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Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.

Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ.

J Clin Oncol. 2019 Aug 9:JCO1901492. doi: 10.1200/JCO.19.01492. [Epub ahead of print]


Targeting Vascular Endothelial Growth Factor in Oesophagogastric Cancer: A Review of Progress to Date and Immunotherapy Combination Strategies.

Butters O, Young K, Cunningham D, Chau I, Starling N.

Front Oncol. 2019 Jul 16;9:618. doi: 10.3389/fonc.2019.00618. eCollection 2019. Review.


Can we see what is invisible? The role of MRI in the evaluation and management of patients with pathological nipple discharge.

Zacharioudakis K, Kontoulis T, Vella JX, Zhao J, Ramakrishnan R, Cunningham DA, Mufti RA, Leff DR, Thiruchelvam P, Hogben K, Hadjiminas DJ.

Breast Cancer Res Treat. 2019 Jul 27. doi: 10.1007/s10549-019-05321-w. [Epub ahead of print]


General practice recruitment - a survey of awareness and influence of the Scottish Targeted Enhanced Recruitment Scheme (TERS).

Lee K, Cunningham DE.

Educ Prim Care. 2019 Jul 17:1-6. doi: 10.1080/14739879.2019.1639554. [Epub ahead of print]


Bilateral Contralaterally Controlled Functional Electrical Stimulation Reveals New Insights Into the Interhemispheric Competition Model in Chronic Stroke.

Cunningham DA, Knutson JS, Sankarasubramanian V, Potter-Baker KA, Machado AG, Plow EB.

Neurorehabil Neural Repair. 2019 Sep;33(9):707-717. doi: 10.1177/1545968319863709. Epub 2019 Jul 18.


Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jiménez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M.

Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013.


Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1.

Eron JJ, Orkin C, Cunningham D, Pulido F, Post FA, De Wit S, Lathouwers E, Hufkens V, Jezorwski J, Petrovic R, Brown K, Van Landuyt E, Opsomer M; EMERALD study group.

Antiviral Res. 2019 Jul 4;170:104543. doi: 10.1016/j.antiviral.2019.104543. [Epub ahead of print]


The A.L.A.N. score identifies prognostic classes in advanced biliary cancer patients receiving first-line chemotherapy.

Salati M, Caputo F, Cunningham D, Marcheselli L, Spallanzani A, Rimini M, Gelsomino F, Reggiani-Bonetti L, Andrikou K, Rovinelli F, Smyth E, Baratelli C, Kouvelakis K, Kalaitzaki R, Gillbanks A, Michalarea V, Cascinu S, Braconi C.

Eur J Cancer. 2019 Aug;117:84-90. doi: 10.1016/j.ejca.2019.05.030. Epub 2019 Jul 2.


Panitumumab Alone for Maintenance Treatment in Advanced Colorectal Cancer.

Anandappa G, Cunningham D.

JAMA Oncol. 2019 Jul 3. doi: 10.1001/jamaoncol.2019.1447. [Epub ahead of print] No abstract available.


Quality assurance of surgery in the randomized ST03 trial of perioperative chemotherapy in carcinoma of the stomach and gastro-oesophageal junction.

Allum WH, Smyth EC, Blazeby JM, Grabsch HI, Griffin SM, Rowley S, Cafferty FH, Langley RE, Cunningham D.

Br J Surg. 2019 Aug;106(9):1204-1215. doi: 10.1002/bjs.11184. Epub 2019 Jul 3.


Reevaluation of the body mass estimate for the KNM-ER 5428 Homo erectus talus.

Cunningham DL, Rogers MV, Wescott DJ, McCarthy RC.

Am J Phys Anthropol. 2019 Sep;170(1):148-155. doi: 10.1002/ajpa.23898. Epub 2019 Jul 3.


Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers.

Stewart A, Coker EA, Pölsterl S, Georgiou A, Minchom AR, Carreira S, Cunningham D, O'Brien ME, Raynaud FI, de Bono JS, Al-Lazikani B, Banerji U.

Mol Cancer Ther. 2019 Aug;18(8):1396-1404. doi: 10.1158/1535-7163.MCT-18-0727. Epub 2019 Jul 1.


Elevated Preoperative Hemoglobin A1c Associated with Increased Wound Complications in Diabetic Patients undergoing Primary, Open Carpal Tunnel Release.

