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Items: 1 to 50 of 265

1.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.

Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, Jones TK, Fraser IP, Grice CA, Ezekowitz RAB, O'Neill GP, Blankman JL.

J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296. doi: 10.1124/jpet.118.252296. [Epub ahead of print]

2.

Genetic associations and phenotypic heterogeneity in the craniosynostotic rabbit.

Gilbert JR, Losee JE, Mooney MP, Cray JJ, Gustafson J, Cunningham ML, Cooper GM.

PLoS One. 2018 Sep 20;13(9):e0204086. doi: 10.1371/journal.pone.0204086. eCollection 2018.

3.

A genotype-specific surgical approach for patients with Pfeiffer syndrome due to W290C pathogenic variant in FGFR2 is associated with improved developmental outcomes and reduced mortality.

Wenger TL, Hopper RA, Rosen A, Tully HM, Cunningham ML, Lee A.

Genet Med. 2018 Jun 18. doi: 10.1038/s41436-018-0073-x. [Epub ahead of print]

PMID:
29915381
4.

Associations between laterality of orofacial clefts and medical and academic outcomes.

Gallagher ER, Siebold B, Collett BR, Cox TC, Aziz V, Cunningham ML.

Am J Med Genet A. 2018 Apr;176(4):1037. doi: 10.1002/ajmg.a.38663. No abstract available.

PMID:
29575621
5.

Associations between laterality of orofacial clefts and medical and academic outcomes.

Gallagher ER, Siebold B, Collett BR, Cox TC, Aziz V, Cunningham ML.

Am J Med Genet A. 2018 Feb;176(2):267-276. doi: 10.1002/ajmg.a.38567. Epub 2017 Dec 12. Erratum in: Am J Med Genet A. 2018 Apr;176(4):1037.

PMID:
29232056
6.

Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms.

Clarke CM, Fok VT, Gustafson JA, Smyth MD, Timms AE, Frazar CD, Smith JD, Birgfeld CB, Lee A, Ellenbogen RG, Gruss JS, Hopper RA, Cunningham ML.

Am J Med Genet A. 2018 Feb;176(2):290-300. doi: 10.1002/ajmg.a.38540. Epub 2017 Nov 23.

PMID:
29168297
7.

Structural brain differences in school-age children with and without single-suture craniosynostosis.

Aldridge K, Collett BR, Wallace ER, Birgfeld C, Austin JR, Yeh R, Feil M, Kapp-Simon KA, Aylward EH, Cunningham ML, Speltz ML.

J Neurosurg Pediatr. 2017 Apr;19(4):479-489. doi: 10.3171/2016.9.PEDS16107. Epub 2017 Feb 3.

8.

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development.

Gordon CT, Xue S, Yigit G, Filali H, Chen K, Rosin N, Yoshiura KI, Oufadem M, Beck TJ, McGowan R, Magee AC, Altmüller J, Dion C, Thiele H, Gurzau AD, Nürnberg P, Meschede D, Mühlbauer W, Okamoto N, Varghese V, Irving R, Sigaudy S, Williams D, Ahmed SF, Bonnard C, Kong MK, Ratbi I, Fejjal N, Fikri M, Elalaoui SC, Reigstad H, Bole-Feysot C, Nitschké P, Ragge N, Lévy N, Tunçbilek G, Teo AS, Cunningham ML, Sefiani A, Kayserili H, Murphy JM, Chatdokmaiprai C, Hillmer AM, Wattanasirichaigoon D, Lyonnet S, Magdinier F, Javed A, Blewitt ME, Amiel J, Wollnik B, Reversade B.

Nat Genet. 2017 Feb;49(2):249-255. doi: 10.1038/ng.3765. Epub 2017 Jan 9.

PMID:
28067911
9.

The 3D Facial Norms Database: Part 1. A Web-Based Craniofacial Anthropometric and Image Repository for the Clinical and Research Community.

