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Items: 1 to 50 of 109

1.

eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH.

Sheldon RD, Meers GM, Morris EM, Linden MA, Cunningham RP, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS.

Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E605-E616. doi: 10.1152/ajpendo.00096.2019. Epub 2019 Jul 30.

PMID:
31361543
2.

Ketogenic diet in combination with voluntary exercise impacts markers of hepatic metabolism and oxidative stress in male and female Wistar rats.

Moore MP, Cunningham RP, Kelty TJ, Boccardi LR, Nguyen NY, Booth FW, Rector RS.

Appl Physiol Nutr Metab. 2019 May 22. doi: 10.1139/apnm-2019-0042. [Epub ahead of print]

PMID:
31116955
3.

Compromised Exercise Capacity and Mitochondrial Dysfunction in the Osteogenesis Imperfecta Murine (oim) Mouse Model.

Gremminger VL, Jeong Y, Cunningham RP, Meers GM, Rector RS, Phillips CL.

J Bone Miner Res. 2019 Sep;34(9):1646-1659. doi: 10.1002/jbmr.3732. Epub 2019 Jun 13.

PMID:
30908713
4.

Role of endonuclease III enzymes in uracil repair.

Yang Y, Park SH, Alford-Zappala M, Lee HW, Li J, Cunningham RP, Cao W.

Mutat Res. 2019 Jan;813:20-30. doi: 10.1016/j.mrfmmm.2018.12.001. Epub 2018 Dec 14.

PMID:
30590231
5.

The PX Motif of DNA Binds Specifically to Escherichia coli DNA Polymerase I.

Gao X, Gethers M, Han SP, Goddard WA 3rd, Sha R, Cunningham RP, Seeman NC.

Biochemistry. 2019 Feb 12;58(6):575-581. doi: 10.1021/acs.biochem.8b01148. Epub 2018 Dec 28.

PMID:
30557012
6.

Estrogen receptor-α signaling maintains immunometabolic function in males and is obligatory for exercise-induced amelioration of nonalcoholic fatty liver.

Winn NC, Jurrissen TJ, Grunewald ZI, Cunningham RP, Woodford ML, Kanaley JA, Lubahn DB, Manrique-Acevedo C, Rector RS, Vieira-Potter VJ, Padilla J.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E156-E167. doi: 10.1152/ajpendo.00259.2018. Epub 2018 Dec 4.

PMID:
30512987
7.

Curcumin supplementation mitigates NASH development and progression in female Wistar rats.

Cunningham RP, Moore MP, Moore AN, Healy JC, Roberts MD, Rector RS, Martin JS.

Physiol Rep. 2018 Jul;6(14):e13789. doi: 10.14814/phy2.13789.

8.

Maternal Physical Activity and Sex Impact Markers of Hepatic Mitochondrial Health.

Cunningham RP, Moore MP, Meers GM, Ruegsegger GN, Booth FW, Rector RS.

Med Sci Sports Exerc. 2018 Oct;50(10):2040-2048. doi: 10.1249/MSS.0000000000001675.

PMID:
29787476
9.

The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA.

Wang J, Dong H, Chionh YH, McBee ME, Sirirungruang S, Cunningham RP, Shi PY, Dedon PC.

Nucleic Acids Res. 2016 Oct 14;44(18):8962-8975. Epub 2016 Jun 30.

10.

Sequential years of dental outreach to Jamaica. Gains toward improved caries status of children.

Larsen CD, Larsen MD, Kim M, Yang E, Brown N, Cunningham RP.

N Y State Dent J. 2014 Aug-Sep;80(5):40-5.

PMID:
25672077
11.

A technique to salvage endodontically compromised maxillary anterior tooth.

Comut A, Foran D, Cunningham RP.

N Y State Dent J. 2014 Jan;80(1):33-7.

PMID:
24654367
12.

Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.

Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA.

J Biol Chem. 2013 Mar 22;288(12):8445-55. doi: 10.1074/jbc.M112.422774. Epub 2013 Jan 25.

13.

Human endonuclease V as a repair enzyme for DNA deamination.

