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Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.

Land MA, Chapman HL, Davis-Reyes BD, Felsing DE, Allen JA, Moeller FG, Elferink LA, Cunningham KA, Anastasio NC.

Sci Rep. 2019 Nov 13;9(1):16737. doi: 10.1038/s41598-019-53124-2.


Translating Pharmacology into Therapeutics to Fight the Opioid Crisis.

Marek GJ, Cunningham KA, Rasmussen K.

J Pharmacol Exp Ther. 2019 Nov;371(2):394-395. doi: 10.1124/jpet.119.262477. No abstract available.


In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog.

Soto CA, Du HC, Fox RG, Yang T, Hooson J, Anastasio NC, Gilbertson SR, Cunningham KA.

Front Pharmacol. 2019 Aug 23;10:907. doi: 10.3389/fphar.2019.00907. eCollection 2019.


Chronic poly-drug administration damages adult mouse brain neural stem cells.

McGrath EL, Schlagal CR, Cortez I, Dunn TJ, Gao J, Fox RG, Stutz SJ, Kuo YF, Hommel JD, Dineley KT, Cunningham KA, Kaphalia BS, Wu P.

Brain Res. 2019 Nov 15;1723:146425. doi: 10.1016/j.brainres.2019.146425. Epub 2019 Aug 29.


Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.

Ma L, Steinberg JL, Bjork JM, Taylor BA, Arias AJ, Terplan M, Anastasio NC, Zuniga EA, Lennon M, Cunningham KA, Moeller FG.

Psychiatry Res Neuroimaging. 2019 Dec 30;294. pii: S0925-4927(19)30026-5. doi: 10.1016/j.pscychresns.2019.08.005. Epub 2019 Aug 13.


Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges.

Sholler DJ, Cunningham KA.

ACS Chem Neurosci. 2019 Jul 17;10(7):3045-3046. doi: 10.1021/acschemneuro.9b00374. No abstract available.


Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.

Wold EA, Wild CT, Cunningham KA, Zhou J.

Curr Top Med Chem. 2019;19(16):1381-1398. doi: 10.2174/1568026619666190709101449. Review.


Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains.

Fongang B, Cunningham KA, Rowicka M, Kudlicki A.

Neuroscience. 2019 Aug 1;412:48-59. doi: 10.1016/j.neuroscience.2019.05.013. Epub 2019 Jun 1.


Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Anastasio NC, Stutz SJ, Price AE, Davis-Reyes BD, Sholler DJ, Ferguson SM, Neumaier JF, Moeller FG, Hommel JD, Cunningham KA.

Neuropsychopharmacology. 2019 Sep;44(10):1752-1761. doi: 10.1038/s41386-019-0394-8. Epub 2019 Apr 19.


Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex.

Price AE, Sholler DJ, Stutz SJ, Anastasio NC, Cunningham KA.

ACS Chem Neurosci. 2019 Jul 17;10(7):3241-3248. doi: 10.1021/acschemneuro.8b00669. Epub 2019 Mar 18.


Pimavanserin and Lorcaserin Attenuate Measures of Binge Eating in Male Sprague-Dawley Rats.

Price AE, Brehm VD, Hommel JD, Anastasio NC, Cunningham KA.

Front Pharmacol. 2018 Dec 7;9:1424. doi: 10.3389/fphar.2018.01424. eCollection 2018.


Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats.

Price AE, Stutz SJ, Hommel JD, Anastasio NC, Cunningham KA.

Appetite. 2019 Feb 1;133:231-239. doi: 10.1016/j.appet.2018.11.011. Epub 2018 Nov 14.


The 5-HT2A Receptor (5-HT2AR) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats.

Sholler DJ, Stutz SJ, Fox RG, Boone EL, Wang Q, Rice KC, Moeller FG, Anastasio NC, Cunningham KA.

J Pharmacol Exp Ther. 2019 Jan;368(1):41-49. doi: 10.1124/jpet.118.251199. Epub 2018 Oct 29.


Positive-allosteric modulation of the 5-HT2C receptor: implications for neuropsychopharmacology and neurotherapeutics.

Zhou J, Cunningham KA.

Neuropsychopharmacology. 2019 Jan;44(1):230-231. doi: 10.1038/s41386-018-0190-x. No abstract available.


Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction.

Felsing DE, Anastasio NC, Miszkiel JM, Gilbertson SR, Allen JA, Cunningham KA.

PLoS One. 2018 Aug 29;13(8):e0203137. doi: 10.1371/journal.pone.0203137. eCollection 2018.


Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.

Wold EA, Chen J, Cunningham KA, Zhou J.

J Med Chem. 2019 Jan 10;62(1):88-127. doi: 10.1021/acs.jmedchem.8b00875. Epub 2018 Aug 28. Review.


Serotonin 5-HT2C Receptor Activation Suppresses Binge Intake and the Reinforcing and Motivational Properties of High-Fat Food.