Cunningham DJ, Baumgartner RE, Federer AE, Richard MJ, Mithani SK.

Plast Reconstr Surg. 2019 Jun 27. doi: 10.1097/PRS.0000000000006023. [Epub ahead of print]


Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial.

Smyth EC, Rowley S, Cafferty FH, Allum W, Grabsch HI, Stenning S, Wotherspoon A, Alderson D, Crosby T, Mansoor W, Waters JS, Neville-Webbe H, Darby S, Dent J, Seymour M, Thompson J, Sothi S, Blazeby J, Langley RE, Cunningham D.

JAMA Oncol. 2019 Jun 20. doi: 10.1001/jamaoncol.2019.1179. [Epub ahead of print]


Analysis of KRAS, NRAS, BRAF, PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients.

Sclafani F, Wilson SH, Cunningham D, Gonzalez De Castro D, Kalaitzaki E, Begum R, Wotherspoon A, Capdevila J, Glimelius B, Roselló S, Thomas J, Tait D, Brown G, Oates J, Chau I.

Int J Cancer. 2019 Jun 14. doi: 10.1002/ijc.32507. [Epub ahead of print]


Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Wagner S, Vlachogiannis G, De Haven Brandon A, Valenti M, Box G, Jenkins L, Mancusi C, Self A, Manodoro F, Assiotis I, Robinson P, Chauhan R, Rust AG, Matthews N, Eason K, Khan K, Starling N, Cunningham D, Sadanandam A, Isacke CM, Kirkin V, Valeri N, Whittaker SR.

Oncogene. 2019 Jul;38(28):5746. doi: 10.1038/s41388-019-0835-1.


CPD preferences and activities of general practitioners, registered pharmacy staff and general practice nurses in NHS Scotland - a questionnaire survey.

Cunningham DE, Alexander A, Luty S, Zlotos L.

Educ Prim Care. 2019 May 30:1-10. doi: 10.1080/14739879.2019.1617644. [Epub ahead of print]


Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma.

Davidson M, Barber LJ, Woolston A, Cafferkey C, Mansukhani S, Griffiths B, Moorcraft SY, Rana I, Begum R, Assiotis I, Matthews N, Rao S, Watkins D, Chau I, Cunningham D, Starling N, Gerlinger M.

Cancers (Basel). 2019 May 27;11(5). pii: E736. doi: 10.3390/cancers11050736.


Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer into Molecular Subtypes.

Ragulan C, Eason K, Fontana E, Nyamundanda G, Tarazona N, Patil Y, Poudel P, Lawlor RT, Del Rio M, Koo SL, Tan WS, Sclafani F, Begum R, Teixeira Mendes LS, Martineau P, Scarpa A, Cervantes A, Tan IB, Cunningham D, Sadanandam A.

Sci Rep. 2019 May 21;9(1):7665. doi: 10.1038/s41598-019-43492-0.


Exploratory Analysis of Plasma Neurotensin as a Novel Biomarker for Early Detection of Colorectal Polyp and Cancer.

Qiu S, Nikolaou S, Fiorentino F, Rasheed S, Darzi A, Cunningham D, Tekkis P, Kontovounisios C.

Horm Cancer. 2019 Jun;10(2-3):128-135. doi: 10.1007/s12672-019-00364-3. Epub 2019 May 15.


International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O'Keefe SJ, Gaskins HR, Teare J, Yu J, Hughes DJ, Verstraelen H, Burton J, O'Toole PW, Rosenberg DW, Marchesi JR, Kinross JM.

Gut. 2019 Sep;68(9):1624-1632. doi: 10.1136/gutjnl-2019-318556. Epub 2019 May 15.


Comparison of Tibiotalocalcaneal Arthrodeses Using a Sustained Dynamic Compression Nail Versus Nondynamized Nails.

Steele JR, Kildow BJ, Cunningham DJ, Dekker TJ, DeOrio JK, Easley ME, Nunley JA, Parekh SG, Adams SB.

Foot Ankle Spec. 2019 Apr 25:1938640019843332. doi: 10.1177/1938640019843332. [Epub ahead of print]


CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids.

Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Barber LJ, Woolston A, Spain G, von Loga K, Challoner B, Patel R, Ranes M, Swain A, Thomas J, Bryant A, Saffery C, Fotiadis N, Guettler S, Mansfield D, Melcher A, Powles T, Rao S, Watkins D, Chau I, Matthews N, Wallberg F, Starling N, Cunningham D, Gerlinger M.

J Immunother Cancer. 2019 Apr 15;7(1):101. doi: 10.1186/s40425-019-0575-3.


Online recruitment of a non-help-seeking sample for an internet intervention: Lessons learned in an alcohol-exposed pregnancy risk reduction study.

MacDonnell K, Cowen E, Cunningham DJ, Ritterband L, Ingersoll K.

Internet Interv. 2019 Mar 11;17:100240. doi: 10.1016/j.invent.2019.100240. eCollection 2019 Sep.


miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial.

Anandappa G, Lampis A, Cunningham D, Khan KH, Kouvelakis K, Vlachogiannis G, Hedayat S, Tunariu N, Rao S, Watkins D, Starling N, Braconi C, Darvish-Damavandi M, Lote H, Thomas J, Peckitt C, Kalaitzaki R, Khan N, Fotiadis N, Rugge M, Begum R, Rana I, Bryant A, Hahne JC, Chau I, Fassan M, Valeri N.

Clin Cancer Res. 2019 Jul 1;25(13):3830-3838. doi: 10.1158/1078-0432.CCR-18-3769. Epub 2019 Apr 5.


Clinical Impact of Routine Complete Blood Counts Following Total Knee Arthroplasty.

Howell EP, Kildow BJ, Karas V, Green CL, Cunningham DJ, Ryan SP, Bolognesi MP, Seyler TM.

J Arthroplasty. 2019 Jul;34(7S):S168-S172. doi: 10.1016/j.arth.2019.03.016. Epub 2019 Mar 12.


A Golden Conundrum.

Garner JL, Donovan J, Meireles I, Padley SPG, Cunningham D, Shah PL.

Am J Respir Crit Care Med. 2019 Apr 2. doi: 10.1164/rccm.201811-2222IM. [Epub ahead of print] No abstract available.


100 notable names from general practice 100 notable names from general practice , Edited by Neil Metcalfe , Abingdon, UK , CRC Press , 313 pp., £43.35 (softback), ISBN 978 1 4987 5198 8.

Cunningham D.

Educ Prim Care. 2019 May;30(3):180. doi: 10.1080/14739879.2019.1595166. Epub 2019 Apr 1. No abstract available.


Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group.

Lancet Oncol. 2019 May;20(5):663-673. doi: 10.1016/S1470-2045(18)30915-X. Epub 2019 Mar 25. Erratum in: Lancet Oncol. 2019 Apr 2;:.


Best Buy in Public Health or Luxury Expense?: The Cost-effectiveness of a Pediatric Operating Room in Uganda From the Societal Perspective.

Yap A, Cheung M, Muzira A, Healy J, Kakembo N, Kisa P, Cunningham D, Youngson G, Sekabira J, Yaesoubi R, Ozgediz D.

Ann Surg. 2019 Mar 19. doi: 10.1097/SLA.0000000000003263. [Epub ahead of print]


Primary Tumor Resection in Patients with Incurable Localized or Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis.

Simillis C, Kalakouti E, Afxentiou T, Kontovounisios C, Smith JJ, Cunningham D, Adamina M, Tekkis PP.

World J Surg. 2019 Jul;43(7):1829-1840. doi: 10.1007/s00268-019-04984-2. Review.


Recently-qualified general practitioners' perceptions and experiences of General Practice Specialty Training (GPST) in deprived areas of NHS Scotland - a qualitative study.

Cunningham D, Yeoman L.

Educ Prim Care. 2019 May;30(3):158-164. doi: 10.1080/14739879.2019.1587317. Epub 2019 Mar 19.


Florid T follicular helper cell hyperplasia associated with extranodal marginal zone lymphoma: a diagnostic pitfall which may mimic T cell lymphoma.

Vroobel KM, O'Connor S, Cunningham D, Wren D, Sharma B, Wotherspoon A, Attygalle AD.

Histopathology. 2019 Aug;75(2):287-290. doi: 10.1111/his.13858. Epub 2019 Jun 10. No abstract available.