Weinberg SM, Raffensperger ZD, Kesterke MJ, Heike CL, Cunningham ML, Hecht JT, Kau CH, Murray JC, Wehby GL, Moreno LM, Marazita ML.

Cleft Palate Craniofac J. 2016 Nov;53(6):e185-e197. Epub 2015 Oct 22.

10.

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.

Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM.

PLoS Genet. 2016 Aug 25;12(8):e1006149. doi: 10.1371/journal.pgen.1006149. eCollection 2016 Aug.

11.

Using the 3D Facial Norms Database to investigate craniofacial sexual dimorphism in healthy children, adolescents, and adults.

Kesterke MJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Marazita ML, Weinberg SM.

Biol Sex Differ. 2016 Apr 22;7:23. doi: 10.1186/s13293-016-0076-8. eCollection 2016.

12.

Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis.

Al-Rekabi Z, Wheeler MM, Leonard A, Fura AM, Juhlin I, Frazar C, Smith JD, Park SS, Gustafson JA, Clarke CM, Cunningham ML, Sniadecki NJ.

J Cell Sci. 2016 Feb 1;129(3):483-91. doi: 10.1242/jcs.175976. Epub 2015 Dec 11.

13.

Intracranial pressure changes during mouse development.

Moazen M, Alazmani A, Rafferty K, Liu ZJ, Gustafson J, Cunningham ML, Fagan MJ, Herring SW.

J Biomech. 2016 Jan 4;49(1):123-126. doi: 10.1016/j.jbiomech.2015.11.012. Epub 2015 Nov 18.

14.

Transcriptional analysis of human cranial compartments with different embryonic origins.

Homayounfar N, Park SS, Afsharinejad Z, Bammler TK, MacDonald JW, Farin FM, Mecham BH, Cunningham ML.

Arch Oral Biol. 2015 Sep;60(9):1450-60. doi: 10.1016/j.archoralbio.2015.06.008. Epub 2015 Jul 2.

15.

Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine.

Goss MA, Lievano F, Buchanan KM, Seminack MM, Cunningham ML, Dana A.

Vaccine. 2015 Jun 26;33(29):3422-8. doi: 10.1016/j.vaccine.2015.04.014. Epub 2015 Apr 11.

PMID:
25869893
16.

Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.

Maga AM, Navarro N, Cunningham ML, Cox TC.

Front Physiol. 2015 Mar 26;6:92. doi: 10.3389/fphys.2015.00092. eCollection 2015.

17.

Osteoblast differentiation profiles define sex specific gene expression patterns in craniosynostosis.

Park SS, Beyer RP, Smyth MD, Clarke CM, Timms AE, Bammler TK, Stamper BD, Mecham BH, Gustafson JA, Cunningham ML.

Bone. 2015 Jul;76:169-76. doi: 10.1016/j.bone.2015.03.001. Epub 2015 Mar 7.

18.

Expanding the genetic and phenotypic spectrum of popliteal pterygium disorders.

Leslie EJ, O'Sullivan J, Cunningham ML, Singh A, Goudy SL, Ababneh F, Alsubaie L, Ch'ng GS, van der Laar IM, Hoogeboom AJ, Dunnwald M, Kapoor S, Jiramongkolchai P, Standley J, Manak JR, Murray JC, Dixon MJ.

Am J Med Genet A. 2015 Mar;167A(3):545-52. doi: 10.1002/ajmg.a.36896.

19.

Craniosynostosis and risk factors related to thyroid dysfunction.

Carmichael SL, Ma C, Rasmussen SA, Cunningham ML, Browne ML, Dosiou C, Lammer EJ, Shaw GM.

Am J Med Genet A. 2015 Apr;167A(4):701-7. doi: 10.1002/ajmg.a.36953. Epub 2015 Feb 5.

20.

Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis.