Mi R, Alford-Zappala M, Kow YW, Cunningham RP, Cao W.

Mutat Res. 2012 Jul 1;735(1-2):12-8. doi: 10.1016/j.mrfmmm.2012.05.003. Epub 2012 Jun 1.

14.

Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA.

Pang B, McFaline JL, Burgis NE, Dong M, Taghizadeh K, Sullivan MR, Elmquist CE, Cunningham RP, Dedon PC.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2319-24. doi: 10.1073/pnas.1118455109. Epub 2012 Jan 30.

15.

DNA sequence context conceals α-anomeric lesions.

Johnson CN, Spring AM, Desai S, Cunningham RP, Germann MW.

J Mol Biol. 2012 Feb 24;416(3):425-37. doi: 10.1016/j.jmb.2011.12.051. Epub 2011 Dec 29.

16.

Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity.

Rooney JP, Patil A, Joseph F, Endres L, Begley U, Zappala MR, Cunningham RP, Begley TJ.

Genomics. 2011 Mar;97(3):133-47. doi: 10.1016/j.ygeno.2010.12.005. Epub 2010 Dec 30.

17.

Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase.

Herting G, Barber K, Zappala MR, Cunningham RP, Burgis NE.

Biochim Biophys Acta. 2010 Feb;1802(2):269-74. doi: 10.1016/j.bbadis.2009.11.002. Epub 2009 Nov 13.

18.

Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.

Rooney JP, George AD, Patil A, Begley U, Bessette E, Zappala MR, Huang X, Conklin DS, Cunningham RP, Begley TJ.

Genomics. 2009 Jan;93(1):42-51. doi: 10.1016/j.ygeno.2008.09.001. Epub 2008 Oct 16.

19.

A molecular bar-coded DNA repair resource for pooled toxicogenomic screens.

Rooney JP, Patil A, Zappala MR, Conklin DS, Cunningham RP, Begley TJ.

DNA Repair (Amst). 2008 Nov 1;7(11):1855-68. doi: 10.1016/j.dnarep.2008.07.013. Epub 2008 Sep 10.

20.

DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.

Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Björas M, Cunningham RP, Tainer JA.

Nat Struct Mol Biol. 2008 May;15(5):515-22. doi: 10.1038/nsmb.1414. Epub 2008 Apr 13.

PMID:
18408731
21.

Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.

Burgis NE, Cunningham RP.

J Biol Chem. 2007 Feb 9;282(6):3531-8. Epub 2006 Nov 6.

22.

Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization.

Ocampo-Hafalla MT, Altamirano A, Basu AK, Chan MK, Ocampo JE, Cummings A Jr, Boorstein RJ, Cunningham RP, Teebor GW.

DNA Repair (Amst). 2006 Apr 8;5(4):444-54. Epub 2006 Jan 30.

PMID:
16446124
23.

Solution structure of a DNA duplex containing an alpha-anomeric adenosine: insights into substrate recognition by endonuclease IV.

Aramini JM, Cleaver SH, Pon RT, Cunningham RP, Germann MW.

J Mol Biol. 2004 Apr 16;338(1):77-91.

PMID:
15050824
24.

Repair system for noncanonical purines in Escherichia coli.

Burgis NE, Brucker JJ, Cunningham RP.

J Bacteriol. 2003 May;185(10):3101-10.

25.

Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.

Marenstein DR, Chan MK, Altamirano A, Basu AK, Boorstein RJ, Cunningham RP, Teebor GW.

J Biol Chem. 2003 Mar 14;278(11):9005-12. Epub 2003 Jan 8.

26.

Kinetics and binding of the thymine-DNA mismatch glycosylase, Mig-Mth, with mismatch-containing DNA substrates.

Begley TJ, Haas BJ, Morales JC, Kool ET, Cunningham RP.

DNA Repair (Amst). 2003 Jan 2;2(1):107-20.

PMID:
12509271
27.

Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

Ocampo MT, Chaung W, Marenstein DR, Chan MK, Altamirano A, Basu AK, Boorstein RJ, Cunningham RP, Teebor GW.