Pseudoprogression on treatment with immune-checkpoint inhibitors in patients with gastrointestinal malignancies: Case series and short literature review.

Michalarea V, Fontana E, Garces AI, Williams A, Smyth EC, Picchia S, Rao S, Chau I, Cunningham D, Bali MA.

Curr Probl Cancer. 2019 Feb 21. pii: S0147-0272(18)30318-0. doi: 10.1016/j.currproblcancer.2019.01.008. [Epub ahead of print]


Response to Letter to the Editor on "When Should Complete Blood Count Tests Be Performed in Primary Total Hip Arthroplasty Patients?"

Kildow BJ, Howell EP, Karas V, Baumgartner WT, Cunningham DJ, Green CL, Bolognesi MP, Seyler TM.

J Arthroplasty. 2019 May;34(5):1040-1041. doi: 10.1016/j.arth.2019.01.045. Epub 2019 Feb 14. No abstract available.


The Effect of Patient Characteristics on 1 to 2-Year and Minimum 5-Year Outcomes After Total Ankle Arthroplasty.

Cunningham DJ, DeOrio JK, Nunley JA, Easley ME, Adams SB.

J Bone Joint Surg Am. 2019 Feb 6;101(3):199-208. doi: 10.2106/JBJS.18.00313.


One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B.

Adams DR, Menezes S, Jauregui R, Valivullah ZM, Power B, Abraham M, Jeffrey BG, Garced A, Alur RP, Cunningham D, Wiggs E, Merideth MA, Chiang PW, Bernstein S, Ito S, Wakamatsu K, Jack RM, Introne WJ, Gahl WA, Brooks BP.

JCI Insight. 2019 Jan 24;4(2). pii: 124387. doi: 10.1172/jci.insight.124387. [Epub ahead of print]


Unifying Children's Surgery and Anesthesia Stakeholders Across Institutions and Clinical Disciplines: Challenges and Solutions from Uganda.

Kisa P, Grabski DF, Ozgediz D, Ajiko M, Aspide R, Baird R, Barker G, Birabwa-Male D, Blair G, Cameron B, Cheung M, Cigliano B, Cunningham D, D'Agostino S, Duffy D, Evans F, Fitzgerald TN, Galiwango G, Gerolmini D, Gerolmini M, Kakembo N, Kambugu JB, Lakhoo K, Langer M, Muhumuza MF, Muzira A, Nabukenya MT, Naik-Mathuria B, Nakku D, Nankunda J, Ogwang M, Okello I, Penny N, Reimer E, Sabatini C, Sekabira J, Situma M, Ssenyonga P, Tumukunde J, Villalona G.

World J Surg. 2019 Jun;43(6):1435-1449. doi: 10.1007/s00268-018-04905-9.


Genomic loss of heterozygosity and survival in the REAL3 trial.

Smyth EC, Cafferkey C, Loehr A, Waddell T, Begum R, Peckitt C, Harding TC, Nguyen M, Okines AF, Raponi M, Rao S, Watkins D, Starling N, Middleton GW, Wadsley J, Mansoor W, Crosby T, Wotherspoon A, Chau I, Cunningham D.

Oncotarget. 2018 Nov 30;9(94):36654-36665. doi: 10.18632/oncotarget.26336. eCollection 2018 Nov 30.


Immunotherapy and pancreatic cancer: unique challenges and potential opportunities.

Young K, Hughes DJ, Cunningham D, Starling N.

Ther Adv Med Oncol. 2018 Dec 17;10:1758835918816281. doi: 10.1177/1758835918816281. eCollection 2018. Review.


Exercise intensity affects acute neurotrophic and neurophysiological responses poststroke.

Boyne P, Meyrose C, Westover J, Whitesel D, Hatter K, Reisman DS, Cunningham D, Carl D, Jansen C, Khoury JC, Gerson M, Kissela B, Dunning K.

J Appl Physiol (1985). 2019 Feb 1;126(2):431-443. doi: 10.1152/japplphysiol.00594.2018. Epub 2018 Dec 20.


Patient-level costs in margin re-excision for breast-conserving surgery.

Grant Y, Al-Khudairi R, St John E, Barschkett M, Cunningham D, Al-Mufti R, Hogben K, Thiruchelvam P, Hadjiminas DJ, Darzi A, Carter AW, Leff DR.

