM, Seys LJ, Bantsimba-Malanda C, Cunoosamy DM, Herbst R, Hammad H, Lambrecht BN, Joos GF, Brusselle GG.

Am J Respir Crit Care Med. 2013 Aug 1;188(3):343-55. doi: 10.1164/rccm.201211-2055OC.


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