Smith JD, Hing AV, Clarke CM, Johnson NM, Perez FA, Park SS, Horst JA, Mecham B, Maves L, Nickerson DA; University of Washington Center for Mendelian Genomics, Cunningham ML.

Am J Hum Genet. 2014 Aug 7;95(2):235-40. doi: 10.1016/j.ajhg.2014.07.008.

21.

Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum.

Keppler-Noreuil KM, Sapp JC, Lindhurst MJ, Parker VE, Blumhorst C, Darling T, Tosi LL, Huson SM, Whitehouse RW, Jakkula E, Grant I, Balasubramanian M, Chandler KE, Fraser JL, Gucev Z, Crow YJ, Brennan LM, Clark R, Sellars EA, Pena LD, Krishnamurty V, Shuen A, Braverman N, Cunningham ML, Sutton VR, Tasic V, Graham JM Jr, Geer J Jr, Henderson A, Semple RK, Biesecker LG.

Am J Med Genet A. 2014 Jul;164A(7):1713-33. doi: 10.1002/ajmg.a.36552. Epub 2014 Apr 29.

22.

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.

Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan BP, Shaw KJ, Fenical W, Nizet V.

J Antibiot (Tokyo). 2014 Aug;67(8):549-53. doi: 10.1038/ja.2014.36. Epub 2014 Apr 16.

23.

Clinical evidence for a mandibular to maxillary transformation in Auriculocondylar syndrome.

Gordon CT, Cunniff CM, Green GE, Zechi-Ceide RM, Johnson JM, Henderson A, Petit F, Kokitsu-Nakata NM, Guion-Almeida ML, Munnich A, Cunningham ML, Lyonnet S, Amiel J.

Am J Med Genet A. 2014 Jul;164A(7):1850-3. doi: 10.1002/ajmg.a.36505. Epub 2014 Mar 26. No abstract available.

PMID:
24677549
24.

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.

Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J.

J Med Chem. 2014 Feb 13;57(3):651-68. doi: 10.1021/jm401204g. Epub 2014 Jan 16.

PMID:
24428639
25.

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.

Tari LW, Li X, Trzoss M, Bensen DC, Chen Z, Lam T, Zhang J, Lee SJ, Hough G, Phillipson D, Akers-Rodriguez S, Cunningham ML, Kwan BP, Nelson KJ, Castellano A, Locke JB, Brown-Driver V, Murphy TM, Ong VS, Pillar CM, Shinabarger DL, Nix J, Lightstone FC, Wong SE, Nguyen TB, Shaw KJ, Finn J.

PLoS One. 2013 Dec 26;8(12):e84409. doi: 10.1371/journal.pone.0084409. eCollection 2013.

26.

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.

Corton JC, Cunningham ML, Hummer BT, Lau C, Meek B, Peters JM, Popp JA, Rhomberg L, Seed J, Klaunig JE.

Crit Rev Toxicol. 2014 Jan;44(1):1-49. doi: 10.3109/10408444.2013.835784. Epub 2013 Nov 4. Review.

PMID:
24180432
27.

Survey of faculty perceptions regarding a peer review system.

Eisenberg RL, Cunningham ML, Siewert B, Kruskal JB.

J Am Coll Radiol. 2014 Apr;11(4):397-401. doi: 10.1016/j.jacr.2013.08.011. Epub 2013 Oct 19.

PMID:
24144835
28.

Perspectives and challenges in advancing research into craniofacial anomalies.

Cox TC, Luquetti DV, Cunningham ML.

Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):213-7. doi: 10.1002/ajmg.c.31383. Epub 2013 Oct 18.

29.

Carcinogenicity of some drugs and herbal products.

Grosse Y, Loomis D, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2013 Aug;14(9):807-8. No abstract available.

PMID:
24058961
30.

Further characterization of atypical features in auriculocondylar syndrome caused by recessive PLCB4 mutations.

Kido Y, Gordon CT, Sakazume S, Ben Bdira E, Dattani M, Wilson LC, Lyonnet S, Murakami N, Cunningham ML, Amiel J, Nagai T.