Br J Surg. 2019 Mar;106(4):384-394. doi: 10.1002/bjs.11050. Epub 2018 Dec 19.


Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern.

Lin JW, Reid AJ, Cunningham D, Böhme U, Tumwine I, Keller-Mclaughlin S, Sanders M, Berriman M, Langhorne J.

Version 2. Wellcome Open Res. 2018 Dec 6 [revised 2018 Jan 1];3:142. doi: 10.12688/wellcomeopenres.14797.2. eCollection 2018.


Polymicrobial Infections in Hip Arthroplasty: Lower Treatment Success Rate, Increased Surgery, and Longer Hospitalization.

Kavolus JJ, Cunningham DJ, Rao SR, Wellman SS, Seyler TM.

J Arthroplasty. 2019 Apr;34(4):710-716.e3. doi: 10.1016/j.arth.2018.09.090. Epub 2018 Oct 9.


A seven-Gene Signature assay improves prognostic risk stratification of perioperative chemotherapy treated gastroesophageal cancer patients from the MAGIC trial.

Smyth EC, Nyamundanda G, Cunningham D, Fontana E, Ragulan C, Tan IB, Lin SJ, Wotherspoon A, Nankivell M, Fassan M, Lampis A, Hahne JC, Davies AR, Lagergren J, Gossage JA, Maisey N, Green M, Zylstra JL, Allum WH, Langley RE, Tan P, Valeri N, Sadanandam A.

Ann Oncol. 2018 Dec 1;29(12):2356-2362. doi: 10.1093/annonc/mdy407.


Comparing Standard Versus Extended Culture Duration in Acute Hip and Knee Periprosthetic Joint Infection.

Klement MR, Cunningham DJ, Wooster BM, Wellman SS, Bolognesi MP, Green CL, Garrigues GE.

J Am Acad Orthop Surg. 2019 May 1;27(9):e437-e443. doi: 10.5435/JAAOS-D-17-00674.


SCOT: a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer.

Robles-Zurita J, Boyd KA, Briggs AH, Iveson T, Kerr RS, Saunders MP, Cassidy J, Hollander NH, Tabernero J, Segelov E, Glimelius B, Harkin A, Allan K, McQueen J, Pearson S, Waterston A, Medley L, Wilson C, Ellis R, Essapen S, Dhadda AS, Hughes R, Falk S, Raouf S, Rees C, Olesen RK, Propper D, Bridgewater J, Azzabi A, Farrugia D, Webb A, Cunningham D, Hickish T, Weaver A, Gollins S, Wasan HS, Paul J.

Br J Cancer. 2018 Nov;119(11):1332-1338. doi: 10.1038/s41416-018-0319-z. Epub 2018 Nov 13.


Survival with nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil and leucovorin in per-protocol and non-per-protocol populations of NAPOLI-1: Expanded analysis of a global phase 3 trial.

Chen LT, Siveke JT, Wang-Gillam A, Li CP, Bodoky G, Dean AP, Shan YS, Jameson GS, Macarulla T, Lee KH, Cunningham D, Blanc JF, Chiu CF, Schwartsmann G, Braiteh FS, Mamlouk K, Belanger B, de Jong FA, Hubner RA.

Eur J Cancer. 2018 Dec;105:71-78. doi: 10.1016/j.ejca.2018.09.010. Epub 2018 Nov 8.


Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.

Khan K, Rane JK, Cunningham D, Rao S, Watkins D, Starling N, Kalaitzaki E, Forster M, Braconi C, Valeri N, Gerlinger M, Chau I.

Clin Colorectal Cancer. 2019 Mar;18(1):64-71.e1. doi: 10.1016/j.clcc.2018.09.010. Epub 2018 Sep 29.


A Multicenter Phase II Study of AMG 337 in Patients with MET-Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other MET-Amplified Solid Tumors.

Van Cutsem E, Karaszewska B, Kang YK, Chung HC, Shankaran V, Siena S, Go NF, Yang H, Schupp M, Cunningham D.

Clin Cancer Res. 2019 Apr 15;25(8):2414-2423. doi: 10.1158/1078-0432.CCR-18-1337. Epub 2018 Oct 26.


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