Price AE, Anastasio NC, Stutz SJ, Hommel JD, Cunningham KA.

Front Pharmacol. 2018 Jul 27;9:821. doi: 10.3389/fphar.2018.00821. eCollection 2018.


A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder.

Dimet AL, Cisneros IE, Fox RG, Stutz SJ, Anastasio NC, Cunningham KA, Dineley KT.

J Vis Exp. 2018 Jun 18;(136). doi: 10.3791/55864.


Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor.

Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J.

J Med Chem. 2019 Jan 10;62(1):288-305. doi: 10.1021/acs.jmedchem.8b00401. Epub 2018 Apr 13.


Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes.

Cisneros IE, Erdenizmenli M, Cunningham KA, Paessler S, Dineley KT.

Neuropharmacology. 2018 Jun;135:431-443. doi: 10.1016/j.neuropharm.2018.03.019. Epub 2018 Mar 23.


Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907.

Gilbertson SR, Chen YC, Soto CA, Yang Y, Rice KC, Cunningham KA, Anastasio NC.

Bioorg Med Chem Lett. 2018 May 1;28(8):1381-1385. doi: 10.1016/j.bmcl.2018.02.058. Epub 2018 Mar 16.


Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience.

Nilsson CL, Cunningham KA.

ACS Chem Neurosci. 2018 Jan 17;9(1):5. doi: 10.1021/acschemneuro.7b00530. No abstract available.


Editors' Favorites of 2017.

Lindsley CW, Cunningham KA, Hooker JM, Andrews AM.

ACS Chem Neurosci. 2018 Jan 17;9(1):1-4. doi: 10.1021/acschemneuro.8b00001. No abstract available.


Innovative Therapeutic Intervention For Opioid Use Disorder.

Moeller FG, Cunningham KA.

Neuropsychopharmacology. 2018 Jan;43(1):220-221. doi: 10.1038/npp.2017.192. No abstract available.


Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption.

McGrath EL, Gao J, Kuo YF, Dunn TJ, Ray MJ, Dineley KT, Cunningham KA, Kaphalia BS, Wu P.

Stem Cell Reports. 2017 Dec 12;9(6):1916-1930. doi: 10.1016/j.stemcr.2017.10.007. Epub 2017 Nov 9.


Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo.

Soto CA, Shashack MJ, Fox RG, Bubar MJ, Rice KC, Watson CS, Cunningham KA, Gilbertson SR, Anastasio NC.

ACS Chem Neurosci. 2018 Mar 21;9(3):514-521. doi: 10.1021/acschemneuro.7b00309. Epub 2017 Nov 21.


Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder.

Ma L, Steinberg JL, Cunningham KA, Bjork JM, Lane SD, Schmitz JM, Burroughs T, Narayana PA, Kosten TR, Bechara A, Moeller FG.

Psychiatry Res Neuroimaging. 2018 Jan 30;271:59-66. doi: 10.1016/j.pscychresns.2017.10.012. Epub 2017 Oct 27.


Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul.


Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.

Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD.

Br J Pharmacol. 2017 Aug;174(16):2716-2738. doi: 10.1111/bph.13899. Epub 2017 Jul 11.


PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.

Schmitz JM, Green CE, Hasan KM, Vincent J, Suchting R, Weaver MF, Moeller FG, Narayana PA, Cunningham KA, Dineley KT, Lane SD.

Addiction. 2017 Oct;112(10):1861-1868. doi: 10.1111/add.13868. Epub 2017 Jul 3.


Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist.

Chen YC, Hartley RM, Anastasio NC, Cunningham KA, Gilbertson SR.

ACS Chem Neurosci. 2017 May 17;8(5):1004-1010. doi: 10.1021/acschemneuro.6b00439. Epub 2017 Apr 19.


Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats.

Neelakantan H, Holliday ED, Fox RG, Stutz SJ, Comer SD, Haney M, Anastasio NC, Moeller FG, Cunningham KA.

ACS Chem Neurosci. 2017 May 17;8(5):1065-1073. doi: 10.1021/acschemneuro.6b00413. Epub 2017 Feb 13.


TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons.

Gao Y, Yao T, Deng Z, Sohn JW, Sun J, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y, Liu T, Williams KW.

Cell Rep. 2017 Jan 17;18(3):583-592. doi: 10.1016/j.celrep.2016.12.072.


Editors' Favorites of 2016.

Lindsley CW, Hooker JM, Cunningham KA, Andrews AM.

ACS Chem Neurosci. 2017 Jan 18;8(1):1-3. doi: 10.1021/acschemneuro.6b00461. No abstract available.


PPARγ agonism attenuates cocaine cue reactivity.

Miller WR, Fox RG, Stutz SJ, Lane SD, Denner L, Cunningham KA, Dineley KT.

Addict Biol. 2018 Jan;23(1):55-68. doi: 10.1111/adb.12471. Epub 2016 Nov 11.


Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning.

Cortez I, Bulavin DV, Wu P, McGrath EL, Cunningham KA, Wakamiya M, Papaconstantinou J, Dineley KT.

Behav Brain Res. 2017 Mar 30;322(Pt B):212-222. doi: 10.1016/j.bbr.2016.10.023. Epub 2016 Oct 17.


Is There a Causal Relation between Maternal Acetaminophen Administration and ADHD?

Saad A, Hegde S, Kechichian T, Gamble P, Rahman M, Stutz SJ, Anastasio NC, Alshehri W, Lei J, Mori S, Kajs B, Cunningham KA, Saade G, Burd I, Costantine M.

PLoS One. 2016 Jun 13;11(6):e0157380. doi: 10.1371/journal.pone.0157380. eCollection 2016.


Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.

Kasper JM, McCue DL, Milton AJ, Szwed A, Sampson CM, Huang M, Carlton S, Meltzer HY, Cunningham KA, Hommel JD.

Biol Psychiatry. 2016 Dec 1;80(11):878-887. doi: 10.1016/j.biopsych.2016.02.031. Epub 2016 Mar 8.


Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system.

Swinford-Jackson SE, Anastasio NC, Fox RG, Stutz SJ, Cunningham KA.

Neuroscience. 2016 Jun 2;324:50-61. doi: 10.1016/j.neuroscience.2016.02.052. Epub 2016 Feb 27.


Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines.

Rudra JS, Ding Y, Neelakantan H, Ding C, Appavu R, Stutz S, Snook JD, Chen H, Cunningham KA, Zhou J.

ACS Chem Neurosci. 2016 May 18;7(5):546-52. doi: 10.1021/acschemneuro.5b00345. Epub 2016 Mar 8.


Detection of Complex Sounds in Quiet Conditions by Seals and Sea Lions.

Cunningham KA, Southall BL, Reichmuth C.

Adv Exp Med Biol. 2016;875:181-7. doi: 10.1007/978-1-4939-2981-8_21.


High-frequency hearing in seals and sea lions.

Cunningham KA, Reichmuth C.

Hear Res. 2016 Jan;331:83-91. doi: 10.1016/j.heares.2015.10.002. Epub 2015 Oct 28.


Prevalence of Food Addiction Among Low-Income Reproductive-Aged Women.

Berenson AB, Laz TH, Pohlmeier AM, Rahman M, Cunningham KA.

J Womens Health (Larchmt). 2015 Sep;24(9):740-4. doi: 10.1089/jwh.2014.5182. Epub 2015 Aug 18.


Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.

Anastasio NC, Stutz SJ, Fink LH, Swinford-Jackson SE, Sears RM, DiLeone RJ, Rice KC, Moeller FG, Cunningham KA.

ACS Chem Neurosci. 2015 Jul 15;6(7):1248-58. doi: 10.1021/acschemneuro.5b00094. Epub 2015 Jul 7.


Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity.

Liu S, Maili L, Lane SD, Schmitz JM, Spellicy CJ, Cunningham KA, Moeller FG, Nielsen DA.

Psychiatr Genet. 2015 Oct;25(5):213-4. doi: 10.1097/YPG.0000000000000094. No abstract available.


Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls.

Ma L, Steinberg JL, Cunningham KA, Lane SD, Bjork JM, Neelakantan H, Price AE, Narayana PA, Kosten TR, Bechara A, Moeller FG.

Neuroimage Clin. 2015 Mar 24;7:837-47. doi: 10.1016/j.nicl.2015.03.015. eCollection 2015.


Rapid-response impulsivity: definitions, measurement issues, and clinical implications.

Hamilton KR, Littlefield AK, Anastasio NC, Cunningham KA, Fink LHL, Wing VC, Mathias CW, Lane SD, Schütz CG, Swann AC, Lejuez CW, Clark L, Moeller FG, Potenza MN.

Personal Disord. 2015 Apr;6(2):168-181. doi: 10.1037/per0000100. Review.


Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System.

Fink LH, Anastasio NC, Fox RG, Rice KC, Moeller FG, Cunningham KA.

Neuropsychopharmacology. 2015 Jul;40(8):1957-68. doi: 10.1038/npp.2015.46. Epub 2015 Feb 10.


Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder.

De La Garza R 2nd, Bubar MJ, Carbone CL, Moeller FG, Newton TF, Anastasio NC, Harper TA, Ware DL, Fuller MA, Holstein GJ, Jayroe JB, Bandak SI, Reiman KZ, Neale AC, Pickford LB, Cunningham KA.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:40-48. doi: 10.1016/j.pnpbp.2015.01.009. Epub 2015 Jan 17.


Kynurenic acid is a nutritional cue that enables behavioral plasticity.

Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K.

Cell. 2015 Jan 15;160(1-2):119-31. doi: 10.1016/j.cell.2014.12.028.

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