Am J Med Genet A. 2013 Sep;161A(9):2339-46. doi: 10.1002/ajmg.a.36066. Epub 2013 Aug 2.

PMID:
23913798
31.

Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay.

Cunningham ML, Kwan BP, Nelson KJ, Bensen DC, Shaw KJ.

J Biomol Screen. 2013 Oct;18(9):1018-26. doi: 10.1177/1087057113487208. Epub 2013 May 17.

PMID:
23686103
32.

Oculoauriculofrontonasal syndrome: case series revealing new bony nasal anomalies in an old syndrome.

Evans KN, Gruss JS, Khanna PC, Cunningham ML, Cox TC, Hing AV.

Am J Med Genet A. 2013 Jun;161A(6):1345-53. doi: 10.1002/ajmg.a.35926. Epub 2013 May 1. Review.

PMID:
23637006
33.

MAPK/ERK Signaling Pathway Analysis in Primary Osteoblasts From Patients With Nonsyndromic Sagittal Craniosynostosis.

Kim SD, Yagnik G, Cunningham ML, Kim J, Boyadjiev SA.

Cleft Palate Craniofac J. 2014 Jan;51(1):115-9. doi: 10.1597/12-136. Epub 2013 Apr 8.

34.

Preferential associated anomalies in 818 cases of microtia in South America.

Luquetti DV, Cox TC, Lopez-Camelo J, Dutra Mda G, Cunningham ML, Castilla EE.

Am J Med Genet A. 2013 May;161A(5):1051-7. doi: 10.1002/ajmg.a.35888. Epub 2013 Mar 29.

35.

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.

Teng M, Hilgers MT, Cunningham ML, Borchardt A, Locke JB, Abraham S, Haley G, Kwan BP, Hall C, Hough GW, Shaw KJ, Finn J.

J Med Chem. 2013 Feb 28;56(4):1748-60. doi: 10.1021/jm301756m. Epub 2013 Feb 12.

PMID:
23362938
36.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Tari LW, Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Nix J, Finn J.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1529-36. doi: 10.1016/j.bmcl.2012.11.032. Epub 2012 Dec 5.

PMID:
23352267
37.

Heterogeneity of mutational mechanisms and modes of inheritance in auriculocondylar syndrome.

Gordon CT, Vuillot A, Marlin S, Gerkes E, Henderson A, AlKindy A, Holder-Espinasse M, Park SS, Omarjee A, Sanchis-Borja M, Bdira EB, Oufadem M, Sikkema-Raddatz B, Stewart A, Palmer R, McGowan R, Petit F, Delobel B, Speicher MR, Aurora P, Kilner D, Pellerin P, Simon M, Bonnefont JP, Tobias ES, García-Miñaúr S, Bitner-Glindzicz M, Lindholm P, Meijer BA, Abadie V, Denoyelle F, Vazquez MP, Rotky-Fast C, Couloigner V, Pierrot S, Manach Y, Breton S, Hendriks YM, Munnich A, Jakobsen L, Kroisel P, Lin A, Kaban LB, Basel-Vanagaite L, Wilson L, Cunningham ML, Lyonnet S, Amiel J.

J Med Genet. 2013 Mar;50(3):174-86. doi: 10.1136/jmedgenet-2012-101331. Epub 2013 Jan 12.

PMID:
23315542
38.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Nelson K, Brown-Driver V, Castellano A, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Finn J, Tari LW.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1537-43. doi: 10.1016/j.bmcl.2012.11.073. Epub 2012 Dec 8.

PMID:
23294697
39.

Directed differentiation of human pluripotent cells to neural crest stem cells.

Menendez L, Kulik MJ, Page AT, Park SS, Lauderdale JD, Cunningham ML, Dalton S.

Nat Protoc. 2013 Jan;8(1):203-12. doi: 10.1038/nprot.2012.156. Epub 2013 Jan 3.