Mol Cell Biol. 2002 Sep;22(17):6111-21.

28.

Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.

Mol CD, Arvai AS, Begley TJ, Cunningham RP, Tainer JA.

J Mol Biol. 2002 Jan 18;315(3):373-84.

PMID:
11786018
29.

The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III.

Hashimoto M, Greenberg MM, Kow YW, Hwang JT, Cunningham RP.

J Am Chem Soc. 2001 Apr 4;123(13):3161-2. No abstract available.

PMID:
11457038
30.

Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.

Marenstein DR, Ocampo MT, Chan MK, Altamirano A, Basu AK, Boorstein RJ, Cunningham RP, Teebor GW.

J Biol Chem. 2001 Jun 15;276(24):21242-9. Epub 2001 Apr 3.

32.

Identification of the Archaeoglobus fulgidus endonuclease III DNA interaction surface using heteronuclear NMR methods.

Shekhtman A, McNaughton L, Cunningham RP, Baxter SM.

Structure. 1999 Aug 15;7(8):919-30.

33.
34.

Mutation identification DNA analysis system (MIDAS) for detection of known mutations.

Bazar LS, Collier GB, Vanek PG, Siles BA, Kow YW, Doetsch PW, Cunningham RP, Chirikjian JG.

Electrophoresis. 1999 Jun;20(6):1141-8.

PMID:
10380753
35.

A new member of the endonuclease III family of DNA repair enzymes that removes methylated purines from DNA.

Begley TJ, Haas BJ, Noel J, Shekhtman A, Williams WA, Cunningham RP.

Curr Biol. 1999 Jun 17;9(12):653-6.

36.
37.
38.

Yield of DNA strand breaks after base oxidation of plasmid DNA.

Milligan JR, Aguilera JA, Nguyen TT, Ward JF, Kow YW, He B, Cunningham RP.

Radiat Res. 1999 Mar;151(3):334-42.

PMID:
10073672
39.

DNA repair: caretakers of the genome?.

Cunningham RP.

Curr Biol. 1997 Sep 1;7(9):R576-9. Review.

40.

DNA glycosylases.

Cunningham RP.

Mutat Res. 1997 May 1;383(3):189-96. Review. No abstract available.

PMID:
9164479
41.

Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.

Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW.

J Biol Chem. 1997 Mar 7;272(10):6733-40.

42.

Ultraviolet irradiation produces novel endonuclease III-sensitive cytosine photoproducts at dipyrimidine sites.

Jen J, Mitchell DL, Cunningham RP, Smith CA, Taylor JS, Cleaver JE.

Photochem Photobiol. 1997 Feb;65(2):323-9.

PMID:
9066307
43.

A common mechanism of action for the N-glycosylase activity of DNA N-glycosylase/AP lyases from E. coli and T4.

Purmal AA, Rabow LE, Lampman GW, Cunningham RP, Kow YW.

Mutat Res. 1996 Dec 2;364(3):193-207.

PMID:
8960131
44.

DNA repair: how yeast repairs radical damage.

Cunningham RP.

Curr Biol. 1996 Oct 1;6(10):1230-3. Review.

45.

Methylperoxyl radicals as intermediates in the damage to DNA irradiated in aqueous dimethyl sulfoxide with gamma rays.

Milligan JR, Ng JY, Wu CC, Aguilera JA, Ward JF, Kow YW, Wallace SS, Cunningham RP.

Radiat Res. 1996 Oct;146(4):436-43.

PMID:
8927715
47.
48.

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

Thayer MM, Ahern H, Xing D, Cunningham RP, Tainer JA.

EMBO J. 1995 Aug 15;14(16):4108-20.

49.

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.

Barzilay G, Mol CD, Robson CN, Walker LJ, Cunningham RP, Tainer JA, Hickson ID.

Nat Struct Biol. 1995 Jul;2(7):561-8.

PMID:
7664124
50.

Structure and function of the multifunctional DNA-repair enzyme exonuclease III.

Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA.

Nature. 1995 Mar 23;374(6520):381-6.

PMID:
7885481

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