PMID:
23288320
40.

Development at age 36 months in children with deformational plagiocephaly.

Collett BR, Gray KE, Starr JR, Heike CL, Cunningham ML, Speltz ML.

Pediatrics. 2013 Jan;131(1):e109-15. doi: 10.1542/peds.2012-1779. Epub 2012 Dec 24.

41.

"Mandibulofacial dysostosis with microcephaly" caused by EFTUD2 mutations: expanding the phenotype.

Luquetti DV, Hing AV, Rieder MJ, Nickerson DA, Turner EH, Smith J, Park S, Cunningham ML.

Am J Med Genet A. 2013 Jan;161A(1):108-13. doi: 10.1002/ajmg.a.35696. Epub 2012 Dec 14.

42.

A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.

Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA.

Nat Genet. 2012 Dec;44(12):1360-4. doi: 10.1038/ng.2463. Epub 2012 Nov 18.

43.

Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.

Stamper BD, Mecham B, Park SS, Wilkerson H, Farin FM, Beyer RP, Bammler TK, Mangravite LM, Cunningham ML.

Physiol Genomics. 2012 Dec 1;44(23):1154-63. doi: 10.1152/physiolgenomics.00085.2012. Epub 2012 Oct 16.

44.

ALX4 gain-of-function mutations in nonsyndromic craniosynostosis.

Yagnik G, Ghuman A, Kim S, Stevens CG, Kimonis V, Stoler J, Sanchez-Lara PA, Bernstein JA, Naydenov C, Drissi H, Cunningham ML, Kim J, Boyadjiev SA.

Hum Mutat. 2012 Dec;33(12):1626-9. doi: 10.1002/humu.22166. Epub 2012 Aug 13.

45.

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.

Lindhurst MJ, Parker VE, Payne F, Sapp JC, Rudge S, Harris J, Witkowski AM, Zhang Q, Groeneveld MP, Scott CE, Daly A, Huson SM, Tosi LL, Cunningham ML, Darling TN, Geer J, Gucev Z, Sutton VR, Tziotzios C, Dixon AK, Helliwell T, O'Rahilly S, Savage DB, Wakelam MJ, Barroso I, Biesecker LG, Semple RK.

Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.

46.

Saethre-Chotzen Syndrome.

Gallagher ER, Ratisoontorn C, Cunningham ML.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2003 May 16 [updated 2012 Jun 14].

47.

Unique sex-based approach identifies transcriptomic biomarkers associated with non-syndromic craniosynostosis.

Stamper BD, Park SS, Beyer RP, Bammler TK, Cunningham ML.

Gene Regul Syst Bio. 2012;6:81-92. doi: 10.4137/GRSB.S9693. Epub 2012 May 16.

48.

A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.

Rieder MJ, Green GE, Park SS, Stamper BD, Gordon CT, Johnson JM, Cunniff CM, Smith JD, Emery SB, Lyonnet S, Amiel J, Holder M, Heggie AA, Bamshad MJ, Nickerson DA, Cox TC, Hing AV, Horst JA, Cunningham ML.

Am J Hum Genet. 2012 May 4;90(5):907-14. doi: 10.1016/j.ajhg.2012.04.002. Erratum in: Am J Hum Genet. 2012 Jun 8;90(6):1116. Am J Hum Genet. 2012 Aug 10;91(2):397.

49.

Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

Bensen DC, Rodriguez S, Nix J, Cunningham ML, Tari LW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):382-5. doi: 10.1107/S1744309112006720. Epub 2012 Mar 27.

50.

Brain volume and shape in infants with deformational plagiocephaly.

Collett BR, Aylward EH, Berg J, Davidoff C, Norden J, Cunningham ML, Speltz ML.

Childs Nerv Syst. 2012 Jul;28(7):1083-90. doi: 10.1007/s00381-012-1731-y. Epub 2012 Mar 25.

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